Glucose variability: a new risk factor for cardiovascular disease
ConclusionsWe reviewed the definition of GV, the pathogenetic mechanisms of atherosclerosis, and its relationship with diabetic complications. (Source: Acta Diabetologica)
Source: Acta Diabetologica - June 21, 2023 Category: Endocrinology Source Type: research

Coexisiting type 1 diabetes and celiac disease is associated with lower Hba1c when compared to type 1 diabetes alone: data from the Australasian Diabetes Data Network (ADDN) registry
ConclusionsAcross all measurements, coexisting T1D and CD is associated with lower HbA1c when compared to T1D alone. However, HbA1c is above target in both groups. (Source: Acta Diabetologica)
Source: Acta Diabetologica - June 20, 2023 Category: Endocrinology Source Type: research

Efficacy and effectiveness of Herpes zoster vaccination in adults with diabetes mellitus: a systematic review and meta-analysis of clinical trials and observational studies
ConclusionsIn our meta-analysis of three observational studies LZV showed a 48% effectiveness in reducing HZ incidence in adults with diabetes whereas in a pooled analysis of two RCTs, RZV showed a 91% efficacy. No data are available on the effects of vaccination on the incidence and severity of HZ-related complications among subjects with diabetes. (Source: Acta Diabetologica)
Source: Acta Diabetologica - June 20, 2023 Category: Endocrinology Source Type: research

Serum bicarbonate concentration and the risk of death in type 2 diabetes: the Fremantle Diabetes Study Phase II
ConclusionsA low serum bicarbonate is not an independent prognostic marker in people with type 2 diabetes but it may be a manifestation of the pathway between the development of impaired renal function and death. (Source: Acta Diabetologica)
Source: Acta Diabetologica - June 17, 2023 Category: Endocrinology Source Type: research

Dose-dependent renoprotection efficacy of sglt2 inhibitors in type 2 diabetes: systematic review and network meta-analysis
ConclusionThe renoprotective efficacy of SGLT2i is independent of the incremental doses suggesting lower doses may suffice for renal outcomes. (Source: Acta Diabetologica)
Source: Acta Diabetologica - June 15, 2023 Category: Endocrinology Source Type: research

Is hyperinsulinemia a possible clinical explanation underlying the myth of Erysichthon?
ConclusionThe myth of Erysichthon provides an interesting range of clinical symptoms which I have argued relate to symptoms found in patients with an insulinoma. Although, insulinomas were unknown in ancient medical lore, this paper has speculated that based on Erysichthon ’s symptoms, the possibility of an insulinoma cannot be ruled out. (Source: Acta Diabetologica)
Source: Acta Diabetologica - June 12, 2023 Category: Endocrinology Source Type: research

MODY in China: two families carrying the KCNJ11 E229K variant
(Source: Acta Diabetologica)
Source: Acta Diabetologica - June 10, 2023 Category: Endocrinology Source Type: research

Comprehensive retinal vascular measurements: time in range is associated with peripheral retinal venular calibers in type 2 diabetes in China
ConclusionsThe TIR was associated with adverse changes to peripheral retinal venules but not central and middle vessels in patients with type 2 diabetes, suggesting that peripheral retinal vascular calibers may be affected by glycemic fluctuations earlier. (Source: Acta Diabetologica)
Source: Acta Diabetologica - June 6, 2023 Category: Endocrinology Source Type: research

AWARE A novel web application to rapidly assess cardiovascular risk in type 2 diabetes mellitus
ConclusionsThe AWARE App proved to be a practical tool for cardiovascular risk stratification of T2DM patients in real-world clinical practice. (Source: Acta Diabetologica)
Source: Acta Diabetologica - June 4, 2023 Category: Endocrinology Source Type: research

The Nobel Prize of Physiology or Medicine, 1923: controversies on the discovery of the antidiabetic hormone
AbstractAimsTo analyze the main contributions to the discovery of the antidiabetic hormone in the period between1889, the year in which Oskar Minkowski demonstrated that complete pancreatectomy in dogs caused diabetes, and the year 1923, the date in which the clinical use of insulin was consolidated. A main objective has been to review the controversies that followed the Nobel Prize and to outline the role of the priority rule in Science.MethodsWe have considered the priority rule defined by Robert Merton in 1957, which takes into account the date of acceptance of the report of a discovery in an accredited scientific journ...
Source: Acta Diabetologica - June 2, 2023 Category: Endocrinology Source Type: research

The association of homocysteine level with the risk of diabetic nephropathy and diabetic retinopathy in NHANES
ConclusionsIn diabetic patients, Hcy was associated with increased risk of DN in a non-linear manner. In addition, Hcy was associated with the risk of DR, but the association was attenuated after adjusting for confounders. In the future, Hcy can potentially be used as an early screening indicator for diabetic microvascular complications. (Source: Acta Diabetologica)
Source: Acta Diabetologica - May 19, 2023 Category: Endocrinology Source Type: research

hsa-mir-(4328, 4422, 548z and -628-5p) in diabetic retinopathy: diagnosis, prediction and linking a new therapeutic target
Conclusionhsa-mir-(4328, 4422, 548z and -628-5p) in whole blood are protective factors for DR as novel biomarkers for diagnosis and prediction. In addition, our research provides new drug directions for the treatment of DR, such as Diosmin, Atorvastatin, and so on. (Source: Acta Diabetologica)
Source: Acta Diabetologica - May 19, 2023 Category: Endocrinology Source Type: research

Longitudinal changes in serum adropin levels and liver fat content during liraglutide treatment in newly diagnosed patients with type 2 diabetes mellitus and metabolic dysfunction-associated fatty liver disease
ConclusionThe increase in serum adropin level following liraglutide treatment was strongly correlated with the reduction in liver fat content and glucolipid metabolism. Hence, adropin might be a potential marker for the beneficial effects of liraglutide on treating T2DM and MAFLD. (Source: Acta Diabetologica)
Source: Acta Diabetologica - May 19, 2023 Category: Endocrinology Source Type: research

Comparing sodium-glucose cotransporter 2 inhibitors and dipeptidyl peptidase-4 inhibitors on new-onset depression: a propensity score-matched study in Hong Kong
ConclusionSGLT2I use is associated with significantly lower risk of depression compared to DPP4 use in T2DM patients using propensity score matching and Cox regression analyses. (Source: Acta Diabetologica)
Source: Acta Diabetologica - May 19, 2023 Category: Endocrinology Source Type: research

Response to letter to the editor: nutrigenetic variants and response to diet/lifestyle intervention in obese subjects —a pilot study
(Source: Acta Diabetologica)
Source: Acta Diabetologica - May 19, 2023 Category: Endocrinology Source Type: research