The association of 25(OH)D, interleukin-4, interleukin-5, and interleukin-13 levels with the burden of soil-transmitted helminth infection in stunted children aged 24-59 months
Autoimmunity. 2024 Dec;57(1):2330394. doi: 10.1080/08916934.2024.2330394. Epub 2024 Mar 18.ABSTRACTSoil-transmitted helminth (STH) among children aged 24-59 months is one cause of chronic infection that could lead to stunting. The association of 25(OH)D and immune responses during chronic infection in stunted populations has not yet been well established. An association study of case-control data was conducted in Bandung district from October 2019 to January 2023. Sociodemographic factors, stool samples, and serum levels of 25(OH)D, interleukin-4 (IL-4), interleukin-5 (IL-5), and interleukin-13 (IL-13) were assessed. Stati...
Source: Autoimmunity - March 18, 2024 Category: Allergy & Immunology Authors: Riyadi Adrizain Monika Verena Nagari Djatnika Setiabudi Afiat Berbudi Budi Setiabudiawan Source Type: research
Animal models of lupus nephritis: the past, present and a future outlook
Autoimmunity. 2024 Dec;57(1):2319203. doi: 10.1080/08916934.2024.2319203. Epub 2024 Mar 13.ABSTRACTLupus nephritis (LN) is the most severe end-organ pathology in Systemic Lupus Erythematosus (SLE). Research has enhanced our understanding of immune effectors and inflammatory pathways in LN. However, even with the best available therapy, the rate of complete remission for proliferative LN remains below 50%. A deeper understanding of the resistance or susceptibility of renal cells to injury during the progression of SLE is critical for identifying new targets and developing effective long-term therapies. The complex and heter...
Source: Autoimmunity - March 13, 2024 Category: Allergy & Immunology Authors: Divya Katikaneni Laurence Morel Yogesh Scindia Source Type: research
Functions of IgM fc receptor (Fc µR) related to autoimmunity
Autoimmunity. 2024 Dec;57(1):2323563. doi: 10.1080/08916934.2024.2323563. Epub 2024 Mar 11.ABSTRACTUnlike Fc receptors for switched immunoglobulin (Ig) isotypes, Fc receptor for IgM (FcµR) is selectively expressed by lymphocytes. The ablation of the FcµR gene in mice impairs B cell tolerance as evidenced by concomitant production of autoantibodies of IgM and IgG isotypes. In this essay, we reiterate the autoimmune phenotypes observed in mutant mice, ie IgM homeostasis, dysregulated humoral immune responses including autoantibodies, and Mott cell formation. We also propose the potential phenotypes in individuals with FCMR...
Source: Autoimmunity - March 11, 2024 Category: Allergy & Immunology Authors: Hiromi Kubagawa Pedram Mahmoudi Aliabadi Khlowd Al-Qaisi Peter K Jani Kazuhito Honjo Shozo Izui Andreas Radbruch Fritz Melchers Source Type: research
Identification of macrophage-related molecular subgroups and risk signature in colorectal cancer based on a bioinformatics analysis
Autoimmunity. 2024 Dec;57(1):2321908. doi: 10.1080/08916934.2024.2321908. Epub 2024 Mar 11.ABSTRACTMacrophages play a crucial role in tumor initiation and progression, while macrophage-associated gene signature in colorectal cancer (CRC) patients has not been investigated. Our study aimed to identify macrophage-related molecular subgroups and develop a macrophage-related risk model to predict CRC prognosis. The mRNA expression profile and clinical information of CRC patients were obtained from TCGA and GEO databases. CRC patients from TCGA were divided into high and low macrophage subgroups based on the median macrophage s...
Source: Autoimmunity - March 11, 2024 Category: Allergy & Immunology Authors: Qi Liu Li Liao Source Type: research
Functions of IgM fc receptor (Fc µR) related to autoimmunity
Autoimmunity. 2024 Dec;57(1):2323563. doi: 10.1080/08916934.2024.2323563. Epub 2024 Mar 11.ABSTRACTUnlike Fc receptors for switched immunoglobulin (Ig) isotypes, Fc receptor for IgM (FcµR) is selectively expressed by lymphocytes. The ablation of the FcµR gene in mice impairs B cell tolerance as evidenced by concomitant production of autoantibodies of IgM and IgG isotypes. In this essay, we reiterate the autoimmune phenotypes observed in mutant mice, ie IgM homeostasis, dysregulated humoral immune responses including autoantibodies, and Mott cell formation. We also propose the potential phenotypes in individuals with FCMR...
Source: Autoimmunity - March 11, 2024 Category: Allergy & Immunology Authors: Hiromi Kubagawa Pedram Mahmoudi Aliabadi Khlowd Al-Qaisi Peter K Jani Kazuhito Honjo Shozo Izui Andreas Radbruch Fritz Melchers Source Type: research
