The protective role of raltegravir in experimental acute lung injury in vitro and in vivo
This study investigated the potential ability of the human immunodeficiency virus-1 (HIV-1) integrase inhibitor raltegravir to protect against acute lung injury (ALI) and the underlying mechanisms. Accordingly, the impact of raltegravir treatment on an in vitro lipopolysaccharide (LPS)-stimulated human pulmonary microvascular endothelial cell (HPMEC) model of ALI and an in vivo LPS-induced two-hit ALI rat model was examined. In the rat model system, raltegravir treatment alleviated ALI-associated histopathological changes, reduced microvascular permeability, decreased Evans blue dye extravasation, suppressed the expression...
Source: Braz J Med Biol Res - November 9, 2022 Category: Research Authors: Zehui Xu Rui Ren Wanglin Jiang Source Type: research
The protective role of raltegravir in experimental acute lung injury in vitro and in vivo
This study investigated the potential ability of the human immunodeficiency virus-1 (HIV-1) integrase inhibitor raltegravir to protect against acute lung injury (ALI) and the underlying mechanisms. Accordingly, the impact of raltegravir treatment on an in vitro lipopolysaccharide (LPS)-stimulated human pulmonary microvascular endothelial cell (HPMEC) model of ALI and an in vivo LPS-induced two-hit ALI rat model was examined. In the rat model system, raltegravir treatment alleviated ALI-associated histopathological changes, reduced microvascular permeability, decreased Evans blue dye extravasation, suppressed the expression...
Source: Brazilian Journal of Medical and Biological Research - November 9, 2022 Category: Research Authors: Zehui Xu Rui Ren Wanglin Jiang Source Type: research
The protective role of raltegravir in experimental acute lung injury in vitro and in vivo
This study investigated the potential ability of the human immunodeficiency virus-1 (HIV-1) integrase inhibitor raltegravir to protect against acute lung injury (ALI) and the underlying mechanisms. Accordingly, the impact of raltegravir treatment on an in vitro lipopolysaccharide (LPS)-stimulated human pulmonary microvascular endothelial cell (HPMEC) model of ALI and an in vivo LPS-induced two-hit ALI rat model was examined. In the rat model system, raltegravir treatment alleviated ALI-associated histopathological changes, reduced microvascular permeability, decreased Evans blue dye extravasation, suppressed the expression...
Source: Braz J Med Biol Res - November 9, 2022 Category: Research Authors: Zehui Xu Rui Ren Wanglin Jiang Source Type: research
The protective role of raltegravir in experimental acute lung injury in vitro and in vivo
This study investigated the potential ability of the human immunodeficiency virus-1 (HIV-1) integrase inhibitor raltegravir to protect against acute lung injury (ALI) and the underlying mechanisms. Accordingly, the impact of raltegravir treatment on an in vitro lipopolysaccharide (LPS)-stimulated human pulmonary microvascular endothelial cell (HPMEC) model of ALI and an in vivo LPS-induced two-hit ALI rat model was examined. In the rat model system, raltegravir treatment alleviated ALI-associated histopathological changes, reduced microvascular permeability, decreased Evans blue dye extravasation, suppressed the expression...
Source: Brazilian Journal of Medical and Biological Research - November 9, 2022 Category: Research Authors: Zehui Xu Rui Ren Wanglin Jiang Source Type: research
The protective role of raltegravir in experimental acute lung injury in vitro and in vivo
This study investigated the potential ability of the human immunodeficiency virus-1 (HIV-1) integrase inhibitor raltegravir to protect against acute lung injury (ALI) and the underlying mechanisms. Accordingly, the impact of raltegravir treatment on an in vitro lipopolysaccharide (LPS)-stimulated human pulmonary microvascular endothelial cell (HPMEC) model of ALI and an in vivo LPS-induced two-hit ALI rat model was examined. In the rat model system, raltegravir treatment alleviated ALI-associated histopathological changes, reduced microvascular permeability, decreased Evans blue dye extravasation, suppressed the expression...
Source: Braz J Med Biol Res - November 9, 2022 Category: Research Authors: Zehui Xu Rui Ren Wanglin Jiang Source Type: research
Effects of Initiating Raltegravir-Based Versus Efavirenz-Based Antiretroviral Regimens During Pregnancy on Weight Changes and Perinatal Outcomes: NICHD P1081
Conclusions:
A raltegravir-based antiretroviral regimen was associated with significantly higher antepartum rate of weight gain and BMI increase compared with efavirenz-based treatment in antiretroviral-naive pregnant women. (Source: JAIDS Journal of Acquired Immune Deficiency Syndromes)
Source: JAIDS Journal of Acquired Immune Deficiency Syndromes - October 31, 2022 Category: Infectious Diseases Tags: Clinical Science Source Type: research
Assessing the contribution of UGT isoforms on raltegravir drug disposition through PBPK modeling
Eur J Pharm Sci. 2022 Oct 17:106309. doi: 10.1016/j.ejps.2022.106309. Online ahead of print.ABSTRACTThis work aimed to develop a physiologically based pharmacokinetic (PBPK) model for raltegravir accounting for UDP-glucuronosyltransferase (UGT) metabolism to assess the effect of UGT gene polymorphisms. Raltegravir elimination was evaluated using Km and Vmax values from human recombinant systems and UGT tissue scalar considering liver, kidney, and intestine. The predicted/observed ratios for raltegravir PK parameters were within a 2-fold error range in UGT1A1 poor and normal metabolizers, except in Asian UGT1A1 poor metabol...
Source: European Journal of Pharmaceutical Sciences - October 20, 2022 Category: Drugs & Pharmacology Authors: Fernanda-de-Lima Moreira Maria-Martha-de-Barros Tarozzo Glauco-Henrique-Balthazar Nardotto Jos é-Carlos-Saraiva Gonçalves Stephan Schmidt Nat ália-Valadares de-Moraes Source Type: research
Assessing the contribution of UGT isoforms on raltegravir drug disposition through PBPK modeling
Eur J Pharm Sci. 2022 Oct 17:106309. doi: 10.1016/j.ejps.2022.106309. Online ahead of print.ABSTRACTThis work aimed to develop a physiologically based pharmacokinetic (PBPK) model for raltegravir accounting for UDP-glucuronosyltransferase (UGT) metabolism to assess the effect of UGT gene polymorphisms. Raltegravir elimination was evaluated using Km and Vmax values from human recombinant systems and UGT tissue scalar considering liver, kidney, and intestine. The predicted/observed ratios for raltegravir PK parameters were within a 2-fold error range in UGT1A1 poor and normal metabolizers, except in Asian UGT1A1 poor metabol...
Source: European Journal of Pharmaceutical Sciences - October 20, 2022 Category: Drugs & Pharmacology Authors: Fernanda-de-Lima Moreira Maria-Martha-de-Barros Tarozzo Glauco-Henrique-Balthazar Nardotto Jos é-Carlos-Saraiva Gonçalves Stephan Schmidt Nat ália-Valadares de-Moraes Source Type: research
Influence of UGT1A1 and SLC22A6 polymorphisms on the population pharmacokinetics and pharmacodynamics of raltegravir in HIV-infected adults: a NEAT001/ANRS143 sub-study
The Pharmacogenomics Journal, Published online: 20 October 2022; doi:10.1038/s41397-022-00293-5Influence of UGT1A1 and SLC22A6 polymorphisms on the population pharmacokinetics and pharmacodynamics of raltegravir in HIV-infected adults: a NEAT001/ANRS143 sub-study (Source: The Pharmacogenomics Journal)
Source: The Pharmacogenomics Journal - October 20, 2022 Category: Drugs & Pharmacology Authors: Rohan Gurjar Laura Dickinson Daniel Carr Wolfgang St öhr Stefano Bonora Andrew Owen Antonio D ’Avolio Adam Cursley Nathalie De Castro Gerd F ätkenheuer Linos Vandekerckhove Giovanni Di Perri Anton Pozniak Christine Schwimmer Fran çois Raffi Marta Bof Source Type: research
Assessment of minority frequency pretreatment HIV drug-resistant variants in pregnant women and associations with virologic non-suppression at term
by Ceejay L. Boyce, Ingrid A. Beck, Sheila M. Styrchak, Samantha R. Hardy, Jackson J. Wallner, Ross S. Milne, R. Leavitt Morrison, David E. Shapiro, Esa ú C. João, Mark H. Mirochnick, Lisa M. Frenkel
ObjectiveTo assess in ART-na ïve pregnant women randomized to efavirenz- versus raltegravir-based ART (IMPAACT P1081) whether pretreatment drug resistance (PDR) with minority frequency variants (200 copies/mL) at delivery to randomly selected ART-suppressed controls. MethodsHIVpol genotypes were derived from pretreatment plasma specimens by Illumina sequencing. Resistance mutations were assessed using the HIV Stanford Datab...
Source: PLoS One - September 27, 2022 Category: Biomedical Science Authors: Ceejay L. Boyce Source Type: research
Safety and efficacy of pharmacotherapy containing INSTIs and chemotherapy drugs in people living with HIV and concomitant colorectal cancer
CONCLUSIONS: DTG- or BIC-containing regimens are good options for patients with HIV and concomitant CRC.PMID:36151562 | DOI:10.1186/s12981-022-00470-3 (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - September 23, 2022 Category: Infectious Diseases Authors: Jing Yang Guo Wei Fuqiang Gui Yong Zhao Tingyu Chen Juan Tan Source Type: research
Safety and efficacy of pharmacotherapy containing INSTIs and chemotherapy drugs in people living with HIV and concomitant colorectal cancer
CONCLUSIONS: DTG- or BIC-containing regimens are good options for patients with HIV and concomitant CRC.PMID:36151562 | DOI:10.1186/s12981-022-00470-3 (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - September 23, 2022 Category: Infectious Diseases Authors: Jing Yang Guo Wei Fuqiang Gui Yong Zhao Tingyu Chen Juan Tan Source Type: research
Safety and efficacy of pharmacotherapy containing INSTIs and chemotherapy drugs in people living with HIV and concomitant colorectal cancer
CONCLUSIONS: DTG- or BIC-containing regimens are good options for patients with HIV and concomitant CRC.PMID:36151562 | PMC:PMC9508721 | DOI:10.1186/s12981-022-00470-3 (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - September 23, 2022 Category: Infectious Diseases Authors: Jing Yang Guo Wei Fuqiang Gui Yong Zhao Tingyu Chen Juan Tan Source Type: research
Safety and efficacy of pharmacotherapy containing INSTIs and chemotherapy drugs in people living with HIV and concomitant colorectal cancer
CONCLUSIONS: DTG- or BIC-containing regimens are good options for patients with HIV and concomitant CRC.PMID:36151562 | PMC:PMC9508721 | DOI:10.1186/s12981-022-00470-3 (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - September 23, 2022 Category: Infectious Diseases Authors: Jing Yang Guo Wei Fuqiang Gui Yong Zhao Tingyu Chen Juan Tan Source Type: research
Safety and efficacy of pharmacotherapy containing INSTIs and chemotherapy drugs in people living with HIV and concomitant colorectal cancer
CONCLUSIONS: DTG- or BIC-containing regimens are good options for patients with HIV and concomitant CRC.PMID:36151562 | PMC:PMC9508721 | DOI:10.1186/s12981-022-00470-3 (Source: AIDS Research and Therapy)
Source: AIDS Research and Therapy - September 23, 2022 Category: Infectious Diseases Authors: Jing Yang Guo Wei Fuqiang Gui Yong Zhao Tingyu Chen Juan Tan Source Type: research
