The interactions of subcellular organelles in pulmonary fibrosis induced by carbon black nanoparticles: a comprehensive review
Arch Toxicol. 2024 Mar 27. doi: 10.1007/s00204-024-03719-0. Online ahead of print.ABSTRACTOwing to the widespread use and improper emissions of carbon black nanoparticles (CBNPs), the adverse effects of CBNPs on human health have attracted much attention. In toxicological research, carbon black is frequently utilized as a negative control because of its low toxicity and poor solubility. However, recent studies have indicated that inhalation exposure to CBNPs could be a risk factor for severe and prolonged pulmonary inflammation and fibrosis. At present, the pathogenesis of pulmonary fibrosis induced by CBNPs is still not f...
Source: Archives of Toxicology - March 27, 2024 Category: Toxicology Authors: Lei Bao Qingping Liu Jingyuan Wang Lili Shi Yaxian Pang Yujie Niu Rong Zhang Source Type: research
PBTK model-based analysis of CYP3A4 induction and the toxicokinetics of the pyrrolizidine alkaloid retrorsine in man
In conclusion, the PBTK model showed to be a promising tool to assess the dynamic interplay of enzyme induction and toxification pathways.PMID:38528153 | DOI:10.1007/s00204-024-03698-2 (Source: Archives of Toxicology)
Source: Archives of Toxicology - March 26, 2024 Category: Toxicology Authors: Anja Lehmann Ina Geburek Stefanie Hessel-Pras Anne-Margarethe Enge Hans Mielke Christine M üller-Graf Charlotte Kloft Christoph Hethey Source Type: research
PBTK model-based analysis of CYP3A4 induction and the toxicokinetics of the pyrrolizidine alkaloid retrorsine in man
In conclusion, the PBTK model showed to be a promising tool to assess the dynamic interplay of enzyme induction and toxification pathways.PMID:38528153 | DOI:10.1007/s00204-024-03698-2 (Source: Archives of Toxicology)
Source: Archives of Toxicology - March 26, 2024 Category: Toxicology Authors: Anja Lehmann Ina Geburek Stefanie Hessel-Pras Anne-Margarethe Enge Hans Mielke Christine M üller-Graf Charlotte Kloft Christoph Hethey Source Type: research
Multi-organ developmental toxicity and its characteristics in fetal mice induced by dexamethasone at different doses, stages, and courses during pregnancy
In conclusion, this study systematically confirmed PDE-induced multi-organ developmental toxicity, elucidated its characteristics, and proposed the potential "glucocorticoid (GC)-IGF1" axis programming mechanism. This research provided an experimental foundation for a comprehensive understanding of the effect and characteristics of dexamethasone on fetal multi-organ development, thereby guiding the application of "precision medicine" during pregnancy.PMID:38522057 | DOI:10.1007/s00204-024-03707-4 (Source: Archives of Toxicology)
Source: Archives of Toxicology - March 24, 2024 Category: Toxicology Authors: Xiaoqi Zhao Hao Xiao Xiaomin Li Lu Zhu Yu Peng Huijun Chen Liaobin Chen Dan Xu Hui Wang Source Type: research
Multi-organ developmental toxicity and its characteristics in fetal mice induced by dexamethasone at different doses, stages, and courses during pregnancy
In conclusion, this study systematically confirmed PDE-induced multi-organ developmental toxicity, elucidated its characteristics, and proposed the potential "glucocorticoid (GC)-IGF1" axis programming mechanism. This research provided an experimental foundation for a comprehensive understanding of the effect and characteristics of dexamethasone on fetal multi-organ development, thereby guiding the application of "precision medicine" during pregnancy.PMID:38522057 | DOI:10.1007/s00204-024-03707-4 (Source: Archives of Toxicology)
Source: Archives of Toxicology - March 24, 2024 Category: Toxicology Authors: Xiaoqi Zhao Hao Xiao Xiaomin Li Lu Zhu Yu Peng Huijun Chen Liaobin Chen Dan Xu Hui Wang Source Type: research
Formation of potentially toxic metabolites of drugs in reactions catalyzed by human drug-metabolizing enzymes
Arch Toxicol. 2024 Mar 23. doi: 10.1007/s00204-024-03710-9. Online ahead of print.ABSTRACTData are presented on the formation of potentially toxic metabolites of drugs that are substrates of human drug metabolizing enzymes. The tabular data lists the formation of potentially toxic/reactive products. The data were obtained from in vitro experiments and showed that the oxidative reactions predominate (with 96% of the total potential toxication reactions). Reductive reactions (e.g., reduction of nitro to amino group and reductive dehalogenation) participate to the extent of 4%. Of the enzymes, cytochrome P450 (P450, CYP) enzy...
Source: Archives of Toxicology - March 23, 2024 Category: Toxicology Authors: Slobodan P Rendic F Peter Guengerich Source Type: research
Formation of potentially toxic metabolites of drugs in reactions catalyzed by human drug-metabolizing enzymes
Arch Toxicol. 2024 Mar 23. doi: 10.1007/s00204-024-03710-9. Online ahead of print.ABSTRACTData are presented on the formation of potentially toxic metabolites of drugs that are substrates of human drug metabolizing enzymes. The tabular data lists the formation of potentially toxic/reactive products. The data were obtained from in vitro experiments and showed that the oxidative reactions predominate (with 96% of the total potential toxication reactions). Reductive reactions (e.g., reduction of nitro to amino group and reductive dehalogenation) participate to the extent of 4%. Of the enzymes, cytochrome P450 (P450, CYP) enzy...
Source: Archives of Toxicology - March 23, 2024 Category: Toxicology Authors: Slobodan P Rendic F Peter Guengerich Source Type: research
Cytogenotoxicity and inflammatory response in liver of rats exposed to different doses of cannabis nano emulsions
Arch Toxicol. 2024 Mar 17. doi: 10.1007/s00204-024-03712-7. Online ahead of print.ABSTRACTCannabis is the most used illicit substance for recreational purposes around the world. However, it has become increasingly common to witness the use of approved cannabis preparations for symptoms management in various diseases. The aim of this study was to investigate the effects of cannabis nano emulsion in the liver of Wistar rats, with different proportions of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). For this, a total of 40 male Wistar rats were distributed into 5 groups, as follows (n = 8 per group): Control: G1,...
Source: Archives of Toxicology - March 18, 2024 Category: Toxicology Authors: Thiago Guedes Pinto Barbara Dos Anjos Rosario Andrea Cristina de Moraes Malinverni Rosana Xavier Yasmin Alaby Martins Ferreira Luciana Pellegrini Pisani Pedro Everson Alexandre de Aquino Glauce Socorro de Barros Viana Daniel Vitor de Souza Milena de Barro Source Type: research
Role of the complement system in kidney cell death induced by Loxosceles venom Sphingomyelinases D
Arch Toxicol. 2024 Mar 18. doi: 10.1007/s00204-024-03711-8. Online ahead of print.ABSTRACTEnvenomation by Loxosceles spiders can result in local and systemic pathologies. Systemic loxoscelism, which can lead to death, is characterized by intravascular hemolysis, platelet aggregation, and acute kidney injury. Sphingomyelinase D (SMase D) in Loxosceles spider venom is responsible for both local and systemic pathologies, and has been shown to induce metalloprotease activity. As the complement system is involved in many renal pathologies and is involved in hemolysis in systemic loxoscelism, the aim of this study was to investi...
Source: Archives of Toxicology - March 18, 2024 Category: Toxicology Authors: Cinthya Kimori Okamoto Carmen W van den Berg Paula C Pohl Denise V Tambourgi Source Type: research
CircRNA: a rising therapeutic strategy for lung injury induced by pulmonary toxicants
Arch Toxicol. 2024 Mar 18. doi: 10.1007/s00204-024-03706-5. Online ahead of print.ABSTRACTLung injury has been a serious medical problem that requires new therapeutic approaches and biomarkers. Circular RNAs (circRNAs) are non-coding RNAs (ncRNAs) that exist widely in eukaryotes. CircRNAs are single-stranded RNAs that form covalently closed loops. CircRNAs are significant gene regulators that have a role in the development, progression, and therapy of lung injury by controlling transcription, translating into protein, and sponging microRNAs (miRNAs) and proteins. Although the study of circRNAs in lung injury caused by pulm...
Source: Archives of Toxicology - March 18, 2024 Category: Toxicology Authors: Cai Liao Zhen-Wei He Rui Yu Ya-Jie Yu Xiao-Ru Liu De-Lei Kong Yun Wang Source Type: research
Cytogenotoxicity and inflammatory response in liver of rats exposed to different doses of cannabis nano emulsions
Arch Toxicol. 2024 Mar 17. doi: 10.1007/s00204-024-03712-7. Online ahead of print.ABSTRACTCannabis is the most used illicit substance for recreational purposes around the world. However, it has become increasingly common to witness the use of approved cannabis preparations for symptoms management in various diseases. The aim of this study was to investigate the effects of cannabis nano emulsion in the liver of Wistar rats, with different proportions of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). For this, a total of 40 male Wistar rats were distributed into 5 groups, as follows (n = 8 per group): Control: G1,...
Source: Archives of Toxicology - March 18, 2024 Category: Toxicology Authors: Thiago Guedes Pinto Barbara Dos Anjos Rosario Andrea Cristina de Moraes Malinverni Rosana Xavier Yasmin Alaby Martins Ferreira Luciana Pellegrini Pisani Pedro Everson Alexandre de Aquino Glauce Socorro de Barros Viana Daniel Vitor de Souza Milena de Barro Source Type: research
Role of the complement system in kidney cell death induced by Loxosceles venom Sphingomyelinases D
Arch Toxicol. 2024 Mar 18. doi: 10.1007/s00204-024-03711-8. Online ahead of print.ABSTRACTEnvenomation by Loxosceles spiders can result in local and systemic pathologies. Systemic loxoscelism, which can lead to death, is characterized by intravascular hemolysis, platelet aggregation, and acute kidney injury. Sphingomyelinase D (SMase D) in Loxosceles spider venom is responsible for both local and systemic pathologies, and has been shown to induce metalloprotease activity. As the complement system is involved in many renal pathologies and is involved in hemolysis in systemic loxoscelism, the aim of this study was to investi...
Source: Archives of Toxicology - March 18, 2024 Category: Toxicology Authors: Cinthya Kimori Okamoto Carmen W van den Berg Paula C Pohl Denise V Tambourgi Source Type: research
CircRNA: a rising therapeutic strategy for lung injury induced by pulmonary toxicants
Arch Toxicol. 2024 Mar 18. doi: 10.1007/s00204-024-03706-5. Online ahead of print.ABSTRACTLung injury has been a serious medical problem that requires new therapeutic approaches and biomarkers. Circular RNAs (circRNAs) are non-coding RNAs (ncRNAs) that exist widely in eukaryotes. CircRNAs are single-stranded RNAs that form covalently closed loops. CircRNAs are significant gene regulators that have a role in the development, progression, and therapy of lung injury by controlling transcription, translating into protein, and sponging microRNAs (miRNAs) and proteins. Although the study of circRNAs in lung injury caused by pulm...
Source: Archives of Toxicology - March 18, 2024 Category: Toxicology Authors: Cai Liao Zhen-Wei He Rui Yu Ya-Jie Yu Xiao-Ru Liu De-Lei Kong Yun Wang Source Type: research
Cytogenotoxicity and inflammatory response in liver of rats exposed to different doses of cannabis nano emulsions
Arch Toxicol. 2024 Mar 17. doi: 10.1007/s00204-024-03712-7. Online ahead of print.ABSTRACTCannabis is the most used illicit substance for recreational purposes around the world. However, it has become increasingly common to witness the use of approved cannabis preparations for symptoms management in various diseases. The aim of this study was to investigate the effects of cannabis nano emulsion in the liver of Wistar rats, with different proportions of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). For this, a total of 40 male Wistar rats were distributed into 5 groups, as follows (n = 8 per group): Control: G1,...
Source: Archives of Toxicology - March 18, 2024 Category: Toxicology Authors: Thiago Guedes Pinto Barbara Dos Anjos Rosario Andrea Cristina de Moraes Malinverni Rosana Xavier Yasmin Alaby Martins Ferreira Luciana Pellegrini Pisani Pedro Everson Alexandre de Aquino Glauce Socorro de Barros Viana Daniel Vitor de Souza Milena de Barro Source Type: research
Role of the complement system in kidney cell death induced by Loxosceles venom Sphingomyelinases D
Arch Toxicol. 2024 Mar 18. doi: 10.1007/s00204-024-03711-8. Online ahead of print.ABSTRACTEnvenomation by Loxosceles spiders can result in local and systemic pathologies. Systemic loxoscelism, which can lead to death, is characterized by intravascular hemolysis, platelet aggregation, and acute kidney injury. Sphingomyelinase D (SMase D) in Loxosceles spider venom is responsible for both local and systemic pathologies, and has been shown to induce metalloprotease activity. As the complement system is involved in many renal pathologies and is involved in hemolysis in systemic loxoscelism, the aim of this study was to investi...
Source: Archives of Toxicology - March 18, 2024 Category: Toxicology Authors: Cinthya Kimori Okamoto Carmen W van den Berg Paula C Pohl Denise V Tambourgi Source Type: research
