Molecular mechanisms of artificial light at night affecting circadian rhythm disturbance
Arch Toxicol. 2023 Dec 16. doi: 10.1007/s00204-023-03647-5. Online ahead of print.ABSTRACTArtificial light at night (ALAN) pollution has been regarded as a global environmental concern. More than 80% of the global population is exposed to light pollution. Exacerbating this issue, artificially lit outdoor areas are growing by 2.2% per year, while continuously lit areas have brightened by 2.2% each year due to rapid population growth and expanding urbanization. Furthermore, the increasing prevalence of night shift work and smart device usage contributes to the inescapable influence of ALAN. Studies have shown that ALAN can d...
Source: Archives of Toxicology - December 16, 2023 Category: Toxicology Authors: Ting Lei Hui Hua Huiying Du Jie Xia Dandan Xu Wei Liu Yutong Wang Tianyao Yang Source Type: research
Molecular mechanisms of artificial light at night affecting circadian rhythm disturbance
Arch Toxicol. 2023 Dec 16. doi: 10.1007/s00204-023-03647-5. Online ahead of print.ABSTRACTArtificial light at night (ALAN) pollution has been regarded as a global environmental concern. More than 80% of the global population is exposed to light pollution. Exacerbating this issue, artificially lit outdoor areas are growing by 2.2% per year, while continuously lit areas have brightened by 2.2% each year due to rapid population growth and expanding urbanization. Furthermore, the increasing prevalence of night shift work and smart device usage contributes to the inescapable influence of ALAN. Studies have shown that ALAN can d...
Source: Archives of Toxicology - December 16, 2023 Category: Toxicology Authors: Ting Lei Hui Hua Huiying Du Jie Xia Dandan Xu Wei Liu Yutong Wang Tianyao Yang Source Type: research
Speciation analysis and toxicity evaluation of arsenolipids-an overview focusing on sea food
Arch Toxicol. 2023 Dec 15. doi: 10.1007/s00204-023-03639-5. Online ahead of print.ABSTRACTArsenic, which can be divided into inorganic and organic arsenic, is a toxic metalloid that has been identified as a human carcinogen. A common source of arsenic exposure in seafood is arsenolipid, which is a complex structure of lipid-soluble organic arsenic compounds. At present, the known arsenolipid species mainly include arsenic-containing fatty acids (AsFAs), arsenic-containing hydrocarbons (AsHCs), arsenic glycophospholipids (AsPLs), and cationic trimethyl fatty alcohols (TMAsFOHs). Furthermore, the toxicity between different s...
Source: Archives of Toxicology - December 15, 2023 Category: Toxicology Authors: Caiyan Li Jing Chen Zhuo Wang Bingbing Song Kit-Leong Cheung Jianping Chen Rui Li Xiaofei Liu Xuejing Jia Sai-Yi Zhong Source Type: research
Evaluating the in vitro developmental toxicity potency of a series of petroleum substance extracts using new approach methodologies (NAMs)
In conclusion, the obtained results support the hypothesis that 3- to 7-ring PACs are the primary inducers of the developmental toxicity induced by some (i.e., poorly refined) petroleum substances and that the observed effect is partially AhR-mediated.PMID:38085275 | DOI:10.1007/s00204-023-03645-7 (Source: Archives of Toxicology)
Source: Archives of Toxicology - December 12, 2023 Category: Toxicology Authors: Jing Fang Ivonne M C M Rietjens Juan-Carlos Carrillo Peter J Boogaard Lenny Kamelia Source Type: research
Evaluating the in vitro developmental toxicity potency of a series of petroleum substance extracts using new approach methodologies (NAMs)
In conclusion, the obtained results support the hypothesis that 3- to 7-ring PACs are the primary inducers of the developmental toxicity induced by some (i.e., poorly refined) petroleum substances and that the observed effect is partially AhR-mediated.PMID:38085275 | DOI:10.1007/s00204-023-03645-7 (Source: Archives of Toxicology)
Source: Archives of Toxicology - December 12, 2023 Category: Toxicology Authors: Jing Fang Ivonne M C M Rietjens Juan-Carlos Carrillo Peter J Boogaard Lenny Kamelia Source Type: research
Evaluating the in vitro developmental toxicity potency of a series of petroleum substance extracts using new approach methodologies (NAMs)
In conclusion, the obtained results support the hypothesis that 3- to 7-ring PACs are the primary inducers of the developmental toxicity induced by some (i.e., poorly refined) petroleum substances and that the observed effect is partially AhR-mediated.PMID:38085275 | DOI:10.1007/s00204-023-03645-7 (Source: Archives of Toxicology)
Source: Archives of Toxicology - December 12, 2023 Category: Toxicology Authors: Jing Fang Ivonne M C M Rietjens Juan-Carlos Carrillo Peter J Boogaard Lenny Kamelia Source Type: research
Cyanobacterial harmful bloom lipopolysaccharides: pro-inflammatory effects on epithelial and immune cells in vitro
In this study, we isolated LPS from 19 CyanoHAB samples collected at 18 water bodies in the Czech Republic over two consecutive seasons. The proportions of cyanobacteria, Gram-negative bacteria (G-), and other bacteria in the biomass were determined by qPCR, while the cyanobacterial genera were identified using light microscopy. In vitro models of keratinocytes (HaCaT), the intestinal epithelium (co-culture of differentiated Caco-2 cells and peripheral blood mononuclear cells - PBMC), and PBMC alone were treated with isolated LPS at concentrations of 50, 100, and 1 µg/ml, respectively. The endotoxin activities of these co...
Source: Archives of Toxicology - December 8, 2023 Category: Toxicology Authors: V Sko čková P Raptov á K Posp íchalová I Sovadinov á E Sychrov á M Smutn á K Hilscherov á P Babica L Šindlerová Source Type: research
Cyanobacterial harmful bloom lipopolysaccharides: pro-inflammatory effects on epithelial and immune cells in vitro
In this study, we isolated LPS from 19 CyanoHAB samples collected at 18 water bodies in the Czech Republic over two consecutive seasons. The proportions of cyanobacteria, Gram-negative bacteria (G-), and other bacteria in the biomass were determined by qPCR, while the cyanobacterial genera were identified using light microscopy. In vitro models of keratinocytes (HaCaT), the intestinal epithelium (co-culture of differentiated Caco-2 cells and peripheral blood mononuclear cells - PBMC), and PBMC alone were treated with isolated LPS at concentrations of 50, 100, and 1 µg/ml, respectively. The endotoxin activities of these co...
Source: Archives of Toxicology - December 8, 2023 Category: Toxicology Authors: V Sko čková P Raptov á K Posp íchalová I Sovadinov á E Sychrov á M Smutn á K Hilscherov á P Babica L Šindlerová Source Type: research
Cyanobacterial harmful bloom lipopolysaccharides: pro-inflammatory effects on epithelial and immune cells in vitro
In this study, we isolated LPS from 19 CyanoHAB samples collected at 18 water bodies in the Czech Republic over two consecutive seasons. The proportions of cyanobacteria, Gram-negative bacteria (G-), and other bacteria in the biomass were determined by qPCR, while the cyanobacterial genera were identified using light microscopy. In vitro models of keratinocytes (HaCaT), the intestinal epithelium (co-culture of differentiated Caco-2 cells and peripheral blood mononuclear cells - PBMC), and PBMC alone were treated with isolated LPS at concentrations of 50, 100, and 1 µg/ml, respectively. The endotoxin activities of these co...
Source: Archives of Toxicology - December 8, 2023 Category: Toxicology Authors: V Sko čková P Raptov á K Posp íchalová I Sovadinov á E Sychrov á M Smutn á K Hilscherov á P Babica L Šindlerová Source Type: research
Cyanobacterial harmful bloom lipopolysaccharides: pro-inflammatory effects on epithelial and immune cells in vitro
In this study, we isolated LPS from 19 CyanoHAB samples collected at 18 water bodies in the Czech Republic over two consecutive seasons. The proportions of cyanobacteria, Gram-negative bacteria (G-), and other bacteria in the biomass were determined by qPCR, while the cyanobacterial genera were identified using light microscopy. In vitro models of keratinocytes (HaCaT), the intestinal epithelium (co-culture of differentiated Caco-2 cells and peripheral blood mononuclear cells - PBMC), and PBMC alone were treated with isolated LPS at concentrations of 50, 100, and 1 µg/ml, respectively. The endotoxin activities of these co...
Source: Archives of Toxicology - December 8, 2023 Category: Toxicology Authors: V Sko čková P Raptov á K Posp íchalová I Sovadinov á E Sychrov á M Smutn á K Hilscherov á P Babica L Šindlerová Source Type: research
Kinetically-derived maximal dose (KMD) indicates lack of human carcinogenicity of ethylbenzene
Arch Toxicol. 2023 Dec 7. doi: 10.1007/s00204-023-03629-7. Online ahead of print.ABSTRACTThe kinetically-derived maximal dose (KMD) is defined as the maximal external dose at which kinetics are unchanged relative to lower doses, e.g., doses at which kinetic processes are not saturated. Toxicity produced at doses above the KMD can be qualitatively different from toxicity produced at lower doses. Here, we test the hypothesis that neoplastic lesions reported in the National Toxicology Program's (NTP) rodent cancer bioassay with ethylbenzene are a high-dose phenomenon secondary to saturation of elimination kinetics. To test th...
Source: Archives of Toxicology - December 7, 2023 Category: Toxicology Authors: Lyle D Burgoon Christopher J Borgert Claudio Fuentes James E Klaunig Source Type: research
Kinetically-derived maximal dose (KMD) indicates lack of human carcinogenicity of ethylbenzene
Arch Toxicol. 2023 Dec 7. doi: 10.1007/s00204-023-03629-7. Online ahead of print.ABSTRACTThe kinetically-derived maximal dose (KMD) is defined as the maximal external dose at which kinetics are unchanged relative to lower doses, e.g., doses at which kinetic processes are not saturated. Toxicity produced at doses above the KMD can be qualitatively different from toxicity produced at lower doses. Here, we test the hypothesis that neoplastic lesions reported in the National Toxicology Program's (NTP) rodent cancer bioassay with ethylbenzene are a high-dose phenomenon secondary to saturation of elimination kinetics. To test th...
Source: Archives of Toxicology - December 7, 2023 Category: Toxicology Authors: Lyle D Burgoon Christopher J Borgert Claudio Fuentes James E Klaunig Source Type: research
Interleukin 1 β and interleukin 6 production in human immune cells is stimulated by the antibacterial compound Triclosan
Arch Toxicol. 2023 Dec 6. doi: 10.1007/s00204-023-03654-6. Online ahead of print.ABSTRACTTriclosan (TCS) is an antimicrobial compound widely used in personal hygiene products such as mouthwash and toothpaste; and has been found in human blood, breast milk, and urine. Interleukin (IL)-6 and IL-1 beta (IL-1β) are pro-inflammatory cytokines regulating cell growth, tissue repair, and immune function; increased levels of each have been associated with many diseases, including cancer. Previous studies showed that TCS at concentrations between 0.05 and 5 µM consistently increased the secretion of IL-1β and IL-6 from human immu...
Source: Archives of Toxicology - December 6, 2023 Category: Toxicology Authors: Wendy J Wilburn Sahra Gabure Margaret M Whalen Source Type: research
Correction: Species-differences in the in vitro biotransformation of trifluoroethene (HFO-1123)
Arch Toxicol. 2023 Dec 6. doi: 10.1007/s00204-023-03640-y. Online ahead of print.NO ABSTRACTPMID:38057564 | DOI:10.1007/s00204-023-03640-y (Source: Archives of Toxicology)
Source: Archives of Toxicology - December 6, 2023 Category: Toxicology Authors: R Dekant R Bertermann J Serban S Sharma M Shinohara Y Morizawa H Okamoto W Brock W Dekant A Mally Source Type: research
Interleukin 1 β and interleukin 6 production in human immune cells is stimulated by the antibacterial compound Triclosan
Arch Toxicol. 2023 Dec 6. doi: 10.1007/s00204-023-03654-6. Online ahead of print.ABSTRACTTriclosan (TCS) is an antimicrobial compound widely used in personal hygiene products such as mouthwash and toothpaste; and has been found in human blood, breast milk, and urine. Interleukin (IL)-6 and IL-1 beta (IL-1β) are pro-inflammatory cytokines regulating cell growth, tissue repair, and immune function; increased levels of each have been associated with many diseases, including cancer. Previous studies showed that TCS at concentrations between 0.05 and 5 µM consistently increased the secretion of IL-1β and IL-6 from human immu...
Source: Archives of Toxicology - December 6, 2023 Category: Toxicology Authors: Wendy J Wilburn Sahra Gabure Margaret M Whalen Source Type: research
