Nitric oxide involvement in post-exercise proteinuria of sedentary young men
ConclusionOur results revealed that exogenous nitric oxide could alter the hemodynamic changes during exercise and thus reduce post-exercise proteinuria. Further, endogenous nitric oxide may prevent excessive elevation in the post-exercise proteinuria during normal physiological conditions.RésuméObjectifsUne protéinurie après un exercice physique est généralement caractérisée par une altération de l’hémodynamique rénale. La présente étude s’est concentrée sur le rôle du monoxyde d’azote dans le cas d’une protéinurie après exercice physique. Le monoxyde d’azote est une biomolécule qui participe a...
Source: Science and Sports - October 25, 2019 Category: Sports Medicine Source Type: research
Effects of Isosorbide Mononitrate and/or Cilostazol on Hematological Markers, Platelet Function, and Hemodynamics in Patients With Lacunar Ischaemic Stroke: Safety Data From the Lacunar Intervention-1 (LACI-1) Trial
Conclusions
Cilostazol increased heart rate and platelet count, and reduced Buckberg index, whilst both drugs may individually reduce arterial stiffness adjusted for heart rate. Neither drug had clinically significant effects on haemoglobin or platelet function over 8 weeks. Further assessment of the safety and efficacy of these medications following lacunar ischaemic stroke is warranted. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - July 2, 2019 Category: Neurology Source Type: research
A Pilot Randomized Controlled Trial to Evaluate Isosorbide Mononitrate (IMN) Efficiency for ...
Our aim was to examine the effect and cost-effectiveness of isosorbide mononitrate (IMN) for outpatient (at home) cervical ripening in Iranian women with term pregnancy. Term pregnant women were randomly selected to receive either 15 mg vaginally administered IMN or placebo. Patients were advised to take the second dose at home 24 h later and return to the hospital for admission after the next 24 h if the onset of spontaneous contraction does not occur. Cervical status, maternal blood pressure, maternal pulse rate, fetal heart rate and various side effects were examined. IMN induced a significant increase in cervical ...
Source: Iranian Journal of Pharmaceutical Research - April 30, 2019 Category: Drugs & Pharmacology Source Type: research
Molecules, Vol. 24, Pages 583: Design, Synthesis and Biological Evaluation of Nitrate Derivatives of Sauropunol A and B as Potent Vasodilatory Agents
ing Wu
Weijia Xie
A group of nitrate derivatives of naturally occurring sauropunol A and B were designed and synthesized. Nitric oxide (NO) releasing capacity and vasodilatory capacity studies were performed to explore the structure-activity relationship of resulted nitrates. Biological evaluation of these compounds revealed that most of the synthesized mononitrate derivatives demonstrated superior releasing capacity than isosorbide mononitrate (ISMN), and 2MNS-6 even demonstrated stronger NO releasing capacity than isosorbide dinitrate (ISDN). Two dinitrates, DNS-1 and DNS-2, showed higher NO releasing capacity than...
Source: Molecules - February 6, 2019 Category: Chemistry Authors: Lu Lu Xuemin Rao Rigang Cong Chenxi Zhang Zhimei Wang Jinyi Xu Genzoh Tanabe Osamu Muraoka Xiaoming Wu Weijia Xie Tags: Article Source Type: research
Ziziphora clinopodioides Flavonoids Protect Myocardial Cell Damage from Myocardial Ischemia-Reperfusion Injury.
Authors: Li Q, Tursun D, Shi C, Heyrulla M, Zhang X, Yang W
Abstract
To investigate effects of Ziziphora clinopodioides Lam. flavonoids on ischemia-reperfusion injury of myocardial cells. After application of 6.25, 25, and 100 μg/mL Ziziphora clinopodioides Lam. flavonoids to H9C2 myocardial cells for 24H, they were treated for 4 hours with hydrogen peroxide to induce oxidative damage, whereas controls were cells without treatment and cells only incubated with hydrogen peroxide. Cell viability, lactate dehydrogenase release and mitochondrial membrane potential, intracellular Na+/K+-ATPase activity and ATP...
Source: Evidence-based Complementary and Alternative Medicine - January 10, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
The Relationship between Compound Danshen Dripping Pills with Isosorbide Mononitrate in the Treatment of Elderly Patients with Unstable Angina Pectoris.
Conclusion: Based on this meta-analysis, the CDDP was superior to ISMN with UAP in the elderly. However, there is still a need to further verify the clinical efficacy and safety of CDDP with more strictly designed RCTs with large sample and multiple centers in the future.
PMID: 30108652 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - August 16, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Don't just say no: differential pathways and pharmacological responses to diverse nitric oxide donors.
This article will comment recent findings regarding physiological responses involving NO• species and their pharmacological modulation with donor drugs, especially in the context of the photic transduction pathways at the hypothalamic circadian clock.
PMID: 30080991 [PubMed - as supplied by publisher] (Source: Biochemical Pharmacology)
Source: Biochemical Pharmacology - August 3, 2018 Category: Drugs & Pharmacology Authors: Chiesa JJ, Baidanoff FM, Golombek DA Tags: Biochem Pharmacol Source Type: research
A painful hemorrhagic blister on the leg
History and clinical findings: A 87-year-old lady was admitted to the medical ward with urinary tract infection. It was noted to have sudden painful bleeding blisters in her lower legs of 1 week duration. She had a background of stage 4 chronic renal failure since 2009 and was diagnosed of urothelial bladder cancer in December 2015. She was on Bisoprolol, calcichew, folic acid, isosorbide mononitrate, zomorph, ranitidine, levothyroxine, buscopan and paracetamol. On examination there was a large 1 cm × 2 cm hemorrhagic blister on her left lower leg on background of multiple tender purpuric and necrotic plaques on both lowe...
Source: Journal of the American Academy of Dermatology - August 2, 2018 Category: Dermatology Source Type: research
Intravaginal rings for continuous low-dose administration of cervical ripening agents
Publication date: Available online 24 July 2018Source: International Journal of PharmaceuticsAuthor(s): Yujing Wang, Peter Boyd, Alyson Hunter, R. Karl MalcolmAbstractIntravaginal rings (VRs) have been widely reported for administration of pharmaceutical drugs – most notably estrogens, progestogens and antiretrovirals – to the vagina for clinical benefit. Here, for the first time, we describe the design, manufacture and preclinical testing of VRs for sustained/controlled release of the cervical ripening agents isosorbide mononitrate (ISMN) and misoprostol (MP), either singly or in combination. Matrix-type silicone elas...
Source: International Journal of Pharmaceutics - July 25, 2018 Category: Drugs & Pharmacology Source Type: research
Nitric oxide donors for treatment of isolated oligohydramnios: A randomized controlled trial
ConclusionNitric oxide donors may offer a promising choice in improving amniotic fluid volume and pregnancy outcomes in cases of isolated oligohydramnios. (Source: Middle East Fertility Society Journal)
Source: Middle East Fertility Society Journal - July 11, 2018 Category: Reproduction Medicine Source Type: research
Stimulation of nitric oxide-sensitive soluble guanylate cyclase in monocrotaline-induced pulmonary hypertensive rats
In this study, we examined whether a disruption in the balance between nitric oxide (NO)-sensitive and -insensitive soluble guanylate cyclase (sGC) is observed in pulmonary hypertension (PH) and whether treatment with NO-enhancing drugs can halt disease progression. Main methods Rats were injected subcutaneously with saline or 60 mg/kg monocrotaline (MCT). At 14 days after injection, the vascular reactivity of isolated extralobar pulmonary arteries was assessed by organ chamber technique. In a separate experiment, isosorbide mononitrate (0.3 or 1 g/L) or sodium nitrite (30 or 300 mg/L) was administered in drinking...
Source: Life Sciences - May 18, 2018 Category: Biology Source Type: research
Nitric Oxide in the Prevention of Pre-eclampsia (NOPE): A Double-Blind Randomized Placebo-Controlled Trial Assessing the Efficacy of Isosorbide Mononitrate in the Prevention of Pre-eclampsia in High-Risk Women
ConclusionThe results of the randomized controlled trial of nitric oxide in the prevention of pre-eclampsia (NOPE) showed that in high-risk women receiving standard aspirin prophylaxis from less than 16 weeks, there is no significant reduction in the incidence of hypertensive disorders of pregnancy in the ISMN group, to the desired extent. There was no significant effect on the severity of disease, gestational age at diagnosis of disease or maternal–perinatal morbidity due to low-dose isosorbid e mononitrate. (Source: The Journal of Obstetrics and Gynecology of India)
Source: The Journal of Obstetrics and Gynecology of India - March 26, 2018 Category: OBGYN Source Type: research
High sucrose/fat diet and isosorbide mononitrate increase insulin resistance, nitric oxide production and myocardial apoptosis in a hypertensive rat model.
Authors: Li T, Bai B, Tian C, Wang H, Jiang D, Ma F, Shan M
Abstract
The present study aimed to investigate the association between insulin resistance (IR), nitric oxide (NO) production and myocardial apoptosis in a background of coexisting hypertension in a rodent animal model. A hypertensive rat model was established by feeding Wistar and spontaneously hypertensive rats (SHR) with a high sucrose/fat (HSF) diet for 12 weeks, in conjunction with isosorbide mononitrate (ISMN). Increased IR, NO content, apoptotic gene and protein expression, and morphological alterations within rat myocardium were evaluated...
Source: Molecular Medicine Reports - March 2, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
A case report of Brugada-like ST-segment elevation probably due to coronary vasospasm
In this report, we discuss an interesting case of a patient who was diagnosed as vasospastic angina according to his coronary angiography, but his electrocardiography showed a Brugada-like ST-segment elevation.Patient concerns:Our patient had a 9-month history of temporary but progressive substernal burning sensation with acid bilges of shoulders and arms, as well as profuse sweating at night.Diagnoses:Although he had no abnormal laboratory test result, no dysfunctional recorded echocardiogram or documented arrhythmia after being admitted to the hospital, his electrocardiography showed a Brugada-like ST-segment elevation. ...
Source: Medicine - March 1, 2018 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
