Investigating family history of diabetes as a predictor of fasting insulin and fasting glucose activity in a sample of healthy weight adults
ConclusionsThese results add to the understanding of how family history influences the biomarkers that contribute to diabetes development. Knowledge of how family history of diabetes relates to fasting insulin and fasting glucose activity in healthy weight individuals can be used to design personalized screening and early prevention strategies. (Source: Acta Diabetologica)
Source: Acta Diabetologica - January 13, 2023 Category: Endocrinology Source Type: research
Predictive value of ferroptosis-related biomarkers for diabetic kidney disease: a prospective observational study
ConclusionsThe GPX4, ACSL4, MDA, and ROS combination might have a good predictive value for DKD. Additionally, the course of disease, ferritin levels, serum iron, transferrin, and GPX4 were independently associated with massive proteinuria. (Source: Acta Diabetologica)
Source: Acta Diabetologica - January 12, 2023 Category: Endocrinology Source Type: research
Seven basement membrane-specific expressed genes are considered potential biomarkers for the diagnosis and treatment of diabetic nephropathy
ConclusionsThis research identified seven BM-related genes as possible diagnostic and therapeutic biomarkers for DN. Analysis of inflammatory infiltration indicated that these genes may be important in inflammatory processes through Macrophages and MHC class I, hence impacting the course and development of DN illness. The development of a correlated column line graph model for it also shown excellent predictive capabilities. In addition, we have found pharmaceuticals, such as Ginsenoside Rh1, that may provide fresh insights into the personalized management of patients with DN. (Source: Acta Diabetologica)
Source: Acta Diabetologica - January 11, 2023 Category: Endocrinology Source Type: research
Autologous blood transfusion impedes glycolysis in macrophages to inhibit red blood cell injury in type 2 diabetes through PI3K/Akt/PKM2 signaling axis
ConclusionAutologous blood transfusion can reduce glycolysis in macrophages and inhibit the release of inflammatory factors through the PI3K/PKM2 signal axis, thereby inhibiting red blood cell damage and improving the oxygen-carrying capacity and survival activity of RBCs in diabetic patients. (Source: Acta Diabetologica)
Source: Acta Diabetologica - January 10, 2023 Category: Endocrinology Source Type: research
Baseline eGFR, albuminuria and renal outcomes in patients with SGLT2 inhibitor treatment: an updated meta-analysis
ConclusionsGenerally, the use of SGLT2i was consistently associated with decreased risk of renal events in all prespecified eGFR and albuminuria spectrums, even in patients with substantial renal impairment. The renal benefits of SGLT2i seemed to be independent of baseline eGFR, while the risk reduction in renal events was more profound among patients with mildly increased albuminuria or severely increased albuminuria. (Source: Acta Diabetologica)
Source: Acta Diabetologica - January 7, 2023 Category: Endocrinology Source Type: research
Short-term neonatal outcomes in women with gestational diabetes treated using metformin versus insulin: a systematic review and meta-analysis of randomized controlled trials
ConclusionsOur meta-analysis provides further evidence that metformin is a safe oral antihyperglycemic drug and has some benefits over insulin when used for the treatment of gestational diabetes, without an increased risk of short-term neonatal adverse outcomes. Metformin may be particularly useful in women with gestational diabetes at high risk for neonatal hypoglycemia, women who want to limit maternal and fetal weight gain, and women with an inability to afford or use insulin safely. (Source: Acta Diabetologica)
Source: Acta Diabetologica - January 3, 2023 Category: Endocrinology Source Type: research
Gender gaps in type 1 diabetes care
ConclusionGender equality exists in the diagnostic process of diabetes care. However, differences in weight control, blood pressure control, and cardiovascular mortality risk scores remain between both sexes, most likely due to multifactorial causes. Indications for interhospital variation in gender disparities in HbA1c control exist. Further focus on performance of process measurements between hospitals may identify areas for improvement of gender-skewed outcomes to further enhance Dutch diabetes care for both sexes. (Source: Acta Diabetologica)
Source: Acta Diabetologica - January 2, 2023 Category: Endocrinology Source Type: research
Effectiveness of periodontal treatment to improve glycemic control: an umbrella review
ConclusionsThe findings of the present study, within its limitations, indicated that non-surgical treatment of periodontitis is an efficacious therapy for improving the glycemic control in type 2 diabetes mellitus patients, both at 3- and 6-month follow-up. (Source: Acta Diabetologica)
Source: Acta Diabetologica - January 1, 2023 Category: Endocrinology Source Type: research
Response to “Pregnancy outcomes in women with type 1 diabetes using insulin degludec: a Danish Population-based prospective Cohort Study”
(Source: Acta Diabetologica)
Source: Acta Diabetologica - January 1, 2023 Category: Endocrinology Source Type: research
Pregnancy outcomes in women with type 1 diabetes using insulin degludec: response to Kamran et al
(Source: Acta Diabetologica)
Source: Acta Diabetologica - January 1, 2023 Category: Endocrinology Source Type: research
On the occasion of the centennial of insulin therapy (1922 –2022), II-Organotherapy of diabetes mellitus (1906–1923): Acomatol. Pancreina. Insulin.
AbstractAimsThe general objective has been the historiographical investigation of the organotherapy of diabetes mellitus between 1906 and 1923 in its scientific, social and political dimensions, with special emphasis on the most relevant contributions of researchers and institutions and on the controversies generated on the priority of the"discovery" of antidiabetic hormone.MethodsWe have analyzed the experimental procedures and determination of biological parameters used by researchers during the investigated period (1906 –1923): pancreatic ablation techniques, induction of acinar atrophy with preservation of ...
Source: Acta Diabetologica - December 31, 2022 Category: Endocrinology Source Type: research
SGLT-2 inhibitors and euglycemic diabetic ketoacidosis/diabetic ketoacidosis in FAERS: a pharmacovigilance assessment
ConclusionsPost-marketing data showed that SGLT-2i was significantly associated with higher reporting of euDKA/DKA. Although euDKA/DKA is rare, clinicians should be aware of SGLT-2i-associated euDKA/DKA events. (Source: Acta Diabetologica)
Source: Acta Diabetologica - December 28, 2022 Category: Endocrinology Source Type: research
Risk prediction of nephropathy by integrating clinical and genetic information among adult patients with type 2 diabetes
ConclusionsWe developed and internally and externally validated a model with clinical factors and SNPs from genes of multiple CKD-related pathways to predict DN in Taiwan. This model can be used in clinical risk management practice as a screening tool to identify persons who are genetically predisposed to DN for early intervention and prevention. (Source: Acta Diabetologica)
Source: Acta Diabetologica - December 28, 2022 Category: Endocrinology Source Type: research
The m6A reader YTHDC2 promotes SIRT3 expression by reducing the stabilization of KDM5B to improve mitochondrial metabolic reprogramming in diabetic peripheral neuropathy
ConclusionsTaken together, YTHDC2 promoted SIRT3 expression by reducing the stabilization of KDM5B to improve mitochondrial metabolic reprogramming in DPN. (Source: Acta Diabetologica)
Source: Acta Diabetologica - December 27, 2022 Category: Endocrinology Source Type: research
Regional divergence and time trends in the prevalence of gestational diabetes mellitus: a national Danish cohort study
ConclusionThe prevalence of GDM increased over time in all Danish regions with substantial regional divergence. Up to a 97%, difference in GDM prevalence was observed between Danish regions, which was not explained by available clinical risk factors. This occurred despite national guidelines and raises the question of whether regional variations in screening efficacy, diagnostic procedures or inequality in clinical health care access may explain the observed differences. (Source: Acta Diabetologica)
Source: Acta Diabetologica - December 20, 2022 Category: Endocrinology Source Type: research
