GhCOL2 Positively Regulates Flowering by Activating the Transcription of GhHD3A in Upland Cotton (Gossypium hirsutum L.)
In this study, a yeast one-hybrid and dual-LUC expression assays were used to elucidate the molecular mechanism through which GhCOL2 regulates the transcription of GhHD3A. RT-qPCR was used to examine the expression of GhCOL2 and GhHD3A. Our findings reveal that GhCOL2 directly binds to CCACA cis-elements and atypical CORE (TGTGTATG) cis-elements in the promoter regions of HEADING DATE 3 A (HD3A), thereby activating GhHD3A transcription. Notably, GhCOL2 and GhHD3A exhibited high expression levels in the adult stage and low levels in the juvenile stage. Interestingly, the expression of GhCOL2 and GhHD3A varied significant be...
Source: Biochemical Genetics - March 4, 2024 Category: Genetics & Stem Cells Authors: Xiaoyu Yin Ye Liu Hang Zhao Qi Su Juan Zong Xueying Zhu Ying Bao Source Type: research
The Combinatorial Effect of Ad-IL-24 and Ad-HSV-tk/GCV on Tumor Size, Autophagy, and UPR Mechanisms in Multiple Myeloma Mouse Model
This study aimed to investigate the effects of combination of Adenovector-carrying interleukin-24 and herpes simplex virus 1 thymidine kinase/ganciclovir on tumor growth, autophagy, and unfolded protein response mechanisms in mouse model of multiple myeloma. Six groups of mice, including Ad-HSV-tk/GCV, Ad-IL-24, Ad-HSV-tk/IL-24, Ad-GFP, and positive and negative controls, were investigated, and each group was injected every 72 h. The tumor size was measured several times. The expression of LC3B evaluated through western blotting and ASK-1, CHOP, Caspase-3, and ATF-6 genes in the UPR and apoptosis pathways were also analyze...
Source: Biochemical Genetics - March 4, 2024 Category: Genetics & Stem Cells Authors: Shima Poorghobadi Seyed Younes Hosseini Seyed Mehdi Sadat Asghar Abdoli Shiva Irani Kazem Baesi Source Type: research
Associations Between BLG, CSN3, DGAT1, GH, PIT1, and PRL Gene Polymorphisms and Milk Production Traits in Holstein Dairy Cows: A Meta-Analysis
Biochem Genet. 2024 Mar 4. doi: 10.1007/s10528-024-10706-8. Online ahead of print.ABSTRACTThe current meta-analysis was employed to combine the results of multiple studies into a single estimate related to B-LG, CSN3, DGAT1, PRL, GH, and PIT1 gene polymorphisms and their effects on milk production traits. The purpose of this meta-analysis was to investigate associations between B-LG, CSN3, DGAT1, GH, PIT1, and PRLgene polymorphisms with milk production traits in Holstein dairy cows. An extensive search was done from 2002 to 2022 year. Statistical analyses were performed by using Stata 11.2 software. Genetic models viz codo...
Source: Biochemical Genetics - March 4, 2024 Category: Genetics & Stem Cells Authors: Memis Ozdemir Zekrullah Motmain Kubra Ekinci Esranur Sayg ılı Source Type: research
Comprehensive Analyses of PANoptosome with Potential Implications in Cancer Prognosis and Immunotherapy
In conclusion, our study suggests that targeting PANoptosome components and modulating PANoptosis may hold tremendous therapeutic potential in the context of cancer.PMID:38436818 | DOI:10.1007/s10528-024-10687-8 (Source: Biochemical Genetics)
Source: Biochemical Genetics - March 4, 2024 Category: Genetics & Stem Cells Authors: Yonghua Cai Heng Xiao Qixiong Zhou Jie Lin Xianqiu Liang Wei Xu Yongfu Cao Xian Zhang Hai Wang Source Type: research
Curcumol Attenuates Portal Hypertension and Collateral Shunting Via Inhibition of Extrahepatic Angiogenesis in Cirrhotic Rats
Biochem Genet. 2024 Mar 4. doi: 10.1007/s10528-024-10684-x. Online ahead of print.ABSTRACTLiver cirrhosis can cause disturbances in blood circulation in the liver, resulting in impaired portal blood flow and ultimately increasing portal venous pressure. Portal hypertension induces portal-systemic collateral formation and fatal complications. Extrahepatic angiogenesis plays a crucial role in the development of portal hypertension. Curcumol is a sesquiterpenoid derived from the rhizome of Curcumae Rhizoma and has been confirmed to alleviate liver fibrosis by inhibiting angiogenesis. Therefore, our study was designed to explo...
Source: Biochemical Genetics - March 4, 2024 Category: Genetics & Stem Cells Authors: Xinyuan Wang Juan Li Jiao Nong Xin Deng Yiping Chen Peibin Wu Xiabing Huang Source Type: research
D-Glucosamine is a Potential Urease Inhibitor from Middle Eastern Medicinal Plants for Combatting Helicobacter Pylori Infections; a Molecular Docking and Simulation Approach
In conclusion, this study provides valuable insights into the potential development of D-glucosamine as a novel urease inhibitor. This promising compound holds the potential to serve as an effective drug for combating H. pylori infections in the near future.PMID:38430447 | DOI:10.1007/s10528-024-10709-5 (Source: Biochemical Genetics)
Source: Biochemical Genetics - March 2, 2024 Category: Genetics & Stem Cells Authors: Mohammed Baqur S Al-Shuhaib Hayder O Hashim Jafar M B Al-Shuhaib Source Type: research
High Expression Level of TRIP6 is Correlated with Poor Prognosis in Colorectal Cancer and Promotes Tumor Cell Proliferation and Migration
Biochem Genet. 2024 Mar 2. doi: 10.1007/s10528-024-10711-x. Online ahead of print.ABSTRACTGlobally, colorectal cancer (CRC) is one of the leading causes of health problems. More reliable molecular biomarkers for early diagnosis in CRC patients are needed. A crucial role for thyroid hormone receptor interacting protein 6 (TRIP6) is played in tumorigenesis and tumor growth. Our study aims to determine the diagnostic and prognostic roles of TRIP6 at CRC. TRIP6 gene expression levels were analyzed in this study from public databases. The relationship between TRIP6 expression and clinicopathological characteristics was explored...
Source: Biochemical Genetics - March 2, 2024 Category: Genetics & Stem Cells Authors: Huijuan Ren Ziwei Su Jian Yang Jialing Cao Yihan Zhang Kangliang Sheng Kun Guo Yongzhong Wang Source Type: research
D-Glucosamine is a Potential Urease Inhibitor from Middle Eastern Medicinal Plants for Combatting Helicobacter Pylori Infections; a Molecular Docking and Simulation Approach
In conclusion, this study provides valuable insights into the potential development of D-glucosamine as a novel urease inhibitor. This promising compound holds the potential to serve as an effective drug for combating H. pylori infections in the near future.PMID:38430447 | DOI:10.1007/s10528-024-10709-5 (Source: Biochemical Genetics)
Source: Biochemical Genetics - March 2, 2024 Category: Genetics & Stem Cells Authors: Mohammed Baqur S Al-Shuhaib Hayder O Hashim Jafar M B Al-Shuhaib Source Type: research
High Expression Level of TRIP6 is Correlated with Poor Prognosis in Colorectal Cancer and Promotes Tumor Cell Proliferation and Migration
Biochem Genet. 2024 Mar 2. doi: 10.1007/s10528-024-10711-x. Online ahead of print.ABSTRACTGlobally, colorectal cancer (CRC) is one of the leading causes of health problems. More reliable molecular biomarkers for early diagnosis in CRC patients are needed. A crucial role for thyroid hormone receptor interacting protein 6 (TRIP6) is played in tumorigenesis and tumor growth. Our study aims to determine the diagnostic and prognostic roles of TRIP6 at CRC. TRIP6 gene expression levels were analyzed in this study from public databases. The relationship between TRIP6 expression and clinicopathological characteristics was explored...
Source: Biochemical Genetics - March 2, 2024 Category: Genetics & Stem Cells Authors: Huijuan Ren Ziwei Su Jian Yang Jialing Cao Yihan Zhang Kangliang Sheng Kun Guo Yongzhong Wang Source Type: research
D-Glucosamine is a Potential Urease Inhibitor from Middle Eastern Medicinal Plants for Combatting Helicobacter Pylori Infections; a Molecular Docking and Simulation Approach
In conclusion, this study provides valuable insights into the potential development of D-glucosamine as a novel urease inhibitor. This promising compound holds the potential to serve as an effective drug for combating H. pylori infections in the near future.PMID:38430447 | DOI:10.1007/s10528-024-10709-5 (Source: Biochemical Genetics)
Source: Biochemical Genetics - March 2, 2024 Category: Genetics & Stem Cells Authors: Mohammed Baqur S Al-Shuhaib Hayder O Hashim Jafar M B Al-Shuhaib Source Type: research
High Expression Level of TRIP6 is Correlated with Poor Prognosis in Colorectal Cancer and Promotes Tumor Cell Proliferation and Migration
Biochem Genet. 2024 Mar 2. doi: 10.1007/s10528-024-10711-x. Online ahead of print.ABSTRACTGlobally, colorectal cancer (CRC) is one of the leading causes of health problems. More reliable molecular biomarkers for early diagnosis in CRC patients are needed. A crucial role for thyroid hormone receptor interacting protein 6 (TRIP6) is played in tumorigenesis and tumor growth. Our study aims to determine the diagnostic and prognostic roles of TRIP6 at CRC. TRIP6 gene expression levels were analyzed in this study from public databases. The relationship between TRIP6 expression and clinicopathological characteristics was explored...
Source: Biochemical Genetics - March 2, 2024 Category: Genetics & Stem Cells Authors: Huijuan Ren Ziwei Su Jian Yang Jialing Cao Yihan Zhang Kangliang Sheng Kun Guo Yongzhong Wang Source Type: research
Molecular Prediction and Correlation of the Structure and Function of Universal Stress Protein A (UspA) from Salmonella Typhimurium
Biochem Genet. 2024 Mar 1. doi: 10.1007/s10528-024-10699-4. Online ahead of print.ABSTRACTSalmonella Typhimurium (ST) is a zoonotic pathogen that can cause gastroenteritis in humans when they consume contaminated food or water. When exposed to various stressors, both from living organisms (biotic) and the environment (abiotic), Salmonella Typhimurium produces Universal Stress Proteins (USPs). These proteins are gaining recognition for their crucial role in bacterial stress resistance and the ability to enter a prolonged state of growth arrest. Additionally, USPs exhibit diverse structures due to the fusion of the USP domai...
Source: Biochemical Genetics - March 1, 2024 Category: Genetics & Stem Cells Authors: Bilkees Nabi Manoj Kumawat Pramod Kumar Yadav Neeraj Ahlawat Manzoor Ahmad Mir Vivek Kumar Manoj Kumar Sushma Ahlawat Source Type: research
Solamargine Induces Hepatocellular Carcinoma Cell Apoptosis and Ferroptosis via Regulating STAT1/MTCH1 Axis
CONCLUSION: SM promoted HCC cell apoptosis and ferroptosis via the STAT1/MTCH1 axis.PMID:38429602 | DOI:10.1007/s10528-024-10749-x (Source: Biochemical Genetics)
Source: Biochemical Genetics - March 1, 2024 Category: Genetics & Stem Cells Authors: Limei Zhang Jinfu Wang Weiping Deng Fenfang Gui Fanzhou Peng Qian Zhu Source Type: research
RBM15 Knockdown Impairs the Malignancy of Cervical Cancer by Mediating m6A Modification of Decorin
Biochem Genet. 2024 Mar 1. doi: 10.1007/s10528-024-10757-x. Online ahead of print.ABSTRACTCervical cancer (CC) is considered to be the most prevalent female malignancies across the globe and a prime cause of mortality among women. RNA-binding motif protein 15 (RBM15) has been elucidated to participate in tumorigenesis in various cancers by regulating RNA N6-methyladenosine (m6A) methylation. However, its significance and detailed molecular mechanisms remain uncertain in CC. Using CGA database and qRT-PCR, the RBM15 expression was found to be elevated in CC tissues. After performing EdU, wound healing, Transwell migration, ...
Source: Biochemical Genetics - March 1, 2024 Category: Genetics & Stem Cells Authors: Huimin Wang Chun Li Qiong Wei Enjing Zhang Yi Yang Linlin Sha Dan Wang Source Type: research
Identification and Validation of Lipid Metabolism Gene FASN-Associated miRNA in Wilms Tumor
This study intends to explore the role of miRNA in the lipid metabolism and development of Wilms tumor (WT) by detecting and analyzing the differences in the expression profiles of miRNAs between the tumor and adjacent normal tissue. Gene detection was performed in tumor tissues and adjacent normal tissues of three cases of WT to screen differentially expressed miRNAs (DEMs). According to our previous research, FASN, which participates in the lipid metabolism pathway, may be a target of WT. The starBase database was used to predict FASN-targeted miRNAs. The above two groups of miRNAs were intersected to obtain FASN-targete...
Source: Biochemical Genetics - February 28, 2024 Category: Genetics & Stem Cells Authors: Xiaoqing Wang Xiao Li Lin Tan Fengjun Zhang Jing Zhang Xu Zhao Yongfei Zhang Guoqiang Du Wei Liu Source Type: research
