The crosstalk between ferroptosis and autophagy in cancer
CONCLUSION: Our results provide insights into the development of recognition related to the crosstalk between ferroptosis and autophagy, and the current molecular crosslinked mechanisms in the context of common signal transduction pathways or affecting cellular environment to induce the adaptive stress response and to activate the particular form of regulated cell death (RCD), and the development of cancer treatment based on novel targets and signaling regulatory networks provided by ferroptosis and autophagy.PMID:38069487 | DOI:10.1080/08916934.2023.2289362 (Source: Autoimmunity)
Source: Autoimmunity - December 9, 2023 Category: Allergy & Immunology Authors: Xiaodi Lv Bin Wang Ming Dong Wenqian Wang Weifeng Tang Jingjing Qin Yanglai Gao Ying Wei Source Type: research
Mesenchymal stem cells-derived exosomes ameliorate high glucose and lipopolysaccharide-induced HPMECs injury through the Nrf2/HO-1 pathway
Autoimmunity. 2023 Dec;56(1):2290357. doi: 10.1080/08916934.2023.2290357. Epub 2023 Dec 8.ABSTRACTMesenchymal stem cells-derived exosomes (MSC-Exo) are considered to have great potential in the treatment of human diseases. However, the role of MSC-Exo in the process of diabetes with sepsis and the underlying molecular mechanism remain unclear. Human pulmonary microvascular endothelial cells (HPMECs) were treated with high glucose (HG) and lipopolysaccharide (LPS). Cell viability, migration, angiogenesis were analyzed by cell counting kit 8 assay, transwell assay and tube formation assay. Transmembrane electrical resistance...
Source: Autoimmunity - December 9, 2023 Category: Allergy & Immunology Authors: Hongyan Sun Shitao Lu Gaowei Qu Junli Li Bo Song Source Type: research
The crosstalk between ferroptosis and autophagy in cancer
CONCLUSION: Our results provide insights into the development of recognition related to the crosstalk between ferroptosis and autophagy, and the current molecular crosslinked mechanisms in the context of common signal transduction pathways or affecting cellular environment to induce the adaptive stress response and to activate the particular form of regulated cell death (RCD), and the development of cancer treatment based on novel targets and signaling regulatory networks provided by ferroptosis and autophagy.PMID:38069487 | DOI:10.1080/08916934.2023.2289362 (Source: Autoimmunity)
Source: Autoimmunity - December 9, 2023 Category: Allergy & Immunology Authors: Xiaodi Lv Bin Wang Ming Dong Wenqian Wang Weifeng Tang Jingjing Qin Yanglai Gao Ying Wei Source Type: research
Mesenchymal stem cells-derived exosomes ameliorate high glucose and lipopolysaccharide-induced HPMECs injury through the Nrf2/HO-1 pathway
Autoimmunity. 2023 Dec;56(1):2290357. doi: 10.1080/08916934.2023.2290357. Epub 2023 Dec 8.ABSTRACTMesenchymal stem cells-derived exosomes (MSC-Exo) are considered to have great potential in the treatment of human diseases. However, the role of MSC-Exo in the process of diabetes with sepsis and the underlying molecular mechanism remain unclear. Human pulmonary microvascular endothelial cells (HPMECs) were treated with high glucose (HG) and lipopolysaccharide (LPS). Cell viability, migration, angiogenesis were analyzed by cell counting kit 8 assay, transwell assay and tube formation assay. Transmembrane electrical resistance...
Source: Autoimmunity - December 9, 2023 Category: Allergy & Immunology Authors: Hongyan Sun Shitao Lu Gaowei Qu Junli Li Bo Song Source Type: research
The crosstalk between ferroptosis and autophagy in cancer
CONCLUSION: Our results provide insights into the development of recognition related to the crosstalk between ferroptosis and autophagy, and the current molecular crosslinked mechanisms in the context of common signal transduction pathways or affecting cellular environment to induce the adaptive stress response and to activate the particular form of regulated cell death (RCD), and the development of cancer treatment based on novel targets and signaling regulatory networks provided by ferroptosis and autophagy.PMID:38069487 | DOI:10.1080/08916934.2023.2289362 (Source: Autoimmunity)
Source: Autoimmunity - December 9, 2023 Category: Allergy & Immunology Authors: Xiaodi Lv Bin Wang Ming Dong Wenqian Wang Weifeng Tang Jingjing Qin Yanglai Gao Ying Wei Source Type: research
Mesenchymal stem cells-derived exosomes ameliorate high glucose and lipopolysaccharide-induced HPMECs injury through the Nrf2/HO-1 pathway
Autoimmunity. 2023 Dec;56(1):2290357. doi: 10.1080/08916934.2023.2290357. Epub 2023 Dec 8.ABSTRACTMesenchymal stem cells-derived exosomes (MSC-Exo) are considered to have great potential in the treatment of human diseases. However, the role of MSC-Exo in the process of diabetes with sepsis and the underlying molecular mechanism remain unclear. Human pulmonary microvascular endothelial cells (HPMECs) were treated with high glucose (HG) and lipopolysaccharide (LPS). Cell viability, migration, angiogenesis were analyzed by cell counting kit 8 assay, transwell assay and tube formation assay. Transmembrane electrical resistance...
Source: Autoimmunity - December 9, 2023 Category: Allergy & Immunology Authors: Hongyan Sun Shitao Lu Gaowei Qu Junli Li Bo Song Source Type: research
Regulatory role of ceRNA network in B lymphocytes of patients with immune thrombocytopenia
CONCLUSIONS: The ceRNA network of miRNA, lncRNA, and mRNA in peripheral CD19 + B lymphocytes plays an essential role in the pathogenesis of ITP.PMID:38053370 | DOI:10.1080/08916934.2023.2281225 (Source: Autoimmunity)
Source: Autoimmunity - December 6, 2023 Category: Allergy & Immunology Authors: Xin He Nianbin Li Donglan Liu Mengtong Zang Manjun Zhao Ningyuan Ran Chunyan Liu Limin Xing Huaquan Wang Ting Wang Zonghong Shao Source Type: research
Isorhynchophylline attenuates proliferation and migration of synovial fibroblasts via the FOXC1/ β-catenin axis
Autoimmunity. 2023 Dec;56(1):2289868. doi: 10.1080/08916934.2023.2289868. Epub 2023 Dec 6.ABSTRACTRheumatoid arthritis (RA) is a common type of chronic inflammatory disease. Elucidating the mechanism of fibroblast-like synovial (FLS) as a pathologic factor in RA may address the urgent medical requirement for the treatment of RA. Isorhynchophylline (IRN) is a tetracyclic hydroxyindole alkaloid isolated from uncinaria, which has multiple biological activities and affects the progression of osteoarthritis. However, the role of IRN in rheumatoid arthritis remains unclear. Herein, our study aimed to elucidate the potential effe...
Source: Autoimmunity - December 6, 2023 Category: Allergy & Immunology Authors: Yingyi Wu Yan Bian Jing Fei Yang Huang Source Type: research
Regulatory role of ceRNA network in B lymphocytes of patients with immune thrombocytopenia
CONCLUSIONS: The ceRNA network of miRNA, lncRNA, and mRNA in peripheral CD19 + B lymphocytes plays an essential role in the pathogenesis of ITP.PMID:38053370 | DOI:10.1080/08916934.2023.2281225 (Source: Autoimmunity)
Source: Autoimmunity - December 6, 2023 Category: Allergy & Immunology Authors: Xin He Nianbin Li Donglan Liu Mengtong Zang Manjun Zhao Ningyuan Ran Chunyan Liu Limin Xing Huaquan Wang Ting Wang Zonghong Shao Source Type: research
Isorhynchophylline attenuates proliferation and migration of synovial fibroblasts via the FOXC1/ β-catenin axis
Autoimmunity. 2023 Dec;56(1):2289868. doi: 10.1080/08916934.2023.2289868. Epub 2023 Dec 6.ABSTRACTRheumatoid arthritis (RA) is a common type of chronic inflammatory disease. Elucidating the mechanism of fibroblast-like synovial (FLS) as a pathologic factor in RA may address the urgent medical requirement for the treatment of RA. Isorhynchophylline (IRN) is a tetracyclic hydroxyindole alkaloid isolated from uncinaria, which has multiple biological activities and affects the progression of osteoarthritis. However, the role of IRN in rheumatoid arthritis remains unclear. Herein, our study aimed to elucidate the potential effe...
Source: Autoimmunity - December 6, 2023 Category: Allergy & Immunology Authors: Yingyi Wu Yan Bian Jing Fei Yang Huang Source Type: research
Regulatory role of ceRNA network in B lymphocytes of patients with immune thrombocytopenia
CONCLUSIONS: The ceRNA network of miRNA, lncRNA, and mRNA in peripheral CD19 + B lymphocytes plays an essential role in the pathogenesis of ITP.PMID:38053370 | DOI:10.1080/08916934.2023.2281225 (Source: Autoimmunity)
Source: Autoimmunity - December 6, 2023 Category: Allergy & Immunology Authors: Xin He Nianbin Li Donglan Liu Mengtong Zang Manjun Zhao Ningyuan Ran Chunyan Liu Limin Xing Huaquan Wang Ting Wang Zonghong Shao Source Type: research
Isorhynchophylline attenuates proliferation and migration of synovial fibroblasts via the FOXC1/ β-catenin axis
Autoimmunity. 2023 Dec;56(1):2289868. doi: 10.1080/08916934.2023.2289868. Epub 2023 Dec 6.ABSTRACTRheumatoid arthritis (RA) is a common type of chronic inflammatory disease. Elucidating the mechanism of fibroblast-like synovial (FLS) as a pathologic factor in RA may address the urgent medical requirement for the treatment of RA. Isorhynchophylline (IRN) is a tetracyclic hydroxyindole alkaloid isolated from uncinaria, which has multiple biological activities and affects the progression of osteoarthritis. However, the role of IRN in rheumatoid arthritis remains unclear. Herein, our study aimed to elucidate the potential effe...
Source: Autoimmunity - December 6, 2023 Category: Allergy & Immunology Authors: Yingyi Wu Yan Bian Jing Fei Yang Huang Source Type: research
Hypoxic tumour-derived exosomal miR-1225-5p regulates M2 macrophage polarisation via toll-like receptor 2 to promote ovarian cancer progress
This study aimed to explore how exosomes secreted by ovarian carcinoma cells regulate the phenotype and function of macrophages. Hypoxic treatment of A2780 cells was postulated to mimic the tumor microenvironment, and exosomes were co-cultured with TAMs. miR-1225-5p was enriched in hypoxic exosomes and contributed to M2 macrophage polarizationby modulating Toll-like receptor 2 expression (TLR2). Furthermore, hypoxia-treated macrophages promote ovarian cancer cell viability, migration, and invasion via the wnt/β-catenin pathway. This study clarified that exosomal miR-1225-5p promotes macrophage M2-like polarization by targ...
Source: Autoimmunity - November 27, 2023 Category: Allergy & Immunology Authors: Shu Tan Hao Yu Zhaocong Zhang Yiming Liu Ge Lou Source Type: research
