Research progress in the application of proteomics technology in brain injury
This study also aims to retrieve all literature on brain injury and proteomics and summarize it. Through searching and screening, the widespread application of proteomics technology in the treatment of traumatic brain injury (TBI) and the use of a large number of TBI biomarkers were discovered. The pathways mediated by some biomarkers and the physiological and pathological mechanisms of occurrence were elucidated. The current classification of brain injury is mainly based on subjective evaluation of clinical symptoms, combined with objective imaging. However, its practical value is often limited when applied to prognosis e...
Source: Biomedical Chromatography : BMC - November 28, 2023 Category: Biomedical Science Authors: Wenhu Liu Zhaomeng Wen Yuwei Shi Juan Bao Shaobo Ma Jin Liang Source Type: research
Identification of the absorbed constituents and metabolites of Huangqi Guizhi Wuwu decoction by ultrahigh-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry
In this study, a rapid, sensitive and selective ultrahigh-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS) method was developed to separate and identify the absorbed components and metabolites of HGWWD in rat plasma after oral administration for the first time. By comparing the retention time, high-resolution mass spectrometry primary and secondary mass spectrometry data of blank plasma and drug-containing plasma, a total of 42 constituents, including 24 prototype compounds and 18 metabolites, were identified or tentatively characterized. The results indicated that...
Source: Biomedical Chromatography : BMC - November 28, 2023 Category: Biomedical Science Authors: Zhuoyu Fan Lele Li Yue Cui Xinmiao Tang Guanghai Shen Bo Feng Jiao Guan Heyun Zhu Source Type: research
Pharmacokinetic study of five components of Fuzheng Huayu tablets in healthy human plasma
This study aimed to examine the pharmacokinetics of FZHY in healthy volunteers following oral administration. Blood samples were collected at designated time intervals after the oral intake of 9.6-g FZHY tablets. A UHPLC-Q/Exactive method was developed to assess the plasma concentrations of five components post-FZHY ingestion. The peak time for all components occurred within 10 min. The peak concentration (Cmax ) values for amygdalin, schisandrin, and schisandrin A ranged from 3.47 to 28.80 ng/mL, with corresponding AUC(0-t) values ranging from 10.63 to 103.20 ng h/mL. For schisandrin B and prunasin, Cmax values were in th...
Source: Biomedical Chromatography : BMC - November 28, 2023 Category: Biomedical Science Authors: Haibo Zhang Yeqing Hu Xueying Liu Rongsheng Li Yifeng Pan Chenghai Liu Tao Yang Source Type: research
An UHPLC-QTOF-MS-based strategy for systematic profiling of chemical constituents and associated in vivo metabolites of a famous traditional Chinese medicine formula, Yinchenhao decoction
In conclusion, this is a systemic study of chemical constituents and in vivo metabolome profiles of YCHD, contributing to the material basis understanding and further mechanism research.PMID:38009806 | DOI:10.1002/bmc.5784 (Source: Biomedical Chromatography : BMC)
Source: Biomedical Chromatography : BMC - November 27, 2023 Category: Biomedical Science Authors: Jing Wang Bingchen Ouyang Rui Cao Yu Xu Source Type: research
An integrated liver, hippocampus and serum metabolomics based on UPLC-Q-TOF-MS revealed the therapeutical mechanism of Ziziphi Spinosae Semen in p-chlorophenylalanine-induced insomnia rats
Biomed Chromatogr. 2023 Nov 27:e5796. doi: 10.1002/bmc.5796. Online ahead of print.ABSTRACTZiziphi Spinosae Semen (ZSS), a well-known herbal medicine for treating insomnia, is popular in not only China but also in Europe, India and Iran. However, its underlying mechanisms remain unclear. In this work, taking the targeted organs of insomnia, the liver and hippocampus, as the objects, a combination metabolomics based on ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) was established to illustrate the abnormality of metabolic characteristics of the liver, h...
Source: Biomedical Chromatography : BMC - November 27, 2023 Category: Biomedical Science Authors: Yingxin Chu Yinjie Zhang Jiaxing Liu Chenhui Du Yan Yan Source Type: research
An UHPLC-QTOF-MS-based strategy for systematic profiling of chemical constituents and associated in vivo metabolites of a famous traditional Chinese medicine formula, Yinchenhao decoction
In conclusion, this is a systemic study of chemical constituents and in vivo metabolome profiles of YCHD, contributing to the material basis understanding and further mechanism research.PMID:38009806 | DOI:10.1002/bmc.5784 (Source: Biomedical Chromatography : BMC)
Source: Biomedical Chromatography : BMC - November 27, 2023 Category: Biomedical Science Authors: Jing Wang Bingchen Ouyang Rui Cao Yu Xu Source Type: research
An integrated liver, hippocampus and serum metabolomics based on UPLC-Q-TOF-MS revealed the therapeutical mechanism of Ziziphi Spinosae Semen in p-chlorophenylalanine-induced insomnia rats
Biomed Chromatogr. 2023 Nov 27:e5796. doi: 10.1002/bmc.5796. Online ahead of print.ABSTRACTZiziphi Spinosae Semen (ZSS), a well-known herbal medicine for treating insomnia, is popular in not only China but also in Europe, India and Iran. However, its underlying mechanisms remain unclear. In this work, taking the targeted organs of insomnia, the liver and hippocampus, as the objects, a combination metabolomics based on ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) was established to illustrate the abnormality of metabolic characteristics of the liver, h...
Source: Biomedical Chromatography : BMC - November 27, 2023 Category: Biomedical Science Authors: Yingxin Chu Yinjie Zhang Jiaxing Liu Chenhui Du Yan Yan Source Type: research
The JAK2 < sup > V617F < /sup > mutation and childhood type1 diabetic nephropathy?
Biomed Chromatogr. 2023 Nov 22:e5786. doi: 10.1002/bmc.5786. Online ahead of print.NO ABSTRACTPMID:37994171 | DOI:10.1002/bmc.5786 (Source: Biomedical Chromatography : BMC)
Source: Biomedical Chromatography : BMC - November 23, 2023 Category: Biomedical Science Authors: Stephen E Langabeer Source Type: research
Development and validation of method for the simultaneous determination of sulfamethazine, trimethoprim and doxycycline in veterinary formulation using high performance liquid chromatography
Biomed Chromatogr. 2023 Nov 22:e5781. doi: 10.1002/bmc.5781. Online ahead of print.ABSTRACTSulfamethazine (SMZ), trimethoprim (TMP) and doxycycline (DOXY) are drugs of choice used in the treatment of intestinal and respiratory infections that affect poultry and swine. The aim of this study was develop and validate a simple, sensitive and fast method for the simultaneous determination of SMZ, TMP and DOXY in veterinary formulations by high-performance liquid chromatography. The separation was performed on a Macherey-Nagel C8 analytical column (4 × 125 mm, 5 μm), with a flow rate of 0.5 ml min-1 and detection at 268, 270 a...
Source: Biomedical Chromatography : BMC - November 23, 2023 Category: Biomedical Science Authors: Patr ícia Espinosa Dos Santos Marcos Serrou do Amaral Te ófilo Fernando Mazon Cardoso N ájla Mohamad Kassab Source Type: research
The JAK2 < sup > V617F < /sup > mutation and childhood type1 diabetic nephropathy?
Biomed Chromatogr. 2023 Nov 22:e5786. doi: 10.1002/bmc.5786. Online ahead of print.NO ABSTRACTPMID:37994171 | DOI:10.1002/bmc.5786 (Source: Biomedical Chromatography : BMC)
Source: Biomedical Chromatography : BMC - November 23, 2023 Category: Biomedical Science Authors: Stephen E Langabeer Source Type: research
Development and validation of method for the simultaneous determination of sulfamethazine, trimethoprim and doxycycline in veterinary formulation using high performance liquid chromatography
Biomed Chromatogr. 2023 Nov 22:e5781. doi: 10.1002/bmc.5781. Online ahead of print.ABSTRACTSulfamethazine (SMZ), trimethoprim (TMP) and doxycycline (DOXY) are drugs of choice used in the treatment of intestinal and respiratory infections that affect poultry and swine. The aim of this study was develop and validate a simple, sensitive and fast method for the simultaneous determination of SMZ, TMP and DOXY in veterinary formulations by high-performance liquid chromatography. The separation was performed on a Macherey-Nagel C8 analytical column (4 × 125 mm, 5 μm), with a flow rate of 0.5 ml min-1 and detection at 268, 270 a...
Source: Biomedical Chromatography : BMC - November 23, 2023 Category: Biomedical Science Authors: Patr ícia Espinosa Dos Santos Marcos Serrou do Amaral Te ófilo Fernando Mazon Cardoso N ájla Mohamad Kassab Source Type: research
The JAK2 < sup > V617F < /sup > mutation and childhood type1 diabetic nephropathy?
Biomed Chromatogr. 2023 Nov 22:e5786. doi: 10.1002/bmc.5786. Online ahead of print.NO ABSTRACTPMID:37994171 | DOI:10.1002/bmc.5786 (Source: Biomedical Chromatography : BMC)
Source: Biomedical Chromatography : BMC - November 23, 2023 Category: Biomedical Science Authors: Stephen E Langabeer Source Type: research
Development and validation of method for the simultaneous determination of sulfamethazine, trimethoprim and doxycycline in veterinary formulation using high performance liquid chromatography
Biomed Chromatogr. 2023 Nov 22:e5781. doi: 10.1002/bmc.5781. Online ahead of print.ABSTRACTSulfamethazine (SMZ), trimethoprim (TMP) and doxycycline (DOXY) are drugs of choice used in the treatment of intestinal and respiratory infections that affect poultry and swine. The aim of this study was develop and validate a simple, sensitive and fast method for the simultaneous determination of SMZ, TMP and DOXY in veterinary formulations by high-performance liquid chromatography. The separation was performed on a Macherey-Nagel C8 analytical column (4 × 125 mm, 5 μm), with a flow rate of 0.5 ml min-1 and detection at 268, 270 a...
Source: Biomedical Chromatography : BMC - November 23, 2023 Category: Biomedical Science Authors: Patr ícia Espinosa Dos Santos Marcos Serrou do Amaral Te ófilo Fernando Mazon Cardoso N ájla Mohamad Kassab Source Type: research
The JAK2 < sup > V617F < /sup > mutation and childhood type1 diabetic nephropathy?
Biomed Chromatogr. 2023 Nov 22:e5786. doi: 10.1002/bmc.5786. Online ahead of print.NO ABSTRACTPMID:37994171 | DOI:10.1002/bmc.5786 (Source: Biomedical Chromatography : BMC)
Source: Biomedical Chromatography : BMC - November 23, 2023 Category: Biomedical Science Authors: Stephen E Langabeer Source Type: research
Development and validation of method for the simultaneous determination of sulfamethazine, trimethoprim and doxycycline in veterinary formulation using high performance liquid chromatography
Biomed Chromatogr. 2023 Nov 22:e5781. doi: 10.1002/bmc.5781. Online ahead of print.ABSTRACTSulfamethazine (SMZ), trimethoprim (TMP) and doxycycline (DOXY) are drugs of choice used in the treatment of intestinal and respiratory infections that affect poultry and swine. The aim of this study was develop and validate a simple, sensitive and fast method for the simultaneous determination of SMZ, TMP and DOXY in veterinary formulations by high-performance liquid chromatography. The separation was performed on a Macherey-Nagel C8 analytical column (4 × 125 mm, 5 μm), with a flow rate of 0.5 ml min-1 and detection at 268, 270 a...
Source: Biomedical Chromatography : BMC - November 23, 2023 Category: Biomedical Science Authors: Patr ícia Espinosa Dos Santos Marcos Serrou do Amaral Te ófilo Fernando Mazon Cardoso N ájla Mohamad Kassab Source Type: research
