Cyp2e1 knockdown attenuates high glucose-induced apoptosis and oxidative stress of cardiomyocytes by activating PI3K/Akt signaling
ConclusionsCyp2e1 knockdown attenuated HG-induced apoptosis and oxidative stress by activating PI3K/Akt signaling in cardiomyocytes. These findings suggested that Cyp2e1 might be potentially used as an effective therapeutic strategy for DCM. (Source: Acta Diabetologica)
Source: Acta Diabetologica - May 17, 2023 Category: Endocrinology Source Type: research
Sensor augmented pump therapy with predictive suspension function for low glucose levels reduces time in hypoglycaemia in pregnant women with type 1 diabetes
(Source: Acta Diabetologica)
Source: Acta Diabetologica - May 16, 2023 Category: Endocrinology Source Type: research
Urinary metabolites associate with the presence of diabetic kidney disease in type 2 diabetes and mediate the effect of inflammation on kidney complication
ConclusionsIn T2D, several associated urinary metabolites were identified to improve the prediction of DKD. Whether interventions aimed at reducing CMI also reduce the risk of DKD especially in patients with high IL-18 needs further investigations. (Source: Acta Diabetologica)
Source: Acta Diabetologica - May 15, 2023 Category: Endocrinology Source Type: research
Real-world treatment patterns and diagnosis of charcot foot in franco-belgian diabetic foot expert centers (The EPiChar Study)
ConclusionsThis observational study highlights the diagnostic and therapeutic practices in 31 diabetic foot centers. Our results highlight that the use of MRI and the modalities of offloading, an essential treatment in the acute phase, need to be better standardized. Centers were highly encouraging about creating a patient registry. (Source: Acta Diabetologica)
Source: Acta Diabetologica - May 15, 2023 Category: Endocrinology Source Type: research
Different associations of anthropometric indices with diabetic retinopathy and diabetic kidney disease in chinese patients with type 2 diabetes mellitus
ConclusionsA median BMI and a large hip might be related to a low risk of DR, while lower levels of all the anthropometric indices were associated with a lower risk of DKD. Our findings suggested maintain a median BMI, a low WHR, a low WHtR and a large hip for prevention of DR and DKD. (Source: Acta Diabetologica)
Source: Acta Diabetologica - May 14, 2023 Category: Endocrinology Source Type: research
Acute kidney injury: a strong risk factor for hypoglycaemia in hospitalized patients with type 2 diabetes
ConclusionsAKI increased the risk of hypoglycaemia during hospitalization of patients with T2D, and its duration was the main risk factor. These results highlight the need for specific protocols to avoid hypoglycaemia and its burden in patients with AKI. (Source: Acta Diabetologica)
Source: Acta Diabetologica - May 13, 2023 Category: Endocrinology Source Type: research
No effects of COVID-19 on the development of type 1 diabetes autoimmunity and no evidence of an increased frequency of SARS-CoV-2 antibodies in newly diagnosed type 1 diabetes patients relative to healthy subjects
ConclusionsThe results of the present study do not confirm, at least in the short term, a role of COVID-19 as a potential trigger of T1D autoimmunity and do not provide evidence of an increased frequency of SARS-CoV-2 antibodies in newly diagnosed T1D patients in comparison with healthy population. (Source: Acta Diabetologica)
Source: Acta Diabetologica - May 12, 2023 Category: Endocrinology Source Type: research
Flash glucose monitoring in gestational diabetes mellitus (FLAMINGO): a randomised controlled trial
ConclusionsStudy results indicate that FGM has an impact on glycaemic control, dietary habits and incidence of fetal macrosomia in patients with GDM.Trial registration clinicaltrials.gov ID: NCT04422821. (Source: Acta Diabetologica)
Source: Acta Diabetologica - May 10, 2023 Category: Endocrinology Source Type: research
Associations between clinical and psychosocial factors and HbA1c in adult insulin pump users with type 1 diabetes
ConclusionsThis study identified several associations between clinical and psychosocial factors and HbA1c that may be considered when developing interventions targeted people with type 1 diabetes. (Source: Acta Diabetologica)
Source: Acta Diabetologica - May 9, 2023 Category: Endocrinology Source Type: research
Glucagon-like peptide-1 analog therapy in rare genetic diseases: monogenic obesity, monogenic diabetes, and spinal muscular atrophy
ConclusionsConsidering the pleiotropic effects of GLP1-a beyond BMI reduction, this treatment modality may serve as a game changer in challenging cases. (Source: Acta Diabetologica)
Source: Acta Diabetologica - May 9, 2023 Category: Endocrinology Source Type: research
Artificial intelligence in diabetic retinopathy screening: clinical assessment using handheld fundus camera in a real-life setting
ConclusionsThe Aurora fundus camera is effective in a first line screening of DR. Its in-built AI software can be considered a reliable tool to automatically identify the presence of signs of DR and therefore employed as a promising resource in large screening campaigns. (Source: Acta Diabetologica)
Source: Acta Diabetologica - May 8, 2023 Category: Endocrinology Source Type: research
Clinical validation of a smartphone-based retinal camera for diabetic retinopathy screening
ConclusionsOur study shows that the handheld retinal camera Eyer performed comparably to standard tabletop fundus cameras for diabetic retinopathy and macular edema screening. The high agreement with tabletop devices, portability, and low costs makes the handheld retinal camera a promising tool for increasing coverage of diabetic retinopathy screening programs, particularly in low-income countries. Early diagnosis and treatment have the potential to prevent avoidable blindness, and the present validation study brings evidence that supports its contribution to diabetic retinopathy early diagnosis and treatment. (Source: Acta Diabetologica)
Source: Acta Diabetologica - May 7, 2023 Category: Endocrinology Source Type: research
Early diagnosis of retinal neurovascular injury in diabetic patients without retinopathy by quantitative analysis of OCT and OCTA
ConclusionsRetinal NVU may have been compromised in patients with DM without retinopathy. Basic clinical information and rapid noninvasive OCT and OCTA techniques are useful for the quantitative assessment of retinal NVU prognosis in patients with DM without retinopathy. (Source: Acta Diabetologica)
Source: Acta Diabetologica - May 5, 2023 Category: Endocrinology Source Type: research
Response to “Nutrigenetic variants and response to diet/lifestyle intervention in obese subjects: a pilot study”
(Source: Acta Diabetologica)
Source: Acta Diabetologica - May 5, 2023 Category: Endocrinology Source Type: research
Effectiveness of a comprehensive telemedicine intervention replacing standard care in gestational diabetes: a randomized controlled trial
ConclusionsTelemedicine offers an effective alternative to delivering care to women with GDM.Trial registration NCT05521893, ClinicalTrials.gov Identifier URL:https://www.clinicaltrials.gov/ct2/show/NCT05521893?term=NCT05521893&draw=2&rank=1 (Source: Acta Diabetologica)
Source: Acta Diabetologica - April 25, 2023 Category: Endocrinology Source Type: research
