Commentary of the SKLM to the EFSA opinion on risk assessment of N-nitrosamines in food
Arch Toxicol. 2024 Apr 4. doi: 10.1007/s00204-024-03726-1. Online ahead of print.ABSTRACTDietary exposure to N-nitrosamines has recently been assessed by the European Food Safety Authority (EFSA) to result in margins of exposure that are conceived to indicate concern with respect to human health risk. However, evidence from more than half a century of international research shows that N-nitroso compounds (NOC) can also be formed endogenously. In this commentary of the Senate Commission on Food Safety (SKLM) of the German Research Foundation (DFG), the complex metabolic and physiological biokinetics network of nitrate, nitr...
Source: Archives of Toxicology - April 4, 2024 Category: Toxicology Authors: Gerhard Eisenbrand Andrea Buettner Patrick Diel Bernd Epe Petra F örst Tillman Grune Dirk Haller Volker Heinz Michael Hellwig Hans-Ulrich Humpf Henry J äger Sabine Kulling Alfonso Lampen Marcel Leist Angela Mally Doris Marko Ute N öthlings Elke R öhrd Source Type: research
Muller and mutations: mouse study of George Snell (a postdoc of Muller) fails to confirm Muller's fruit fly findings, and Muller fails to cite Snell's findings
Arch Toxicol. 2024 Apr 4. doi: 10.1007/s00204-024-03718-1. Online ahead of print.ABSTRACTIn 1931, Hermann J. Muller's postdoctoral student, George D. Snell (Nobel Prize recipient--1980) initiated research to replicate with mice Muller's X-ray-induced mutational findings with fruit flies. Snell failed to induce the two types of mutations of interest, based on fly data (sex-linked lethals/recessive visible mutations) even though the study was well designed, used large doses of X-rays, and was published in Genetics. These findings were never cited by Muller, and the Snell paper (Snell, Genetics 20:545-567, 1935) did not cite ...
Source: Archives of Toxicology - April 4, 2024 Category: Toxicology Authors: Edward J Calabrese Paul B Selby Source Type: research
The Bach1/HO-1 pathway regulates oxidative stress and contributes to ferroptosis in doxorubicin-induced cardiomyopathy in H9c2 cells and mice
Arch Toxicol. 2024 Apr 4. doi: 10.1007/s00204-024-03697-3. Online ahead of print.ABSTRACTDoxorubicin (DOX) is one of the most frequently used chemotherapeutic drugs belonging to the class of anthracyclines. However, the cardiotoxic effects of anthracyclines limit their clinical use. Recent studies have suggested that ferroptosis is the main underlying pathogenetic mechanism of DOX-induced cardiomyopathy (DIC). BTB-and-CNC homology 1 (Bach1) acts as a key role in the regulation of ferroptosis. However, the mechanistic role of Bach1 in DIC remains unclear. Therefore, this study aimed to investigate the underlying mechanistic...
Source: Archives of Toxicology - April 4, 2024 Category: Toxicology Authors: Yanwei Wang Jingru Qiu Hua Yan Nan Zhang Shixuan Gao Ning Xu Cuiyan Wang Haiyan Lou Source Type: research
Validation of putative biomarkers of furan exposure through quantitative analysis of furan metabolites in urine of F344 rats exposed to stable isotope labeled furan
Arch Toxicol. 2024 Apr 4. doi: 10.1007/s00204-024-03722-5. Online ahead of print.ABSTRACTHumans are chronically exposed to furan, a potent liver toxicant and carcinogen that occurs in a variety of heat-processed foods. Assessment of human exposure based on the furan content in foods is, however, subject to some uncertainty due to the high volatility of furan. Biomarker monitoring is thus considered an alternative or complementary approach to furan exposure assessment. Previous work suggested that urinary furan metabolites derived from the reaction of cis-2-butene-1,4-dial (BDA), the reactive intermediate of furan, with glu...
Source: Archives of Toxicology - April 4, 2024 Category: Toxicology Authors: C Kalisch M Reiter M Krieger L W üst C Klotz R Dekant D W Lachenmeier O Scherf-Clavel A Mally Source Type: research
Commentary of the SKLM to the EFSA opinion on risk assessment of N-nitrosamines in food
Arch Toxicol. 2024 Apr 4. doi: 10.1007/s00204-024-03726-1. Online ahead of print.ABSTRACTDietary exposure to N-nitrosamines has recently been assessed by the European Food Safety Authority (EFSA) to result in margins of exposure that are conceived to indicate concern with respect to human health risk. However, evidence from more than half a century of international research shows that N-nitroso compounds (NOC) can also be formed endogenously. In this commentary of the Senate Commission on Food Safety (SKLM) of the German Research Foundation (DFG), the complex metabolic and physiological biokinetics network of nitrate, nitr...
Source: Archives of Toxicology - April 4, 2024 Category: Toxicology Authors: Gerhard Eisenbrand Andrea Buettner Patrick Diel Bernd Epe Petra F örst Tillman Grune Dirk Haller Volker Heinz Michael Hellwig Hans-Ulrich Humpf Henry J äger Sabine Kulling Alfonso Lampen Marcel Leist Angela Mally Doris Marko Ute N öthlings Elke R öhrd Source Type: research
Muller and mutations: mouse study of George Snell (a postdoc of Muller) fails to confirm Muller's fruit fly findings, and Muller fails to cite Snell's findings
Arch Toxicol. 2024 Apr 4. doi: 10.1007/s00204-024-03718-1. Online ahead of print.ABSTRACTIn 1931, Hermann J. Muller's postdoctoral student, George D. Snell (Nobel Prize recipient--1980) initiated research to replicate with mice Muller's X-ray-induced mutational findings with fruit flies. Snell failed to induce the two types of mutations of interest, based on fly data (sex-linked lethals/recessive visible mutations) even though the study was well designed, used large doses of X-rays, and was published in Genetics. These findings were never cited by Muller, and the Snell paper (Snell, Genetics 20:545-567, 1935) did not cite ...
Source: Archives of Toxicology - April 4, 2024 Category: Toxicology Authors: Edward J Calabrese Paul B Selby Source Type: research
The Bach1/HO-1 pathway regulates oxidative stress and contributes to ferroptosis in doxorubicin-induced cardiomyopathy in H9c2 cells and mice
Arch Toxicol. 2024 Apr 4. doi: 10.1007/s00204-024-03697-3. Online ahead of print.ABSTRACTDoxorubicin (DOX) is one of the most frequently used chemotherapeutic drugs belonging to the class of anthracyclines. However, the cardiotoxic effects of anthracyclines limit their clinical use. Recent studies have suggested that ferroptosis is the main underlying pathogenetic mechanism of DOX-induced cardiomyopathy (DIC). BTB-and-CNC homology 1 (Bach1) acts as a key role in the regulation of ferroptosis. However, the mechanistic role of Bach1 in DIC remains unclear. Therefore, this study aimed to investigate the underlying mechanistic...
Source: Archives of Toxicology - April 4, 2024 Category: Toxicology Authors: Yanwei Wang Jingru Qiu Hua Yan Nan Zhang Shixuan Gao Ning Xu Cuiyan Wang Haiyan Lou Source Type: research
Validation of putative biomarkers of furan exposure through quantitative analysis of furan metabolites in urine of F344 rats exposed to stable isotope labeled furan
Arch Toxicol. 2024 Apr 4. doi: 10.1007/s00204-024-03722-5. Online ahead of print.ABSTRACTHumans are chronically exposed to furan, a potent liver toxicant and carcinogen that occurs in a variety of heat-processed foods. Assessment of human exposure based on the furan content in foods is, however, subject to some uncertainty due to the high volatility of furan. Biomarker monitoring is thus considered an alternative or complementary approach to furan exposure assessment. Previous work suggested that urinary furan metabolites derived from the reaction of cis-2-butene-1,4-dial (BDA), the reactive intermediate of furan, with glu...
Source: Archives of Toxicology - April 4, 2024 Category: Toxicology Authors: C Kalisch M Reiter M Krieger L W üst C Klotz R Dekant D W Lachenmeier O Scherf-Clavel A Mally Source Type: research
Commentary of the SKLM to the EFSA opinion on risk assessment of N-nitrosamines in food
Arch Toxicol. 2024 Apr 4. doi: 10.1007/s00204-024-03726-1. Online ahead of print.ABSTRACTDietary exposure to N-nitrosamines has recently been assessed by the European Food Safety Authority (EFSA) to result in margins of exposure that are conceived to indicate concern with respect to human health risk. However, evidence from more than half a century of international research shows that N-nitroso compounds (NOC) can also be formed endogenously. In this commentary of the Senate Commission on Food Safety (SKLM) of the German Research Foundation (DFG), the complex metabolic and physiological biokinetics network of nitrate, nitr...
Source: Archives of Toxicology - April 4, 2024 Category: Toxicology Authors: Gerhard Eisenbrand Andrea Buettner Patrick Diel Bernd Epe Petra F örst Tillman Grune Dirk Haller Volker Heinz Michael Hellwig Hans-Ulrich Humpf Henry J äger Sabine Kulling Alfonso Lampen Marcel Leist Angela Mally Doris Marko Ute N öthlings Elke R öhrd Source Type: research
Muller and mutations: mouse study of George Snell (a postdoc of Muller) fails to confirm Muller's fruit fly findings, and Muller fails to cite Snell's findings
Arch Toxicol. 2024 Apr 4. doi: 10.1007/s00204-024-03718-1. Online ahead of print.ABSTRACTIn 1931, Hermann J. Muller's postdoctoral student, George D. Snell (Nobel Prize recipient--1980) initiated research to replicate with mice Muller's X-ray-induced mutational findings with fruit flies. Snell failed to induce the two types of mutations of interest, based on fly data (sex-linked lethals/recessive visible mutations) even though the study was well designed, used large doses of X-rays, and was published in Genetics. These findings were never cited by Muller, and the Snell paper (Snell, Genetics 20:545-567, 1935) did not cite ...
Source: Archives of Toxicology - April 4, 2024 Category: Toxicology Authors: Edward J Calabrese Paul B Selby Source Type: research
The Bach1/HO-1 pathway regulates oxidative stress and contributes to ferroptosis in doxorubicin-induced cardiomyopathy in H9c2 cells and mice
Arch Toxicol. 2024 Apr 4. doi: 10.1007/s00204-024-03697-3. Online ahead of print.ABSTRACTDoxorubicin (DOX) is one of the most frequently used chemotherapeutic drugs belonging to the class of anthracyclines. However, the cardiotoxic effects of anthracyclines limit their clinical use. Recent studies have suggested that ferroptosis is the main underlying pathogenetic mechanism of DOX-induced cardiomyopathy (DIC). BTB-and-CNC homology 1 (Bach1) acts as a key role in the regulation of ferroptosis. However, the mechanistic role of Bach1 in DIC remains unclear. Therefore, this study aimed to investigate the underlying mechanistic...
Source: Archives of Toxicology - April 4, 2024 Category: Toxicology Authors: Yanwei Wang Jingru Qiu Hua Yan Nan Zhang Shixuan Gao Ning Xu Cuiyan Wang Haiyan Lou Source Type: research
Validation of putative biomarkers of furan exposure through quantitative analysis of furan metabolites in urine of F344 rats exposed to stable isotope labeled furan
Arch Toxicol. 2024 Apr 4. doi: 10.1007/s00204-024-03722-5. Online ahead of print.ABSTRACTHumans are chronically exposed to furan, a potent liver toxicant and carcinogen that occurs in a variety of heat-processed foods. Assessment of human exposure based on the furan content in foods is, however, subject to some uncertainty due to the high volatility of furan. Biomarker monitoring is thus considered an alternative or complementary approach to furan exposure assessment. Previous work suggested that urinary furan metabolites derived from the reaction of cis-2-butene-1,4-dial (BDA), the reactive intermediate of furan, with glu...
Source: Archives of Toxicology - April 4, 2024 Category: Toxicology Authors: C Kalisch M Reiter M Krieger L W üst C Klotz R Dekant D W Lachenmeier O Scherf-Clavel A Mally Source Type: research
Calcium channel inhibitor and extracellular calcium improve aminoglycoside-induced hair cell loss in zebrafish
This study aimed to investigate whether the calcium channel blocker verapamil and changes in intracellular & extracellular calcium could ameliorate aminoglycoside-induced ototoxicity in zebrafish. The present findings showed that a significant decreased number of neuromasts in the lateral lines of zebrafish larvae at 5 days' post fertilization after neomycin (20 μM) and gentamicin (20 mg/mL) exposure, which was prevented by verapamil. Moreover, verapamil (10-100 μM) attenuated aminoglycoside-induced toxic response in different external calcium concentrations (33-3300 μM). The increasing extracellular calcium reduced...
Source: Archives of Toxicology - April 2, 2024 Category: Toxicology Authors: Liao-Chen Chen Hwei-Hsien Chen Ming-Huan Chan Source Type: research
Intestinal carcinogenicity screening of environmental pollutants using organoid-based cell transformation assay
Arch Toxicol. 2024 Apr 2. doi: 10.1007/s00204-024-03729-y. Online ahead of print.ABSTRACTThe high incidence of colorectal cancer (CRC) is closely associated with environmental pollutant exposure. To identify potential intestinal carcinogens, we developed a cell transformation assay (CTA) using mouse adult stem cell-derived intestinal organoids (mASC-IOs) and assessed the transformation potential on 14 representative chemicals, including Cd, iPb, Cr-VI, iAs-III, Zn, Cu, PFOS, BPA, MEHP, AOM, DMH, MNNG, aspirin, and metformin. We optimized the experimental protocol based on cytotoxicity, amplification, and colony formation o...
Source: Archives of Toxicology - April 2, 2024 Category: Toxicology Authors: Ziwei Wang Shen Chen Yuzhi Guo Rui Zhang Qi Zhang Xinhang Jiang Miao Li Yue Jiang Lizhu Ye Xiaoyu Guo Chuang Li Guangtong Zhang Daochuan Li Liping Chen Wen Chen Source Type: research
Calcium channel inhibitor and extracellular calcium improve aminoglycoside-induced hair cell loss in zebrafish
This study aimed to investigate whether the calcium channel blocker verapamil and changes in intracellular & extracellular calcium could ameliorate aminoglycoside-induced ototoxicity in zebrafish. The present findings showed that a significant decreased number of neuromasts in the lateral lines of zebrafish larvae at 5 days' post fertilization after neomycin (20 μM) and gentamicin (20 mg/mL) exposure, which was prevented by verapamil. Moreover, verapamil (10-100 μM) attenuated aminoglycoside-induced toxic response in different external calcium concentrations (33-3300 μM). The increasing extracellular calcium reduced...
Source: Archives of Toxicology - April 2, 2024 Category: Toxicology Authors: Liao-Chen Chen Hwei-Hsien Chen Ming-Huan Chan Source Type: research
