Intravaginal administration of isosorbide mononitrate for cervical ripening in prolonged pregnancy: a randomised clinical trial.
This study was performed to evaluate the efficacy of intravaginal isosorbide mononitrate (IMN) for cervical ripening in prolonged pregnancies. 122 pregnant women were recruited. Women were assigned to 25 µg sublingual misoprostol plus 40 mg isosorbide mononitrate or placebo. Statistical analysis was done using SPSS software (version 23) and T-test, Mann-Whitney and Chi-square test. p ≤ .05 was considered significant. The mean time between beginning of cervical ripening to Bishop score>6 was significantly shorter in IMN plus misoprostol group when compared to misoprostol plus placebo ...
Source: Journal of Obstetrics and Gynaecology - December 20, 2019 Category: OBGYN Tags: J Obstet Gynaecol Source Type: research

Nitric oxide involvement in post-exercise proteinuria of sedentary young men
ConclusionOur results revealed that exogenous nitric oxide could alter the hemodynamic changes during exercise and thus reduce post-exercise proteinuria. Further, endogenous nitric oxide may prevent excessive elevation in the post-exercise proteinuria during normal physiological conditions.RésuméObjectifsUne protéinurie après un exercice physique est généralement caractérisée par une altération de l’hémodynamique rénale. La présente étude s’est concentrée sur le rôle du monoxyde d’azote dans le cas d&rs...
Source: Science and Sports - October 25, 2019 Category: Sports Medicine Source Type: research

Effects of Isosorbide Mononitrate and/or Cilostazol on Hematological Markers, Platelet Function, and Hemodynamics in Patients With Lacunar Ischaemic Stroke: Safety Data From the Lacunar Intervention-1 (LACI-1) Trial
Conclusions Cilostazol increased heart rate and platelet count, and reduced Buckberg index, whilst both drugs may individually reduce arterial stiffness adjusted for heart rate. Neither drug had clinically significant effects on haemoglobin or platelet function over 8 weeks. Further assessment of the safety and efficacy of these medications following lacunar ischaemic stroke is warranted. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - July 3, 2019 Category: Neurology Source Type: research

A Pilot Randomized Controlled Trial to Evaluate Isosorbide Mononitrate (IMN) Efficiency for ...
Our aim was to examine the effect and cost-effectiveness of isosorbide mononitrate (IMN) for outpatient (at home) cervical ripening in Iranian women with term pregnancy. Term pregnant women were randomly selected to receive either 15 mg vaginally administered IMN or placebo. Patients were advised to take the second dose at home 24 h later and return to the hospital for admission after the next 24 h if the onset of spontaneous contraction does not occur. Cervical status, maternal blood pressure, maternal pulse rate, fetal heart rate and various side effects were examined. IMN induced a significant increase in cervical ...
Source: Iranian Journal of Pharmaceutical Research - April 30, 2019 Category: Drugs & Pharmacology Source Type: research

Molecules, Vol. 24, Pages 583: Design, Synthesis and Biological Evaluation of Nitrate Derivatives of Sauropunol A and B as Potent Vasodilatory Agents
ing Wu Weijia Xie A group of nitrate derivatives of naturally occurring sauropunol A and B were designed and synthesized. Nitric oxide (NO) releasing capacity and vasodilatory capacity studies were performed to explore the structure-activity relationship of resulted nitrates. Biological evaluation of these compounds revealed that most of the synthesized mononitrate derivatives demonstrated superior releasing capacity than isosorbide mononitrate (ISMN), and 2MNS-6 even demonstrated stronger NO releasing capacity than isosorbide dinitrate (ISDN). Two dinitrates, DNS-1 and DNS-2, showed higher NO releasing capacity than...
Source: Molecules - February 6, 2019 Category: Chemistry Authors: Lu Lu Xuemin Rao Rigang Cong Chenxi Zhang Zhimei Wang Jinyi Xu Genzoh Tanabe Osamu Muraoka Xiaoming Wu Weijia Xie Tags: Article Source Type: research

Ziziphora clinopodioides Flavonoids Protect Myocardial Cell Damage from Myocardial Ischemia-Reperfusion Injury.
Authors: Li Q, Tursun D, Shi C, Heyrulla M, Zhang X, Yang W Abstract To investigate effects of Ziziphora clinopodioides Lam. flavonoids on ischemia-reperfusion injury of myocardial cells. After application of 6.25, 25, and 100 μg/mL Ziziphora clinopodioides Lam. flavonoids to H9C2 myocardial cells for 24H, they were treated for 4 hours with hydrogen peroxide to induce oxidative damage, whereas controls were cells without treatment and cells only incubated with hydrogen peroxide. Cell viability, lactate dehydrogenase release and mitochondrial membrane potential, intracellular Na+/K+-ATPase activity and ATP conten...
Source: Evidence-based Complementary and Alternative Medicine - January 10, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

The Relationship between Compound Danshen Dripping Pills with Isosorbide Mononitrate in the Treatment of Elderly Patients with Unstable Angina Pectoris.
Authors: Liang Y, Zou J, Zhang X, Wang Y, Tai J, Guo D, Cui C, Wang J, Cheng J, Shi Y Abstract Objective: To evaluate the clinical efficacy and safety of Compound Danshen Dripping Pill (CDDP) and Isosorbide Mononitrate (ISMN) in the treatment of unstable angina pectoris (UAP) in the elderly. Materials and Methods: CNKI, Wanfang, VIP, CBM, and PubMed databases were searched for appropriate articles without language limitations on keywords. RevMan 5.3 software was used to perform the meta-analysis. Results: This analysis compared CDDP with ISMN of 21 randomized controlled trials (RCTs) that involved a total o...
Source: Evidence-based Complementary and Alternative Medicine - August 16, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Don't just say no: differential pathways and pharmacological responses to diverse nitric oxide donors.
This article will comment recent findings regarding physiological responses involving NO• species and their pharmacological modulation with donor drugs, especially in the context of the photic transduction pathways at the hypothalamic circadian clock. PMID: 30080991 [PubMed - as supplied by publisher] (Source: Biochemical Pharmacology)
Source: Biochemical Pharmacology - August 3, 2018 Category: Drugs & Pharmacology Authors: Chiesa JJ, Baidanoff FM, Golombek DA Tags: Biochem Pharmacol Source Type: research

A painful hemorrhagic blister on the leg
History and clinical findings: A 87-year-old lady was admitted to the medical ward with urinary tract infection. It was noted to have sudden painful bleeding blisters in her lower legs of 1 week duration. She had a background of stage 4 chronic renal failure since 2009 and was diagnosed of urothelial bladder cancer in December 2015. She was on Bisoprolol, calcichew, folic acid, isosorbide mononitrate, zomorph, ranitidine, levothyroxine, buscopan and paracetamol. On examination there was a large 1 cm × 2 cm hemorrhagic blister on her left lower leg on background of multiple tender purpuric and necrotic plaques on both...
Source: Journal of the American Academy of Dermatology - August 2, 2018 Category: Dermatology Source Type: research

Intravaginal rings for continuous low-dose administration of cervical ripening agents
Publication date: Available online 24 July 2018Source: International Journal of PharmaceuticsAuthor(s): Yujing Wang, Peter Boyd, Alyson Hunter, R. Karl MalcolmAbstractIntravaginal rings (VRs) have been widely reported for administration of pharmaceutical drugs – most notably estrogens, progestogens and antiretrovirals – to the vagina for clinical benefit. Here, for the first time, we describe the design, manufacture and preclinical testing of VRs for sustained/controlled release of the cervical ripening agents isosorbide mononitrate (ISMN) and misoprostol (MP), either singly or in combination. Matrix-type silic...
Source: International Journal of Pharmaceutics - July 25, 2018 Category: Drugs & Pharmacology Source Type: research

Nitric oxide donors for treatment of isolated oligohydramnios: A randomized controlled trial
ConclusionNitric oxide donors may offer a promising choice in improving amniotic fluid volume and pregnancy outcomes in cases of isolated oligohydramnios. (Source: Middle East Fertility Society Journal)
Source: Middle East Fertility Society Journal - July 11, 2018 Category: Reproduction Medicine Source Type: research

Stimulation of nitric oxide-sensitive soluble guanylate cyclase in monocrotaline-induced pulmonary hypertensive rats
In this study, we examined whether a disruption in the balance between nitric oxide (NO)-sensitive and -insensitive soluble guanylate cyclase (sGC) is observed in pulmonary hypertension (PH) and whether treatment with NO-enhancing drugs can halt disease progression. Main methods Rats were injected subcutaneously with saline or 60 mg/kg monocrotaline (MCT). At 14 days after injection, the vascular reactivity of isolated extralobar pulmonary arteries was assessed by organ chamber technique. In a separate experiment, isosorbide mononitrate (0.3 or 1 g/L) or sodium nitrite (30 or 300 mg/L) was administered in drinking ...
Source: Life Sciences - May 18, 2018 Category: Biology Source Type: research

Nitric Oxide in the Prevention of Pre-eclampsia (NOPE): A Double-Blind Randomized Placebo-Controlled Trial Assessing the Efficacy of Isosorbide Mononitrate in the Prevention of Pre-eclampsia in High-Risk Women
ConclusionThe results of the randomized controlled trial of nitric oxide in the prevention of pre-eclampsia (NOPE) showed that in high-risk women receiving standard aspirin prophylaxis from less than 16  weeks, there is no significant reduction in the incidence of hypertensive disorders of pregnancy in the ISMN group, to the desired extent. There was no significant effect on the severity of disease, gestational age at diagnosis of disease or maternal–perinatal morbidity due to low-dose isosorbid e mononitrate. (Source: The Journal of Obstetrics and Gynecology of India)
Source: The Journal of Obstetrics and Gynecology of India - March 26, 2018 Category: OBGYN Source Type: research

High sucrose/fat diet and isosorbide mononitrate increase insulin resistance, nitric oxide production and myocardial apoptosis in a hypertensive rat model.
Authors: Li T, Bai B, Tian C, Wang H, Jiang D, Ma F, Shan M Abstract The present study aimed to investigate the association between insulin resistance (IR), nitric oxide (NO) production and myocardial apoptosis in a background of coexisting hypertension in a rodent animal model. A hypertensive rat model was established by feeding Wistar and spontaneously hypertensive rats (SHR) with a high sucrose/fat (HSF) diet for 12 weeks, in conjunction with isosorbide mononitrate (ISMN). Increased IR, NO content, apoptotic gene and protein expression, and morphological alterations within rat myocardium were evaluated. Fol...
Source: Molecular Medicine Reports - March 2, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

A case report of Brugada-like ST-segment elevation probably due to coronary vasospasm
In this report, we discuss an interesting case of a patient who was diagnosed as vasospastic angina according to his coronary angiography, but his electrocardiography showed a Brugada-like ST-segment elevation.Patient concerns:Our patient had a 9-month history of temporary but progressive substernal burning sensation with acid bilges of shoulders and arms, as well as profuse sweating at night.Diagnoses:Although he had no abnormal laboratory test result, no dysfunctional recorded echocardiogram or documented arrhythmia after being admitted to the hospital, his electrocardiography showed a Brugada-like ST-segment elevation. ...
Source: Medicine - March 1, 2018 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Mechanistic studies of the antibiofilm activity and synergy with antibiotics of isosorbide mononitrate.
Abstract The use of nitric oxide (NO), a naturally occurring antimicrobial agent, as an alternative strategy to combat bacterial biofilms has recently gained considerable momentum in light of the global threat of emerging antibiotic resistance. While previous NO-based anti-biofilm approaches were aimed at killing bacteria cells within biofilms, NO has also been recently identified as a key mediator of biofilm dispersal, causing the release of cells from the biofilm community. This is of great interest towards the design of more effective anti-biofilm strategies but further studies are warranted to validate this co...
Source: European Journal of Pharmaceutical Sciences - January 3, 2018 Category: Drugs & Pharmacology Authors: Hasan S, Albayaty YNS, Thierry B, Prestidge CA, Thomas N Tags: Eur J Pharm Sci Source Type: research

318: Endothelial function is unaltered by prophylactic nitric oxide donor in women at high-risk for preeclampsia
To study the effect of low dose prophylactic isosorbide mononitrate (ISMN) 20mg/d on the endothelial function in high-risk women receiving standard aspirin prophylaxis (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - January 1, 2018 Category: OBGYN Authors: K. Manikandan, G. Ponmozhi, Anish Keepanasseril, M. Jayanthi Tags: Poster Session II Source Type: research

Favorable Effects of Endoscopic Ligation Combined with Drugs on Rebleeding and Mortality in Cirrhotic Patients: A Network Meta-Analysis
Background: To assess the effects of combination therapies (endoscopic plus drug[s], drug combinations) on variceal/any-cause rebleeding and mortality among cirrhotic patients with one previous episode of variceal hemorrhage.Summary: We searched PubMed, Embase, Cochrane Library, and Web of Science for eligible studies. We included 26 randomized controlled trials involving 2,536 adults using OR to measure the effects. Endoscopic variceal ligation (EVL) plus nadolol ranked first for reducing recurrent bleeds. Both EVL  + nadolol and EVL + drugs (nadolol, sucralfate) decreased the risk of any-cause rebleeding than EVL al...
Source: Digestive Diseases - November 21, 2017 Category: Gastroenterology Source Type: research

Pharmacological and mechanical interventions for labour induction in outpatient settings.
CONCLUSIONS: Induction of labour in outpatient settings appears feasible and important adverse events seem rare, however, in general there is insufficient evidence to detect differences. There was no strong evidence that agents used to induce labour in outpatient settings had an impact (positive or negative) on maternal or neonatal health. There was some evidence that compared to placebo or no treatment, induction agents administered on an outpatient basis reduced the need for further interventions to induce labour, and shortened the interval from intervention to birth.We do not have sufficient evidence to know which induc...
Source: Cochrane Database of Systematic Reviews - September 13, 2017 Category: General Medicine Authors: Vogel JP, Osoti AO, Kelly AJ, Livio S, Norman JE, Alfirevic Z Tags: Cochrane Database Syst Rev Source Type: research

Out-of-hospital cardiac arrest related to coronary arterial spasm in three elderly patients with no obstructive coronary artery disease
This article reports a case series of out-of-hospital cardiac arrest (OHCA) likely due to coronary spastic angina (CSA) in the presence of non-obstructive coronary artery disease in elderly patients. Although CSA is associated with an increased risk of OHCA, little is known regarding clinical risk factors, the effectiveness of implanted defibrillators for the secondary prevention of cardiac arrest, or the long-term prognosis of elderly CSA patients who survive OHCA.> (Source: Journal of Cardiology Cases)
Source: Journal of Cardiology Cases - August 25, 2017 Category: Cardiology Source Type: research

Fixed-Dose Versus Off-Label Combination of Isosorbide Dinitrate Plus Hydralazine Hydrochloride: Retrospective Propensity-Matched Analysis in Black Medicare Patients with Heart Failure
ConclusionThe 1-year survival advantage for FDC-ISDN/HYD compared with off-label combinations in adherent black Medicare beneficiaries with HF suggests a genuine difference between these medications and warrants prospective investigation. (Source: Advances in Therapy)
Source: Advances in Therapy - July 13, 2017 Category: Drugs & Pharmacology Source Type: research

Hyponatremia induced by hyperinsulinemia-euglycemia therapy.
CONCLUSION: A woman who overdosed on amlodipine, metoprolol tartrate, and isosorbide mononitrate was treated with HIE therapy and developed symptomatic hyponatremia. Hyponatremia resolved after administration of dextrose with sodium bicarbonate infusion and 3% sodium chloride infusion and cessation of HIE therapy. PMID: 28687552 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - July 10, 2017 Category: Drugs & Pharmacology Authors: Beavers JR, Stollings JL, Rice TW Tags: Am J Health Syst Pharm Source Type: research

Methods of term labour induction for women with a previous caesarean section.
CONCLUSIONS: RCT evidence on methods of induction of labour for women with a prior caesarean section is inadequate, and studies are underpowered to detect clinically relevant differences for many outcomes. Several studies reported few of our prespecified outcomes and reporting of infant outcomes was especially scarce. The GRADE level for quality of evidence was moderate to very low, due to imprecision and study design limitations.High-quality, adequately-powered RCTs would be the best approach to determine the optimal method for induction of labour in women with a prior caesarean birth. However, such trials are unlikely to...
Source: Cochrane Database of Systematic Reviews - June 9, 2017 Category: General Medicine Authors: West HM, Jozwiak M, Dodd JM Tags: Cochrane Database Syst Rev Source Type: research

Accelerometer-Measured Daily Activity in Heart Failure With Preserved Ejection Fraction: Clinical Correlates and Association With Standard Heart Failure Severity Indices [Original Articles]
Background— Daily physical activity assessed by accelerometers represents a novel method to assess the impact of interventions on heart failure (HF) patients’ functional status. We hypothesized that daily activity varies by patient characteristics and correlates with established measures of HF severity in HF with preserved ejection fraction. Methods and Results— In this ancillary study of the NEAT-HFpEF trial (Nitrate’s Effects on Activity Tolerance in HF With Preserved Ejection Fraction), average daily accelerometer units (ADAU) and hours active per day were assessed during a 14-day period before ...
Source: Circulation: Heart Failure - June 6, 2017 Category: Cardiology Authors: Snipelisky, D., Kelly, J., Levine, J. A., Koepp, G. A., Anstrom, K. J., McNulty, S. E., Zakeri, R., Felker, G. M., Hernandez, A. F., Braunwald, E., Redfield, M. M. Tags: Lifestyle, Heart Failure Original Articles Source Type: research

A pilot controlled trial to evaluate isosorbide mononitrate efficiency for cervical ripening ...
Conclusion: Vaginal administration of 15mg of IMN induced cervical ripening in term pregnant women; however, the administration of IMN for cervical ripening is not recommended as it produced headache in significant number of Iranian pregnant women. (Source: Iranian Journal of Pharmaceutical Research)
Source: Iranian Journal of Pharmaceutical Research - May 9, 2017 Category: Drugs & Pharmacology Source Type: research

A Pilot Randomized Controlled Trial to Evaluate Isosorbide Mononitrate (IMN) Efficiency for ...
Our aim was to examine the effect and cost-effectiveness of isosorbide mononitrate (IMN) for outpatient (at home) cervical ripening in Iranian women with term pregnancy. Term pregnant women were randomly selected to receive either 15 mg vaginally administered IMN or placebo. Patients were advised to take the second dose at home 24 h later and return to the hospital for admission after the next 24 h if the onset of spontaneous contraction does not occur. Cervical status, maternal blood pressure, maternal pulse rate, fetal heart rate and various side effects were examined. IMN induced a significant increase in cervical ...
Source: Iranian Journal of Pharmaceutical Research - May 9, 2017 Category: Drugs & Pharmacology Source Type: research

Nitric oxide donors for cervical ripening and induction of labour.
CONCLUSIONS: Available data suggests that NO donors can be a useful tool in the process of induction of labour causing the cervix to be more favourable in comparison to placebo. However, additional data are needed to assess the true impact of NO donors on all important labour process and delivery outcomes. PMID: 27918616 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - December 5, 2016 Category: Journals (General) Authors: Ghosh A, Lattey KR, Kelly AJ Tags: Cochrane Database Syst Rev Source Type: research

The Validity of Left Ventricular Mass as a Surrogate End Point for All-Cause and Cardiovascular Mortality Outcomes in People With CKD: A Systematic Review and Meta-analysis
Conclusions There was no clear and consistent association between intervention-induced LVM change and mortality. Evidence for LVM as a valid surrogate end point in CKD is currently lacking. (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - September 23, 2016 Category: Urology & Nephrology Source Type: research

Fatal Intoxications Due to Administration of Isosorbide Tablets Contaminated with Pyrimethamine.
Abstract In January 2012, 664 cases of pyrimethamine toxicity and 151 deaths were reported among cardiac patients that had recently received free medicines from pharmacy of Punjab Institute of Cardiology, Lahore, Pakistan. These patients, ages ranged from 58 to 75 years, were prescribed simvastatin, clopidogrel, aspirin soluble, isosorbide mononitrate, and amlodipine. On examination of medications being given to them, it was found that a particular batch of isosorbide mononitrate tablets was contaminated with 50 mg pyrimethamine. Cardiac patients were taking isosorbide contaminated with pyrimethamine twice daily (...
Source: Journal of Forensic Sciences - June 21, 2016 Category: Forensic Medicine Authors: Imran M, Shafi H, Mahmood Z, Sarwar M, Usman HF, Tahir MA, Ashiq MZ Tags: J Forensic Sci Source Type: research

Dyspnea and Hemoptysis
An 83-year-old white woman presented with dyspnea on exertion, nonproductive cough, hemoptysis, and fatigue. Past medical history included diastolic heart failure, mitral regurgitation, coronary artery disease, paroxysmal atrial fibrillation, a pacemaker, hyperlipidemia, hypothyroidism, and hypertension. Medications included alprazolam, amiodarone 200 mg, amlodipine, aspirin, atenolol, furosemide, isosorbide mononitrate, levothyroxine, ramipril, pravastatin, and warfarin. Surgical history was unremarkable. (Source: The Journal for Nurse Practitioners)
Source: The Journal for Nurse Practitioners - April 30, 2016 Category: Nursing Authors: Stephanie Lickerman Tags: Image of the Month Source Type: research

Treating angina pectoris by acupuncture therapy.
Authors: Xu L, Xu H, Gao W, Wang W, Zhang H, Lu DP Abstract Acupuncture therapy on PC 6 (Neiguan) has a therapeutic effect on cardiac and chest ailments including angina pectoris. Additional beneficial acupuncture points are PC 4 (Ximen), HT 7 (Shenmen point), PC 7 (Daling point), PC 5 (Jianshi point), PC 3 (Quze point), CV 17 (Danzhong point), CV 6 (Qihai point), BL 15 (Xinshu point), L 20 (Pishu point), BL 17 (Geshu point), BL23 (Shenshu point), BL18 (Ganshu point), HT 5 (Tongli point), and ST36 (Zusanli point). Acupuncture not only quickly relieve the symptoms of acute angina pectoris, but also improve nitroglyc...
Source: Acupuncture and Electro-Therapeutics Research - November 30, 2015 Category: Complementary Medicine Tags: Acupunct Electrother Res Source Type: research

Cervical ripening before first trimester surgical evacuation for non-viable pregnancy.
CONCLUSIONS: This review found no evidence to evaluate cervical ripening prior to first trimester surgical evacuation for miscarriage for reducing the rate of cervical or uterine injury, however, this may be because these outcomes are very rare. Cervical preparation was shown to reduce the need for manual cervical dilatation compared with placebo.Misoprostol and isosorbide mononitrate and dinitrate were similarly effective in ripening the cervix, however there was more vomiting with misoprostol. Mechanical (Dilapan-S hygroscopic) dilators performed similarly to chemical dilators.The nine studies included in this review wer...
Source: Cochrane Database of Systematic Reviews - November 10, 2015 Category: Journals (General) Authors: Webber K, Grivell RM Tags: Cochrane Database Syst Rev Source Type: research

Isosorbide Mononitrate in Heart Failure with Preserved Ejection Fraction
New England Journal of Medicine, Ahead of Print. (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - November 9, 2015 Category: Internal Medicine Tags: article Source Type: research

Re: Comparison of the Efficacy of Isosorbide Mononitrate and Doxazosin in the Treatment of Lower Urinary Tract Symptoms and Benign Prostatic Hyperplasia: A Randomized Clinical Trial
F. Tarhan, O. Çelik, Ç. Tosun, G. Faydacı and B. Eryıldırım (Source: The Journal of Urology)
Source: The Journal of Urology - September 18, 2015 Category: Urology & Nephrology Authors: Steven A. Kaplan Tags: Urological Survey Source Type: research

Anti-hypoxia Activity of the Novel NO Donor Acetyl Ferulic Isosorbide Mononitrate in Acute High-Altitude Hypoxia Mice.
Abstract Nitric oxide (NO) may act as either a pro-oxidant or an antioxidant in biological systems. Previous work has found inhalation of NO improved survival in a high altitude rat model. NO donor isosorbide mononitrate derivants might have a protective effect against hypoxia. We synthesized a series of isosorbide mononitrate derivant compounds to test their anti-hypoxia activities. Normobaric hypoxia and hypobaric hypoxia models were used to study the protective role of NO donor in mice. The results showed isosorbide mononitrate derivants had protective effects in hypoxia mice. Among those compounds, acetyl feru...
Source: Biological and Pharmaceutical Bulletin - September 4, 2015 Category: Drugs & Pharmacology Authors: Fan PC, Ma HP, Jiang W, Li L, Ren J, Jing LL, Jia ZP Tags: Biol Pharm Bull Source Type: research

Relationship between Nitrate-Induced Headache and Coronary Artery Lesion Complexity
Objective: The aim of the present study was to investigate the association between nitrate-induced headache (NIH) and the complexity of coronary artery lesions in patients with stable coronary artery disease (CAD). Subjects and Methods: Two hundred and seventy-five patients with anginal chest pain who underwent coronary angiography were enrolled in the present study. NIH was defined as the presence of headache due to nitrate treatment (isosorbide mononitrate 40 mg) after excluding confounding factors. Coronary artery lesion complexity was assessed by the SYNTAX score (SXscore) using a dedicated computer software system. Re...
Source: Medical Principles and Practice - July 9, 2015 Category: Internal Medicine Source Type: research

An in vivo safety and efficacy demonstration of a topical liposomal nitric oxide donor treatment for Staphylococcus aureus biofilm-associated rhinosinusitis.
An in vivo safety and efficacy demonstration of a topical liposomal nitric oxide donor treatment for Staphylococcus aureus biofilm-associated rhinosinusitis. Transl Res. 2015 Jun 24; Authors: Jardeleza C, Thierry B, Rao S, Rajiv S, Drilling A, Miljkovic D, Paramasivan S, James C, Dong D, Thomas N, Vreugde S, Prestidge CA, Wormald PJ Abstract The burden of drug resistance emerges in the wake of chronic and repeated antibiotic use. This underpins the importance of discovering alternatives to current antibiotic regimens. In chronic rhinosinusitis (CRS), topical therapy such as nasal douches and ster...
Source: Translational Research : the journal of laboratory and clinical medicine - June 24, 2015 Category: Laboratory Medicine Authors: Jardeleza C, Thierry B, Rao S, Rajiv S, Drilling A, Miljkovic D, Paramasivan S, James C, Dong D, Thomas N, Vreugde S, Prestidge CA, Wormald PJ Tags: Transl Res Source Type: research

Synergistic apoptosis-inducing effect of aspirin and isosorbide mononitrate on human colon cancer cells.
In conclusion, the present study was the first, to the best of our knowledge, to report on the synergistic apoptosis-inducing effects of aspirin and ISMN in human colon cancer cells, which were mediated via Wnt and NO signaling pathways. The results of the present study will facilitate the development of future therapeutic strategies. PMID: 26094902 [PubMed - as supplied by publisher] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - June 23, 2015 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

The role of sustained release isosorbide mononitrate on corticosteroid-induced hypertension in healthy human subjects
J J Kelly (Source: Journal of Human Hypertension)
Source: Journal of Human Hypertension - March 26, 2015 Category: Cardiology Authors: P M WilliamsonS L H OngJ A WhitworthJ J Kelly Source Type: research

Comparing vaginal misoprostol versus Foley catheter plus vaginal isosorbide mononitrate for labor induction
The Journal of Maternal-Fetal & Neonatal Medicine, Ahead of Print. (Source: Journal of Maternal-Fetal and Neonatal Medicine)
Source: Journal of Maternal-Fetal and Neonatal Medicine - February 19, 2015 Category: Perinatology & Neonatology Tags: article Source Type: research

Outpatient cervical ripening by nitric oxide donors for prolonged pregnancy: a randomized controlled trial.
CONCLUSION: Outpatient cervical ripening with vaginal isosorbide mononitrate for prolonged pregnancy in nulliparous women does not reduce cesarean delivery rate. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, www.clinicaltrials.gov, NCT00930618. LEVEL OF EVIDENCE: : I. PMID: 25415159 [PubMed - in process] (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - November 27, 2014 Category: OBGYN Authors: Schmitz T, Fuchs F, Closset E, Rozenberg P, Winer N, Perrotin F, Verspyck E, Azria E, Carbonne B, Lepercq J, Maillard F, Goffinet F, Groupe de Recherche en Obstétrique et Gynécologie (GROG) Tags: Obstet Gynecol Source Type: research

Successful treatment using corticosteroids in a patient with refractory vasospastic angina and bronchial asthma
We report a 55-year-old female patient with refractory vasospastic angina and bronchial asthma treated successfully with corticosteroids. She was diagnosed with vasospastic angina by coronary angiography and the acetylcholine provocation test. Even after administration of oral vasodilators (benidipine, diltiazem, nicorandil, isosorbide mononitrate) she had recurrent chest pain with ST elevation. She had a history of bronchial asthma, so we added 30mg/day of oral prednisolone. Her symptoms disappeared completely upon treatment. This case report suggests that corticosteroids are a therapeutic choice for patients with refract...
Source: Journal of Cardiology Cases - November 3, 2014 Category: Cardiology Source Type: research

Drug efficacy in treating stable angina pectoris: a protocol for network meta-analysis of randomised controlled trials
This study aims to fill this gap of research by conducting a Bayesian network meta-analysis to compare all these antianginal drugs. Methods and analyses Randomised controlled trials (RCT) on the drug therapy of stable angina pectoris with multiple outcome measures, selected from symptomatic relief, ECG tests, exercise tests, heart rates and blood pressures, etc, will be included. Overall effect sizes will be represented as mean differences with 95% credible intervals (CrI) for continuous outcome data and as ORs with 95% CrI for dichotomous outcome data. Bayesian network meta-analysis by WinBUGS will be conducted to compar...
Source: BMJ Open - June 19, 2014 Category: Journals (General) Authors: Jia, Y., Leung, S.-w. Tags: Open access, Cardiovascular medicine, Evidence based practice Protocol Source Type: research

Analysis of the pretreatment effect of ethanol on the stratum corneum- and hair follicular-penetration of drugs using the hair follicle-plugging method.
Abstract The hair follicle-plugging method was used to analyze the effects of EtOH on skin permeation pathways. Methods: In vitro permeation experiments were performed on 4 model drugs [isosorbide mononitrate (ISMN), ionized lidocaine (ionized LC), fluorescein (FL), and fluorescein isothiocyanate (FITC)-dextran 4 kDa (FD-4)] using excised pig ear skin. The skin permeations of ionized LC, FL, and FD-4 were decreased by hair follicle-plugging. Hair follicle-plugging prevented the skin permeation of FL and FD-4 in EtOH-pretreated skin, but did not prevent that of ISMN. On the other hand, the effect of hair fol...
Source: Chemical and Pharmaceutical Bulletin - June 7, 2014 Category: Drugs & Pharmacology Authors: Horita D, Todo H, Sugibayashi K Tags: Chem Pharm Bull (Tokyo) Source Type: research

Drugs plus ligation to prevent rebleeding in cirrhosis: an updated systematic review
Abstract Background & AimsCombined therapy with endoscopic variceal ligation (EVL) and β‐blockers ± isosorbide mononitrate (ISMN) is currently recommended to prevent variceal rebleeding. However, the role of this combined therapy has been challenged by some studies. We performed a systematic review to assess the value of combined therapy with EVL and β‐blockers ± ISMN as compared with each treatment alone to prevent rebleeding. MethodsDatabases, references and meeting abstracts were searched to retrieve randomized trials comparing combined therapy with EVL and β‐bl...
Source: Liver International - January 24, 2014 Category: Gastroenterology Authors: Angela Puente, Virginia Hernández‐Gea, Isabel Graupera, Marta Roque, Alan Colomo, Maria Poca, Carles Aracil, Ignasi Gich, Carlos Guarner, Càndid Villanueva Tags: Review Article Source Type: research

Combined treatment with variceal ligation and β‐blockers ± nitrates to prevent recurrent variceal bleeding in cirrhosis. An updated systematic review
Abstract Background&AimsCombined therapy with endoscopic variceal ligation (EVL) and ß‐blockers±isosorbide mononitrate (ISMN) is currently recommended to prevent variceal rebleeding. However, the role of this combined therapy has been challenged by some studies. We performed a systematic review to assess the value of combined therapy with EVL and ß‐blockers±ISMN as compared with each treatment alone to prevent rebleeding. MethodsDatabases, references and meeting abstracts were searched to retrieve randomized trials comparing combined therapy with EVL and ß‐blockers±ISMN vs e...
Source: Liver International - December 24, 2013 Category: Gastroenterology Authors: Angela Puente, Virginia Hernández‐Gea, Isabel Graupera, Marta Roque, Alan Colomo, Maria Poca, Carles Aracil, Ignasi Gich, Carlos Guarner, Càndid Villanueva Tags: Reviews Source Type: research

Effect of oral nitrates on pulse pressure and arterial elasticity in patients aged over 65 years with refractory isolated systolic hypertension: study protocol for a randomized controlled trial
Background: Isolated systolic hypertension is a highly prevalent disease among the elderly. The little available evidence on the efficacy of nitrates for treating the disease is based on small experimental studies. Methods: We performed a multicenter, randomized, double-blind, phase III, placebo-controlled trial in 154 patients aged over 65 years with refractory isolated systolic hypertension. Patients were randomized to placebo or 40 mg/day of extended-release isosorbide mononitrate added to standard therapy and titrated to 60 mg/day at week 6 if blood pressure exceeded 140/90 mmHg.The primary objective was to assess the ...
Source: Trials - November 14, 2013 Category: Journals (General) Authors: Daniel Abad-PérezBlanca Novella-ArribasFrancisco Rodríguez-SalvanésLuis Sánchez-GómezIluminada García-PoloCarmen Verge-GonzálezCarmen Suárez-Fernández Source Type: research

Long-term isosorbide mononitrate treatment impairs endothelial function in patients with coronary artery disease
ConclusionLong-term ISMN treatment may impair endothelial function in patients with CAD. (Source: Coronary Artery Disease)
Source: Coronary Artery Disease - September 30, 2013 Category: Cardiology Tags: Original Research Source Type: research