Determinants of diabetes self-care activities in patients with type 2 diabetes based on self-determination theory
ConclusionExercise is crucial for achieving good individualized glycemic control and reducing the risk of diabetes complications. The findings provided valuable insights into the determinants of self-care activities in patients with type 2 diabetes and underscore the need for interventions that address socioeconomic disparities, enhance perceived competence, and provide autonomy support to improve diabetes self-care. (Source: Acta Diabetologica)
Source: Acta Diabetologica - October 19, 2023 Category: Endocrinology Source Type: research
Higher circulating levels of non-esterified fatty acids are associated with faster kidney function decline in post-menopausal women with type 2 diabetes: a pilot prospective study
ConclusionsThe findings of this exploratory prospective study show that in post-menopausal women with T2DM and preserved kidney function at baseline, higher circulating levels of NEFA were strongly associated with a faster kidney function decline, even after adjustment for established renal risk factors and potential confounders. (Source: Acta Diabetologica)
Source: Acta Diabetologica - October 18, 2023 Category: Endocrinology Source Type: research
In blood we trust: anemia as a negative healing prognostic factor in diabetic foot patients
ConclusionsAnemia is frequent in DF and associates to a reduction in healing chances and an increase in recurrences representing an independent predictor of healing failure. (Source: Acta Diabetologica)
Source: Acta Diabetologica - October 17, 2023 Category: Endocrinology Source Type: research
Family structures and parents ’ occupational models: its impact on children’s diabetes
ConclusionsThese findings emphasise the importance of carefully considering family structure and working time models in the management of paediatric T1DM. Our results highlight risk factors within the family environment and emphasise the need for family-focused counselling of high-risk patients or severe cases in clinical practice. (Source: Acta Diabetologica)
Source: Acta Diabetologica - October 17, 2023 Category: Endocrinology Source Type: research
GLP-1RAs inhibit the activation of the NLRP3 inflammasome signaling pathway to regulate mouse renal podocyte pyroptosis
ConclusionThe protective effect of liraglutide and semaglutide on podocytes may be achieved by regulating the NLRP3 inflammasome pathway and inhibiting pyroptosis, and there were no significant differences between the two GLP-1RAs (liraglutide and semaglutide) in inhibiting podocyte pyroptosis. (Source: Acta Diabetologica)
Source: Acta Diabetologica - October 17, 2023 Category: Endocrinology Source Type: research
Virtual reality's impact on children with type 1 diabetes: a proof-of-concept randomized cross-over trial on anxiety, pain, adherence, and glycemic control
ConclusionsVR was shown to be effective in reducing pain and anxiety, improving adherence, PROM, and glycemic control among children with T1D. We suggest incorporating VR technology in pediatric diabetes clinics to facilitate and improve coping and management of diabetes.Trial registrationTrial registration number and date of registration for prospectively registered trials:ClinicalTrials.gov Identifier: NCT05883267, May 10th, 2023. (Source: Acta Diabetologica)
Source: Acta Diabetologica - October 16, 2023 Category: Endocrinology Source Type: research
Synergistic effect between pre-pregnancy smoking and assisted reproductive technology on gestational diabetes mellitus in twin pregnancies
ConclusionPre-pregnancy smoking may further increase the risk of GDM from ART in women with twin pregnancies. In clinical, women who are ready to receive ART treatment are recommend to quit smoking, which may reduce the risk of GDM and prevent adverse pregnancy outcomes. (Source: Acta Diabetologica)
Source: Acta Diabetologica - October 13, 2023 Category: Endocrinology Source Type: research
A novel stop-loss mutation in NKX2-2 gene as a cause of neonatal diabetes mellitus: molecular characterization and structural analysis
ConclusionThis study presents the first report of a stop-loss mutation in theNKX2-2 gene associated with NDM. Our findings emphasize the importance of functional and structural characterization to understand the biological consequences of such mutations. This comprehensive analysis provides insights into the molecular mechanisms underlying NDM and its clinical phenotype, which may aid in better diagnosis and management of patients with similar variants in the future. (Source: Acta Diabetologica)
Source: Acta Diabetologica - October 11, 2023 Category: Endocrinology Source Type: research
Associations between retinal microvascular flow, geometry, and progression of diabetic retinopathy in type 2 diabetes: a 2-year longitudinal study
ConclusionsOCTA-derived VD, FD and BVT in the DCP were independent predictors of DR progression and showed additive value when added to established risk models predicting DR progression. (Source: Acta Diabetologica)
Source: Acta Diabetologica - October 11, 2023 Category: Endocrinology Source Type: research
Gremlin-1 in pregnancy and postpartum: health risk monitoring of women with gestational diabetes mellitus
(Source: Acta Diabetologica)
Source: Acta Diabetologica - October 11, 2023 Category: Endocrinology Source Type: research
Identification of monogenic diabetes in an Australian cohort using the Exeter maturity-onset diabetes of the young (MODY) probability calculator and next-generation sequencing gene panel testing
ConclusionsContemporary genetic testing produces a high yield of positive results in individuals with clinically suspected monogenic diabetes and their relatives with diabetes, highlighting the value of genetic testing for this condition. An EMPC score cutoff of ≥ 25% correctly yielded a positive predictive value of ≥ 25% in this multiethnic demographic. This is the first Australian study to describe EMPC scores in the Australian clinic setting, albeit a biased referral cohort. Larger studies may help characterise EMPC performance between ethni c subsets, noting differences in the expected probability of monog...
Source: Acta Diabetologica - October 9, 2023 Category: Endocrinology Source Type: research
Comparison and evaluation of the 2009 and 2021 chronic kidney disease-epidemiological collaboration equations among Jordanian patients with type 2 diabetes mellitus
ConclusionsAlthough there was significant agreement with the 2009 equation, the 2021 equation increased eGFR and resulted in the reclassification of a subset of subjects according to KDIGO criteria. The uncertain impact of reducing high-risk category patients raises concerns about potential delays in referral and intervention, while holding the potential to enhance high-risk patient categorization, thus alleviating healthcare burden. (Source: Acta Diabetologica)
Source: Acta Diabetologica - October 8, 2023 Category: Endocrinology Source Type: research
Autoimmune diseases and risk of gestational diabetes mellitus: a Mendelian randomization study
ConclusionThis two-sample MR study found that both SLE and RA are positively associated with the risk of GDM. Our findings provide help for the future prevention and treatment of GDM to reduce associated maternal and fetal complications. However, more research is needed to obviate the role of the GC and the HCQ to ensure this relationship is causal. (Source: Acta Diabetologica)
Source: Acta Diabetologica - October 7, 2023 Category: Endocrinology Source Type: research
Bypass surgery versus endovascular revascularization for occlusive infrainguinal peripheral artery disease: a meta-analysis of randomized controlled trials for the development of the Italian Guidelines for the treatment of diabetic foot syndrome
AbstractTo report a review and meta-analysis of all randomized controlled trials (RCTs) comparing bypass surgery (BS) and endovascular treatment (ET) in infrainguinal peripheral arterial disease (PAD) for several endpoints, such as major and minor amputation, major adverse limb events (MALEs), ulcer healing, time to healing, and all-cause mortality to support the development of the Italian Guidelines for the Treatment of Diabetic Foot Syndrome (DFS). A MEDLINE and EMBASE search was performed to identify RCTs, published since 1991 up to June 21, 2023, enrolling patients with lower limb ischemia due to atherosclerotic diseas...
Source: Acta Diabetologica - October 4, 2023 Category: Endocrinology Source Type: research
The CEBPA-FGF21 regulatory network may participate in the T2DM-induced skeletal muscle atrophy by regulating the autophagy-lysosomal pathway
ConclusionThe CEBPA-FGF21 regulatory network may participate in the T2DM-induced skeletal muscle atrophy by regulating the autophagy-lysosomal pathway. Thus, our study provides interesting targets for prevention of skeletal muscle atrophy in T2DM. (Source: Acta Diabetologica)
Source: Acta Diabetologica - September 26, 2023 Category: Endocrinology Source Type: research
