Greater Combined Reductions of HbA1c ≥ 1.0% and Body Weight Loss ≥ 5.0% or ≥ 10.0% with Orally Administered Semaglutide Versus Comparators
ConclusionIn PIONEER 1–5 and 8, odds of achieving clinically relevant reductions in both HbA1c and body weight were significantly greater with orally administered semaglutide versus comparators.Graphical Abstract (Source: Diabetes Therapy)
Source: Diabetes Therapy - May 31, 2023 Category: Endocrinology Source Type: research
Finding the most cost-effective option from commonly used Dipeptidyl peptidase-4 inhibitors in India: a systematic study
CONCLUSIONS: Teneligliptin 20 mg could be considered as the preferred and most cost-effective agent among commonly used DPP4Is for the effective management of patients with T2DM in India.PMID:37232153 | DOI:10.1080/17446651.2023.2216279 (Source: Expert Review of Endocrinology and Metabolism)
Source: Expert Review of Endocrinology and Metabolism - May 26, 2023 Category: Endocrinology Authors: Harmanjit Singh Ekta Arora Seerat Narula Mandeep Singla Armaan Otaal Jatin Sharma Source Type: research
Repurposing DPP4-Inhibition to Improve Hair Follicle Activation and Regeneration
Skin-injury and several diseases elicit fibrosis and induce hair follicle (HF)-growth arrest and loss. Resulting alopecia and disfiguration represent a severe burden for patients both physically and psychologically. Reduction of pro-fibrotic factors such as DPP4 might be a strategy to tackle this issue. We demonstrate DPP4-overrepresentation in settings with HF-growth arrest (telogen), HF-loss and non-regenerative wound areas in mice skin and human scalp. Topical DPP4-inhibition (DPP4i) with FDA/EMA-approved Sitagliptin (Sit) on preclinical models of murine HF-activation/regeneration results in accelerated anagen-progress,...
Source: Journal of Investigative Dermatology - May 24, 2023 Category: Dermatology Authors: Maria Helm, Maria Schmidt, Ester Del Duca, Ying Liu, Lena S ünke Mortensen, Juliane Loui, Ying Zheng, Hans Binder, Emma Guttman-Yassky, George Cotsarelis, Jan C. Simon, Rubén A. Ferrer Tags: Original Article Source Type: research
Repurposing DPP4 Inhibition to Improve Hair Follicle Activation and Regeneration
Skin injury and several diseases elicit fibrosis and induce hair follicle (HF) growth arrest and loss. The resulting alopecia and disfiguration represent a severe burden for patients, both physically and psychologically. Reduction of profibrotic factors such as dipeptidyl peptidase 4 (DPP4) might be a strategy to tackle this issue. We show DPP4 overrepresentation in settings with HF growth arrest (telogen), HF loss, and nonregenerative wound areas in mouse skin and human scalp. Topical DPP4 inhibition with Food and Drug Administration/European Medicines Agency −approved sitagliptin on preclinical models of murine HF acti...
Source: Journal of Investigative Dermatology - May 24, 2023 Category: Dermatology Authors: Maria Helm, Maria Schmidt, Ester Del Duca, Ying Liu, Lena S ünke Mortensen, Juliane Loui, Ying Zheng, Hans Binder, Emma Guttman-Yassky, George Cotsarelis, Jan C. Simon, Rubén A. Ferrer Tags: Original Article Source Type: research
Identification of ribosomal protein family as immune-cell-related biomarkers of NAFLD by bioinformatics and experimental analyses
ConclusionsThis study identified four ribosomal protein genes (RPL35, RPS3A, RPS8, and MRPL16) as immune-cell-related biomarkers of NAFLD, which may actively participate in the immune processes during NAFLD progression and could serve as potential targets for the diagnosis and treatment of NAFLD. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - May 19, 2023 Category: Endocrinology Source Type: research
Alogliptin: a DPP-4 inhibitor modulating adipose tissue insulin resistance and atherogenic lipid
ConclusionsIn contrast to other tested DPP-4 inhibitors, alogliptin demonstrated the ability to down-regulate insulin resistance in adipose tissue, as well as certain atherogenic lipids. This study provides the initial evidence of a DPP-4 inhibitor ’s potential to regulate adipose tissue insulin resistance. Furthermore, adipo-IR is associated with non-LDL-C lipid parameters instead of glycemic control in those receiving alogliptin. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - May 17, 2023 Category: Drugs & Pharmacology Source Type: research
Evaluation of anti-atherosclerotic effects of Sitagliptin via modulation of the mTOR pathway in male rabbits
This study aimed to investigate the effect of Sitagliptin on the progression of atherosclerosis. Twenty-one male New Zealand White rabbits weighing 2-2.5 kg each were split into three groups: normal control, atherogenic control, and Sitagliptin-treated. The following parameters: serum triglycerides (TG), total cholesterol (TC), LDL, and a tissue autophagy marker (p62) using ELISA, aortic mRNA expression of mTORC1 marker using Real-Time Quantitative PCR(RT-qPCR), and histological inspection of the aorta were assessed. The mRNA expression of mTORC1 and the lipid profile of aortic tissue are considerably elevated in atherogen...
Source: Journal of Medicine and Life - May 11, 2023 Category: General Medicine Authors: Hussam Hamza Sahib Bassim Mohammad Najah Rayish Hadi Source Type: research
Evaluation of anti-atherosclerotic effects of Sitagliptin via modulation of the mTOR pathway in male rabbits
This study aimed to investigate the effect of Sitagliptin on the progression of atherosclerosis. Twenty-one male New Zealand White rabbits weighing 2-2.5 kg each were split into three groups: normal control, atherogenic control, and Sitagliptin-treated. The following parameters: serum triglycerides (TG), total cholesterol (TC), LDL, and a tissue autophagy marker (p62) using ELISA, aortic mRNA expression of mTORC1 marker using Real-Time Quantitative PCR(RT-qPCR), and histological inspection of the aorta were assessed. The mRNA expression of mTORC1 and the lipid profile of aortic tissue are considerably elevated in atherogen...
Source: Atherosclerosis - May 11, 2023 Category: Cardiology Authors: Hussam Hamza Sahib Bassim Mohammad Najah Rayish Hadi Source Type: research
Evaluation of anti-atherosclerotic effects of Sitagliptin via modulation of the mTOR pathway in male rabbits
This study aimed to investigate the effect of Sitagliptin on the progression of atherosclerosis. Twenty-one male New Zealand White rabbits weighing 2-2.5 kg each were split into three groups: normal control, atherogenic control, and Sitagliptin-treated. The following parameters: serum triglycerides (TG), total cholesterol (TC), LDL, and a tissue autophagy marker (p62) using ELISA, aortic mRNA expression of mTORC1 marker using Real-Time Quantitative PCR(RT-qPCR), and histological inspection of the aorta were assessed. The mRNA expression of mTORC1 and the lipid profile of aortic tissue are considerably elevated in atherogen...
Source: Journal of Medicine and Life - May 11, 2023 Category: General Medicine Authors: Hussam Hamza Sahib Bassim Mohammad Najah Rayish Hadi Source Type: research
