Long-term HbA1c variability and macro-/micro-vascular complications in type 2 diabetes mellitus: a meta-analysis update
ConclusionsOur meta-analysis on HbA1c variability performed on the most recent published data since 2015 indicates positive association between HbA1c variability and macro-/micro-vascular complications, as well as mortality events, in T2DM, suggesting that this long-term glycaemic parameter merits further attention as a predictive, independent risk factor for T2DM population. (Source: Acta Diabetologica)
Source: Acta Diabetologica - January 30, 2023 Category: Endocrinology Source Type: research
Relationship between IL-22 and IL-22BP in diabetic cognitive dysfunction
ConclusionA decrease in the IL-22/IL-22BP ratio plays an important role in diabetic cognitive dysfunction, and rIL-22 can effectively alleviate DE. Herein, we shed light on the interaction between IL-22 and IL-22BP as therapeutic targets for DM. (Source: Acta Diabetologica)
Source: Acta Diabetologica - January 30, 2023 Category: Endocrinology Source Type: research
Gestational weight gain and pregnancy outcomes in women with type 1 and type 2 diabetes mellitus
ConclusionIn this cohort of women with type 1 or type 2 diabetes, inadequate GWG after IOM was associated with adverse pregnancy outcomes; associations were unfavorable for eGWG and mixed for iGWG. The attributable fractions were not moderate, pointing to the potential impact of modifying inadequate GWG. (Source: Acta Diabetologica)
Source: Acta Diabetologica - January 27, 2023 Category: Endocrinology Source Type: research
A new proposal for a second insulin bolus to optimize postprandial glucose profile in adolescents with type 1 diabetes
ConclusionsThe new way to calculate and administer correction boluses 3 h after HF and HP meals is effective and safe in reducing PPG and the hypoglycemia risk. (Source: Acta Diabetologica)
Source: Acta Diabetologica - January 27, 2023 Category: Endocrinology Source Type: research
Correction to: MODY patients carrying mutation in syndromic diabetes genes. An Italian single-center experience
(Source: Acta Diabetologica)
Source: Acta Diabetologica - January 27, 2023 Category: Endocrinology Source Type: research
Clinical and biochemical profile of childhood –adolescent-onset type 1 diabetes and adult-onset type 1 diabetes among Asian Indians
ConclusionAO with T1D had higher prevalence of microvascular complications compared to CAO. Among AO, GAD negative individuals had higher percentage of retinopathy and CKD compared to GAD positive group. (Source: Acta Diabetologica)
Source: Acta Diabetologica - January 26, 2023 Category: Endocrinology Source Type: research
Effect of sodium –glucose cotransporter 2 inhibitors on insulin resistance; a systematic review and meta-analysis
ConclusionSGLT2Is, particularly dapagliflozin, could increase IS. These results need to be consolidated by further studies. (Source: Acta Diabetologica)
Source: Acta Diabetologica - January 20, 2023 Category: Endocrinology Source Type: research
The ability of pGCD59 to predict adverse pregnancy outcomes: a prospective study of non-diabetic pregnant women in Ireland
ConclusionsThis study has shown that pGCD59 has the potential to predict adverse pregnancy outcomes. Prospective studies with a larger number of cases are necessary to fully explore and validate the potential of this emerging biomarker in predicting adverse pregnancy outcomes. (Source: Acta Diabetologica)
Source: Acta Diabetologica - January 20, 2023 Category: Endocrinology Source Type: research
Screening for diabetes in the adult population above the age of 20 years among inhabitants of rural agricultural and rural desert areas of Egypt
ConclusionsThe prevalence of DM, IFG, and overall dysglycemia (DM + IFG) in Egypt has generally increased in rural areas, with a lower prevalence in rural desert compared to rural agricultural areas. (Source: Acta Diabetologica)
Source: Acta Diabetologica - January 20, 2023 Category: Endocrinology Source Type: research
In vitro fertilization increases the odds of gestational diabetes: a nationwide register-based cohort study
(Source: Acta Diabetologica)
Source: Acta Diabetologica - January 20, 2023 Category: Endocrinology Source Type: research
LncRNA SNHG16 regulates RAS and NF- κB pathway-mediated NLRP3 inflammasome activation to aggravate diabetes nephropathy through stabilizing TLR4
ConclusionSNHG16 accelerated HG-induced renal injuries via recruiting EIF4A3 to enhance the stabilization of TLR4 mRNA. The SNGHG16/ELF4A3/TLR4 axis might be a novel target for treating DRI. (Source: Acta Diabetologica)
Source: Acta Diabetologica - January 20, 2023 Category: Endocrinology Source Type: research
Insulin pump therapy with and without continuous glucose monitoring in pregnant women with type 1 diabetes: a prospective observational Orchestra Foundation study in Poland
ConclusionsObservational assessment of women withT1D using CSII therapy demonstrated low HbA1c throughout pregnancy and low rates of LGA. The addition of CGM to CSII therapy compared to CSII therapy alone was associated with some improved maternal glycemic and neonatal outcomes.Clinicaltrials.gov identifierNCT01779141 (January 2013). (Source: Acta Diabetologica)
Source: Acta Diabetologica - January 19, 2023 Category: Endocrinology Source Type: research
Glycemic control in people with diabetes treated with cancer chemotherapy: contribution of continuous glucose monitoring
ConclusionsCGM use in blinded mode could be an interesting tool to reduce the risk of hypoglycemia in people with diabetes starting chemotherapy. Our findings fully support the recommendation that assessing hypoglycemia risk should be mandatory in patients with diabetes before starting chemotherapy. (Source: Acta Diabetologica)
Source: Acta Diabetologica - January 13, 2023 Category: Endocrinology Source Type: research
Pre-pregnancy body surface area and risk for gestational diabetes mellitus
ConclusionThis study showed that in comparison with women with a higher BSA, underweight, and normal weight pregnant women with a smaller BSA may be more susceptible to GDM and have a pathological OGTT. (Source: Acta Diabetologica)
Source: Acta Diabetologica - January 13, 2023 Category: Endocrinology Source Type: research
Family coaggregation of type 1 diabetes mellitus, major depressive disorder, attention-deficiency hyperactivity disorder and autism spectrum disorder in affected families: a nationwide study
ConclusionsThe individual risks of T1D, MDD, and ADHD were increased in families that included patients with T1D, and DKA might play a role in such coaggregation with MDD and ADHD. Future studies are warranted to investigate the underlying mechanisms. (Source: Acta Diabetologica)
Source: Acta Diabetologica - January 13, 2023 Category: Endocrinology Source Type: research
