Evaluation of the health-related quality of life of patients with type 2 diabetes in relation to macrovascular and microvascular complications
ConclusionThe complications, sociodemographic and clinical characteristics of patients with T2DM affect the HRQoL domains differently. Understanding the point of which complication types and stages impact HRQoL the most can provide insights to clinicians to prioritise on effective interventions. The study findings may assist researchers and policymakers in selecting appropriate health state values when conducting cost-effectiveness studies to aid decision making. (Source: Acta Diabetologica)
Source: Acta Diabetologica - August 4, 2023 Category: Endocrinology Source Type: research
Intermittent scanning continuous glucose monitoring is safe and useful in postsurgical glucose monitoring after pancreatoduodenectomy
ConclusionsA hybrid approach with isCGM/POC is a safe and effective treatment option in a non-ICU setting after pancreatoduodenectomy. (Source: Acta Diabetologica)
Source: Acta Diabetologica - August 4, 2023 Category: Endocrinology Source Type: research
Effect of obesity on fragility fractures, BMD and vitamin D levels in postmenopausal women. Influence of type 2 diabetes mellitus
(Source: Acta Diabetologica)
Source: Acta Diabetologica - August 3, 2023 Category: Endocrinology Source Type: research
The correlation between serum uric acid and diabetic kidney disease in adult-onset type 1 diabetes patients in China
ConclusionsThe serum UA level was negatively correlated with eGFR and had a curve correlation with urinary ACR in adult-onset T1DM patients of China. (Source: Acta Diabetologica)
Source: Acta Diabetologica - July 21, 2023 Category: Endocrinology Source Type: research
Applying WHO2013 diagnostic criteria for gestational diabetes mellitus reveals currently untreated women at increased risk
ConclusionsGDM prevalence increased tenfold when applying WHO2013 criteria in a Danish population, mainly driven by higher fasting glucose levels. Untreated GDM in the gap between the current Danish and the WHO2013 diagnostic criteria resulted in higher risks of adverse pregnancy outcomes. (Source: Acta Diabetologica)
Source: Acta Diabetologica - July 18, 2023 Category: Endocrinology Source Type: research
Response to “Below‑the‑ankle arterial disease: a new marker of coronary artery disease in patients with diabetes and foot ulcers”
(Source: Acta Diabetologica)
Source: Acta Diabetologica - July 18, 2023 Category: Endocrinology Source Type: research
Pregnancy glucagon-like peptide 1 predicts insulin but not glucose concentrations
ConclusionsThese results suggest that the relationship between insulin and incretins is preserved in pregnancy, but that other factors, such as placental hormones or counter-regulatory hormones, may be more important determinants of glycaemia and gestational diabetes aetiology. (Source: Acta Diabetologica)
Source: Acta Diabetologica - July 13, 2023 Category: Endocrinology Source Type: research
Blood pressure-lowering effects of SGLT2 inhibitors and GLP-1 receptor agonists for preventing of cardiovascular events and death in type 2 diabetes: a systematic review and meta-analysis
ConclusionIn patients with type 2 diabetes, the hypotensive effects of SGLT2i and GLP-1 RAs were significantly associated with a reduction in mortality and cardiorenal events. These findings suggest that the lowering BP effect could be seen as an additive indicator of cardiovascular protection by SGLT2i and GLP-1 RAs drugs. (Source: Acta Diabetologica)
Source: Acta Diabetologica - July 13, 2023 Category: Endocrinology Source Type: research
Association between urinary C-megalin levels and progressive kidney dysfunction: a cohort study based on the diabetes distress and care registry at Tenri (DDCRT 24)
ConclusionsHigh urinary C-megalin levels were associated with progressive kidney dysfunction in individuals with diabetes, and this association was attenuated by high UACRs. (Source: Acta Diabetologica)
Source: Acta Diabetologica - July 13, 2023 Category: Endocrinology Source Type: research
A cohort follow-up study for diabetic retinopathy screening incidence in the North Denmark Region
ConclusionsNearly all patients were screened for DR over a 5-year timespan. Female patients with T1D who attended screening at hospitals were significantly more likely to be screened. Validation of screening visits at hospitals was reported with a high mean positive predictive value. Most other studies, to the best of our knowledge, only report screening attendance for patients already enrolled in a DR screening programme. This study describes the overall screening attendance for the total eligible diabetes population. (Source: Acta Diabetologica)
Source: Acta Diabetologica - July 12, 2023 Category: Endocrinology Source Type: research
METTL14 promotes the development of diabetic kidney disease by regulating m6A modification of TUG1
ConclusionMETTL14 promoted renal tubular epithelial cell apoptosis and ERS by activating MAPK/ERK pathway through m6A modification of TUG1, thereby accelerating DKD progression. (Source: Acta Diabetologica)
Source: Acta Diabetologica - July 10, 2023 Category: Endocrinology Source Type: research
The effect of GLP-1 receptor agonist lixisenatide on experimental diabetic retinopathy
ConclusionsOur data suggest that lixisenatide has a protective effect on the diabetic retina, most likely due to a combination of neuroprotective, anti-inflammatory and antioxidative effects of lixisenatide on the neurovascular unit. (Source: Acta Diabetologica)
Source: Acta Diabetologica - July 9, 2023 Category: Endocrinology Source Type: research
Bariatric surgery in individuals with type 2 diabetes is not associated with short or long-term risk of diabetic retinopathy progression: results from a nationwide cohort study
ConclusionsIn this nationwide study, bariatric surgery did not associate with increased risk of short- or long-term DR worsening. (Source: Acta Diabetologica)
Source: Acta Diabetologica - July 8, 2023 Category: Endocrinology Source Type: research
Does nutritional guidance reduce cardiovascular events in patients with type 2 diabetes mellitus? A retrospective cohort study using a nationwide claims database
ConclusionsReceiving NG in early-stage diabetes may reduce the incidence of cardiovascular events, especially cerebrovascular events. (Source: Acta Diabetologica)
Source: Acta Diabetologica - July 8, 2023 Category: Endocrinology Source Type: research
On the occasion of the centennial of the Nobel Prize in Physiology or Medicine, 1923: Nicolae C. Paulescu —between scientific creativity and political fanatism
ConclusionsA-The Romanian scientist NC Paulescu started an intense research program aimed at the isolation of the antidiabetic hormone before 1916, including an original procedure of pancreatectomy in the dog and the elaboration of a pancreatic extract that achieved excellent results in the treatment of experimental diabetes, demonstrating its beneficial effects on the metabolism of carbohydrates, proteins and fats and reducing both glycosuria and glycemia and the urinary excretion of ketone bodies of depancreatized dogs toward normality. The results of these investigations were published in 1920 and 1921, predating the fi...
Source: Acta Diabetologica - July 5, 2023 Category: Endocrinology Source Type: research
