Gbp3 is associated with the progression of lupus nephritis by regulating cell proliferation, inflammation and pyroptosis
Autoimmunity. 2023 Dec;56(1):2250095. doi: 10.1080/08916934.2023.2250095.ABSTRACTLupus nephritis (LN) is a major cause death in patients with systemic lupus erythematosus. We aimed to find the differentially expressed genes (DEGs) in LN and confirm the regulatory mechanism on LN. The mouse model of LN was constructed by subcutaneous injection of pristane. RNA-seq screened 392 up-regulated and 447 down-regulated DEGs in LN mouse model, and KEGG analysis found that the top 20 DEGs were enriched in arachidonic acid metabolism, tryptophan metabolism, etc. The hub genes, Kynu, Spidr, Gbp3, Cbr1, Cyp4b1, and Cndp2 were identifie...
Source: Autoimmunity - August 25, 2023 Category: Allergy & Immunology Authors: Zhongfeng Zhang Wenyu Song Run Yan Source Type: research
Systemic lupus erythematosus is associated with the risk of coeliac disease: a Mendelian randomisation study
Autoimmunity. 2023 Dec;56(1):2250103. doi: 10.1080/08916934.2023.2250103.ABSTRACTAs an autoimmune disease, systemic lupus erythematosus (SLE) can affect multiple organs and systems. Whether SLE can increase the risk of coeliac disease (CeD) was not evaluated until now. We performed a two-sample Mendelian randomisation study to evaluate the relationship between SLE and CeD, and found that SLE can significantly increase the risk of CeD, suggesting the association between SLE and abnormal intestinal immune microenvironment.PMID:37621181 | DOI:10.1080/08916934.2023.2250103 (Source: Autoimmunity)
Source: Autoimmunity - August 25, 2023 Category: Allergy & Immunology Authors: Qiaolin Wang Sujie Jia Qianjin Lu Ming Zhao Source Type: research
Prognostic characteristics of T-cell mediated cell killing-related genes in lung adenocarcinoma
Autoimmunity. 2023 Dec;56(1):2250097. doi: 10.1080/08916934.2023.2250097.ABSTRACTConstituted by various heterogeneous cells, the tumor microenvironment (TME) is capable of promoting tumor proliferation, invasion, and metastasis through extensive crosstalk. The pivotal factor influencing the survival time of patients and their response to immunotherapy lies in the intratumoral immune environment. We obtained 112 differential genes related to T cell-mediated tumor killing in LUAD by employing bioinformatics analysis on the basis of the TCGA and TISIDB databases. Then the 6-gene prognostic risk score model (CA9, OIP5, TIMP1, ...
Source: Autoimmunity - August 25, 2023 Category: Allergy & Immunology Authors: Lei Bi Cheng Ai Hong Zhang Zhengyu Chen Yiping Deng Jing Xiong Zhongzhu Lv Source Type: research
Gbp3 is associated with the progression of lupus nephritis by regulating cell proliferation, inflammation and pyroptosis
Autoimmunity. 2023 Dec;56(1):2250095. doi: 10.1080/08916934.2023.2250095.ABSTRACTLupus nephritis (LN) is a major cause death in patients with systemic lupus erythematosus. We aimed to find the differentially expressed genes (DEGs) in LN and confirm the regulatory mechanism on LN. The mouse model of LN was constructed by subcutaneous injection of pristane. RNA-seq screened 392 up-regulated and 447 down-regulated DEGs in LN mouse model, and KEGG analysis found that the top 20 DEGs were enriched in arachidonic acid metabolism, tryptophan metabolism, etc. The hub genes, Kynu, Spidr, Gbp3, Cbr1, Cyp4b1, and Cndp2 were identifie...
Source: Autoimmunity - August 25, 2023 Category: Allergy & Immunology Authors: Zhongfeng Zhang Wenyu Song Run Yan Source Type: research
Systemic lupus erythematosus is associated with the risk of coeliac disease: a Mendelian randomisation study
Autoimmunity. 2023 Dec;56(1):2250103. doi: 10.1080/08916934.2023.2250103.ABSTRACTAs an autoimmune disease, systemic lupus erythematosus (SLE) can affect multiple organs and systems. Whether SLE can increase the risk of coeliac disease (CeD) was not evaluated until now. We performed a two-sample Mendelian randomisation study to evaluate the relationship between SLE and CeD, and found that SLE can significantly increase the risk of CeD, suggesting the association between SLE and abnormal intestinal immune microenvironment.PMID:37621181 | DOI:10.1080/08916934.2023.2250103 (Source: Autoimmunity)
Source: Autoimmunity - August 25, 2023 Category: Allergy & Immunology Authors: Qiaolin Wang Sujie Jia Qianjin Lu Ming Zhao Source Type: research
Prognostic characteristics of T-cell mediated cell killing-related genes in lung adenocarcinoma
Autoimmunity. 2023 Dec;56(1):2250097. doi: 10.1080/08916934.2023.2250097.ABSTRACTConstituted by various heterogeneous cells, the tumor microenvironment (TME) is capable of promoting tumor proliferation, invasion, and metastasis through extensive crosstalk. The pivotal factor influencing the survival time of patients and their response to immunotherapy lies in the intratumoral immune environment. We obtained 112 differential genes related to T cell-mediated tumor killing in LUAD by employing bioinformatics analysis on the basis of the TCGA and TISIDB databases. Then the 6-gene prognostic risk score model (CA9, OIP5, TIMP1, ...
Source: Autoimmunity - August 25, 2023 Category: Allergy & Immunology Authors: Lei Bi Cheng Ai Hong Zhang Zhengyu Chen Yiping Deng Jing Xiong Zhongzhu Lv Source Type: research
Gbp3 is associated with the progression of lupus nephritis by regulating cell proliferation, inflammation and pyroptosis
Autoimmunity. 2023 Dec;56(1):2250095. doi: 10.1080/08916934.2023.2250095.ABSTRACTLupus nephritis (LN) is a major cause death in patients with systemic lupus erythematosus. We aimed to find the differentially expressed genes (DEGs) in LN and confirm the regulatory mechanism on LN. The mouse model of LN was constructed by subcutaneous injection of pristane. RNA-seq screened 392 up-regulated and 447 down-regulated DEGs in LN mouse model, and KEGG analysis found that the top 20 DEGs were enriched in arachidonic acid metabolism, tryptophan metabolism, etc. The hub genes, Kynu, Spidr, Gbp3, Cbr1, Cyp4b1, and Cndp2 were identifie...
Source: Autoimmunity - August 25, 2023 Category: Allergy & Immunology Authors: Zhongfeng Zhang Wenyu Song Run Yan Source Type: research
Systemic lupus erythematosus is associated with the risk of coeliac disease: a Mendelian randomisation study
Autoimmunity. 2023 Dec;56(1):2250103. doi: 10.1080/08916934.2023.2250103.ABSTRACTAs an autoimmune disease, systemic lupus erythematosus (SLE) can affect multiple organs and systems. Whether SLE can increase the risk of coeliac disease (CeD) was not evaluated until now. We performed a two-sample Mendelian randomisation study to evaluate the relationship between SLE and CeD, and found that SLE can significantly increase the risk of CeD, suggesting the association between SLE and abnormal intestinal immune microenvironment.PMID:37621181 | DOI:10.1080/08916934.2023.2250103 (Source: Autoimmunity)
Source: Autoimmunity - August 25, 2023 Category: Allergy & Immunology Authors: Qiaolin Wang Sujie Jia Qianjin Lu Ming Zhao Source Type: research
Prognostic characteristics of T-cell mediated cell killing-related genes in lung adenocarcinoma
Autoimmunity. 2023 Dec;56(1):2250097. doi: 10.1080/08916934.2023.2250097.ABSTRACTConstituted by various heterogeneous cells, the tumor microenvironment (TME) is capable of promoting tumor proliferation, invasion, and metastasis through extensive crosstalk. The pivotal factor influencing the survival time of patients and their response to immunotherapy lies in the intratumoral immune environment. We obtained 112 differential genes related to T cell-mediated tumor killing in LUAD by employing bioinformatics analysis on the basis of the TCGA and TISIDB databases. Then the 6-gene prognostic risk score model (CA9, OIP5, TIMP1, ...
Source: Autoimmunity - August 25, 2023 Category: Allergy & Immunology Authors: Lei Bi Cheng Ai Hong Zhang Zhengyu Chen Yiping Deng Jing Xiong Zhongzhu Lv Source Type: research
Gbp3 is associated with the progression of lupus nephritis by regulating cell proliferation, inflammation and pyroptosis
Autoimmunity. 2023 Dec;56(1):2250095. doi: 10.1080/08916934.2023.2250095.ABSTRACTLupus nephritis (LN) is a major cause death in patients with systemic lupus erythematosus. We aimed to find the differentially expressed genes (DEGs) in LN and confirm the regulatory mechanism on LN. The mouse model of LN was constructed by subcutaneous injection of pristane. RNA-seq screened 392 up-regulated and 447 down-regulated DEGs in LN mouse model, and KEGG analysis found that the top 20 DEGs were enriched in arachidonic acid metabolism, tryptophan metabolism, etc. The hub genes, Kynu, Spidr, Gbp3, Cbr1, Cyp4b1, and Cndp2 were identifie...
Source: Autoimmunity - August 25, 2023 Category: Allergy & Immunology Authors: Zhongfeng Zhang Wenyu Song Run Yan Source Type: research
Systemic lupus erythematosus is associated with the risk of coeliac disease: a Mendelian randomisation study
Autoimmunity. 2023 Dec;56(1):2250103. doi: 10.1080/08916934.2023.2250103.ABSTRACTAs an autoimmune disease, systemic lupus erythematosus (SLE) can affect multiple organs and systems. Whether SLE can increase the risk of coeliac disease (CeD) was not evaluated until now. We performed a two-sample Mendelian randomisation study to evaluate the relationship between SLE and CeD, and found that SLE can significantly increase the risk of CeD, suggesting the association between SLE and abnormal intestinal immune microenvironment.PMID:37621181 | DOI:10.1080/08916934.2023.2250103 (Source: Autoimmunity)
Source: Autoimmunity - August 25, 2023 Category: Allergy & Immunology Authors: Qiaolin Wang Sujie Jia Qianjin Lu Ming Zhao Source Type: research
