Digging Deeper into the Epigenetics of Supercentenarians
Supercentenarians, much as one might expect, exhibit signs of being biologically younger than their years. It is a lower burden of age-related damage and dysfunction that allows them the chance to survive. That said, it is worth noting that many characteristics so far observed in studies of supercentenarians are also present in large numbers of people who die well before reaching a century of life. The fortunately biochemistry of supercentarians adjusts small odds of survival to be slightly more favorable, but still small odds of survival. It is far from an assurance, and it certainly doesn't prevent one from becoming frai...
Source: Fight Aging! - February 17, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Elia Stupka, Angelini Ventures
I’ve been friends with Roberto Ascione for many years. Roberto is a keen Napoli fan who on the side runs the Healthware Group and also the Frontiers Health Conference that I’ve been going to for many years (and where Jess DaMassa is co-MC). Recently Healthware acquired the media company pharmaphorum and hired star reporter (and another friend) Jonah Comstock, ex MobiHealthNews and HIMSS Media. THCB will be doing some occasional cross-posting with pharmaphorum starting with this interview of the boss of a new and well heeled Italian health tech VC fund!–Matthew Holt
Elia Stupka, Managing Director at Ang...
Source: The Health Care Blog - February 8, 2023 Category: Consumer Health News Authors: matthew holt Tags: The Business of Health Care Angelini Ventures Elia Stupka Healthware Jonah Comstock Paul Tunnah pharmaphorum Roberto Ascione Source Type: blogs
The New Deal and Recovery, Part 23: The Great Rapprochement
George SelginWhat finally brought the Great Depression to an end? We ' ve seen that, whatever it was, it took place not during the 30s but sometime between then and the end of World War II, when a remarkable postwar revival occurred instead of the renewed depression many feared. We ' ve also seen that, while postwar fiscal and monetary policies weren ' t austere to the point of preventing that revival, they alone can ' t explain it, because they can ' t explain the reawakening of private business investment from its decade-and-a-half-long slumber.Animal SpiritsTo get to the bottom of that reawakening, we must first recall ...
Source: Cato-at-liberty - February 7, 2023 Category: American Health Authors: George Selgin Source Type: blogs
Fight Aging! Newsletter, January 23rd 2023
This study explored the association between tap drinking water and longevity in Cilento, Italy, to understand whether trace elements in local drinking water may have an influence on old, nonagenarian, and centenarian people and promote their health and longevity.
Data on population and water sources were collected through the National Demographic Statistics, the Cilento Municipal Archives, and the Cilento Integrated Water Service. Ordinary least squares (OLS) regression and a geographically weight regression (GWR) model were used to study the spatial relationship between the explanatory and outcome variables of long...
Source: Fight Aging! - January 22, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Chicken with Dried Mushrooms & Tomatoes
When it comes time to figure out what to make for dinner, I love the internet as much as anyone. I usually head straight to the NY Times Cooking section, or to Epicurious, Saveur or Food 52 for ideas and inspiration. But one weekend this past year, with our Philly travel plans cancelled by an upcoming storm (there is nothing worse than the Jersey turnpike in a thunderstorm with tornado and flood warnings), I had the unexpected luxury of free time on a Saturday morning. Sitting with a cup of coffee, I opened Biba’s Taste of Italy, a cookbook whose spine I had yet to crack in the year since it had been gifted to me by ...
Source: The Blog That Ate Manhattan - January 19, 2023 Category: Primary Care Authors: Margaret Polaneczky, MD Tags: Meat & Poultry Borgotaro braised Chicken Dinner party Dried mushrooms Emilia Romagna italian Make-ahead PGI Porcini recipe Stove top Tomatoes Source Type: blogs
Exploring Correlations Between Trace Elements in Drinking Water and Longevity
This study explored the association between tap drinking water and longevity in Cilento, Italy, to understand whether trace elements in local drinking water may have an influence on old, nonagenarian, and centenarian people and promote their health and longevity.
Data on population and water sources were collected through the National Demographic Statistics, the Cilento Municipal Archives, and the Cilento Integrated Water Service. Ordinary least squares (OLS) regression and a geographically weight regression (GWR) model were used to study the spatial relationship between the explanatory and outcome variables of long...
Source: Fight Aging! - January 19, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, January 16th 2023
Conclusions
Implanted Hair Follicle Cells Produce Remodeling of Scar Tissue
Assessment of Somatic Mosaicism as a Biomarker of Aging
The Gut Microbiome of Centenarians
https://www.fightaging.org/archives/2023/01/the-gut-microbiome-of-centenarians/
The state of the gut microbiome is arguably as influential on health as exercise. Various microbial species present in the gut produce beneficial metabolites, such as butyrate, or harmful metabolites, such as isoamylamine, or can provoke chronic inflammation in a variety of ways. An individual can have a better or worse microbiome, assessing these and other...
Source: Fight Aging! - January 15, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Commentary on More Drastic Scenarios of Partial Brain and Full Body Replacement
Is outright replacement of tissues a viable option for the treatment of aging? There are factions within the longevity-interested community who think that the paths to either (a) engineering replacement brain tissue for parts of the brain not involved in memory, or (b) transplantation of an old head onto a young body or brain into a young body, are short enough to be worth pursuing, where "short enough" means a few decades of work given sufficient funding. To my mind, major surgery of the sort implied by replacement of large sections of tissue or entire organs is something to be avoided in later life, given the risks and c...
Source: Fight Aging! - January 10, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The Gut Microbiome of Centenarians
In this study, we combined metagenomic sequencing and large-scale in vitro culture to reveal the unique gut microbial structure of the world's longevity town - Jiaoling, China, centenarians, and people of different ages. Functional strains were isolated and screened in vitro, and the possible relationship between gut microbes and longevity was explored and validated in vivo, revealing associations of the gut microbiota with age and a number of clinical and metabolic parameters.
We uncovered age-specific gut microbiota characteristics, including a core set of seven microbial taxa enriched in centenarians and the gut ...
Source: Fight Aging! - January 9, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Happy New Year!!!
Okay, okay, so I’m a bit (!) late for holiday greetings…but, in my defense, Stefano and I have had lots to do…We spent the holidays with his family in southern Italy and only returned to Florence a few days ago to our kitties and heaps of laundry .
Before we left Florence, I came across a super interesting article about curcumin and myeloma, but of course I’ve “lost” it and will have to look for it again. And even though I hate posting from my iPad, so annoying and slow, I will do so ASAP. Or rather ASIFTA (as soon as I find the article… ).
Anyway, all is well here in Florence…and I will be blogging soon...
Source: Margaret's Corner - January 9, 2023 Category: Cancer & Oncology Authors: Margaret Tags: Blogroll Source Type: blogs
4 Signs Of Machiavellian Personality Traits
Machiavellianism is named for a 15th century Italian diplomat famous for manipulating people to get what he wanted. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - December 7, 2022 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Personality Source Type: blogs
Having “The Talk”: How to Discuss End-of-Life Issues with Parents
Photo credit Bennett Tobias
...In my experience, I’ve found that it isn’t always seniors who avoid talking about death. Some do, of course, but many of our aging loved ones would like to discuss the legal and financial arrangements they’ve made, as well as their preferences for end-of-life care and how they would like to handle their medical decisions if they were to become incapacitated. On the other hand, adult children often find excuses to delay frank discussions about serious illness and death.
Few of us like to consider that our parents will die, but nothing will change this truth. In actuality, avoiding end-...
Source: Minding Our Elders - November 30, 2022 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs
Why Do Some People with Dementia Who Never Swore Use Coarse Language?
Dear Carol: My mother always considered swearing cheap and a sign that people couldn’t find the right words to express themselves. Even so, she didn’t chastise others unless they strayed into obscene territory. Now, the world has turned upside down! She’s in mid-stage dementia and is coming out with words that we didn’t even know she’d heard. What causes this? She was a cheerful person, certainly not “repressed” as some people suggest. Do you know a better explanation? – TL
Continue reading on Inforum to learn more about why your older adult who never swore might suddenly spew obscenities:
Minding O...
Source: Minding Our Elders - November 27, 2022 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs
Caregiving: Could Your Body Language Be Making Your Loved One Anxious?
Dear Candid Caregiver (Carol): My parents were always open about their long-term plans for retirement, saying that they’d worked hard, and retirement was going to be the payoff. Travel was huge on the horizon. Now, my dad has been diagnosed with mixed dementia, which, in his case, means Alzheimer’s and possibly Lewy body dementia, so their dreams are pretty much canceled. Mom is, for the most part, a good caregiver, but she’s resentful about what happened, and why wouldn’t she be? She has a right to these feelings except that her resentment shows through to Dad through her body language as well the tone of her voic...
Source: Minding Our Elders - November 26, 2022 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs
10 Things Not to Say to a Person Living with Dementia
Providing care for someone who lives with any type of dementia — whether it’s Alzheimer’s, vascular, Lewy body, or any of the myriad incarnations — can be intimidating. We watch helplessly as someone we love changes dramatically in how they view the world, and in the words and actions that they can understand. These changes can lead to situations where we unintentionally say and do things that make life harder for everyone involved.
...It seems natural to ask your dad who is living with Alzheimer’s about events from his past. However, doing so directly can be a problem. Why? Because he may not remember th...
Source: Minding Our Elders - November 25, 2022 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs
