Applied Physiologically Based Pharmacokinetic Modeling to assess UGT ‐mediated Drug–Drug Interactions for Vericiguat
This study is a first cornerstone to qualify the PK-Sim® pla tform for use of UGT-mediated DDI predictions including PBPK models of perpetrators such as mefenamic acid and atazanavir, and sensitive UGT substrates such as dapagliflozin and raltegravir. (Source: CPT: Pharmacometrics and Systems Pharmacology)
Source: CPT: Pharmacometrics and Systems Pharmacology - October 5, 2023 Category: Drugs & Pharmacology Authors: Sebastian Frechen,
Ibrahim Ince,
Andr é Dallmann,
Michael Gerisch,
Natalia A. Jungmann,
Corina Becker,
Maximilian Lobmeyer,
Maria E. Trujillo,
Shiyao Xu,
Rolf Burghaus,
Michaela Meyer Tags: ARTICLE Source Type: research
Antiretroviral therapy among people with HIV with comorbidities in the United States: a retrospective cohort study
CONCLUSION: From our analyses, ART prescribing did not appear to vary with the presence of comorbidities and potential medication contraindications. ART regimens may have comparable efficacy profiles; however, selection should be guided by each patient's comorbidities to prevent potential comedication drug toxicities.PMID:37766585 | DOI:10.1080/03007995.2023.2262379 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 28, 2023 Category: Research Authors: Erin K Buysman Princy Kumar Kimberly McNiff Swarnali Goswami Misti Paudel Girish Prajapati Bekana K Tadese Source Type: research
Effect of Integrase Strand Transfer Inhibitor Use on Time to HIV Viral Suppression before Delivery
CONCLUSIONS: Despite recommendations to prescribe INSTI in pregnancy for rapid viral suppression, we did not find a significant difference in time to viral suppression when pregnant individuals were taking non-INSTI ARVs. We did not find that one INSTI ARV was superior for viral suppression.PMID:37657778 | DOI:10.14423/SMJ.0000000000001602 (Source: Southern Medical Journal)
Source: Southern Medical Journal - September 1, 2023 Category: General Medicine Authors: Oriel A Nissim Marjorie C Spitznagel Stephanie E Kirk Jessica L Tarleton Gweneth B Lazenby Source Type: research
