Unique biomedical application of fluorescence derivatization based on palladium-catalyzed coupling reactions for HPLC analysis of pharmaceuticals and biomolecules
Biomed Chromatogr. 2024 Mar 20:e5857. doi: 10.1002/bmc.5857. Online ahead of print.ABSTRACTPalladium-catalyzed coupling reactions are versatile and powerful tools for the construction of carbon-carbon bonds in organic synthesis. Although these reactions have favorable features that proceed selectively in mild reaction conditions using aqueous organic solvents, no attention has been given to their application in the field of biomedical analysis. Therefore, we focused on these reactions and evaluated the scope and limitations of their analytical performance. In this review, we describe the pros and cons and future trends of ...
Source: Biomedical Chromatography : BMC - March 21, 2024 Category: Biomedical Science Authors: Mahmoud El-Maghrabey Naoya Kishikawa Naotaka Kuroda Source Type: research
UPLC-Q-TOF/MS analysis of chemical components of single decoction and combined decoction of Qige decoction reveals the differences between various preparation processes
Biomed Chromatogr. 2024 Mar 21:e5865. doi: 10.1002/bmc.5865. Online ahead of print.ABSTRACTThe aim of this work was to explore the differences between various pharmaceutical processes in combined solutions of a single decoction (QGHBY) and a combined decoction (QGHJY) of Qi-Ge decoction from the perspective of chemical composition changes, so as to further guide the clinical application of drugs. A combined solution of a single decoction and a combined decoction of Astragali Radix, Puerariae Lobatae Radix and Citri Reticulatae Chachiensis Pericarpium was prepared with the same technological parameters. The chemical compone...
Source: Biomedical Chromatography : BMC - March 21, 2024 Category: Biomedical Science Authors: Kai-Xin Guo Xiao-Qing Yu Hui Tang Hao-Yang Wei Yan-Fang Li Si-Min Fan Ke-Er Huang Xue-Hong Ke Source Type: research
Unique biomedical application of fluorescence derivatization based on palladium-catalyzed coupling reactions for HPLC analysis of pharmaceuticals and biomolecules
Biomed Chromatogr. 2024 Mar 20:e5857. doi: 10.1002/bmc.5857. Online ahead of print.ABSTRACTPalladium-catalyzed coupling reactions are versatile and powerful tools for the construction of carbon-carbon bonds in organic synthesis. Although these reactions have favorable features that proceed selectively in mild reaction conditions using aqueous organic solvents, no attention has been given to their application in the field of biomedical analysis. Therefore, we focused on these reactions and evaluated the scope and limitations of their analytical performance. In this review, we describe the pros and cons and future trends of ...
Source: Biomedical Chromatography : BMC - March 21, 2024 Category: Biomedical Science Authors: Mahmoud El-Maghrabey Naoya Kishikawa Naotaka Kuroda Source Type: research
UPLC-Q-TOF/MS analysis of chemical components of single decoction and combined decoction of Qige decoction reveals the differences between various preparation processes
Biomed Chromatogr. 2024 Mar 21:e5865. doi: 10.1002/bmc.5865. Online ahead of print.ABSTRACTThe aim of this work was to explore the differences between various pharmaceutical processes in combined solutions of a single decoction (QGHBY) and a combined decoction (QGHJY) of Qi-Ge decoction from the perspective of chemical composition changes, so as to further guide the clinical application of drugs. A combined solution of a single decoction and a combined decoction of Astragali Radix, Puerariae Lobatae Radix and Citri Reticulatae Chachiensis Pericarpium was prepared with the same technological parameters. The chemical compone...
Source: Biomedical Chromatography : BMC - March 21, 2024 Category: Biomedical Science Authors: Kai-Xin Guo Xiao-Qing Yu Hui Tang Hao-Yang Wei Yan-Fang Li Si-Min Fan Ke-Er Huang Xue-Hong Ke Source Type: research
Unique biomedical application of fluorescence derivatization based on palladium-catalyzed coupling reactions for HPLC analysis of pharmaceuticals and biomolecules
Biomed Chromatogr. 2024 Mar 20:e5857. doi: 10.1002/bmc.5857. Online ahead of print.ABSTRACTPalladium-catalyzed coupling reactions are versatile and powerful tools for the construction of carbon-carbon bonds in organic synthesis. Although these reactions have favorable features that proceed selectively in mild reaction conditions using aqueous organic solvents, no attention has been given to their application in the field of biomedical analysis. Therefore, we focused on these reactions and evaluated the scope and limitations of their analytical performance. In this review, we describe the pros and cons and future trends of ...
Source: Biomedical Chromatography : BMC - March 21, 2024 Category: Biomedical Science Authors: Mahmoud El-Maghrabey Naoya Kishikawa Naotaka Kuroda Source Type: research
UPLC-Q-TOF/MS analysis of chemical components of single decoction and combined decoction of Qige decoction reveals the differences between various preparation processes
Biomed Chromatogr. 2024 Mar 21:e5865. doi: 10.1002/bmc.5865. Online ahead of print.ABSTRACTThe aim of this work was to explore the differences between various pharmaceutical processes in combined solutions of a single decoction (QGHBY) and a combined decoction (QGHJY) of Qi-Ge decoction from the perspective of chemical composition changes, so as to further guide the clinical application of drugs. A combined solution of a single decoction and a combined decoction of Astragali Radix, Puerariae Lobatae Radix and Citri Reticulatae Chachiensis Pericarpium was prepared with the same technological parameters. The chemical compone...
Source: Biomedical Chromatography : BMC - March 21, 2024 Category: Biomedical Science Authors: Kai-Xin Guo Xiao-Qing Yu Hui Tang Hao-Yang Wei Yan-Fang Li Si-Min Fan Ke-Er Huang Xue-Hong Ke Source Type: research
Unique biomedical application of fluorescence derivatization based on palladium-catalyzed coupling reactions for HPLC analysis of pharmaceuticals and biomolecules
Biomed Chromatogr. 2024 Mar 20:e5857. doi: 10.1002/bmc.5857. Online ahead of print.ABSTRACTPalladium-catalyzed coupling reactions are versatile and powerful tools for the construction of carbon-carbon bonds in organic synthesis. Although these reactions have favorable features that proceed selectively in mild reaction conditions using aqueous organic solvents, no attention has been given to their application in the field of biomedical analysis. Therefore, we focused on these reactions and evaluated the scope and limitations of their analytical performance. In this review, we describe the pros and cons and future trends of ...
Source: Biomedical Chromatography : BMC - March 21, 2024 Category: Biomedical Science Authors: Mahmoud El-Maghrabey Naoya Kishikawa Naotaka Kuroda Source Type: research
Spectrum-effect relationship between ultra-performance liquid chromatography fingerprints and melanogenic effect of Vernonia anthelmintica effective part
Biomed Chromatogr. 2024 Mar 20:e5863. doi: 10.1002/bmc.5863. Online ahead of print.ABSTRACTThe fingerprint of Vernonia anthelmintica effective part (VAEP) from 15 different producing areas was established, followed by cluster analysis and principal component analysis. The relationship between the fingerprint and the melanogenesis-promoting activity of VAEP was then analyzed using the grey correlation degree and the orthogonal partial least square method. The characteristic peaks reflecting the pharmacodynamic effect of VAEP were identified as vernodalin, 3,5-O-dicaffeoyl quinic acid (3,5-diCQA), and butin. Based on the dis...
Source: Biomedical Chromatography : BMC - March 20, 2024 Category: Biomedical Science Authors: Xiaoling Ma Ablajan Turak Rahima Abdulla Maitinuer Maiwulanjiang Qingling Ma Tao Wu Haji Akber Aisa Source Type: research
Chemical characterization, multivariate analysis and comparison of biological activities of different parts of Fraxinus mandshurica
This study establishes an identification and evaluation method applicable to phytochemistry of different origins, which is a guideline for quality control, origin evaluation and clinical application of traditional medicinal plants. This is also an unprecedented study on the identification of the chemical composition of different parts of F. mandshurica, characteristic compounds and the inhibition of enzyme activity of extracts from different parts.PMID:38501361 | DOI:10.1002/bmc.5861 (Source: Biomedical Chromatography : BMC)
Source: Biomedical Chromatography : BMC - March 19, 2024 Category: Biomedical Science Authors: Jianjin Guo Shaojing Liu Yan Guo Lu Bai Chi-Tang Ho Naisheng Bai Source Type: research
Serum metabolomics analysis combined with network pharmacology reveals possible mechanisms of postoperative cognitive dysfunction in the treatment of Mongolian medicine Eerdun Wurile basic formula
This study analyzed the endogenous metabolites and metabolic pathways in the serum of Sprague-Dawley (SD) rats gavaged with the Eerdun Wurile basic formula (EWB) using metabolomics methods and network pharmacology to explore the possible mechanism of action of the EWB in improving postoperative cognitive dysfunction (POCD). SD rats were divided into the basic formula group, which received the EWB, and the control group, which received equal amounts of distilled water. The blood was collected from the abdominal aorta and analyzed for metabolite profiles using ultra-high-performance liquid chromatography-mass spectrometry (U...
Source: Biomedical Chromatography : BMC - March 19, 2024 Category: Biomedical Science Authors: Yan Li Jiaxin Wang Yun Qiao Huiru Li Zhe Wang Mengke Tian Limuge Che Yiri Du Source Type: research
A novel strategy for the quality control of carbonized Typhae pollen using colorimeter, liquid chromatography-mass spectrometry, and efficacy evaluation coupled with multivariate statistical analysis
In this study, a novel quality control strategy was proposed, aiming to establish a multivariate specification for the processing step by exploring the correlation between colors, chemical components, and hemostatic effects of the carbonized Typhae pollen (CTP) using multivariate statistical analysis. The CTP samples were stir-fried at different durations. Afterward, the colorimeter and LC-MS techniques were applied to characterize the CTP samples, followed by the determination of bleeding time and clotting time using mice to evaluate their hemostatic effect. Then, principal component analysis, hierarchical cluster analysi...
Source: Biomedical Chromatography : BMC - March 15, 2024 Category: Biomedical Science Authors: Li Jiaqi Tang Min Zhong Yongqi Li Xiaolong Ge Yuewei Wang Shumei Liang Shengwang Meng Jiang Sun Fei Source Type: research
Integrated network pharmacology, molecular docking, and lipidomics to reveal the regulatory effect of Qingxuan Zhike granules on lipid metabolism in lipopolysaccharide-induced acute lung injury
This study enhances our understanding of the active compounds and targets of QXZKG, as well as the potential of lipid metabolism in the treatment of ALI.PMID:38486466 | DOI:10.1002/bmc.5853 (Source: Biomedical Chromatography : BMC)
Source: Biomedical Chromatography : BMC - March 15, 2024 Category: Biomedical Science Authors: Hui Chen Jiabin Chen Lu Feng Hua Shao Yang Zhou Jinjun Shan Lili Lin Jin Ye Shouchuan Wang Source Type: research
A novel strategy for the quality control of carbonized Typhae pollen using colorimeter, liquid chromatography-mass spectrometry, and efficacy evaluation coupled with multivariate statistical analysis
In this study, a novel quality control strategy was proposed, aiming to establish a multivariate specification for the processing step by exploring the correlation between colors, chemical components, and hemostatic effects of the carbonized Typhae pollen (CTP) using multivariate statistical analysis. The CTP samples were stir-fried at different durations. Afterward, the colorimeter and LC-MS techniques were applied to characterize the CTP samples, followed by the determination of bleeding time and clotting time using mice to evaluate their hemostatic effect. Then, principal component analysis, hierarchical cluster analysi...
Source: Biomedical Chromatography : BMC - March 15, 2024 Category: Biomedical Science Authors: Li Jiaqi Tang Min Zhong Yongqi Li Xiaolong Ge Yuewei Wang Shumei Liang Shengwang Meng Jiang Sun Fei Source Type: research
Integrated network pharmacology, molecular docking, and lipidomics to reveal the regulatory effect of Qingxuan Zhike granules on lipid metabolism in lipopolysaccharide-induced acute lung injury
This study enhances our understanding of the active compounds and targets of QXZKG, as well as the potential of lipid metabolism in the treatment of ALI.PMID:38486466 | DOI:10.1002/bmc.5853 (Source: Biomedical Chromatography : BMC)
Source: Biomedical Chromatography : BMC - March 15, 2024 Category: Biomedical Science Authors: Hui Chen Jiabin Chen Lu Feng Hua Shao Yang Zhou Jinjun Shan Lili Lin Jin Ye Shouchuan Wang Source Type: research
A novel strategy for the quality control of carbonized Typhae pollen using colorimeter, liquid chromatography-mass spectrometry, and efficacy evaluation coupled with multivariate statistical analysis
In this study, a novel quality control strategy was proposed, aiming to establish a multivariate specification for the processing step by exploring the correlation between colors, chemical components, and hemostatic effects of the carbonized Typhae pollen (CTP) using multivariate statistical analysis. The CTP samples were stir-fried at different durations. Afterward, the colorimeter and LC-MS techniques were applied to characterize the CTP samples, followed by the determination of bleeding time and clotting time using mice to evaluate their hemostatic effect. Then, principal component analysis, hierarchical cluster analysi...
Source: Biomedical Chromatography : BMC - March 15, 2024 Category: Biomedical Science Authors: Li Jiaqi Tang Min Zhong Yongqi Li Xiaolong Ge Yuewei Wang Shumei Liang Shengwang Meng Jiang Sun Fei Source Type: research
