Evaluation of neurological behavior alterations and metabolic changes in mice under chronic glyphosate exposure
Arch Toxicol. 2023 Nov 3. doi: 10.1007/s00204-023-03622-0. Online ahead of print.ABSTRACTGlyphosate is a widely used active ingredient in agricultural herbicides, inhibiting the biosynthesis of aromatic amino acids in plants by targeting their shikimate pathway. Our gut microbiota also facilitates the shikimate pathway, making it a vulnerable target when encountering glyphosate. Dysbiosis in the gut microbiota may impair the gut-brain axis, bringing neurological outcomes. To evaluate the neurotoxicity and biochemical changes attributed to glyphosate, we exposed mice with the reference dose (RfD) set by the U.S. EPA (1.75 m...
Source: Archives of Toxicology - November 3, 2023 Category: Toxicology Authors: Yun-Chung Hsiao Gregory Johnson Yifei Yang Chih-Wei Liu Jiahao Feng Haoduo Zhao Sheryl S Moy Kathryn M Harper Kun Lu Source Type: research
Evaluation of neurological behavior alterations and metabolic changes in mice under chronic glyphosate exposure
Arch Toxicol. 2023 Nov 3. doi: 10.1007/s00204-023-03622-0. Online ahead of print.ABSTRACTGlyphosate is a widely used active ingredient in agricultural herbicides, inhibiting the biosynthesis of aromatic amino acids in plants by targeting their shikimate pathway. Our gut microbiota also facilitates the shikimate pathway, making it a vulnerable target when encountering glyphosate. Dysbiosis in the gut microbiota may impair the gut-brain axis, bringing neurological outcomes. To evaluate the neurotoxicity and biochemical changes attributed to glyphosate, we exposed mice with the reference dose (RfD) set by the U.S. EPA (1.75 m...
Source: Archives of Toxicology - November 3, 2023 Category: Toxicology Authors: Yun-Chung Hsiao Gregory Johnson Yifei Yang Chih-Wei Liu Jiahao Feng Haoduo Zhao Sheryl S Moy Kathryn M Harper Kun Lu Source Type: research
Partial dechlorination of 2,4,4'-trichlorobiphenyl (PCB 28) mediated by recombinant human CYP1A2
Arch Toxicol. 2023 Nov 2. doi: 10.1007/s00204-023-03621-1. Online ahead of print.NO ABSTRACTPMID:37917334 | DOI:10.1007/s00204-023-03621-1 (Source: Archives of Toxicology)
Source: Archives of Toxicology - November 2, 2023 Category: Toxicology Authors: Isabella Randerath Natalia Quinete Julian Peter M üller Julia Stingl Jens Bertram Thomas Schettgen Thomas Kraus Patrick Ziegler Source Type: research
Critical assessment of the endocrine potential of Linalool and Linalyl acetate: proactive testing strategy assessing estrogenic and androgenic activity of Lavender oil main components
This study aims to follow-up on these critical findings reported by testing Lin and LinAc in several studies in line with current guidance and regulatory framework. No relevant anti-/ER and AR-mediated activity was observed in recombinant yeast cell-based screening tests and guideline reporter gene in vitro assays in mammalian cells. Findings in the screening test suggested an anti-androgenic activity, which could not be confirmed in the respective mammalian cell guideline assay. Mechanistic guideline in vivo studies (Uterotrophic and Hershberger assays) with Lin did not show significant dose related changes in estrogen or...
Source: Archives of Toxicology - October 31, 2023 Category: Toxicology Authors: Lars Hareng Susanne N Kolle Caroline Gomes Steffen Schneider Markus Wahl Source Type: research
Critical assessment of the endocrine potential of Linalool and Linalyl acetate: proactive testing strategy assessing estrogenic and androgenic activity of Lavender oil main components
This study aims to follow-up on these critical findings reported by testing Lin and LinAc in several studies in line with current guidance and regulatory framework. No relevant anti-/ER and AR-mediated activity was observed in recombinant yeast cell-based screening tests and guideline reporter gene in vitro assays in mammalian cells. Findings in the screening test suggested an anti-androgenic activity, which could not be confirmed in the respective mammalian cell guideline assay. Mechanistic guideline in vivo studies (Uterotrophic and Hershberger assays) with Lin did not show significant dose related changes in estrogen or...
Source: Archives of Toxicology - October 31, 2023 Category: Toxicology Authors: Lars Hareng Susanne N Kolle Caroline Gomes Steffen Schneider Markus Wahl Source Type: research
Critical assessment of the endocrine potential of Linalool and Linalyl acetate: proactive testing strategy assessing estrogenic and androgenic activity of Lavender oil main components
This study aims to follow-up on these critical findings reported by testing Lin and LinAc in several studies in line with current guidance and regulatory framework. No relevant anti-/ER and AR-mediated activity was observed in recombinant yeast cell-based screening tests and guideline reporter gene in vitro assays in mammalian cells. Findings in the screening test suggested an anti-androgenic activity, which could not be confirmed in the respective mammalian cell guideline assay. Mechanistic guideline in vivo studies (Uterotrophic and Hershberger assays) with Lin did not show significant dose related changes in estrogen or...
Source: Archives of Toxicology - October 31, 2023 Category: Toxicology Authors: Lars Hareng Susanne N Kolle Caroline Gomes Steffen Schneider Markus Wahl Source Type: research
Two-year dermal carcinogenicity bioassay of triclosan in B6C3F1 mice
Arch Toxicol. 2023 Oct 24. doi: 10.1007/s00204-023-03613-1. Online ahead of print.ABSTRACTTriclosan is a widely used antimicrobial agent in personal care products, household items, medical devices, and clinical settings. Due to its extensive use, there is potential for humans in all age groups to receive lifetime exposures to triclosan, yet data on the chronic dermal toxicity/carcinogenicity of triclosan are still lacking. We evaluated the toxicity/carcinogenicity of triclosan administered dermally to B6C3F1 mice for 104 weeks. Groups of 48 male and 48 female B6C3F1 mice received dermal applications of 0, 1.25, 2.7, 5.8, o...
Source: Archives of Toxicology - October 24, 2023 Category: Toxicology Authors: Jia-Long Fang Michelle M Vanlandingham Greg R Olson Mackean P Maisha Robert Felton Frederick A Beland Source Type: research
Two-year dermal carcinogenicity bioassay of triclosan in B6C3F1 mice
Arch Toxicol. 2023 Oct 24. doi: 10.1007/s00204-023-03613-1. Online ahead of print.ABSTRACTTriclosan is a widely used antimicrobial agent in personal care products, household items, medical devices, and clinical settings. Due to its extensive use, there is potential for humans in all age groups to receive lifetime exposures to triclosan, yet data on the chronic dermal toxicity/carcinogenicity of triclosan are still lacking. We evaluated the toxicity/carcinogenicity of triclosan administered dermally to B6C3F1 mice for 104 weeks. Groups of 48 male and 48 female B6C3F1 mice received dermal applications of 0, 1.25, 2.7, 5.8, o...
Source: Archives of Toxicology - October 24, 2023 Category: Toxicology Authors: Jia-Long Fang Michelle M Vanlandingham Greg R Olson Mackean P Maisha Robert Felton Frederick A Beland Source Type: research
Two-year dermal carcinogenicity bioassay of triclosan in B6C3F1 mice
Arch Toxicol. 2023 Oct 24. doi: 10.1007/s00204-023-03613-1. Online ahead of print.ABSTRACTTriclosan is a widely used antimicrobial agent in personal care products, household items, medical devices, and clinical settings. Due to its extensive use, there is potential for humans in all age groups to receive lifetime exposures to triclosan, yet data on the chronic dermal toxicity/carcinogenicity of triclosan are still lacking. We evaluated the toxicity/carcinogenicity of triclosan administered dermally to B6C3F1 mice for 104 weeks. Groups of 48 male and 48 female B6C3F1 mice received dermal applications of 0, 1.25, 2.7, 5.8, o...
Source: Archives of Toxicology - October 24, 2023 Category: Toxicology Authors: Jia-Long Fang Michelle M Vanlandingham Greg R Olson Mackean P Maisha Robert Felton Frederick A Beland Source Type: research
Two-year dermal carcinogenicity bioassay of triclosan in B6C3F1 mice
Arch Toxicol. 2023 Oct 24. doi: 10.1007/s00204-023-03613-1. Online ahead of print.ABSTRACTTriclosan is a widely used antimicrobial agent in personal care products, household items, medical devices, and clinical settings. Due to its extensive use, there is potential for humans in all age groups to receive lifetime exposures to triclosan, yet data on the chronic dermal toxicity/carcinogenicity of triclosan are still lacking. We evaluated the toxicity/carcinogenicity of triclosan administered dermally to B6C3F1 mice for 104 weeks. Groups of 48 male and 48 female B6C3F1 mice received dermal applications of 0, 1.25, 2.7, 5.8, o...
Source: Archives of Toxicology - October 24, 2023 Category: Toxicology Authors: Jia-Long Fang Michelle M Vanlandingham Greg R Olson Mackean P Maisha Robert Felton Frederick A Beland Source Type: research
Two-year dermal carcinogenicity bioassay of triclosan in B6C3F1 mice
Arch Toxicol. 2023 Oct 24. doi: 10.1007/s00204-023-03613-1. Online ahead of print.ABSTRACTTriclosan is a widely used antimicrobial agent in personal care products, household items, medical devices, and clinical settings. Due to its extensive use, there is potential for humans in all age groups to receive lifetime exposures to triclosan, yet data on the chronic dermal toxicity/carcinogenicity of triclosan are still lacking. We evaluated the toxicity/carcinogenicity of triclosan administered dermally to B6C3F1 mice for 104 weeks. Groups of 48 male and 48 female B6C3F1 mice received dermal applications of 0, 1.25, 2.7, 5.8, o...
Source: Archives of Toxicology - October 24, 2023 Category: Toxicology Authors: Jia-Long Fang Michelle M Vanlandingham Greg R Olson Mackean P Maisha Robert Felton Frederick A Beland Source Type: research
Two-year dermal carcinogenicity bioassay of triclosan in B6C3F1 mice
Arch Toxicol. 2023 Oct 24. doi: 10.1007/s00204-023-03613-1. Online ahead of print.ABSTRACTTriclosan is a widely used antimicrobial agent in personal care products, household items, medical devices, and clinical settings. Due to its extensive use, there is potential for humans in all age groups to receive lifetime exposures to triclosan, yet data on the chronic dermal toxicity/carcinogenicity of triclosan are still lacking. We evaluated the toxicity/carcinogenicity of triclosan administered dermally to B6C3F1 mice for 104 weeks. Groups of 48 male and 48 female B6C3F1 mice received dermal applications of 0, 1.25, 2.7, 5.8, o...
Source: Archives of Toxicology - October 24, 2023 Category: Toxicology Authors: Jia-Long Fang Michelle M Vanlandingham Greg R Olson Mackean P Maisha Robert Felton Frederick A Beland Source Type: research
Combined in vivo metabolic effects of quetiapine and methadone in brain and blood of rats
In conclusion, this study in rats suggests a few but important additive metabolic effects when quetiapine and methadone are co-administered.PMID:37870577 | DOI:10.1007/s00204-023-03620-2 (Source: Archives of Toxicology)
Source: Archives of Toxicology - October 23, 2023 Category: Toxicology Authors: Laura Smedegaard Heisel Freja Drost Andersen S âmia Joca Lambert Kristiansen S ørensen Ulf Simonsen J ørgen Bo Hasselstrøm Charlotte Uggerh øj Andersen Kirstine Lykke Nielsen Source Type: research
Combined in vivo metabolic effects of quetiapine and methadone in brain and blood of rats
In conclusion, this study in rats suggests a few but important additive metabolic effects when quetiapine and methadone are co-administered.PMID:37870577 | DOI:10.1007/s00204-023-03620-2 (Source: Archives of Toxicology)
Source: Archives of Toxicology - October 23, 2023 Category: Toxicology Authors: Laura Smedegaard Heisel Freja Drost Andersen S âmia Joca Lambert Kristiansen S ørensen Ulf Simonsen J ørgen Bo Hasselstrøm Charlotte Uggerh øj Andersen Kirstine Lykke Nielsen Source Type: research
Elucidating the toxicity mechanisms of organophosphate esters by adverse outcome pathway network
This study provides a theoretical basis for OPEs risk assessment in the future.PMID:37864630 | DOI:10.1007/s00204-023-03624-y (Source: Archives of Toxicology)
Source: Archives of Toxicology - October 21, 2023 Category: Toxicology Authors: Wanyu He Jiaqi Ding Ning Gao Lingyan Zhu Lin Zhu Jianfeng Feng Source Type: research
