Prognostic characteristics of T-cell mediated cell killing-related genes in lung adenocarcinoma
Autoimmunity. 2023 Dec;56(1):2250097. doi: 10.1080/08916934.2023.2250097.ABSTRACTConstituted by various heterogeneous cells, the tumor microenvironment (TME) is capable of promoting tumor proliferation, invasion, and metastasis through extensive crosstalk. The pivotal factor influencing the survival time of patients and their response to immunotherapy lies in the intratumoral immune environment. We obtained 112 differential genes related to T cell-mediated tumor killing in LUAD by employing bioinformatics analysis on the basis of the TCGA and TISIDB databases. Then the 6-gene prognostic risk score model (CA9, OIP5, TIMP1, ...
Source: Autoimmunity - August 25, 2023 Category: Allergy & Immunology Authors: Lei Bi Cheng Ai Hong Zhang Zhengyu Chen Yiping Deng Jing Xiong Zhongzhu Lv Source Type: research
Gbp3 is associated with the progression of lupus nephritis by regulating cell proliferation, inflammation and pyroptosis
Autoimmunity. 2023 Dec;56(1):2250095. doi: 10.1080/08916934.2023.2250095.ABSTRACTLupus nephritis (LN) is a major cause death in patients with systemic lupus erythematosus. We aimed to find the differentially expressed genes (DEGs) in LN and confirm the regulatory mechanism on LN. The mouse model of LN was constructed by subcutaneous injection of pristane. RNA-seq screened 392 up-regulated and 447 down-regulated DEGs in LN mouse model, and KEGG analysis found that the top 20 DEGs were enriched in arachidonic acid metabolism, tryptophan metabolism, etc. The hub genes, Kynu, Spidr, Gbp3, Cbr1, Cyp4b1, and Cndp2 were identifie...
Source: Autoimmunity - August 25, 2023 Category: Allergy & Immunology Authors: Zhongfeng Zhang Wenyu Song Run Yan Source Type: research
Systemic lupus erythematosus is associated with the risk of coeliac disease: a Mendelian randomisation study
Autoimmunity. 2023 Dec;56(1):2250103. doi: 10.1080/08916934.2023.2250103.ABSTRACTAs an autoimmune disease, systemic lupus erythematosus (SLE) can affect multiple organs and systems. Whether SLE can increase the risk of coeliac disease (CeD) was not evaluated until now. We performed a two-sample Mendelian randomisation study to evaluate the relationship between SLE and CeD, and found that SLE can significantly increase the risk of CeD, suggesting the association between SLE and abnormal intestinal immune microenvironment.PMID:37621181 | DOI:10.1080/08916934.2023.2250103 (Source: Autoimmunity)
Source: Autoimmunity - August 25, 2023 Category: Allergy & Immunology Authors: Qiaolin Wang Sujie Jia Qianjin Lu Ming Zhao Source Type: research
Prognostic characteristics of T-cell mediated cell killing-related genes in lung adenocarcinoma
Autoimmunity. 2023 Dec;56(1):2250097. doi: 10.1080/08916934.2023.2250097.ABSTRACTConstituted by various heterogeneous cells, the tumor microenvironment (TME) is capable of promoting tumor proliferation, invasion, and metastasis through extensive crosstalk. The pivotal factor influencing the survival time of patients and their response to immunotherapy lies in the intratumoral immune environment. We obtained 112 differential genes related to T cell-mediated tumor killing in LUAD by employing bioinformatics analysis on the basis of the TCGA and TISIDB databases. Then the 6-gene prognostic risk score model (CA9, OIP5, TIMP1, ...
Source: Autoimmunity - August 25, 2023 Category: Allergy & Immunology Authors: Lei Bi Cheng Ai Hong Zhang Zhengyu Chen Yiping Deng Jing Xiong Zhongzhu Lv Source Type: research
Proanthocyanidin A2 attenuates the activation of hepatic stellate cells by activating the PPAR- γ signalling pathway
In conclusion, PA2 inhibited TGF-β1-induced activation of HSCs by activating the PPAR-γ/Smad pathway. The findings suggested that PA2 may be an effective treatment for liver fibrosis.PMID:37615088 | DOI:10.1080/08916934.2023.2250101 (Source: Autoimmunity)
Source: Autoimmunity - August 24, 2023 Category: Allergy & Immunology Authors: Yacong Xiao Xiujuan Li Li Wang Mingyue Hu Youlin Liu Source Type: research
High-throughput autoantibody profiling of different stages of Schistosomiasis japonica
Autoimmunity. 2023 Dec;56(1):2250102. doi: 10.1080/08916934.2023.2250102.ABSTRACTInfection by the Schistosoma japonicum can result in acute, chronic and late-stage manifestations. The latter often presents with severe organ failures and premature death. Importantly, infection can also produce autoimmune phenomena reflected by the development of autoantibodies. We wished to explore and profile the presence of autoantibodies in sera of patients with different stages of S. japonicum infection with the added aim of providing a reference assisting diagnosis. Blood samples from 55 patients with chronic and 20 patients with late-...
Source: Autoimmunity - August 21, 2023 Category: Allergy & Immunology Authors: Xiaorong Zhou Xi Wang Jing Xu Qi Tang Robert Bergquist Leming Shi Zhiqiang Qin Source Type: research
Identification of prognostic biomarkers of breast cancer based on the immune-related gene module
In this study, cell immune-related gene modules in TCGA-BRCA were successfully excavated, and a five-gene (TNFRSF14, NFKBIA, DLG3, IRF2, and CYP27A1) prognostic model was established. The prognostic model could effectively forecast the prognosis and survival rate of BC patients. The result showed that human leukocyte antigen-related proteins and macrophage M2 scores were remarkably highly expressed in the high-risk group, whereas CD8+ T cells, natural killer cells, M1, and other anti-tumor cells were lowly expressed. The model could be used as an independent prognostic factor to predict the prognosis of BC patients. The re...
Source: Autoimmunity - August 16, 2023 Category: Allergy & Immunology Authors: Ruijuan Wang Huanhong Zeng Xueming Xiao Junjie Zheng Naizhuo Ke Wenjun Xie Qiang Lin Hui Zhang Source Type: research
DNA polymerase ζ suppresses the radiosensitivity of glioma cells by regulating the PI3K/AKT/mTOR pathway
Autoimmunity. 2023 Dec;56(1):2234101. doi: 10.1080/08916934.2023.2234101.ABSTRACTGlioblastoma is the most common glioma with high mortality and poor prognosis. Radiation resistance is one of the large challenges in the treatment of glioma. The study aimed to identify whether DNA polymerase ζ affects glioma cell radiosensitivity. The mRNA and protein levels of REV3L and REV7 were examined using quantitative real-time PCR and western blot. After REV3L and REV7 knockdown in a GBM cell line (A172), we assessed cell viability, colonies, apoptosis, and immune escape. The underlying mechanisms were evaluated using western blot a...
Source: Autoimmunity - July 14, 2023 Category: Allergy & Immunology Authors: Jiqiang Ding Zhisheng Chen Weilong Ding Yongsheng Xiang Junbao Yang Source Type: research
