EE183 Cost-Effectiveness of Raltegravir Oral Granules Prophylaxis in Neonates to Prevent HIV Mother-to-Child Transmission in Brazil
This study aimed to evaluate the cost-effectiveness of raltegravir oral granules prophylaxis compared to nevirapine to prevent HIV MTCT in Brazil in high-risk neonates with gestational age ≥ 37 weeks. (Source: Value in Health)
Source: Value in Health - December 1, 2023 Category: International Medicine & Public Health Authors: R. Castro, C. Casas, R. Santos-de-Souza, R.D.C. de Albuquerque Source Type: research
Efficacy and safety of raltegravir plus lamivudine maintenance therapy
ConclusionsSwitching to raltegravir and lamivudine in PWH with virological suppression maintains efficacy and is well tolerated. This maintenance regimen might be a cost-effective option for PWH at risk of drug –drug interactions or needing to avoid specific toxicities of certain antiretroviral drugs or their negative impact on comorbidities. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - December 1, 2023 Category: Microbiology Source Type: research
Applied physiologically ‐based pharmacokinetic modeling to assess uridine diphosphate‐glucuronosyltransferase‐mediated drug–drug interactions for Vericiguat
This study is a first cornerstone to qualify the PK- Sim platform for use of UGT-mediated DDI predictions, including PBPK models of perpetrators, such as mefenamic acid and atazanavir, and sensitive UGT substrates, such as dapagliflozin and raltegravir. (Source: CPT: Pharmacometrics and Systems Pharmacology)
Source: CPT: Pharmacometrics and Systems Pharmacology - October 12, 2023 Category: Drugs & Pharmacology Authors: Sebastian Frechen,
Ibrahim Ince,
Andr é Dallmann,
Michael Gerisch,
Natalia A. Jungmann,
Corina Becker,
Maximilian Lobmeyer,
Maria E. Trujillo,
Shiyao Xu,
Rolf Burghaus,
Michaela Meyer Tags: ARTICLE Source Type: research
