Drugs plus ligation to prevent rebleeding in cirrhosis: an updated systematic review
ConclusionsThe addition of drug therapy to EVL improves the efficacy of EVL alone. However, the addition of EVL to β‐blockers and ISMN achieves a non‐significant decrease of rebleeding with no effect on mortality. Although combination therapy with EVL plus β‐blockers ± ISMN is adequate to prevent rebleeding, β‐blockers + ISMN alone may be a valid alternative. (Source: Liver International)
Source: Liver International - January 24, 2014 Category: Gastroenterology Authors: Angela Puente, Virginia Hernández‐Gea, Isabel Graupera, Marta Roque, Alan Colomo, Maria Poca, Carles Aracil, Ignasi Gich, Carlos Guarner, Càndid Villanueva Tags: Review Article Source Type: research
Combined treatment with variceal ligation and β‐blockers ± nitrates to prevent recurrent variceal bleeding in cirrhosis. An updated systematic review
ConclusionsThe addition of drug therapy to EVL improves the efficacy of EVL alone. However, the addition of EVL to ß‐blockers and ISMN achieves a non‐significant decrease of rebleeding with no effect on mortality. Although combination therapy with EVL plus β‐blockers±ISMN is adequate to prevent rebleeding, β‐blockers+ISMN alone may be a valid alternative.This article is protected by copyright. All rights reserved. (Source: Liver International)
Source: Liver International - December 24, 2013 Category: Gastroenterology Authors: Angela Puente, Virginia Hernández‐Gea, Isabel Graupera, Marta Roque, Alan Colomo, Maria Poca, Carles Aracil, Ignasi Gich, Carlos Guarner, Càndid Villanueva Tags: Reviews Source Type: research
Effect of oral nitrates on pulse pressure and arterial elasticity in patients aged over 65 years with refractory isolated systolic hypertension: study protocol for a randomized controlled trial
Background:
Isolated systolic hypertension is a highly prevalent disease among the elderly. The little available evidence on the efficacy of nitrates for treating the disease is based on small experimental studies.
Methods:
We performed a multicenter, randomized, double-blind, phase III, placebo-controlled trial in 154 patients aged over 65 years with refractory isolated systolic hypertension. Patients were randomized to placebo or 40 mg/day of extended-release isosorbide mononitrate added to standard therapy and titrated to 60 mg/day at week 6 if blood pressure exceeded 140/90 mmHg.The primary objective was to assess the ...
Source: Trials - November 14, 2013 Category: Journals (General) Authors: Daniel Abad-PérezBlanca Novella-ArribasFrancisco Rodríguez-SalvanésLuis Sánchez-GómezIluminada García-PoloCarmen Verge-GonzálezCarmen Suárez-Fernández Source Type: research
Long-term isosorbide mononitrate treatment impairs endothelial function in patients with coronary artery disease
ConclusionLong-term ISMN treatment may impair endothelial function in patients with CAD. (Source: Coronary Artery Disease)
Source: Coronary Artery Disease - September 30, 2013 Category: Cardiology Tags: Original Research Source Type: research
Comparison of topical isosorbide mononitrate, topical diltiazem, and their combination in the treatment of chronic anal fissure.
CONCLUSION: Topical diltiazem and a combination of nitrate and diltiazem can be used in the treatment of anal fissure. However, the agents are not significantly superior each other.
PMID: 24054756 [PubMed - in process] (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - September 27, 2013 Category: Surgery Authors: Bulus H, Varol N, Tas A, Coskun A Tags: Asian J Surg Source Type: research
Nitrates and bone turnover (NABT) - a trial to select the best nitrate preparation: study protocol for a randomized controlled trial
DiscussionData from this protocol will be used to develop a randomized, controlled trial of nitrates to prevent osteoporotic fractures.Trial registration: ClinicalTrials.gov Identifier: NCT01387672. Controlled-Trials.com: ISRCTN08860742. (Source: Trials)
Source: Trials - September 8, 2013 Category: Journals (General) Authors: Roxana BucurLauren ReidCeleste HamiltonSteven CummingsSophie Jamal Source Type: research
More answers to the still unresolved question of nitrate tolerance
Organic nitrates are traditionally felt to be a safe adjuvant in the chronic therapy of patients with coronary artery disease. Despite their long use, progress in the understanding of the pharmacology and mechanism of action of these drugs has been achieved only in the last two decades, with the identification of the role of oxidative stress in the pathophysiology of nitrate tolerance, with, the discovery of the ancillary effects of nitrates, and with the demonstration that nitrate therapy has important chronic side effects that might modify patients' prognosis. These advances are however mostly confined to the molecular l...
Source: European Heart Journal - September 7, 2013 Category: Cardiology Authors: Munzel, T., Daiber, A., Gori, T. Tags: REVIEWS Source Type: research
An Unusual Case of Chronic Diarrhea
Question: An 80-year-old man with a history of Henoch–Schonlein purpura at the age of 59 requiring partial jejunal resection, coronary artery disease, chronic kidney disease, gout, gastroesophageal reflux disease, and prior cholecystectomy was admitted for 2 weeks of guaiac-positive watery brown diarrhea and dehydration. Medications included aspirin 81 mg/d, clopidogrel, aldactazide, furosemide, hydralazine, isosorbide mononitrate, metoprolol, simvastatin, lansoprazole, allopurinol, trazodone, and tamsulosin. He had switched from citalopram to bupropion 2 weeks prior. He was afebrile and hemodynamically stable. His abdom...
Source: Gastroenterology - February 26, 2013 Category: Gastroenterology Authors: Gauree Gupta Konijeti, Vikram Deshpande, Cheryl J. Bunker Tags: Clinical Challenges and Images in GI Source Type: research
Carvedilol for Preventing Recurrent Variceal Bleeding: Waiting for convincing evidence
Conclusions:Carvedilol was as effective as nadolol plus isorsorbide‐5 ‐mononitrate mononitrate in the prevention of gastroesophageal variceal rebleeding with fewer severe adverse events and similar survival. (Source: Hepatology)
Source: Hepatology - January 28, 2013 Category: Internal Medicine Authors: Jaime Bosch Tags: Hepatology Elsewhere Source Type: research
Can isosorbide mononitrate be useful in second trimester termination of pregnancies?
Abstract: Background: Isosorbide mononitrate (IMN) administration is thought to enhance in the cervical ripening process. We sought to identify the clinical usefulness and safety of IMN administration for shortening the time to termination of the second trimester pregnancy procedures when used in addition to misoprostol.Study Design: Women were randomly selected to receive either the standard misoprostol treatment (control group) or, additionally, receive vaginally IMN as well as the misoprostol treatment.Results: The mean induction to complete abortion interval was 20.4 h [95% confidence interval (CI)=16.63–24.17] in th...
Source: Contraception - January 4, 2013 Category: OBGYN Authors: Athanasios Mousiolis, Mihalis Sindos, Nikolaos Papantoniou, Aris Antsaklis Tags: Original Research Articles Source Type: research
