LncRNA SNHG16 regulates RAS and NF- κB pathway-mediated NLRP3 inflammasome activation to aggravate diabetes nephropathy through stabilizing TLR4

ConclusionSNHG16 accelerated HG-induced renal injuries via recruiting EIF4A3 to enhance the stabilization of TLR4 mRNA. The SNGHG16/ELF4A3/TLR4 axis might be a novel target for treating DRI.
Source: Acta Diabetologica - Category: Endocrinology Source Type: research