Bioinformatics and systems-biology approach to identify common pathogenic mechanisms for COVID-19 and systemic lupus erythematosus
CONCLUSION: COVID-19 and SLE patients share many common hub genes, related pathways and regulatory networks. Based on these common targets, we found many potential drugs that could be used in treating patient with COVID-19 or COVID-19 combined with SLE.PMID:38332666 | DOI:10.1080/08916934.2024.2304826 (Source: Autoimmunity)
Source: Autoimmunity - February 9, 2024 Category: Allergy & Immunology Authors: Yinlan Wu Yanhong Li Yu Zhou Xiufeng Bai Yi Liu Source Type: research
The role of NLRP3 inflammasome in type 2 inflammation related diseases
Autoimmunity. 2024 Dec;57(1):2310269. doi: 10.1080/08916934.2024.2310269. Epub 2024 Feb 8.ABSTRACTType 2 inflammation related diseases, such as atopic dermatitis, asthma, and allergic rhinitis, are diverse and affect multiple systems in the human body. It is common for individuals to have multiple co-existing type 2 inflammation related diseases, which can impose a significant financial and living burden on patients. However, the exact pathogenesis of these diseases is still unclear. The NLRP3 inflammasome is a protein complex composed of the NLRP3 protein, ASC, and Caspase-1, and is activated through various mechanisms, i...
Source: Autoimmunity - February 9, 2024 Category: Allergy & Immunology Authors: Shenming Xu Dan Wang Lina Tan Jianyun Lu Source Type: research
Circ_0036490 and DKK1 competitively bind miR-29a to promote lipopolysaccharides-induced human gingival fibroblasts injury
This study aimed to explore whether miR-29a could affect lipopolysaccharides (LPSs)-induced injury in human gingival fibroblasts (HGFs) through the competitive endogenous RNAs (ceRNA) mechanism. Periodontal ligament (PDL) tissues and HGFs were derived from patients with periodontitis and healthy volunteers. Periodontitis cell model was established by treating HGFs with LPS. Expression levels of circ_0036490, miR-29a, and DKK1 were evaluated by the reverse transcription quantitative real-time PCR (RT-qPCR) method. Western blotting assay was performed to assess protein expression levels of pyroptosis-related proteins and Wnt...
Source: Autoimmunity - February 7, 2024 Category: Allergy & Immunology Authors: Yeke Wu Bin Li Disi Deng Hongling Zhou Min Liu Huangping Ai Yilin Xin Weihan Hua Lixing Zhao Li Li Source Type: research
CircNRIP1 promotes proliferation, migration and phenotypic switch of Ang II-induced HA-VSMCs by increasing CXCL5 mRNA stability via recruiting IGF2BP1
Autoimmunity. 2024 Dec;57(1):2304820. doi: 10.1080/08916934.2024.2304820. Epub 2024 Jan 25.ABSTRACTCircular RNA (circRNA) has been found to be differentially expressed and involved in regulating the processes of human diseases, including thoracic aortic dissection (TAD). However, the role and mechanism of circNRIP1 in the TAD process are still unclear. GEO database was used to screen the differentially expressed circRNA and mRNA in type A TAD patients and age-matched normal donors. Angiotensin II (Ang II)-induced human aortic vascular smooth muscle cells (HA-VSMCs) were used to construct TAD cell models. The expression lev...
Source: Autoimmunity - January 25, 2024 Category: Allergy & Immunology Authors: Xianzhao Cao Hongyan Fang Longshu Zhou Source Type: research
Circ_0011058 alleviates RA pathology through the circ_0011058/miR-335-5p/CUL4B signal axis
Autoimmunity. 2024 Dec;57(1):2299587. doi: 10.1080/08916934.2023.2299587. Epub 2024 Jan 22.ABSTRACTOur previous study found that Cullin 4B (CUL4B) inhibited rheumatoid arthritis (RA) pathology through glycogen synthase kinase-3beta (GSK3β)/canonical Wnt signalling pathway. In this work, pre-experiment and bioinformatics analysis suggested that circ_0011058 may lead to the up-regulation of CUL4B expression by inhibiting miR-335-5p. Therefore, we studied whether circ_0011058 can promote the expression of CUL4B through sponging the miR-335-5p and further promote the pathological development of RA. Bioinformatics prediction, ...
Source: Autoimmunity - January 23, 2024 Category: Allergy & Immunology Authors: Xiaomei Wang Qiuyun Xue Qiangjun Duan Ziyi Sun Yajie Wu Shuo Yang Pengfei Xu Huibo Cao Faxue Liao Xiao Wang Chenggui Miao Source Type: research
KISS-1 knockdown inhibits cell growth, migration, and invasion in HTR-8/SVneo cells by regulating the GRP54-mediated PI3K/AKT signaling pathway
Autoimmunity. 2024 Dec;57(1):2297564. doi: 10.1080/08916934.2023.2297564. Epub 2023 Dec 28.ABSTRACTRecurrent spontaneous abortions (RSA) affect reproductive health and increase the risk of subsequent abortions. To investigate the role of KISS-1/GPR-54 signaling in RSA progression. Villus tissue was collected from RSA patients, and human trophoblastic HTR-8/SVneo cells were used. KISS-1 and GRP54 levels were detected using RT-qPCR and immunohistochemistry. Western blotting was performed to analyze ZO-1 and ZEB1 levels. Cell proliferation was determined via CCK-8 and cell clone formation assays. Transwell assays were perform...
Source: Autoimmunity - December 29, 2023 Category: Allergy & Immunology Authors: Lingna Chen Yuying Ruan Liping Ni Guiting Wang Yajuan Gao Jindi Zhang Dingheng Li Haiou Xu Source Type: research
