Toxicokinetics of homosalate in humans after dermal application: applicability of oral-route data for exposure assessment by human biomonitoring
Arch Toxicol. 2024 Mar 14. doi: 10.1007/s00204-024-03704-7. Online ahead of print.ABSTRACTHomosalate (HMS) is a UV filter used in sunscreens and personal care products as a mixture of cis- and trans-isomers. Systemic absorption after sunscreen use has been demonstrated in humans, and concerns have been raised about possible endocrine activity of HMS, making a general population exposure assessment desirable. In a previous study, it was shown that the oral bioavailability of cis-HMS (cHMS) is lower than that of trans-HMS (tHMS) by a factor of 10, calling for a separate evaluation of both isomers in exposure and risk assessm...
Source: Archives of Toxicology - March 15, 2024 Category: Toxicology Authors: Katharina E Ebert Peter Griem Tobias Weiss Thomas Br üning Heiko Hayen Holger M Koch Daniel Bury Source Type: research
Recent advances and current challenges of new approach methodologies in developmental and adult neurotoxicity testing
Arch Toxicol. 2024 Mar 13. doi: 10.1007/s00204-024-03703-8. Online ahead of print.ABSTRACTAdult neurotoxicity (ANT) and developmental neurotoxicity (DNT) assessments aim to understand the adverse effects and underlying mechanisms of toxicants on the human nervous system. In recent years, there has been an increasing focus on the so-called new approach methodologies (NAMs). The Organization for Economic Co-operation and Development (OECD), together with European and American regulatory agencies, promote the use of validated alternative test systems, but to date, guidelines for regulatory DNT and ANT assessment rely primaril...
Source: Archives of Toxicology - March 14, 2024 Category: Toxicology Authors: Melania Maria Serafini Sara Sepehri Miriam Midali Marth Stinckens Marta Biesiekierska Anna Wolniakowska Alexandra Gatzios Elise Rund én-Pran Edyta Reszka Marina Marinovich Tamara Vanhaecke Joanna Roszak Barbara Viviani Tanima SenGupta Source Type: research
Cellular senescence gene TACC3 associated with colorectal cancer risk via genetic and DNA methylated alteration
Arch Toxicol. 2024 Mar 14. doi: 10.1007/s00204-024-03702-9. Online ahead of print.ABSTRACTCell senescence genes play a vital role in the pathogenesis of colorectal cancer, a process that may involve the triggering of genetic variations and reversible phenotypes caused by epigenetic modifications. However, the specific regulatory mechanisms remain unclear. Using CellAge and The Cancer Genome Atlas databases and in-house RNA-seq data, DNA methylation-modified cellular senescence genes (DMCSGs) were validated by Support Vector Machine and correlation analyses. In 1150 cases and 1342 controls, we identified colorectal cancer r...
Source: Archives of Toxicology - March 14, 2024 Category: Toxicology Authors: Hengyang Shen Yang Chen Menghuan Xu Jieyu Zhou Changzhi Huang Zhenling Wang Yu Shao Hongqiang Zhang Yunfei Lu Shuwei Li Zan Fu Source Type: research
Use of human predictive patch test (HPPT) data for the classification of skin sensitization hazard and potency
Arch Toxicol. 2024 Mar 14. doi: 10.1007/s00204-023-03656-4. Online ahead of print.ABSTRACTSince the 1940s, patch tests in healthy volunteers (Human Predictive Patch Tests, HPPTs) have been used to identify chemicals that cause skin sensitization in humans. Recently, we reported the results of a major curation effort to support the development of OECD Guideline 497 on Defined Approaches (DAs) for skin sensitization (OECD in Guideline No. 497: Defined Approaches on Skin Sensitisation, 2021a. https://doi.org/10.1787/b92879a4-en ). In the course of this work, we compiled and published a database of 2277 HPPT results for 1366 u...
Source: Archives of Toxicology - March 14, 2024 Category: Toxicology Authors: Matthias Herzler Jaleh Abedini David G Allen Dori Germolec John Gordon Hon-Sum Ko Joanna Matheson Emily Reinke Judy Strickland Hermann-Josef Thierse Kim To James Truax Jens T Vanselow Nicole Kleinstreuer Source Type: research
Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants
Arch Toxicol. 2024 Mar 14. doi: 10.1007/s00204-024-03696-4. Online ahead of print.ABSTRACTReactive oxygen species (ROS) and reactive nitrogen species (RNS) are well recognized for playing a dual role, since they can be either deleterious or beneficial to biological systems. An imbalance between ROS production and elimination is termed oxidative stress, a critical factor and common denominator of many chronic diseases such as cancer, cardiovascular diseases, metabolic diseases, neurological disorders (Alzheimer's and Parkinson's diseases), and other disorders. To counteract the harmful effects of ROS, organisms have evolved...
Source: Archives of Toxicology - March 14, 2024 Category: Toxicology Authors: Klaudia Jomova Suliman Y Alomar Saleh H Alwasel Eugenie Nepovimova Kamil Kuca Marian Valko Source Type: research
Combined use of multiparametric high-content-screening and in vitro circadian reporter assays in neurotoxicity evaluation
Arch Toxicol. 2024 Mar 14. doi: 10.1007/s00204-024-03686-6. Online ahead of print.ABSTRACTAccumulating evidence indicates that chronic circadian rhythm disruption is associated with the development of neurodegenerative diseases induced by exposure to neurotoxic chemicals. Herein, we examined the relationship between cellular circadian rhythm disruption and cytotoxicity in neural cells. Moreover, we evaluated the potential application of an in vitro cellular circadian rhythm assay in determining circadian rhythm disruption as a sensitive and early marker of neurotoxicant-induced adverse effects. To explore these objectives,...
Source: Archives of Toxicology - March 14, 2024 Category: Toxicology Authors: Youngil Park Hwan-Goo Kang Seok-Jin Kang Hyun-Ok Ku Helmut Zarbl Ming-Zhu Fang Jae-Hak Park Source Type: research
Involvement of per- and polyfluoroalkyl compounds in tumor development
Arch Toxicol. 2024 Mar 13. doi: 10.1007/s00204-024-03685-7. Online ahead of print.ABSTRACTPer- and polyfluoroalkyl substances (PFAS) are a large group of synthetic persistent chemicals, which are used in many industrial and commercial applications. Hundreds of different PFAS have been identified in the environment and they are commonly found also in human blood. Due to the chemical stability and extensive use, PFAS pose a risk for human health and wildlife. Mounting evidence indicates that PFAS-exposure adversely affects many organs including liver, kidney, and reproductive tissues and induces tumors in laboratory rodents....
Source: Archives of Toxicology - March 13, 2024 Category: Toxicology Authors: Maija Pesonen Kirsi V ähäkangas Source Type: research
Involvement of per- and polyfluoroalkyl compounds in tumor development
Arch Toxicol. 2024 Mar 13. doi: 10.1007/s00204-024-03685-7. Online ahead of print.ABSTRACTPer- and polyfluoroalkyl substances (PFAS) are a large group of synthetic persistent chemicals, which are used in many industrial and commercial applications. Hundreds of different PFAS have been identified in the environment and they are commonly found also in human blood. Due to the chemical stability and extensive use, PFAS pose a risk for human health and wildlife. Mounting evidence indicates that PFAS-exposure adversely affects many organs including liver, kidney, and reproductive tissues and induces tumors in laboratory rodents....
Source: Archives of Toxicology - March 13, 2024 Category: Toxicology Authors: Maija Pesonen Kirsi V ähäkangas Source Type: research
Acetaminophen overdose causes a breach of the blood-bile barrier in mice but not in rats
In conclusion, different mechanisms cause cell death in rats and mice, whereby oxidative stress and a breach of the blood-bile barrier are seen only in mice. Since transient cholestasis also occurs in human patients with APAP overdose, mice are a clinically relevant species to study APAP hepatotoxicity but not rats.PMID:38466352 | DOI:10.1007/s00204-024-03705-6 (Source: Archives of Toxicology)
Source: Archives of Toxicology - March 11, 2024 Category: Toxicology Authors: Reham Hassan Zaynab Hobloss Maiju Myllys Daniela Gonz ález Brigitte Begher-Tibbe Joerg Reinders Adrian Friebel Stefan Hoehme Noha Abdelmageed Aya A Abbas Abdel-Latief Seddek Samy A F Morad Jan G Hengstler Ahmed Ghallab Source Type: research
Acetaminophen overdose causes a breach of the blood-bile barrier in mice but not in rats
In conclusion, different mechanisms cause cell death in rats and mice, whereby oxidative stress and a breach of the blood-bile barrier are seen only in mice. Since transient cholestasis also occurs in human patients with APAP overdose, mice are a clinically relevant species to study APAP hepatotoxicity but not rats.PMID:38466352 | DOI:10.1007/s00204-024-03705-6 (Source: Archives of Toxicology)
Source: Archives of Toxicology - March 11, 2024 Category: Toxicology Authors: Reham Hassan Zaynab Hobloss Maiju Myllys Daniela Gonz ález Brigitte Begher-Tibbe Joerg Reinders Adrian Friebel Stefan Hoehme Noha Abdelmageed Aya A Abbas Abdel-Latief Seddek Samy A F Morad Jan G Hengstler Ahmed Ghallab Source Type: research
Future in the past: paternal reprogramming of offspring phenotype and the epigenetic mechanisms
Arch Toxicol. 2024 Mar 9. doi: 10.1007/s00204-024-03713-6. Online ahead of print.ABSTRACTThat certain preconceptual paternal exposures reprogram the developmental phenotypic plasticity in future generation(s) has conceptualized the "paternal programming of offspring health" hypothesis. This transgenerational effect is transmitted primarily through sperm epigenetic mechanisms-DNA methylation, non-coding RNAs (ncRNAs) and associated RNA modifications, and histone modifications-and potentially through non-sperm-specific mechanisms-seminal plasma and circulating factors-that create 'imprinted' memory of ancestral information. ...
Source: Archives of Toxicology - March 9, 2024 Category: Toxicology Authors: Di Wu Kejia Zhang Kaifeng Guan Faheem Ahmed Khan Nuruliarizki Shinta Pandupuspitasari Windu Negara Fei Sun Chunjie Huang Source Type: research
Circular RNA MKLN1 promotes epithelial-mesenchymal transition in pulmonary fibrosis by regulating the miR-26a/b-5p/CDK8 axis in human alveolar epithelial cells and mice models
This study provides a theoretical basis for finding new targets or biomarkers in pulmonary fibrosis.PMID:38460002 | DOI:10.1007/s00204-024-03700-x (Source: Archives of Toxicology)
Source: Archives of Toxicology - March 9, 2024 Category: Toxicology Authors: Yong Zhu Xiaoxiao Meng Xian Zhu Jiaxiang Zhang Hui Lv Feiyao Wang Jinfeng Wang Cheng Chen Mengting Chen Dapeng Wang Wei Jin Rui Tian Ruilan Wang Source Type: research
Future in the past: paternal reprogramming of offspring phenotype and the epigenetic mechanisms
Arch Toxicol. 2024 Mar 9. doi: 10.1007/s00204-024-03713-6. Online ahead of print.ABSTRACTThat certain preconceptual paternal exposures reprogram the developmental phenotypic plasticity in future generation(s) has conceptualized the "paternal programming of offspring health" hypothesis. This transgenerational effect is transmitted primarily through sperm epigenetic mechanisms-DNA methylation, non-coding RNAs (ncRNAs) and associated RNA modifications, and histone modifications-and potentially through non-sperm-specific mechanisms-seminal plasma and circulating factors-that create 'imprinted' memory of ancestral information. ...
Source: Archives of Toxicology - March 9, 2024 Category: Toxicology Authors: Di Wu Kejia Zhang Kaifeng Guan Faheem Ahmed Khan Nuruliarizki Shinta Pandupuspitasari Windu Negara Fei Sun Chunjie Huang Source Type: research
Circular RNA MKLN1 promotes epithelial-mesenchymal transition in pulmonary fibrosis by regulating the miR-26a/b-5p/CDK8 axis in human alveolar epithelial cells and mice models
This study provides a theoretical basis for finding new targets or biomarkers in pulmonary fibrosis.PMID:38460002 | DOI:10.1007/s00204-024-03700-x (Source: Archives of Toxicology)
Source: Archives of Toxicology - March 9, 2024 Category: Toxicology Authors: Yong Zhu Xiaoxiao Meng Xian Zhu Jiaxiang Zhang Hui Lv Feiyao Wang Jinfeng Wang Cheng Chen Mengting Chen Dapeng Wang Wei Jin Rui Tian Ruilan Wang Source Type: research
A-series agent A-234: initial in vitro and in vivo characterization
This study is the first to provide essential experimental preclinical data on the A-234 compound.PMID:38446233 | DOI:10.1007/s00204-024-03689-3 (Source: Archives of Toxicology)
Source: Archives of Toxicology - March 6, 2024 Category: Toxicology Authors: Martina Hrabinova Jaroslav Pejchal Vendula Hepnarova Lubica Muckova Lucie Junova Jakub Opravil Jana Zdarova Karasova Tomas Rozsypal Alzbeta Dlabkova Helena Rehulkova Tomas Kucera Zbyn ěk Vecera Filip Caisberger Monika Schmidt Ondrej Soukup Daniel Jun Source Type: research
