AdultCarbQuiz for the Portuguese population with type 1 diabetes mellitus: translation, cultural adaptation and validation of its metabolic impact
ConclusionsIn this study, theAdultCarbQuiz questionnaire, translated and culturally adapted to the Portuguese context, proved to be a useful tool in assessing knowledge about CH counting in patients with T1DM, allowing to optimize, individually, the therapeutic strategy in consultation. (Source: Acta Diabetologica)
Source: Acta Diabetologica - January 14, 2024 Category: Endocrinology Source Type: research
Retinal neurodegeneration in diabetic retinopathy with systemic hypertension
ConclusionsPatients with both DR and HTN exhibited much thinner pRNFL and GC-IPL, compared with patients with DR only. These results may have been related to the amplified diabetic retinal neurodegeneration and synergistic impact of ischemia in DR patients with concurrent HTN. Additionally, the progression of DR resulted in more severe inner retinal damage when combined with HTN. (Source: Acta Diabetologica)
Source: Acta Diabetologica - January 12, 2024 Category: Endocrinology Source Type: research
Safety and effectiveness of Medtronic MiniMed ™ 780G in a neonate with transient neonatal diabetes mellitus: a case report
(Source: Acta Diabetologica)
Source: Acta Diabetologica - January 10, 2024 Category: Endocrinology Source Type: research
Comment to the letter to the editor “Gremlin-1 in pregnancy and postpartum: health risk monitoring of women with gestational diabetes mellitus” by Tamayuki Kawada, published in Acta Diabetologica as a comment to the publication “Gremlin-1 in pregnancy and postpartum: relation to the fatty liver index, markers of bone health, glu cose metabolism and gestational diabetes mellitus status”
(Source: Acta Diabetologica)
Source: Acta Diabetologica - January 1, 2024 Category: Endocrinology Source Type: research
Downregulation of Sirt3 contributes to β-cell dedifferentiation via FoxO1 in type 2 diabetic mellitus
ConclusionDownregulation of Sirt3 contributes to β-cell dedifferentiation in high glucose via FoxO1. Intervention of Sirt3 may be an effective approach to prevent β-cell failure in T2DM. (Source: Acta Diabetologica)
Source: Acta Diabetologica - December 27, 2023 Category: Endocrinology Source Type: research
A case of type 1 diabetes mellitus and advanced chronic kidney disease in pregnancy: Which glucose monitoring system is the most accurate?
(Source: Acta Diabetologica)
Source: Acta Diabetologica - December 26, 2023 Category: Endocrinology Source Type: research
Assessing early tubular protective effects of SGLT2 inhibitor empagliflozin against type 2 diabetes mellitus using functional magnetic resonance imaging
ConclusionsSGLT2 inhibitor empagliflozin can reduce UACR and eGFR levels in early type 2 diabetic patients with normal proteinuria. Moreover, empagliflozin therapy led to an increase in the MD value and a decrease in the MR2* value of the renal medulla, evidencing the early tubular protective effects of this therapy. (Source: Acta Diabetologica)
Source: Acta Diabetologica - December 20, 2023 Category: Endocrinology Source Type: research
Advanced hybrid closed-loop use in children less than 2 years old with diluted insulin: a case series
(Source: Acta Diabetologica)
Source: Acta Diabetologica - December 15, 2023 Category: Endocrinology Source Type: research
Diabetes-related distress and quality of life among people with type 2 diabetes at primary care level in Brazil
ConclusionElevated diabetes-related stress scores significantly affect patients ’ QOL. Therefore, early screening of individuals at risk for this condition, using well-coordinated protocols, could mitigate adverse QOL effects and enhance their overall experience during disease management. (Source: Acta Diabetologica)
Source: Acta Diabetologica - December 14, 2023 Category: Endocrinology Source Type: research
MIDD due to variants m.3243A & gt; G or m.12258C & gt; A not necessarily carries an increased risk of obstetric complications
(Source: Acta Diabetologica)
Source: Acta Diabetologica - December 14, 2023 Category: Endocrinology Source Type: research
Downregulating lncRNA MIAT attenuates apoptosis of podocytes exposed to high glucose
ConclusionsHigh glucose upregulates MIAT level in HKPs and induces cellular injury. Knockdown of MIAT alleviates the injury likely via deactivating apoptosis pathways. (Source: Acta Diabetologica)
Source: Acta Diabetologica - December 11, 2023 Category: Endocrinology Source Type: research
No correlation between carotid intima-media thickness and long-term glycemic control in individuals with type 1 diabetes
ConclusionsWe observed no correlation between long-term blood glucose control and CIMT in individuals with T1D. This finding suggests that the development of early signs of macrovascular atherosclerosis is not strongly affected by the glycemic control in people with T1D. (Source: Acta Diabetologica)
Source: Acta Diabetologica - December 10, 2023 Category: Endocrinology Source Type: research
Unravelling the effect of renal denervation on glucose homeostasis: more questions than answers?
AbstractRenal Denervation (RDN) is an interventional, endovascular procedure used for the management of hypertension. The procedure itself aims to ablate the renal sympathetic nerves and to interrupt the renal sympathetic nervous system overactivation, thus decreasing blood pressure (BP) levels and total sympathetic drive in the body. Recent favorable evidence for RDN resulted in the procedure being included in the recent European Guidelines for the management of Hypertension, while RDN is considered the third pillar, along with pharmacotherapy, for managing hypertension. Sympathetic overactivation, however, is associated ...
Source: Acta Diabetologica - December 8, 2023 Category: Endocrinology Source Type: research
Alanine transferase levels (ALT) and triglyceride-glucose index are risk factors for type 2 diabetes mellitus in obese patients
ConclusionsThese data suggest an association between elevated ALT levels and the risk of incident T2DM in obesity. (Source: Acta Diabetologica)
Source: Acta Diabetologica - December 6, 2023 Category: Endocrinology Source Type: research
Aerobic exercise improves BKCa channel-mediated vasodilation in diabetic vascular smooth muscle via AMPK/Nrf2/HO-1 pathway
ConclusionsBKCa channel protein expression reduction in VSMCs contributes to vasodilation and vascular remodeling dysfunction in diabetes mellitus. Aerobic exercise can promote the expression of BKCa channel and improve BKCa-mediated vascular dysfunction in diabetic VSMCs through AMPK/Nrf2/HO-1 signaling pathway. (Source: Acta Diabetologica)
Source: Acta Diabetologica - December 2, 2023 Category: Endocrinology Source Type: research
