MiR-526b-3p enhances sensitivity of head and neck squamous cell carcinoma cells to radiotherapy via suppressing exosomal LAMP3-mediated autophagy
Autoimmunity. 2023 Dec;56(1):2259125. doi: 10.1080/08916934.2023.2259125. Epub 2023 Sep 23.ABSTRACTLysosomal associated membrane protein 3 (LAMP3) has been reported to be a tumour promoter in multiple cancer types by modulating tumour cell autophagy. However, the potential mechanism of LAMP3 in radio-resistance of head and neck squamous cell carcinoma (HNSCC) remains unknown. Therefore, our current study aims to detect the impacts of LAMP3 on the resistance of HNSCC cells to radiotherapy and meanwhile explore its functional mechanism. Through RT-Qpcr examination, LAMP3 expression was identified to be expressed at a signifi...
Source: Autoimmunity - September 23, 2023 Category: Allergy & Immunology Authors: Huixiang Lu Junnian Zhou Xiaojun Li Xiaoqin Han Shuping Ma Chunlan Feng Source Type: research
The emerging role of the hedgehog signaling pathway in immunity response and autoimmune diseases
Autoimmunity. 2023 Dec;56(1):2259127. doi: 10.1080/08916934.2023.2259127. Epub 2023 Sep 23.ABSTRACTThe Hedgehog (Hh) family is a prototypical morphogen involved in embryonic patterning, multi-lineage differentiation, self-renewal, morphogenesis, and regeneration. There are studies that have demonstrated that the Hh signaling pathway differentiates developing T cells into MHC-restricted self-antigen tolerant T cells in a concentration-dependent manner in the thymus. Whereas Hh signaling pathway is not required in the differentiation of B cells but is indispensable in maintaining the regeneration of hematopoietic stem cells ...
Source: Autoimmunity - September 23, 2023 Category: Allergy & Immunology Authors: Yunfei Li Min Ming Chunyang Li Songpo Liu Dan Zhang Tao Song Jun Tan Jidong Zhang Source Type: research
MiR-526b-3p enhances sensitivity of head and neck squamous cell carcinoma cells to radiotherapy via suppressing exosomal LAMP3-mediated autophagy
Autoimmunity. 2023 Dec;56(1):2259125. doi: 10.1080/08916934.2023.2259125. Epub 2023 Sep 23.ABSTRACTLysosomal associated membrane protein 3 (LAMP3) has been reported to be a tumour promoter in multiple cancer types by modulating tumour cell autophagy. However, the potential mechanism of LAMP3 in radio-resistance of head and neck squamous cell carcinoma (HNSCC) remains unknown. Therefore, our current study aims to detect the impacts of LAMP3 on the resistance of HNSCC cells to radiotherapy and meanwhile explore its functional mechanism. Through RT-Qpcr examination, LAMP3 expression was identified to be expressed at a signifi...
Source: Autoimmunity - September 23, 2023 Category: Allergy & Immunology Authors: Huixiang Lu Junnian Zhou Xiaojun Li Xiaoqin Han Shuping Ma Chunlan Feng Source Type: research
The emerging role of the hedgehog signaling pathway in immunity response and autoimmune diseases
Autoimmunity. 2023 Dec;56(1):2259127. doi: 10.1080/08916934.2023.2259127. Epub 2023 Sep 23.ABSTRACTThe Hedgehog (Hh) family is a prototypical morphogen involved in embryonic patterning, multi-lineage differentiation, self-renewal, morphogenesis, and regeneration. There are studies that have demonstrated that the Hh signaling pathway differentiates developing T cells into MHC-restricted self-antigen tolerant T cells in a concentration-dependent manner in the thymus. Whereas Hh signaling pathway is not required in the differentiation of B cells but is indispensable in maintaining the regeneration of hematopoietic stem cells ...
Source: Autoimmunity - September 23, 2023 Category: Allergy & Immunology Authors: Yunfei Li Min Ming Chunyang Li Songpo Liu Dan Zhang Tao Song Jun Tan Jidong Zhang Source Type: research
MiR-526b-3p enhances sensitivity of head and neck squamous cell carcinoma cells to radiotherapy via suppressing exosomal LAMP3-mediated autophagy
Autoimmunity. 2023 Dec;56(1):2259125. doi: 10.1080/08916934.2023.2259125. Epub 2023 Sep 23.ABSTRACTLysosomal associated membrane protein 3 (LAMP3) has been reported to be a tumour promoter in multiple cancer types by modulating tumour cell autophagy. However, the potential mechanism of LAMP3 in radio-resistance of head and neck squamous cell carcinoma (HNSCC) remains unknown. Therefore, our current study aims to detect the impacts of LAMP3 on the resistance of HNSCC cells to radiotherapy and meanwhile explore its functional mechanism. Through RT-Qpcr examination, LAMP3 expression was identified to be expressed at a signifi...
Source: Autoimmunity - September 23, 2023 Category: Allergy & Immunology Authors: Huixiang Lu Junnian Zhou Xiaojun Li Xiaoqin Han Shuping Ma Chunlan Feng Source Type: research
The emerging role of the hedgehog signaling pathway in immunity response and autoimmune diseases
Autoimmunity. 2023 Dec;56(1):2259127. doi: 10.1080/08916934.2023.2259127. Epub 2023 Sep 23.ABSTRACTThe Hedgehog (Hh) family is a prototypical morphogen involved in embryonic patterning, multi-lineage differentiation, self-renewal, morphogenesis, and regeneration. There are studies that have demonstrated that the Hh signaling pathway differentiates developing T cells into MHC-restricted self-antigen tolerant T cells in a concentration-dependent manner in the thymus. Whereas Hh signaling pathway is not required in the differentiation of B cells but is indispensable in maintaining the regeneration of hematopoietic stem cells ...
Source: Autoimmunity - September 23, 2023 Category: Allergy & Immunology Authors: Yunfei Li Min Ming Chunyang Li Songpo Liu Dan Zhang Tao Song Jun Tan Jidong Zhang Source Type: research
MiR-526b-3p enhances sensitivity of head and neck squamous cell carcinoma cells to radiotherapy via suppressing exosomal LAMP3-mediated autophagy
Autoimmunity. 2023 Dec;56(1):2259125. doi: 10.1080/08916934.2023.2259125. Epub 2023 Sep 23.ABSTRACTLysosomal associated membrane protein 3 (LAMP3) has been reported to be a tumour promoter in multiple cancer types by modulating tumour cell autophagy. However, the potential mechanism of LAMP3 in radio-resistance of head and neck squamous cell carcinoma (HNSCC) remains unknown. Therefore, our current study aims to detect the impacts of LAMP3 on the resistance of HNSCC cells to radiotherapy and meanwhile explore its functional mechanism. Through RT-Qpcr examination, LAMP3 expression was identified to be expressed at a signifi...
Source: Autoimmunity - September 23, 2023 Category: Allergy & Immunology Authors: Huixiang Lu Junnian Zhou Xiaojun Li Xiaoqin Han Shuping Ma Chunlan Feng Source Type: research
The emerging role of the hedgehog signaling pathway in immunity response and autoimmune diseases
Autoimmunity. 2023 Dec;56(1):2259127. doi: 10.1080/08916934.2023.2259127. Epub 2023 Sep 23.ABSTRACTThe Hedgehog (Hh) family is a prototypical morphogen involved in embryonic patterning, multi-lineage differentiation, self-renewal, morphogenesis, and regeneration. There are studies that have demonstrated that the Hh signaling pathway differentiates developing T cells into MHC-restricted self-antigen tolerant T cells in a concentration-dependent manner in the thymus. Whereas Hh signaling pathway is not required in the differentiation of B cells but is indispensable in maintaining the regeneration of hematopoietic stem cells ...
Source: Autoimmunity - September 23, 2023 Category: Allergy & Immunology Authors: Yunfei Li Min Ming Chunyang Li Songpo Liu Dan Zhang Tao Song Jun Tan Jidong Zhang Source Type: research
MiR-526b-3p enhances sensitivity of head and neck squamous cell carcinoma cells to radiotherapy via suppressing exosomal LAMP3-mediated autophagy
Autoimmunity. 2023 Dec;56(1):2259125. doi: 10.1080/08916934.2023.2259125. Epub 2023 Sep 23.ABSTRACTLysosomal associated membrane protein 3 (LAMP3) has been reported to be a tumour promoter in multiple cancer types by modulating tumour cell autophagy. However, the potential mechanism of LAMP3 in radio-resistance of head and neck squamous cell carcinoma (HNSCC) remains unknown. Therefore, our current study aims to detect the impacts of LAMP3 on the resistance of HNSCC cells to radiotherapy and meanwhile explore its functional mechanism. Through RT-Qpcr examination, LAMP3 expression was identified to be expressed at a signifi...
Source: Autoimmunity - September 23, 2023 Category: Allergy & Immunology Authors: Huixiang Lu Junnian Zhou Xiaojun Li Xiaoqin Han Shuping Ma Chunlan Feng Source Type: research
Oncolytic virus oHSV2 combined with PD-1/PD-L1 inhibitors exert antitumor activity by mediating CD4 + T and CD8 + T cell infiltration in the lymphoma tumor microenvironment
Autoimmunity. 2023 Dec;56(1):2259126. doi: 10.1080/08916934.2023.2259126. Epub 2023 Sep 22.ABSTRACTA novel therapeutic regimen showed that the oncolytic type II herpes simplex virus (oHSV2) was able to prevent colorectal cancer growth, recurrence, and metastasis. However, no study has yet explored whether oHSV2 has an impact on the development of diffuse large B-cell lymphoma (DLBCL). We chose the clinical chemotherapeutic drug doxorubicin (DOX) as a positive control to evaluate the effect of oHSV2 infection on the apoptotic, invasive, and proliferative capacity of DLBCL cells. We next further explored the therapeutic effi...
Source: Autoimmunity - September 22, 2023 Category: Allergy & Immunology Authors: Jingbo Zhang Yiwei Guo Huiying Fang Xiuchen Guo Lina Zhao Source Type: research
Circ_0007535 upregulates TGFBR1 to promote pulmonary fibrosis in TGF- β1-treated lung fibroblasts via sequestering miR-18a-5p
This study evidenced that circ_0007535 facilitated TGF-β1-induced pulmonary fibrosis by depending on the absorption of miR-18a-5p to upregulate TGFBR1.PMID:37724521 | DOI:10.1080/08916934.2023.2259128 (Source: Autoimmunity)
Source: Autoimmunity - September 19, 2023 Category: Allergy & Immunology Authors: Ming Shen Xinyi Wang Xiaofeng Chang Zhun Li Na Jiang Zhuoyue Han Xin Liu Source Type: research
SARS-CoV-2 spike-specific regulatory T cells (Treg) expand and develop memory in vaccine recipients suggesting a role for immune regulation in preventing severe symptoms in COVID-19
Autoimmunity. 2023 Dec;56(1):2259133. doi: 10.1080/08916934.2023.2259133. Epub 2023 Sep 19.ABSTRACTWe enrolled healthy subjects that received 2 to 4 injections of mRNA-based vaccination to prevent COVID-19 months to a year from the last vaccine boost, and we found numerous SARS-CoV-2 spike-specific regulatory T cell (Treg) that developed T cell memory as effector memory T cells (TEM) and central memory T cells (TCM). CD4+ CD25high Treg expressed the chemokine receptor CCR6 in a considerable percentage, suggesting T cell homing to the vascular endothelium, lung and gut epithelial cells and brain. Treg phenotype was differen...
Source: Autoimmunity - September 19, 2023 Category: Allergy & Immunology Authors: Alessandra Franco Jaeyoon Song Christina Chambers Alessandro Sette Alba Grifoni Source Type: research
