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In vitro validation of an in vivo phenotyping drug cocktail for major drug transporters in humans
CONCLUSION: The inhibition of hOCT2 in vitro by sitagliptin is in agreement with the borderline inhibition of renal metformin elimination observed clinically, supporting a dose reduction of sitagliptin in the cocktail.PMID:37142000 | DOI:10.1016/j.ejps.2023.106459 (Source: European Journal of Pharmaceutical Sciences)
Source: European Journal of Pharmaceutical Sciences - May 4, 2023 Category: Drugs & Pharmacology Authors: Chih-Hsuan Hsin Annett Kuehne Yi Gu Gabriele Jedlitschky Yohannes Hagos Dirk Gr ündemann Uwe Fuhr Source Type: research

Letter to the Editor regarding “Mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes diagnosed after metformin-triggered stroke-like episodes”
We read with interest the article by Murakami et al. about a 40 years-old male with mitochondrial encephalopathy, lactic acidosis, and stroke-like episode (MELAS) syndrome due to the variant m.3243A>G with a heteroplasmy rate of 27%, in whom metformin was suspected to have triggered a stroke-like episode (SLE), the phenotypic hallmark of MELAS.1 Metformin was replaced by sitagliptin and the patient was discharged in a stable condition after three weeks.1 The study is excellent, but has limitations that are objectionable and should be discussed. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - April 20, 2023 Category: Neurology Authors: Josef Finsterer Tags: Letter to the Editor Source Type: research

Comparative evaluation of metformin & amp; sitaformin in classic PCOS patients undergoing intracytoplasmic sperm injection: A randomized controlled pilot study
CONCLUSIONS: This is the first study to compare the impact of sitaformin with metformin on oocyte and embryo quality in women with PCOS undergoing a gonadotropin-releasing hormone (GnRH) antagonist cycle. In conclusion, sitaformin can be more effective in decreasing immature oocytes and increasing the quality of embryos than the use of metformin.PMID:37040229 | DOI:10.4103/ijmr.IJMR_2139_20 (Source: Indian J Med Res)
Source: Indian J Med Res - April 11, 2023 Category: Research Authors: Shahrzad Zadeh Modarres Delbar Daneshjou Malek Soleimani Mehranjani Seyed Mohammad Ali Shariatzadeh Source Type: research

Comparative evaluation of metformin & amp; sitaformin in classic PCOS patients undergoing intracytoplasmic sperm injection: A randomized controlled pilot study
CONCLUSIONS: This is the first study to compare the impact of sitaformin with metformin on oocyte and embryo quality in women with PCOS undergoing a gonadotropin-releasing hormone (GnRH) antagonist cycle. In conclusion, sitaformin can be more effective in decreasing immature oocytes and increasing the quality of embryos than the use of metformin.PMID:37040229 | DOI:10.4103/ijmr.IJMR_2139_20 (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - April 11, 2023 Category: Biomedical Science Authors: Shahrzad Zadeh Modarres Delbar Daneshjou Malek Soleimani Mehranjani Seyed Mohammad Ali Shariatzadeh Source Type: research