Dysregulated CXCL12 expression in osteoblasts promotes B-lymphocytes preferentially homing to the bone marrow in MRL/lpr mice
Conclusions: our results indicated that there is a shifted distribution of B-lymphocytes between BM and peripheral compartments in both SLE patients and MRL/lpr mice. Besides, the up-regulated levels of CXCL12 in OBs was indicated to contribute to the enhanced chemotactic migration and anchorage of B-lymphocytes to OBs.PMID:38404066 | DOI:10.1080/08916934.2024.2319207 (Source: Autoimmunity)
Source: Autoimmunity - February 26, 2024 Category: Allergy & Immunology Authors: Wenjuan Zheng Yu Tang Mengwei Cheng Cui Ma Xiaoming Fei Wei Shi Source Type: research
Effects of autoimmune abnormalities on fertility and placental morphology in mice
This study investigated the effects of AIDs on pregnancy and the placenta in AID-prone MRL/MpJ-Faslpr/lpr mice and wild-type MRL/MpJ, which were mated with male MRL/MpJ and MRL/MpJ-Faslpr/lpr at five months and defined as moLpr and moMpJ, respectively. AID indices (spleen weight and serum autoantibody levels) and fertility status (number and size of fetuses, morphology, and comprehensive gene expression of placentas) were evaluated on gestational day 15.5. Both strains showed equivalent fertility, but moLpr showed lighter placentas and fetuses than moMpJ, and decreased fertility with AID severity. moLpr placentas had a hig...
Source: Autoimmunity - February 23, 2024 Category: Allergy & Immunology Authors: Risa Yamanaka Osamu Ichii Teppei Nakamura Yuki Otani Takashi Namaba Yasuhiro Kon Source Type: research
OGT-induced O-GlcNAcylation of NEK7 protein aggravates osteoarthritis progression by enhancing NEK7/NLRP3 axis
CONCLUSION: OGT-induced NEK7 O-GlcNAcylation promotes OA progression by promoting chondrocyte pyroptosis via the suppressing interaction between NEK7 and NLRP3.PMID:38389178 | DOI:10.1080/08916934.2024.2319202 (Source: Autoimmunity)
Source: Autoimmunity - February 23, 2024 Category: Allergy & Immunology Authors: Chunlei He Qiang Wu Zhaogan Zeng Yadong Yang Huabin He Meiyu Hu Sheng Liu Source Type: research
Effects of autoimmune abnormalities on fertility and placental morphology in mice
This study investigated the effects of AIDs on pregnancy and the placenta in AID-prone MRL/MpJ-Faslpr/lpr mice and wild-type MRL/MpJ, which were mated with male MRL/MpJ and MRL/MpJ-Faslpr/lpr at five months and defined as moLpr and moMpJ, respectively. AID indices (spleen weight and serum autoantibody levels) and fertility status (number and size of fetuses, morphology, and comprehensive gene expression of placentas) were evaluated on gestational day 15.5. Both strains showed equivalent fertility, but moLpr showed lighter placentas and fetuses than moMpJ, and decreased fertility with AID severity. moLpr placentas had a hig...
Source: Autoimmunity - February 23, 2024 Category: Allergy & Immunology Authors: Risa Yamanaka Osamu Ichii Teppei Nakamura Yuki Otani Takashi Namaba Yasuhiro Kon Source Type: research
OGT-induced O-GlcNAcylation of NEK7 protein aggravates osteoarthritis progression by enhancing NEK7/NLRP3 axis
CONCLUSION: OGT-induced NEK7 O-GlcNAcylation promotes OA progression by promoting chondrocyte pyroptosis via the suppressing interaction between NEK7 and NLRP3.PMID:38389178 | DOI:10.1080/08916934.2024.2319202 (Source: Autoimmunity)
Source: Autoimmunity - February 23, 2024 Category: Allergy & Immunology Authors: Chunlei He Qiang Wu Zhaogan Zeng Yadong Yang Huabin He Meiyu Hu Sheng Liu Source Type: research
Effects of autoimmune abnormalities on fertility and placental morphology in mice
This study investigated the effects of AIDs on pregnancy and the placenta in AID-prone MRL/MpJ-Faslpr/lpr mice and wild-type MRL/MpJ, which were mated with male MRL/MpJ and MRL/MpJ-Faslpr/lpr at five months and defined as moLpr and moMpJ, respectively. AID indices (spleen weight and serum autoantibody levels) and fertility status (number and size of fetuses, morphology, and comprehensive gene expression of placentas) were evaluated on gestational day 15.5. Both strains showed equivalent fertility, but moLpr showed lighter placentas and fetuses than moMpJ, and decreased fertility with AID severity. moLpr placentas had a hig...
Source: Autoimmunity - February 23, 2024 Category: Allergy & Immunology Authors: Risa Yamanaka Osamu Ichii Teppei Nakamura Yuki Otani Takashi Namaba Yasuhiro Kon Source Type: research
OGT-induced O-GlcNAcylation of NEK7 protein aggravates osteoarthritis progression by enhancing NEK7/NLRP3 axis
CONCLUSION: OGT-induced NEK7 O-GlcNAcylation promotes OA progression by promoting chondrocyte pyroptosis via the suppressing interaction between NEK7 and NLRP3.PMID:38389178 | DOI:10.1080/08916934.2024.2319202 (Source: Autoimmunity)
Source: Autoimmunity - February 23, 2024 Category: Allergy & Immunology Authors: Chunlei He Qiang Wu Zhaogan Zeng Yadong Yang Huabin He Meiyu Hu Sheng Liu Source Type: research
Effects of autoimmune abnormalities on fertility and placental morphology in mice
This study investigated the effects of AIDs on pregnancy and the placenta in AID-prone MRL/MpJ-Faslpr/lpr mice and wild-type MRL/MpJ, which were mated with male MRL/MpJ and MRL/MpJ-Faslpr/lpr at five months and defined as moLpr and moMpJ, respectively. AID indices (spleen weight and serum autoantibody levels) and fertility status (number and size of fetuses, morphology, and comprehensive gene expression of placentas) were evaluated on gestational day 15.5. Both strains showed equivalent fertility, but moLpr showed lighter placentas and fetuses than moMpJ, and decreased fertility with AID severity. moLpr placentas had a hig...
Source: Autoimmunity - February 23, 2024 Category: Allergy & Immunology Authors: Risa Yamanaka Osamu Ichii Teppei Nakamura Yuki Otani Takashi Namaba Yasuhiro Kon Source Type: research
OGT-induced O-GlcNAcylation of NEK7 protein aggravates osteoarthritis progression by enhancing NEK7/NLRP3 axis
CONCLUSION: OGT-induced NEK7 O-GlcNAcylation promotes OA progression by promoting chondrocyte pyroptosis via the suppressing interaction between NEK7 and NLRP3.PMID:38389178 | DOI:10.1080/08916934.2024.2319202 (Source: Autoimmunity)
Source: Autoimmunity - February 23, 2024 Category: Allergy & Immunology Authors: Chunlei He Qiang Wu Zhaogan Zeng Yadong Yang Huabin He Meiyu Hu Sheng Liu Source Type: research
Research progress in the construction of animal models of autoimmune thyroiditis
This report summarises and analyzes the current literature on AIT and combines actual operability to explain the selection and specific implementation processes behind the uses of different modelling approaches, to provide a better overall understanding of autoimmune thyroid diseases.PMID:38377122 | DOI:10.1080/08916934.2024.2317190 (Source: Autoimmunity)
Source: Autoimmunity - February 20, 2024 Category: Allergy & Immunology Authors: Ke Liu Pei Zhang Ling Zhou Lin Han Linhua Zhao Xiaotong Yu Source Type: research
Single-cell analysis with childhood and adult systemic lupus erythematosus
In this study, we analysed single-cell RNA sequencing data (scRNA-seq) to profile the PBMC clusters of cSLE/aSLE patients and matched healthy donors and compared the PBMC composition and transcriptional variations between the two groups. Our analysis revealed that the PBMC composition and transcriptional variations in cSLE patients were similar to those in aSLE patients. Comparative single-cell transcriptome analysis between healthy donors and SLE patients revealed IFITM3, ISG15, IFI16 and LY6E as potential therapeutic targets for both aSLE and cSLE patients. Additionally, we observed that the percentage of pre-B cells (CD...
Source: Autoimmunity - February 13, 2024 Category: Allergy & Immunology Authors: Jing Wang Xiran Yang Yanhua Zhang Xuemei Jiang Yanfang Li Jingjing Cui Yabin Liao Source Type: research
