MiR-526b-3p enhances sensitivity of head and neck squamous cell carcinoma cells to radiotherapy via suppressing exosomal LAMP3-mediated autophagy
Autoimmunity. 2023 Dec;56(1):2259125. doi: 10.1080/08916934.2023.2259125. Epub 2023 Sep 23.ABSTRACTLysosomal associated membrane protein 3 (LAMP3) has been reported to be a tumour promoter in multiple cancer types by modulating tumour cell autophagy. However, the potential mechanism of LAMP3 in radio-resistance of head and neck squamous cell carcinoma (HNSCC) remains unknown. Therefore, our current study aims to detect the impacts of LAMP3 on the resistance of HNSCC cells to radiotherapy and meanwhile explore its functional mechanism. Through RT-Qpcr examination, LAMP3 expression was identified to be expressed at a signifi...
Source: Autoimmunity - September 23, 2023 Category: Allergy & Immunology Authors: Huixiang Lu Junnian Zhou Xiaojun Li Xiaoqin Han Shuping Ma Chunlan Feng Source Type: research
Oncolytic virus oHSV2 combined with PD-1/PD-L1 inhibitors exert antitumor activity by mediating CD4 + T and CD8 + T cell infiltration in the lymphoma tumor microenvironment
Autoimmunity. 2023 Dec;56(1):2259126. doi: 10.1080/08916934.2023.2259126. Epub 2023 Sep 22.ABSTRACTA novel therapeutic regimen showed that the oncolytic type II herpes simplex virus (oHSV2) was able to prevent colorectal cancer growth, recurrence, and metastasis. However, no study has yet explored whether oHSV2 has an impact on the development of diffuse large B-cell lymphoma (DLBCL). We chose the clinical chemotherapeutic drug doxorubicin (DOX) as a positive control to evaluate the effect of oHSV2 infection on the apoptotic, invasive, and proliferative capacity of DLBCL cells. We next further explored the therapeutic effi...
Source: Autoimmunity - September 22, 2023 Category: Allergy & Immunology Authors: Jingbo Zhang Yiwei Guo Huiying Fang Xiuchen Guo Lina Zhao Source Type: research
Circ_0007535 upregulates TGFBR1 to promote pulmonary fibrosis in TGF- β1-treated lung fibroblasts via sequestering miR-18a-5p
This study evidenced that circ_0007535 facilitated TGF-β1-induced pulmonary fibrosis by depending on the absorption of miR-18a-5p to upregulate TGFBR1.PMID:37724521 | DOI:10.1080/08916934.2023.2259128 (Source: Autoimmunity)
Source: Autoimmunity - September 19, 2023 Category: Allergy & Immunology Authors: Ming Shen Xinyi Wang Xiaofeng Chang Zhun Li Na Jiang Zhuoyue Han Xin Liu Source Type: research
SARS-CoV-2 spike-specific regulatory T cells (Treg) expand and develop memory in vaccine recipients suggesting a role for immune regulation in preventing severe symptoms in COVID-19
Autoimmunity. 2023 Dec;56(1):2259133. doi: 10.1080/08916934.2023.2259133. Epub 2023 Sep 19.ABSTRACTWe enrolled healthy subjects that received 2 to 4 injections of mRNA-based vaccination to prevent COVID-19 months to a year from the last vaccine boost, and we found numerous SARS-CoV-2 spike-specific regulatory T cell (Treg) that developed T cell memory as effector memory T cells (TEM) and central memory T cells (TCM). CD4+ CD25high Treg expressed the chemokine receptor CCR6 in a considerable percentage, suggesting T cell homing to the vascular endothelium, lung and gut epithelial cells and brain. Treg phenotype was differen...
Source: Autoimmunity - September 19, 2023 Category: Allergy & Immunology Authors: Alessandra Franco Jaeyoon Song Christina Chambers Alessandro Sette Alba Grifoni Source Type: research
DNA methylation differences within < em > INS < /em > , < em > PTPN22 < /em > and < em > IL2RA < /em > promoters in lymphocyte subsets in children with type 1 diabetes and controls
Autoimmunity. 2023 Dec;56(1):2259118. doi: 10.1080/08916934.2023.2259118. Epub 2023 Sep 19.ABSTRACTWe elucidated the effect of four known T1D-susceptibility associated single nucleotide polymorphism (SNP) markers in three genes (rs12722495 and rs2104286 in IL2RA, rs689 in INS and rs2476601 in PTPN22) on CpG site methylation of their proximal promoters in different lymphocyte subsets using pyrosequencing. The study cohort comprised 25 children with newly diagnosed T1D and 25 matched healthy controls. The rs689 SNP was associated with methylation at four CpG sites in INS promoter: -234, -206, -102 and -69. At all four CpG si...
Source: Autoimmunity - September 19, 2023 Category: Allergy & Immunology Authors: Sirpa Pahkuri Ilse Ekman C éline Vandamme Kirsti N äntö-Salonen Jorma Toppari Riitta Veijola Mikael Knip Tuure Kinnunen Jorma Ilonen Johanna Lempainen Source Type: research
CircFLNA/miR-214 modulates regulatory T cells by regulating PD-1 in acute lung injury induced by sepsis
In this study, patients with sepsis-induced ARDS along with non-ARDS controls were obtained, and bronchoalveolar lavage fluid (BALF) was collected as clinical samples. Additionally, cecal ligation and puncture (CLP) was performed to construct a septic ARDS model, and lung tissues as well as peripheral blood were collected. mRNA expressions were measured by RT-qPCR. ELISA was carried out to measure the concentration of inflammatory factors. A combination of online bioinformatics, dual-luciferase reporter, and RND pull-down assays was performed to verify interactions between microRNA (miRNA) and circRNA/mRNA. Tregs were meas...
Source: Autoimmunity - September 19, 2023 Category: Allergy & Immunology Authors: Jian Zhong Wei Zhang Leiyun Zhang Jieying Li Lingkai Kang Xiaoyue Li Source Type: research
Circ_0007535 upregulates TGFBR1 to promote pulmonary fibrosis in TGF- β1-treated lung fibroblasts via sequestering miR-18a-5p
This study evidenced that circ_0007535 facilitated TGF-β1-induced pulmonary fibrosis by depending on the absorption of miR-18a-5p to upregulate TGFBR1.PMID:37724521 | DOI:10.1080/08916934.2023.2259128 (Source: Autoimmunity)
Source: Autoimmunity - September 19, 2023 Category: Allergy & Immunology Authors: Ming Shen Xinyi Wang Xiaofeng Chang Zhun Li Na Jiang Zhuoyue Han Xin Liu Source Type: research
SARS-CoV-2 spike-specific regulatory T cells (Treg) expand and develop memory in vaccine recipients suggesting a role for immune regulation in preventing severe symptoms in COVID-19
Autoimmunity. 2023 Dec;56(1):2259133. doi: 10.1080/08916934.2023.2259133. Epub 2023 Sep 19.ABSTRACTWe enrolled healthy subjects that received 2 to 4 injections of mRNA-based vaccination to prevent COVID-19 months to a year from the last vaccine boost, and we found numerous SARS-CoV-2 spike-specific regulatory T cell (Treg) that developed T cell memory as effector memory T cells (TEM) and central memory T cells (TCM). CD4+ CD25high Treg expressed the chemokine receptor CCR6 in a considerable percentage, suggesting T cell homing to the vascular endothelium, lung and gut epithelial cells and brain. Treg phenotype was differen...
Source: Autoimmunity - September 19, 2023 Category: Allergy & Immunology Authors: Alessandra Franco Jaeyoon Song Christina Chambers Alessandro Sette Alba Grifoni Source Type: research
DNA methylation differences within < em > INS < /em > , < em > PTPN22 < /em > and < em > IL2RA < /em > promoters in lymphocyte subsets in children with type 1 diabetes and controls
Autoimmunity. 2023 Dec;56(1):2259118. doi: 10.1080/08916934.2023.2259118. Epub 2023 Sep 19.ABSTRACTWe elucidated the effect of four known T1D-susceptibility associated single nucleotide polymorphism (SNP) markers in three genes (rs12722495 and rs2104286 in IL2RA, rs689 in INS and rs2476601 in PTPN22) on CpG site methylation of their proximal promoters in different lymphocyte subsets using pyrosequencing. The study cohort comprised 25 children with newly diagnosed T1D and 25 matched healthy controls. The rs689 SNP was associated with methylation at four CpG sites in INS promoter: -234, -206, -102 and -69. At all four CpG si...
Source: Autoimmunity - September 19, 2023 Category: Allergy & Immunology Authors: Sirpa Pahkuri Ilse Ekman C éline Vandamme Kirsti N äntö-Salonen Jorma Toppari Riitta Veijola Mikael Knip Tuure Kinnunen Jorma Ilonen Johanna Lempainen Source Type: research
CircFLNA/miR-214 modulates regulatory T cells by regulating PD-1 in acute lung injury induced by sepsis
In this study, patients with sepsis-induced ARDS along with non-ARDS controls were obtained, and bronchoalveolar lavage fluid (BALF) was collected as clinical samples. Additionally, cecal ligation and puncture (CLP) was performed to construct a septic ARDS model, and lung tissues as well as peripheral blood were collected. mRNA expressions were measured by RT-qPCR. ELISA was carried out to measure the concentration of inflammatory factors. A combination of online bioinformatics, dual-luciferase reporter, and RND pull-down assays was performed to verify interactions between microRNA (miRNA) and circRNA/mRNA. Tregs were meas...
Source: Autoimmunity - September 19, 2023 Category: Allergy & Immunology Authors: Jian Zhong Wei Zhang Leiyun Zhang Jieying Li Lingkai Kang Xiaoyue Li Source Type: research
Circ_0007535 upregulates TGFBR1 to promote pulmonary fibrosis in TGF- β1-treated lung fibroblasts via sequestering miR-18a-5p
This study evidenced that circ_0007535 facilitated TGF-β1-induced pulmonary fibrosis by depending on the absorption of miR-18a-5p to upregulate TGFBR1.PMID:37724521 | DOI:10.1080/08916934.2023.2259128 (Source: Autoimmunity)
Source: Autoimmunity - September 19, 2023 Category: Allergy & Immunology Authors: Ming Shen Xinyi Wang Xiaofeng Chang Zhun Li Na Jiang Zhuoyue Han Xin Liu Source Type: research
SARS-CoV-2 spike-specific regulatory T cells (Treg) expand and develop memory in vaccine recipients suggesting a role for immune regulation in preventing severe symptoms in COVID-19
Autoimmunity. 2023 Dec;56(1):2259133. doi: 10.1080/08916934.2023.2259133. Epub 2023 Sep 19.ABSTRACTWe enrolled healthy subjects that received 2 to 4 injections of mRNA-based vaccination to prevent COVID-19 months to a year from the last vaccine boost, and we found numerous SARS-CoV-2 spike-specific regulatory T cell (Treg) that developed T cell memory as effector memory T cells (TEM) and central memory T cells (TCM). CD4+ CD25high Treg expressed the chemokine receptor CCR6 in a considerable percentage, suggesting T cell homing to the vascular endothelium, lung and gut epithelial cells and brain. Treg phenotype was differen...
Source: Autoimmunity - September 19, 2023 Category: Allergy & Immunology Authors: Alessandra Franco Jaeyoon Song Christina Chambers Alessandro Sette Alba Grifoni Source Type: research
DNA methylation differences within < em > INS < /em > , < em > PTPN22 < /em > and < em > IL2RA < /em > promoters in lymphocyte subsets in children with type 1 diabetes and controls
Autoimmunity. 2023 Dec;56(1):2259118. doi: 10.1080/08916934.2023.2259118. Epub 2023 Sep 19.ABSTRACTWe elucidated the effect of four known T1D-susceptibility associated single nucleotide polymorphism (SNP) markers in three genes (rs12722495 and rs2104286 in IL2RA, rs689 in INS and rs2476601 in PTPN22) on CpG site methylation of their proximal promoters in different lymphocyte subsets using pyrosequencing. The study cohort comprised 25 children with newly diagnosed T1D and 25 matched healthy controls. The rs689 SNP was associated with methylation at four CpG sites in INS promoter: -234, -206, -102 and -69. At all four CpG si...
Source: Autoimmunity - September 19, 2023 Category: Allergy & Immunology Authors: Sirpa Pahkuri Ilse Ekman C éline Vandamme Kirsti N äntö-Salonen Jorma Toppari Riitta Veijola Mikael Knip Tuure Kinnunen Jorma Ilonen Johanna Lempainen Source Type: research
CircFLNA/miR-214 modulates regulatory T cells by regulating PD-1 in acute lung injury induced by sepsis
In this study, patients with sepsis-induced ARDS along with non-ARDS controls were obtained, and bronchoalveolar lavage fluid (BALF) was collected as clinical samples. Additionally, cecal ligation and puncture (CLP) was performed to construct a septic ARDS model, and lung tissues as well as peripheral blood were collected. mRNA expressions were measured by RT-qPCR. ELISA was carried out to measure the concentration of inflammatory factors. A combination of online bioinformatics, dual-luciferase reporter, and RND pull-down assays was performed to verify interactions between microRNA (miRNA) and circRNA/mRNA. Tregs were meas...
Source: Autoimmunity - September 19, 2023 Category: Allergy & Immunology Authors: Jian Zhong Wei Zhang Leiyun Zhang Jieying Li Lingkai Kang Xiaoyue Li Source Type: research
Autoimmune inflammatory reactions triggered by the COVID-19 genetic vaccines in terminally differentiated tissues
Autoimmunity. 2023 Dec;56(1):2259123. doi: 10.1080/08916934.2023.2259123.ABSTRACTAs a result of the spread of SARS-CoV-2, a global pandemic was declared. Indiscriminate COVID-19 vaccination has been extended to include age groups and naturally immune people with minimal danger of suffering serious complications due to COVID-19. Solid immuno-histopathological evidence demonstrates that the COVID-19 genetic vaccines can display a wide distribution within the body, affecting tissues that are terminally differentiated and far away from the injection site. These include the heart and brain, which may incur in situ production of...
Source: Autoimmunity - September 15, 2023 Category: Allergy & Immunology Authors: Panagis Polykretis Alberto Donzelli Janci C Lindsay David Wiseman Anthony M Kyriakopoulos Michael M örz Paolo Bellavite Masanori Fukushima Stephanie Seneff Peter A McCullough Source Type: research
