Two-year dermal carcinogenicity bioassay of triclosan in B6C3F1 mice
Arch Toxicol. 2023 Oct 24. doi: 10.1007/s00204-023-03613-1. Online ahead of print.ABSTRACTTriclosan is a widely used antimicrobial agent in personal care products, household items, medical devices, and clinical settings. Due to its extensive use, there is potential for humans in all age groups to receive lifetime exposures to triclosan, yet data on the chronic dermal toxicity/carcinogenicity of triclosan are still lacking. We evaluated the toxicity/carcinogenicity of triclosan administered dermally to B6C3F1 mice for 104 weeks. Groups of 48 male and 48 female B6C3F1 mice received dermal applications of 0, 1.25, 2.7, 5.8, o...
Source: Archives of Toxicology - October 24, 2023 Category: Toxicology Authors: Jia-Long Fang Michelle M Vanlandingham Greg R Olson Mackean P Maisha Robert Felton Frederick A Beland Source Type: research
Two-year dermal carcinogenicity bioassay of triclosan in B6C3F1 mice
Arch Toxicol. 2023 Oct 24. doi: 10.1007/s00204-023-03613-1. Online ahead of print.ABSTRACTTriclosan is a widely used antimicrobial agent in personal care products, household items, medical devices, and clinical settings. Due to its extensive use, there is potential for humans in all age groups to receive lifetime exposures to triclosan, yet data on the chronic dermal toxicity/carcinogenicity of triclosan are still lacking. We evaluated the toxicity/carcinogenicity of triclosan administered dermally to B6C3F1 mice for 104 weeks. Groups of 48 male and 48 female B6C3F1 mice received dermal applications of 0, 1.25, 2.7, 5.8, o...
Source: Archives of Toxicology - October 24, 2023 Category: Toxicology Authors: Jia-Long Fang Michelle M Vanlandingham Greg R Olson Mackean P Maisha Robert Felton Frederick A Beland Source Type: research
Combined in vivo metabolic effects of quetiapine and methadone in brain and blood of rats
In conclusion, this study in rats suggests a few but important additive metabolic effects when quetiapine and methadone are co-administered.PMID:37870577 | DOI:10.1007/s00204-023-03620-2 (Source: Archives of Toxicology)
Source: Archives of Toxicology - October 23, 2023 Category: Toxicology Authors: Laura Smedegaard Heisel Freja Drost Andersen S âmia Joca Lambert Kristiansen S ørensen Ulf Simonsen J ørgen Bo Hasselstrøm Charlotte Uggerh øj Andersen Kirstine Lykke Nielsen Source Type: research
Combined in vivo metabolic effects of quetiapine and methadone in brain and blood of rats
In conclusion, this study in rats suggests a few but important additive metabolic effects when quetiapine and methadone are co-administered.PMID:37870577 | DOI:10.1007/s00204-023-03620-2 (Source: Archives of Toxicology)
Source: Archives of Toxicology - October 23, 2023 Category: Toxicology Authors: Laura Smedegaard Heisel Freja Drost Andersen S âmia Joca Lambert Kristiansen S ørensen Ulf Simonsen J ørgen Bo Hasselstrøm Charlotte Uggerh øj Andersen Kirstine Lykke Nielsen Source Type: research
Elucidating the toxicity mechanisms of organophosphate esters by adverse outcome pathway network
This study provides a theoretical basis for OPEs risk assessment in the future.PMID:37864630 | DOI:10.1007/s00204-023-03624-y (Source: Archives of Toxicology)
Source: Archives of Toxicology - October 21, 2023 Category: Toxicology Authors: Wanyu He Jiaqi Ding Ning Gao Lingyan Zhu Lin Zhu Jianfeng Feng Source Type: research
Elucidating the toxicity mechanisms of organophosphate esters by adverse outcome pathway network
This study provides a theoretical basis for OPEs risk assessment in the future.PMID:37864630 | DOI:10.1007/s00204-023-03624-y (Source: Archives of Toxicology)
Source: Archives of Toxicology - October 21, 2023 Category: Toxicology Authors: Wanyu He Jiaqi Ding Ning Gao Lingyan Zhu Lin Zhu Jianfeng Feng Source Type: research
Effect of bisphenol A on the neurological system: a review update
Arch Toxicol. 2023 Oct 19. doi: 10.1007/s00204-023-03614-0. Online ahead of print.ABSTRACTBisphenol A (BPA) is an endocrine-disrupting chemical (EDC) and one of the most produced synthetic compounds worldwide. BPA can be found in epoxy resins and polycarbonate plastics, which are frequently used in food storage and baby bottles. However, BPA can bind mainly to estrogen receptors, interfering with various neurologic functions, its use is a topic of significant concern. Nonetheless, the neurotoxicity of BPA has not been fully understood despite numerous investigations on its disruptive effects. Therefore, this review aims to...
Source: Archives of Toxicology - October 19, 2023 Category: Toxicology Authors: Henrique Eloi Costa Elisa Cairrao Source Type: research
Effect of bisphenol A on the neurological system: a review update
Arch Toxicol. 2023 Oct 19. doi: 10.1007/s00204-023-03614-0. Online ahead of print.ABSTRACTBisphenol A (BPA) is an endocrine-disrupting chemical (EDC) and one of the most produced synthetic compounds worldwide. BPA can be found in epoxy resins and polycarbonate plastics, which are frequently used in food storage and baby bottles. However, BPA can bind mainly to estrogen receptors, interfering with various neurologic functions, its use is a topic of significant concern. Nonetheless, the neurotoxicity of BPA has not been fully understood despite numerous investigations on its disruptive effects. Therefore, this review aims to...
Source: Archives of Toxicology - October 19, 2023 Category: Toxicology Authors: Henrique Eloi Costa Elisa Cairrao Source Type: research
In silico and in vitro metabolism studies of the new synthetic opiate AP-237 (bucinnazine) using bioinformatics tools
Arch Toxicol. 2023 Oct 15. doi: 10.1007/s00204-023-03617-x. Online ahead of print.ABSTRACTThe recent emergence of new synthetic opioids (NSOs) compounds in the illicit market is increasingly related to fatal cases. Identification and medical care of NSO intoxication cases are challenging, particularly due to high frequency of new products and extensive metabolism. As the study of NSO metabolism is crucial for the identification of these drugs in cases of intoxication, we aimed to investigate the metabolism of the piperazine NSO AP-237 (= bucinnazine). Two complementary approaches (in silico and in vitro) were used to ident...
Source: Archives of Toxicology - October 15, 2023 Category: Toxicology Authors: Romain Pelletier Alexis Bourdais Nicolas Fabresse Pierre-Jean Ferron Isabelle Morel Thomas Gicquel Brendan Le Dar é Source Type: research
In silico and in vitro metabolism studies of the new synthetic opiate AP-237 (bucinnazine) using bioinformatics tools
Arch Toxicol. 2023 Oct 15. doi: 10.1007/s00204-023-03617-x. Online ahead of print.ABSTRACTThe recent emergence of new synthetic opioids (NSOs) compounds in the illicit market is increasingly related to fatal cases. Identification and medical care of NSO intoxication cases are challenging, particularly due to high frequency of new products and extensive metabolism. As the study of NSO metabolism is crucial for the identification of these drugs in cases of intoxication, we aimed to investigate the metabolism of the piperazine NSO AP-237 (= bucinnazine). Two complementary approaches (in silico and in vitro) were used to ident...
Source: Archives of Toxicology - October 15, 2023 Category: Toxicology Authors: Romain Pelletier Alexis Bourdais Nicolas Fabresse Pierre-Jean Ferron Isabelle Morel Thomas Gicquel Brendan Le Dar é Source Type: research
In silico and in vitro metabolism studies of the new synthetic opiate AP-237 (bucinnazine) using bioinformatics tools
Arch Toxicol. 2023 Oct 15. doi: 10.1007/s00204-023-03617-x. Online ahead of print.ABSTRACTThe recent emergence of new synthetic opioids (NSOs) compounds in the illicit market is increasingly related to fatal cases. Identification and medical care of NSO intoxication cases are challenging, particularly due to high frequency of new products and extensive metabolism. As the study of NSO metabolism is crucial for the identification of these drugs in cases of intoxication, we aimed to investigate the metabolism of the piperazine NSO AP-237 (= bucinnazine). Two complementary approaches (in silico and in vitro) were used to ident...
Source: Archives of Toxicology - October 15, 2023 Category: Toxicology Authors: Romain Pelletier Alexis Bourdais Nicolas Fabresse Pierre-Jean Ferron Isabelle Morel Thomas Gicquel Brendan Le Dar é Source Type: research
In silico and in vitro metabolism studies of the new synthetic opiate AP-237 (bucinnazine) using bioinformatics tools
Arch Toxicol. 2023 Oct 15. doi: 10.1007/s00204-023-03617-x. Online ahead of print.ABSTRACTThe recent emergence of new synthetic opioids (NSOs) compounds in the illicit market is increasingly related to fatal cases. Identification and medical care of NSO intoxication cases are challenging, particularly due to high frequency of new products and extensive metabolism. As the study of NSO metabolism is crucial for the identification of these drugs in cases of intoxication, we aimed to investigate the metabolism of the piperazine NSO AP-237 (= bucinnazine). Two complementary approaches (in silico and in vitro) were used to ident...
Source: Archives of Toxicology - October 15, 2023 Category: Toxicology Authors: Romain Pelletier Alexis Bourdais Nicolas Fabresse Pierre-Jean Ferron Isabelle Morel Thomas Gicquel Brendan Le Dar é Source Type: research
Identification, synthesis and quantification of eutylone consumption markers in a chemsex context
We report here an eutylone intoxication involving a 38-year-old man and a 29-year-old woman in a chemsex context. A bag containing a white crystalline powder labelled as a research product was found in their vehicle. Nuclear magnetic resonance and liquid chromatography-high-resolution mass spectrometry (LC-HRMS) analyses identified the powder as eutylone and confirmed purity superior to 99%. LC-HRMS data analysis using molecular networking allowed to propose new eutylone metabolites in blood samples in a graphical manner. We described 16 phase I (e.g. hydroxylated or demethylated) and phase II metabolites (glucuroconjugate...
Source: Archives of Toxicology - October 13, 2023 Category: Toxicology Authors: Romain Pelletier Brendan Le Dar é Diane Le Bou ëdec Alexis Bourdais Pierre-Jean Ferron Isabelle Morel Fran çois-Hugues Porée Thomas Gicquel Source Type: research
Rifabutin but not rifampicin can partly out-balance P-glycoprotein induction by concurrent P-glycoprotein inhibition through high affinity binding to the inhibitory site
Arch Toxicol. 2023 Oct 14. doi: 10.1007/s00204-023-03618-w. Online ahead of print.ABSTRACTPhysiology-based pharmacokinetic modeling suggests that rifabutin can out-balance P-glycoprotein (P-gp) induction by concurrent P-gp inhibition. However, clinical or experimental evidence for this Janus-faced rifabutin effect is missing. Consequently, LS180 cells were exposed to a moderately (2 µM) and strongly (10 µM) P-gp-inducing concentration of rifampicin or rifabutin for 6 days. Cellular accumulation of the fluorescent P-gp substrate rhodamine 123 was evaluated using flow cytometry, either without (induction only) or with addi...
Source: Archives of Toxicology - October 13, 2023 Category: Toxicology Authors: Lottida Phondeth Rajamanikkam Kamaraj Julie Nilles Johanna Weiss Walter E Haefeli Petr P ávek Dirk Theile Source Type: research
Identification, synthesis and quantification of eutylone consumption markers in a chemsex context
We report here an eutylone intoxication involving a 38-year-old man and a 29-year-old woman in a chemsex context. A bag containing a white crystalline powder labelled as a research product was found in their vehicle. Nuclear magnetic resonance and liquid chromatography-high-resolution mass spectrometry (LC-HRMS) analyses identified the powder as eutylone and confirmed purity superior to 99%. LC-HRMS data analysis using molecular networking allowed to propose new eutylone metabolites in blood samples in a graphical manner. We described 16 phase I (e.g. hydroxylated or demethylated) and phase II metabolites (glucuroconjugate...
Source: Archives of Toxicology - October 13, 2023 Category: Toxicology Authors: Romain Pelletier Brendan Le Dar é Diane Le Bou ëdec Alexis Bourdais Pierre-Jean Ferron Isabelle Morel Fran çois-Hugues Porée Thomas Gicquel Source Type: research
