Medication adjustment of afatinib and combination therapy with sitagliptin for alleviating afatinib-induced diarrhea in rats
In conclusion, sitagliptin exhibits promising potential as a therapeutic option for managing afatinib-induced diarrhea. Taken together, our study provides valuable insights into alleviating afatinib-induced diarrhea through both afatinib medication adjustment and sitagliptin combination therapy.PMID:37567055 | DOI:10.1016/j.neo.2023.100922 (Source: Neoplasia)
Source: Neoplasia - August 11, 2023 Category: Cancer & Oncology Authors: Li Zhang Anna Hu Yan Wang Yuxin Yang Yalan Liu Lian Xu Lei Wang Zeneng Cheng Source Type: research
Medication adjustment of afatinib and combination therapy with sitagliptin for alleviating afatinib-induced diarrhea in rats
In conclusion, sitagliptin exhibits promising potential as a therapeutic option for managing afatinib-induced diarrhea. Taken together, our study provides valuable insights into alleviating afatinib-induced diarrhea through both afatinib medication adjustment and sitagliptin combination therapy.PMID:37567055 | DOI:10.1016/j.neo.2023.100922 (Source: Neoplasia)
Source: Neoplasia - August 11, 2023 Category: Cancer & Oncology Authors: Li Zhang Anna Hu Yan Wang Yuxin Yang Yalan Liu Lian Xu Lei Wang Zeneng Cheng Source Type: research
Medication adjustment of afatinib and combination therapy with sitagliptin for alleviating afatinib-induced diarrhea in rats
In conclusion, sitagliptin exhibits promising potential as a therapeutic option for managing afatinib-induced diarrhea. Taken together, our study provides valuable insights into alleviating afatinib-induced diarrhea through both afatinib medication adjustment and sitagliptin combination therapy.PMID:37567055 | DOI:10.1016/j.neo.2023.100922 (Source: Neoplasia)
Source: Neoplasia - August 11, 2023 Category: Cancer & Oncology Authors: Li Zhang Anna Hu Yan Wang Yuxin Yang Yalan Liu Lian Xu Lei Wang Zeneng Cheng Source Type: research
Comparison of therapeutic efficacy and safety of sitagliptin, dapagliflozin, or lobeglitazone adjunct therapy in patients with type 2 diabetes mellitus inadequately controlled on sulfonylurea and metformin: third agent study
Critically, more than 60% of patients with diabetes do not reach their treatment target goal, as indicated by an HbA1c level greater than 7% [1]. In many countries, metformin and sulfonylurea are still the most commonly prescribed agents for early treatment of diabetes. However, over time, additional medication is often needed due to the decrease in insulin secretory capacity of pancreatic β-cells and aggravation by insulin resistance [2]. Recently, new oral antidiabetic agents, such as a dipeptidyl peptidase-4 (DPP-4) inhibitor and sodium-glucose cotransporter-2 (SGLT-2) inhibitors have been developed, providing a wider ...
Source: Diabetes Research and Clinical Practice - August 11, 2023 Category: Endocrinology Authors: Jun Hwa Hong, Jun Sung Moon, Kayeon Seong, Soo Lim Source Type: research
Gliptins normalize posttraumatic hippocampal neurogenesis and restore cognitive function after controlled cortical impact on sensorimotor cortex
Biomed Pharmacother. 2023 Aug 4;165:115270. doi: 10.1016/j.biopha.2023.115270. Online ahead of print.ABSTRACTTraumatic brain injury (TBI) often leads to long-term neurocognitive dysfunctions. Adult neurogenesis in the hippocampal dentate gyrus (DG) serves critical functions in cognition but can be disrupted by brain injury and insult in serval forms. In the present study, we explore the cellular and molecular targets of DPP-4 inhibitors (or gliptins) as related to hippocampal function and TBI cognitive sequelae. Two structurally different gliptins, sitagliptin and vildagliptin, were examined using a controlled cortical imp...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 6, 2023 Category: Drugs & Pharmacology Authors: Yu-Wen Hung Guan-Ling Lu Hwei-Hsien Chen Hsiu-Hui Tung Sheau-Ling Lee Source Type: research
Gliptins normalize posttraumatic hippocampal neurogenesis and restore cognitive function after controlled cortical impact on sensorimotor cortex
Biomed Pharmacother. 2023 Aug 4;165:115270. doi: 10.1016/j.biopha.2023.115270. Online ahead of print.ABSTRACTTraumatic brain injury (TBI) often leads to long-term neurocognitive dysfunctions. Adult neurogenesis in the hippocampal dentate gyrus (DG) serves critical functions in cognition but can be disrupted by brain injury and insult in serval forms. In the present study, we explore the cellular and molecular targets of DPP-4 inhibitors (or gliptins) as related to hippocampal function and TBI cognitive sequelae. Two structurally different gliptins, sitagliptin and vildagliptin, were examined using a controlled cortical imp...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 6, 2023 Category: Drugs & Pharmacology Authors: Yu-Wen Hung Guan-Ling Lu Hwei-Hsien Chen Hsiu-Hui Tung Sheau-Ling Lee Source Type: research
Molecules, Vol. 28, Pages 5860: Insight into Structure Activity Relationship of DPP-4 Inhibitors for Development of Antidiabetic Agents
In conclusion, the use of halogenated scaffolds for the development of DPP-4 inhibitors is likely to be an area of increasing interest in the future. (Source: Molecules)
Source: Molecules - August 3, 2023 Category: Chemistry Authors: Vishal Mathur Ozair Alam Nadeem Siddiqui Mukund Jha Ajay Manaithiya Sandhya Bawa Naveen Sharma Sultan Alshehri Prawez Alam Faiyaz Shakeel Tags: Review Source Type: research
Cardiometabolic outcomes of sitagliptin-enhanced metformin treatment in uncontrolled type 2 diabetes patients without atherosclerotic manifestations
This study assessed the cardio-metabolic outcomes of sitagliptin added to metformin treatment in uncontrolled T2DM patients without atherosclerotic manifestations. (Source: Atherosclerosis)
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: E.-D. Grigorescu, C.-M. L ăcătușu, M. Floria, G.-D. Cazac, A. Onofriescu, V. Șorodoc, A. Ceasovschih, L. Șorodoc, B.-M. Mihai Source Type: research
