Transcriptome analysis of the cerebral cortex of acrylamide-exposed wild-type and IL-1 β-knockout mice
We reported recently that deletion of IL-1β gene exacerbates ACR-induced neurotoxicity in mice. The aim of this study was to identify genes or signaling pathway(s) involved in enhancement of ACR-induced neurotoxicity by IL-1β gene deletion or ACR-induced neurotoxicity to generate a hypothesis mechanism explaining ACR-induced neurotoxicity. C57BL/6 J wild-type and IL-1β KO mice were exposed to ACR at 0, 12.5, 25 mg/kg by oral gavage for 7 days/week for 4 weeks, followed by extraction of mRNA from mice cerebral cortex for RNA sequence analysis. IL-1β deletion altered the expression of genes involved in extracellular regi...
Source: Archives of Toxicology - November 16, 2023 Category: Toxicology Authors: Alzahraa Fergany Cai Zong Frederick Adams Ekuban Bin Wu Satoshi Ueha Shigeyuki Shichino Kouji Matsushima Yoichiro Iwakura Sahoko Ichihara Gaku Ichihara Source Type: research

Transcriptome analysis of the cerebral cortex of acrylamide-exposed wild-type and IL-1 β-knockout mice
We reported recently that deletion of IL-1β gene exacerbates ACR-induced neurotoxicity in mice. The aim of this study was to identify genes or signaling pathway(s) involved in enhancement of ACR-induced neurotoxicity by IL-1β gene deletion or ACR-induced neurotoxicity to generate a hypothesis mechanism explaining ACR-induced neurotoxicity. C57BL/6 J wild-type and IL-1β KO mice were exposed to ACR at 0, 12.5, 25 mg/kg by oral gavage for 7 days/week for 4 weeks, followed by extraction of mRNA from mice cerebral cortex for RNA sequence analysis. IL-1β deletion altered the expression of genes involved in extracellular regi...
Source: Archives of Toxicology - November 16, 2023 Category: Toxicology Authors: Alzahraa Fergany Cai Zong Frederick Adams Ekuban Bin Wu Satoshi Ueha Shigeyuki Shichino Kouji Matsushima Yoichiro Iwakura Sahoko Ichihara Gaku Ichihara Source Type: research

Inflammation as common link to progressive neurological diseases
Arch Toxicol. 2023 Nov 15. doi: 10.1007/s00204-023-03628-8. Online ahead of print.ABSTRACTLife expectancy has increased immensely over the past decades, bringing new challenges to the health systems as advanced age increases the predisposition for many diseases. One of those is the burden of neurologic disorders. While many hypotheses have been placed to explain aging mechanisms, it has been widely accepted that the increasing pro-inflammatory status with advanced age or "inflammaging" is a main determinant of biological aging. Furthermore, inflammaging is at the cornerstone of many age-related diseases and its involvement...
Source: Archives of Toxicology - November 14, 2023 Category: Toxicology Authors: Ana Dias-Carvalho Susana Isabel S á F élix Carvalho Eduarda Fernandes Vera Marisa Costa Source Type: research

Inflammation as common link to progressive neurological diseases
Arch Toxicol. 2023 Nov 15. doi: 10.1007/s00204-023-03628-8. Online ahead of print.ABSTRACTLife expectancy has increased immensely over the past decades, bringing new challenges to the health systems as advanced age increases the predisposition for many diseases. One of those is the burden of neurologic disorders. While many hypotheses have been placed to explain aging mechanisms, it has been widely accepted that the increasing pro-inflammatory status with advanced age or "inflammaging" is a main determinant of biological aging. Furthermore, inflammaging is at the cornerstone of many age-related diseases and its involvement...
Source: Archives of Toxicology - November 14, 2023 Category: Toxicology Authors: Ana Dias-Carvalho Susana Isabel S á F élix Carvalho Eduarda Fernandes Vera Marisa Costa Source Type: research

Inflammation as common link to progressive neurological diseases
Arch Toxicol. 2023 Nov 15. doi: 10.1007/s00204-023-03628-8. Online ahead of print.ABSTRACTLife expectancy has increased immensely over the past decades, bringing new challenges to the health systems as advanced age increases the predisposition for many diseases. One of those is the burden of neurologic disorders. While many hypotheses have been placed to explain aging mechanisms, it has been widely accepted that the increasing pro-inflammatory status with advanced age or "inflammaging" is a main determinant of biological aging. Furthermore, inflammaging is at the cornerstone of many age-related diseases and its involvement...
Source: Archives of Toxicology - November 14, 2023 Category: Toxicology Authors: Ana Dias-Carvalho Susana Isabel S á F élix Carvalho Eduarda Fernandes Vera Marisa Costa Source Type: research

Caspase-3/GSDME dependent pyroptosis contributes to offspring lung injury induced by gestational PFOS exposure via PERK/ATF4 signaling
In this study, we investigated the role of gasdermin E (GSDME) in lung injury of offspring and its underlying mechanisms using in vivo and in vitro approaches. Pregnant SD rats were exposed to PFOS (1 mg/kg BW/d) between gestational day 12-18, and the lung tissue of the offspring was evaluated on postnatal day 7. PFOS treated animals exhibited alveolar septal thickening and inflammation-related damages, with an increased expression of GSDME in alveolar type II epithelial cells (AECII). Furthermore, in vitro experiments demonstrated that PFOS exposure (with 225 μM and up) upregulated the caspase-3/GSDME signaling pathway i...
Source: Archives of Toxicology - November 13, 2023 Category: Toxicology Authors: Cong Li Huishan Zhang Jiali Mo Jingye Zuo Leping Ye Source Type: research

Caspase-3/GSDME dependent pyroptosis contributes to offspring lung injury induced by gestational PFOS exposure via PERK/ATF4 signaling
In this study, we investigated the role of gasdermin E (GSDME) in lung injury of offspring and its underlying mechanisms using in vivo and in vitro approaches. Pregnant SD rats were exposed to PFOS (1 mg/kg BW/d) between gestational day 12-18, and the lung tissue of the offspring was evaluated on postnatal day 7. PFOS treated animals exhibited alveolar septal thickening and inflammation-related damages, with an increased expression of GSDME in alveolar type II epithelial cells (AECII). Furthermore, in vitro experiments demonstrated that PFOS exposure (with 225 μM and up) upregulated the caspase-3/GSDME signaling pathway i...
Source: Archives of Toxicology - November 13, 2023 Category: Toxicology Authors: Cong Li Huishan Zhang Jiali Mo Jingye Zuo Leping Ye Source Type: research

Ferroptosis: potential targets and emerging roles in pancreatic diseases
Arch Toxicol. 2023 Nov 7. doi: 10.1007/s00204-023-03625-x. Online ahead of print.ABSTRACTFerroptosis is a newly discovered form of regulatory cell death characterized by excessive iron-dependent lipid peroxidation. In the past decade, significant breakthroughs have been made in comprehending the features and regulatory mechanisms of ferroptosis, and it has been confirmed that ferroptosis plays a pivotal role in the pathophysiological processes of various diseases, including tumors, inflammation, neurodegenerative diseases, and infectious diseases. The pancreas, which is the second largest digestive gland in the human body ...
Source: Archives of Toxicology - November 7, 2023 Category: Toxicology Authors: Zijian Huang Yuan Ma Zhiguo Sun Long Cheng Gang Wang Source Type: research

Ferroptosis: potential targets and emerging roles in pancreatic diseases
Arch Toxicol. 2023 Nov 7. doi: 10.1007/s00204-023-03625-x. Online ahead of print.ABSTRACTFerroptosis is a newly discovered form of regulatory cell death characterized by excessive iron-dependent lipid peroxidation. In the past decade, significant breakthroughs have been made in comprehending the features and regulatory mechanisms of ferroptosis, and it has been confirmed that ferroptosis plays a pivotal role in the pathophysiological processes of various diseases, including tumors, inflammation, neurodegenerative diseases, and infectious diseases. The pancreas, which is the second largest digestive gland in the human body ...
Source: Archives of Toxicology - November 7, 2023 Category: Toxicology Authors: Zijian Huang Yuan Ma Zhiguo Sun Long Cheng Gang Wang Source Type: research

Ferroptosis: potential targets and emerging roles in pancreatic diseases
Arch Toxicol. 2023 Nov 7. doi: 10.1007/s00204-023-03625-x. Online ahead of print.ABSTRACTFerroptosis is a newly discovered form of regulatory cell death characterized by excessive iron-dependent lipid peroxidation. In the past decade, significant breakthroughs have been made in comprehending the features and regulatory mechanisms of ferroptosis, and it has been confirmed that ferroptosis plays a pivotal role in the pathophysiological processes of various diseases, including tumors, inflammation, neurodegenerative diseases, and infectious diseases. The pancreas, which is the second largest digestive gland in the human body ...
Source: Archives of Toxicology - November 7, 2023 Category: Toxicology Authors: Zijian Huang Yuan Ma Zhiguo Sun Long Cheng Gang Wang Source Type: research

Ferroptosis: potential targets and emerging roles in pancreatic diseases
Arch Toxicol. 2023 Nov 7. doi: 10.1007/s00204-023-03625-x. Online ahead of print.ABSTRACTFerroptosis is a newly discovered form of regulatory cell death characterized by excessive iron-dependent lipid peroxidation. In the past decade, significant breakthroughs have been made in comprehending the features and regulatory mechanisms of ferroptosis, and it has been confirmed that ferroptosis plays a pivotal role in the pathophysiological processes of various diseases, including tumors, inflammation, neurodegenerative diseases, and infectious diseases. The pancreas, which is the second largest digestive gland in the human body ...
Source: Archives of Toxicology - November 7, 2023 Category: Toxicology Authors: Zijian Huang Yuan Ma Zhiguo Sun Long Cheng Gang Wang Source Type: research

Ferroptosis: potential targets and emerging roles in pancreatic diseases
Arch Toxicol. 2023 Nov 7. doi: 10.1007/s00204-023-03625-x. Online ahead of print.ABSTRACTFerroptosis is a newly discovered form of regulatory cell death characterized by excessive iron-dependent lipid peroxidation. In the past decade, significant breakthroughs have been made in comprehending the features and regulatory mechanisms of ferroptosis, and it has been confirmed that ferroptosis plays a pivotal role in the pathophysiological processes of various diseases, including tumors, inflammation, neurodegenerative diseases, and infectious diseases. The pancreas, which is the second largest digestive gland in the human body ...
Source: Archives of Toxicology - November 7, 2023 Category: Toxicology Authors: Zijian Huang Yuan Ma Zhiguo Sun Long Cheng Gang Wang Source Type: research

Evaluation of neurological behavior alterations and metabolic changes in mice under chronic glyphosate exposure
Arch Toxicol. 2023 Nov 3. doi: 10.1007/s00204-023-03622-0. Online ahead of print.ABSTRACTGlyphosate is a widely used active ingredient in agricultural herbicides, inhibiting the biosynthesis of aromatic amino acids in plants by targeting their shikimate pathway. Our gut microbiota also facilitates the shikimate pathway, making it a vulnerable target when encountering glyphosate. Dysbiosis in the gut microbiota may impair the gut-brain axis, bringing neurological outcomes. To evaluate the neurotoxicity and biochemical changes attributed to glyphosate, we exposed mice with the reference dose (RfD) set by the U.S. EPA (1.75 m...
Source: Archives of Toxicology - November 3, 2023 Category: Toxicology Authors: Yun-Chung Hsiao Gregory Johnson Yifei Yang Chih-Wei Liu Jiahao Feng Haoduo Zhao Sheryl S Moy Kathryn M Harper Kun Lu Source Type: research

Evaluation of neurological behavior alterations and metabolic changes in mice under chronic glyphosate exposure
Arch Toxicol. 2023 Nov 3. doi: 10.1007/s00204-023-03622-0. Online ahead of print.ABSTRACTGlyphosate is a widely used active ingredient in agricultural herbicides, inhibiting the biosynthesis of aromatic amino acids in plants by targeting their shikimate pathway. Our gut microbiota also facilitates the shikimate pathway, making it a vulnerable target when encountering glyphosate. Dysbiosis in the gut microbiota may impair the gut-brain axis, bringing neurological outcomes. To evaluate the neurotoxicity and biochemical changes attributed to glyphosate, we exposed mice with the reference dose (RfD) set by the U.S. EPA (1.75 m...
Source: Archives of Toxicology - November 3, 2023 Category: Toxicology Authors: Yun-Chung Hsiao Gregory Johnson Yifei Yang Chih-Wei Liu Jiahao Feng Haoduo Zhao Sheryl S Moy Kathryn M Harper Kun Lu Source Type: research

Evaluation of neurological behavior alterations and metabolic changes in mice under chronic glyphosate exposure
Arch Toxicol. 2023 Nov 3. doi: 10.1007/s00204-023-03622-0. Online ahead of print.ABSTRACTGlyphosate is a widely used active ingredient in agricultural herbicides, inhibiting the biosynthesis of aromatic amino acids in plants by targeting their shikimate pathway. Our gut microbiota also facilitates the shikimate pathway, making it a vulnerable target when encountering glyphosate. Dysbiosis in the gut microbiota may impair the gut-brain axis, bringing neurological outcomes. To evaluate the neurotoxicity and biochemical changes attributed to glyphosate, we exposed mice with the reference dose (RfD) set by the U.S. EPA (1.75 m...
Source: Archives of Toxicology - November 3, 2023 Category: Toxicology Authors: Yun-Chung Hsiao Gregory Johnson Yifei Yang Chih-Wei Liu Jiahao Feng Haoduo Zhao Sheryl S Moy Kathryn M Harper Kun Lu Source Type: research