Applied Physiologically Based Pharmacokinetic Modeling to assess UGT ‐mediated Drug–Drug Interactions for Vericiguat

This study is a first cornerstone to qualify the PK-Sim® pla tform for use of UGT-mediated DDI predictions including PBPK models of perpetrators such as mefenamic acid and atazanavir, and sensitive UGT substrates such as dapagliflozin and raltegravir.

Source: CPT: Pharmacometrics and Systems Pharmacology - October 5, 2023 Category: Drugs & Pharmacology Authors: Sebastian Frechen, Ibrahim Ince, Andr é Dallmann, Michael Gerisch, Natalia A. Jungmann, Corina Becker, Maximilian Lobmeyer, Maria E. Trujillo, Shiyao Xu, Rolf Burghaus, Michaela Meyer Tags: ARTICLE Source Type: research