Cytogenotoxicity and inflammatory response in liver of rats exposed to different doses of cannabis nano emulsions
Arch Toxicol. 2024 Mar 17. doi: 10.1007/s00204-024-03712-7. Online ahead of print.ABSTRACTCannabis is the most used illicit substance for recreational purposes around the world. However, it has become increasingly common to witness the use of approved cannabis preparations for symptoms management in various diseases. The aim of this study was to investigate the effects of cannabis nano emulsion in the liver of Wistar rats, with different proportions of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). For this, a total of 40 male Wistar rats were distributed into 5 groups, as follows (n = 8 per group): Control: G1,...
Source: Archives of Toxicology - March 18, 2024 Category: Toxicology Authors: Thiago Guedes Pinto Barbara Dos Anjos Rosario Andrea Cristina de Moraes Malinverni Rosana Xavier Yasmin Alaby Martins Ferreira Luciana Pellegrini Pisani Pedro Everson Alexandre de Aquino Glauce Socorro de Barros Viana Daniel Vitor de Souza Milena de Barro Source Type: research
Role of the complement system in kidney cell death induced by Loxosceles venom Sphingomyelinases D
Arch Toxicol. 2024 Mar 18. doi: 10.1007/s00204-024-03711-8. Online ahead of print.ABSTRACTEnvenomation by Loxosceles spiders can result in local and systemic pathologies. Systemic loxoscelism, which can lead to death, is characterized by intravascular hemolysis, platelet aggregation, and acute kidney injury. Sphingomyelinase D (SMase D) in Loxosceles spider venom is responsible for both local and systemic pathologies, and has been shown to induce metalloprotease activity. As the complement system is involved in many renal pathologies and is involved in hemolysis in systemic loxoscelism, the aim of this study was to investi...
Source: Archives of Toxicology - March 18, 2024 Category: Toxicology Authors: Cinthya Kimori Okamoto Carmen W van den Berg Paula C Pohl Denise V Tambourgi Source Type: research
CircRNA: a rising therapeutic strategy for lung injury induced by pulmonary toxicants
Arch Toxicol. 2024 Mar 18. doi: 10.1007/s00204-024-03706-5. Online ahead of print.ABSTRACTLung injury has been a serious medical problem that requires new therapeutic approaches and biomarkers. Circular RNAs (circRNAs) are non-coding RNAs (ncRNAs) that exist widely in eukaryotes. CircRNAs are single-stranded RNAs that form covalently closed loops. CircRNAs are significant gene regulators that have a role in the development, progression, and therapy of lung injury by controlling transcription, translating into protein, and sponging microRNAs (miRNAs) and proteins. Although the study of circRNAs in lung injury caused by pulm...
Source: Archives of Toxicology - March 18, 2024 Category: Toxicology Authors: Cai Liao Zhen-Wei He Rui Yu Ya-Jie Yu Xiao-Ru Liu De-Lei Kong Yun Wang Source Type: research
Cytogenotoxicity and inflammatory response in liver of rats exposed to different doses of cannabis nano emulsions
Arch Toxicol. 2024 Mar 17. doi: 10.1007/s00204-024-03712-7. Online ahead of print.ABSTRACTCannabis is the most used illicit substance for recreational purposes around the world. However, it has become increasingly common to witness the use of approved cannabis preparations for symptoms management in various diseases. The aim of this study was to investigate the effects of cannabis nano emulsion in the liver of Wistar rats, with different proportions of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). For this, a total of 40 male Wistar rats were distributed into 5 groups, as follows (n = 8 per group): Control: G1,...
Source: Archives of Toxicology - March 18, 2024 Category: Toxicology Authors: Thiago Guedes Pinto Barbara Dos Anjos Rosario Andrea Cristina de Moraes Malinverni Rosana Xavier Yasmin Alaby Martins Ferreira Luciana Pellegrini Pisani Pedro Everson Alexandre de Aquino Glauce Socorro de Barros Viana Daniel Vitor de Souza Milena de Barro Source Type: research
The estimation of acute oral toxicity (LD < sub > 50 < /sub > ) of G-series organophosphorus-based chemical warfare agents using quantitative and qualitative toxicology in silico methods
This study employs qualitative (STopTox and AdmetSAR) and quantitative (TEST; CATMoS; ProTox-II and QSAR Toolbox) in silico methods to predict LD50 values, offering an ethical alternative to animal testing. Additionally, we conducted quantitative extrapolation from animals, and the results of qualitative tests confirmed the acute toxicity potential of these substances and enabled the identification of toxicophoric groups. According to our estimations, the most lethal agents within this category were GV, soman (GD), sarin (GB), thiosarin (GBS), and chlorosarin (GC), with t-LD50 values (oral administration, extrapolated from...
Source: Archives of Toxicology - March 17, 2024 Category: Toxicology Authors: Maciej Noga Agata Michalska Kamil Jurowski Source Type: research
Prediction of cytochrome P450-mediated bioactivation using machine learning models and in vitro validation
Arch Toxicol. 2024 Mar 16. doi: 10.1007/s00204-024-03701-w. Online ahead of print.ABSTRACTCytochrome P450 (P450)-mediated bioactivation, which can lead to the hepatotoxicity through the formation of reactive metabolites (RMs), has been regarded as the major problem of drug failures. Herein, we purposed to establish machine learning models to predict the bioactivation of P450. On the basis of the literature-derived bioactivation dataset, models for Benzene ring, Nitrogen heterocycle and Sulfur heterocycle were developed with machine learning methods, i.e., Random Forest, Random Subspace, SVM and Naïve Bayes. The models wer...
Source: Archives of Toxicology - March 16, 2024 Category: Toxicology Authors: Xin-Man Hu Yan-Yao Hou Xin-Ru Teng Yong Liu Yu Li Wei Li Yan Li Chun-Zhi Ai Source Type: research
Prediction of cytochrome P450-mediated bioactivation using machine learning models and in vitro validation
Arch Toxicol. 2024 Mar 16. doi: 10.1007/s00204-024-03701-w. Online ahead of print.ABSTRACTCytochrome P450 (P450)-mediated bioactivation, which can lead to the hepatotoxicity through the formation of reactive metabolites (RMs), has been regarded as the major problem of drug failures. Herein, we purposed to establish machine learning models to predict the bioactivation of P450. On the basis of the literature-derived bioactivation dataset, models for Benzene ring, Nitrogen heterocycle and Sulfur heterocycle were developed with machine learning methods, i.e., Random Forest, Random Subspace, SVM and Naïve Bayes. The models wer...
Source: Archives of Toxicology - March 16, 2024 Category: Toxicology Authors: Xin-Man Hu Yan-Yao Hou Xin-Ru Teng Yong Liu Yu Li Wei Li Yan Li Chun-Zhi Ai Source Type: research
Elevated aerobic glycolysis driven by p62-mTOR axis promotes arsenic-induced oncogenic phenotypes in human mammary epithelial cells
Arch Toxicol. 2024 Mar 14. doi: 10.1007/s00204-024-03709-2. Online ahead of print.ABSTRACTChronic arsenic exposure is considered to increase the risk of breast cancer. p62 is a multifunctional adaptor protein that controls myriad cellular processes and is overexpressed in breast cancer tissues. Although previous studies have indicated the involvement of p62 accumulation in arsenic tumorigenesis, the underlying mechanism remains obscure. Here, we found that 0.1 µM or 0.5 µM arsenite exposure for 24 weeks induced oncogenic phenotypes in human mammary epithelial cells. Elevated aerobic glycolysis, cell proliferation capacit...
Source: Archives of Toxicology - March 15, 2024 Category: Toxicology Authors: Yongfang Li Jiao Liu Dianqi Yao Zijun Guo Xuheng Jiang Chengwen Zhang Litong Qu Yuyan Liu Yuxin Hu Lanyue Gao Yi Wang Yuanyuan Xu Source Type: research
Toxicokinetics of homosalate in humans after dermal application: applicability of oral-route data for exposure assessment by human biomonitoring
Arch Toxicol. 2024 Mar 14. doi: 10.1007/s00204-024-03704-7. Online ahead of print.ABSTRACTHomosalate (HMS) is a UV filter used in sunscreens and personal care products as a mixture of cis- and trans-isomers. Systemic absorption after sunscreen use has been demonstrated in humans, and concerns have been raised about possible endocrine activity of HMS, making a general population exposure assessment desirable. In a previous study, it was shown that the oral bioavailability of cis-HMS (cHMS) is lower than that of trans-HMS (tHMS) by a factor of 10, calling for a separate evaluation of both isomers in exposure and risk assessm...
Source: Archives of Toxicology - March 15, 2024 Category: Toxicology Authors: Katharina E Ebert Peter Griem Tobias Weiss Thomas Br üning Heiko Hayen Holger M Koch Daniel Bury Source Type: research
Elevated aerobic glycolysis driven by p62-mTOR axis promotes arsenic-induced oncogenic phenotypes in human mammary epithelial cells
Arch Toxicol. 2024 Mar 14. doi: 10.1007/s00204-024-03709-2. Online ahead of print.ABSTRACTChronic arsenic exposure is considered to increase the risk of breast cancer. p62 is a multifunctional adaptor protein that controls myriad cellular processes and is overexpressed in breast cancer tissues. Although previous studies have indicated the involvement of p62 accumulation in arsenic tumorigenesis, the underlying mechanism remains obscure. Here, we found that 0.1 µM or 0.5 µM arsenite exposure for 24 weeks induced oncogenic phenotypes in human mammary epithelial cells. Elevated aerobic glycolysis, cell proliferation capacit...
Source: Archives of Toxicology - March 15, 2024 Category: Toxicology Authors: Yongfang Li Jiao Liu Dianqi Yao Zijun Guo Xuheng Jiang Chengwen Zhang Litong Qu Yuyan Liu Yuxin Hu Lanyue Gao Yi Wang Yuanyuan Xu Source Type: research
Toxicokinetics of homosalate in humans after dermal application: applicability of oral-route data for exposure assessment by human biomonitoring
Arch Toxicol. 2024 Mar 14. doi: 10.1007/s00204-024-03704-7. Online ahead of print.ABSTRACTHomosalate (HMS) is a UV filter used in sunscreens and personal care products as a mixture of cis- and trans-isomers. Systemic absorption after sunscreen use has been demonstrated in humans, and concerns have been raised about possible endocrine activity of HMS, making a general population exposure assessment desirable. In a previous study, it was shown that the oral bioavailability of cis-HMS (cHMS) is lower than that of trans-HMS (tHMS) by a factor of 10, calling for a separate evaluation of both isomers in exposure and risk assessm...
Source: Archives of Toxicology - March 15, 2024 Category: Toxicology Authors: Katharina E Ebert Peter Griem Tobias Weiss Thomas Br üning Heiko Hayen Holger M Koch Daniel Bury Source Type: research
Recent advances and current challenges of new approach methodologies in developmental and adult neurotoxicity testing
Arch Toxicol. 2024 Mar 13. doi: 10.1007/s00204-024-03703-8. Online ahead of print.ABSTRACTAdult neurotoxicity (ANT) and developmental neurotoxicity (DNT) assessments aim to understand the adverse effects and underlying mechanisms of toxicants on the human nervous system. In recent years, there has been an increasing focus on the so-called new approach methodologies (NAMs). The Organization for Economic Co-operation and Development (OECD), together with European and American regulatory agencies, promote the use of validated alternative test systems, but to date, guidelines for regulatory DNT and ANT assessment rely primaril...
Source: Archives of Toxicology - March 14, 2024 Category: Toxicology Authors: Melania Maria Serafini Sara Sepehri Miriam Midali Marth Stinckens Marta Biesiekierska Anna Wolniakowska Alexandra Gatzios Elise Rund én-Pran Edyta Reszka Marina Marinovich Tamara Vanhaecke Joanna Roszak Barbara Viviani Tanima SenGupta Source Type: research
Cellular senescence gene TACC3 associated with colorectal cancer risk via genetic and DNA methylated alteration
Arch Toxicol. 2024 Mar 14. doi: 10.1007/s00204-024-03702-9. Online ahead of print.ABSTRACTCell senescence genes play a vital role in the pathogenesis of colorectal cancer, a process that may involve the triggering of genetic variations and reversible phenotypes caused by epigenetic modifications. However, the specific regulatory mechanisms remain unclear. Using CellAge and The Cancer Genome Atlas databases and in-house RNA-seq data, DNA methylation-modified cellular senescence genes (DMCSGs) were validated by Support Vector Machine and correlation analyses. In 1150 cases and 1342 controls, we identified colorectal cancer r...
Source: Archives of Toxicology - March 14, 2024 Category: Toxicology Authors: Hengyang Shen Yang Chen Menghuan Xu Jieyu Zhou Changzhi Huang Zhenling Wang Yu Shao Hongqiang Zhang Yunfei Lu Shuwei Li Zan Fu Source Type: research
Use of human predictive patch test (HPPT) data for the classification of skin sensitization hazard and potency
Arch Toxicol. 2024 Mar 14. doi: 10.1007/s00204-023-03656-4. Online ahead of print.ABSTRACTSince the 1940s, patch tests in healthy volunteers (Human Predictive Patch Tests, HPPTs) have been used to identify chemicals that cause skin sensitization in humans. Recently, we reported the results of a major curation effort to support the development of OECD Guideline 497 on Defined Approaches (DAs) for skin sensitization (OECD in Guideline No. 497: Defined Approaches on Skin Sensitisation, 2021a. https://doi.org/10.1787/b92879a4-en ). In the course of this work, we compiled and published a database of 2277 HPPT results for 1366 u...
Source: Archives of Toxicology - March 14, 2024 Category: Toxicology Authors: Matthias Herzler Jaleh Abedini David G Allen Dori Germolec John Gordon Hon-Sum Ko Joanna Matheson Emily Reinke Judy Strickland Hermann-Josef Thierse Kim To James Truax Jens T Vanselow Nicole Kleinstreuer Source Type: research
Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants
Arch Toxicol. 2024 Mar 14. doi: 10.1007/s00204-024-03696-4. Online ahead of print.ABSTRACTReactive oxygen species (ROS) and reactive nitrogen species (RNS) are well recognized for playing a dual role, since they can be either deleterious or beneficial to biological systems. An imbalance between ROS production and elimination is termed oxidative stress, a critical factor and common denominator of many chronic diseases such as cancer, cardiovascular diseases, metabolic diseases, neurological disorders (Alzheimer's and Parkinson's diseases), and other disorders. To counteract the harmful effects of ROS, organisms have evolved...
Source: Archives of Toxicology - March 14, 2024 Category: Toxicology Authors: Klaudia Jomova Suliman Y Alomar Saleh H Alwasel Eugenie Nepovimova Kamil Kuca Marian Valko Source Type: research
