Correction: Species-differences in the in vitro biotransformation of trifluoroethene (HFO-1123)
Arch Toxicol. 2023 Dec 6. doi: 10.1007/s00204-023-03640-y. Online ahead of print.NO ABSTRACTPMID:38057564 | DOI:10.1007/s00204-023-03640-y (Source: Archives of Toxicology)
Source: Archives of Toxicology - December 6, 2023 Category: Toxicology Authors: R Dekant R Bertermann J Serban S Sharma M Shinohara Y Morizawa H Okamoto W Brock W Dekant A Mally Source Type: research
Interleukin 1 β and interleukin 6 production in human immune cells is stimulated by the antibacterial compound Triclosan
Arch Toxicol. 2023 Dec 6. doi: 10.1007/s00204-023-03654-6. Online ahead of print.ABSTRACTTriclosan (TCS) is an antimicrobial compound widely used in personal hygiene products such as mouthwash and toothpaste; and has been found in human blood, breast milk, and urine. Interleukin (IL)-6 and IL-1 beta (IL-1β) are pro-inflammatory cytokines regulating cell growth, tissue repair, and immune function; increased levels of each have been associated with many diseases, including cancer. Previous studies showed that TCS at concentrations between 0.05 and 5 µM consistently increased the secretion of IL-1β and IL-6 from human immu...
Source: Archives of Toxicology - December 6, 2023 Category: Toxicology Authors: Wendy J Wilburn Sahra Gabure Margaret M Whalen Source Type: research
Quantification of 108 illicit drugs and metabolites in bile matrix by LC-MS/MS for the toxicological testing of sudden death cases
Arch Toxicol. 2023 Dec 5. doi: 10.1007/s00204-023-03631-z. Online ahead of print.ABSTRACTSudden death could occur after assumption of illicit drugs for recreational purposes in adults or after intoxication in children, and toxicological testing would help identify the cause of the death. Analytical methods sensitive and specific for the quantification of a great number of drugs and metabolites in at least 2 matrices should be used. Bile, collected postmortem, may be considered a specimen alternative to blood and urine to perform toxicological testing because of its extended detection window. The present study proposed a LC...
Source: Archives of Toxicology - December 5, 2023 Category: Toxicology Authors: Martina Franzin Rachele Ruoso Michela Peruch Gabriele Stocco Stefano D'Errico Riccardo Addobbati Source Type: research
Characterization of drug-induced liver injury associated with drug reaction with eosinophilia and systemic symptoms in two prospective DILI registries
Arch Toxicol. 2023 Dec 5. doi: 10.1007/s00204-023-03630-0. Online ahead of print.ABSTRACTIdiosyncratic drug-induced liver injury (DILI) associated with drug reactions with eosinophilia and systemic symptoms (DRESS) is poorly characterized among patients of Western countries. We aimed to comprehensively assess the clinical characteristics, outcomes, and causative agents in a prospective, well-vetted cohort of DILI patients with DRESS (DILI-DRESS). We identified 53 DILI-DRESS cases from the Spanish DILI Registry and the Latin American DILI Network. For comparison purposes, we defined a group of DILI patients (n = 881). DILI-...
Source: Archives of Toxicology - December 5, 2023 Category: Toxicology Authors: Inmaculada Medina-C áliz Judith Sanabria-Cabrera Marina Villanueva-Paz Lauryna Auk štikalnė Camilla Stephens Mercedes Robles-D íaz Jos é M Pinazo-Bandera Miren Garc ía-Cortes Isabel Conde German Soriano Fernando Bessone Nelia Hernandez Vinicius Nune Source Type: research
The prediction of acute toxicity (LD < sub > 50 < /sub > ) for organophosphorus-based chemical warfare agents (V-series) using toxicology in silico methods
Arch Toxicol. 2023 Dec 5. doi: 10.1007/s00204-023-03632-y. Online ahead of print.ABSTRACTNerve agents are organophosphate chemical warfare agents that exert their toxic effects by irreversibly inhibiting acetylcholinesterase, affecting the breakdown of the neurotransmitter acetylcholine in the synaptic cleft. Due to the risk of exposure to dangerous nerve agents and for animal welfare reasons, in silico methods have been used to assess acute toxicity safely. The next-generation risk assessment (NGRA) is a new approach for predicting toxicological parameters that can meet modern requirements for toxicological research. The ...
Source: Archives of Toxicology - December 5, 2023 Category: Toxicology Authors: Maciej Noga Agata Michalska Kamil Jurowski Source Type: research
Grouping of esters of 4-hydroxybenzoic acid for hazard assessment
Arch Toxicol. 2023 Dec 5. doi: 10.1007/s00204-023-03641-x. Online ahead of print.ABSTRACTHazardous properties of a large number of esters of 4-hydroxybenzoic acid (parabens) have been proposed by ECHA to be assessed as a group. We recommend to restrict the grouping approach to short chain esters, i.e. methyl, ethyl, propyl and butyl paraben which are very similar in chemical structures, physicochemical properties, toxicokinetics, and hazardous properties. While these parabens show a weak estrogenicity in some in vitro or in vivo screening assays, they do not induce estrogen-receptor-mediated adverse effects in intact anima...
Source: Archives of Toxicology - December 5, 2023 Category: Toxicology Authors: Thomas Colnot Wolfgang Dekant Helmut Greim Source Type: research
Re-evaluation of the occupational exposure limit for ZnO is warranted. Comments on 'Systemic inflammatory effects of zinc oxide particles: is a re-evaluation of exposure limits needed?' by Christian Mons é et al
Arch Toxicol. 2023 Dec 1. doi: 10.1007/s00204-023-03634-w. Online ahead of print.NO ABSTRACTPMID:38038737 | DOI:10.1007/s00204-023-03634-w (Source: Archives of Toxicology)
Source: Archives of Toxicology - December 1, 2023 Category: Toxicology Authors: Ulla Vogel Anne T Saber Nicklas R Jacobsen Pernille H Danielsen Karin S Hougaard Niels Hadrup Source Type: research
Re-evaluation of the occupational exposure limit for ZnO is warranted. Comments on 'Systemic inflammatory effects of zinc oxide particles: is a re-evaluation of exposure limits needed?' by Christian Mons é et al
Arch Toxicol. 2023 Dec 1. doi: 10.1007/s00204-023-03634-w. Online ahead of print.NO ABSTRACTPMID:38038737 | DOI:10.1007/s00204-023-03634-w (Source: Archives of Toxicology)
Source: Archives of Toxicology - December 1, 2023 Category: Toxicology Authors: Ulla Vogel Anne T Saber Nicklas R Jacobsen Pernille H Danielsen Karin S Hougaard Niels Hadrup Source Type: research
Re-evaluation of the occupational exposure limit for ZnO is warranted. Comments on 'Systemic inflammatory effects of zinc oxide particles: is a re-evaluation of exposure limits needed?' by Christian Mons é et al
Arch Toxicol. 2023 Dec 1. doi: 10.1007/s00204-023-03634-w. Online ahead of print.NO ABSTRACTPMID:38038737 | DOI:10.1007/s00204-023-03634-w (Source: Archives of Toxicology)
Source: Archives of Toxicology - December 1, 2023 Category: Toxicology Authors: Ulla Vogel Anne T Saber Nicklas R Jacobsen Pernille H Danielsen Karin S Hougaard Niels Hadrup Source Type: research
Re-evaluation of the occupational exposure limit for ZnO is warranted. Comments on 'Systemic inflammatory effects of zinc oxide particles: is a re-evaluation of exposure limits needed?' by Christian Mons é et al
Arch Toxicol. 2023 Dec 1. doi: 10.1007/s00204-023-03634-w. Online ahead of print.NO ABSTRACTPMID:38038737 | DOI:10.1007/s00204-023-03634-w (Source: Archives of Toxicology)
Source: Archives of Toxicology - December 1, 2023 Category: Toxicology Authors: Ulla Vogel Anne T Saber Nicklas R Jacobsen Pernille H Danielsen Karin S Hougaard Niels Hadrup Source Type: research
Evolution of hormesis research: a bibliometric analysis
Arch Toxicol. 2023 Nov 28. doi: 10.1007/s00204-023-03635-9. Online ahead of print.NO ABSTRACTPMID:38017292 | DOI:10.1007/s00204-023-03635-9 (Source: Archives of Toxicology)
Source: Archives of Toxicology - November 28, 2023 Category: Toxicology Authors: Evgenios Agathokleous Edward J Calabrese Source Type: research
Evolution of hormesis research: a bibliometric analysis
Arch Toxicol. 2023 Nov 28. doi: 10.1007/s00204-023-03635-9. Online ahead of print.NO ABSTRACTPMID:38017292 | DOI:10.1007/s00204-023-03635-9 (Source: Archives of Toxicology)
Source: Archives of Toxicology - November 28, 2023 Category: Toxicology Authors: Evgenios Agathokleous Edward J Calabrese Source Type: research
Evolution of hormesis research: a bibliometric analysis
Arch Toxicol. 2023 Nov 28. doi: 10.1007/s00204-023-03635-9. Online ahead of print.NO ABSTRACTPMID:38017292 | DOI:10.1007/s00204-023-03635-9 (Source: Archives of Toxicology)
Source: Archives of Toxicology - November 28, 2023 Category: Toxicology Authors: Evgenios Agathokleous Edward J Calabrese Source Type: research
Transcriptome analysis of the cerebral cortex of acrylamide-exposed wild-type and IL-1 β-knockout mice
We reported recently that deletion of IL-1β gene exacerbates ACR-induced neurotoxicity in mice. The aim of this study was to identify genes or signaling pathway(s) involved in enhancement of ACR-induced neurotoxicity by IL-1β gene deletion or ACR-induced neurotoxicity to generate a hypothesis mechanism explaining ACR-induced neurotoxicity. C57BL/6 J wild-type and IL-1β KO mice were exposed to ACR at 0, 12.5, 25 mg/kg by oral gavage for 7 days/week for 4 weeks, followed by extraction of mRNA from mice cerebral cortex for RNA sequence analysis. IL-1β deletion altered the expression of genes involved in extracellular regi...
Source: Archives of Toxicology - November 16, 2023 Category: Toxicology Authors: Alzahraa Fergany Cai Zong Frederick Adams Ekuban Bin Wu Satoshi Ueha Shigeyuki Shichino Kouji Matsushima Yoichiro Iwakura Sahoko Ichihara Gaku Ichihara Source Type: research
Transcriptome analysis of the cerebral cortex of acrylamide-exposed wild-type and IL-1 β-knockout mice
We reported recently that deletion of IL-1β gene exacerbates ACR-induced neurotoxicity in mice. The aim of this study was to identify genes or signaling pathway(s) involved in enhancement of ACR-induced neurotoxicity by IL-1β gene deletion or ACR-induced neurotoxicity to generate a hypothesis mechanism explaining ACR-induced neurotoxicity. C57BL/6 J wild-type and IL-1β KO mice were exposed to ACR at 0, 12.5, 25 mg/kg by oral gavage for 7 days/week for 4 weeks, followed by extraction of mRNA from mice cerebral cortex for RNA sequence analysis. IL-1β deletion altered the expression of genes involved in extracellular regi...
Source: Archives of Toxicology - November 16, 2023 Category: Toxicology Authors: Alzahraa Fergany Cai Zong Frederick Adams Ekuban Bin Wu Satoshi Ueha Shigeyuki Shichino Kouji Matsushima Yoichiro Iwakura Sahoko Ichihara Gaku Ichihara Source Type: research
