Brief Report: Efficacy and Safety of Efavirenz, Raltegravir, and Dolutegravir in HIV-1/TB Coinfection. A Multicenter Retrospective Cohort Study in France
Conclusions:
In this retrospective cohort study, raltegravir and dolutegravir yielded similar efficacy and safety results to efavirenz for the treatment of HIV-1/TB coinfected patients. (Source: JAIDS Journal of Acquired Immune Deficiency Syndromes)
Source: JAIDS Journal of Acquired Immune Deficiency Syndromes - August 24, 2022 Category: Infectious Diseases Tags: Clinical Science Source Type: research
Viruses, Vol. 14, Pages 1677: Changes in Body Mass Index after Initiation of Antiretroviral Treatment: Differences by Class of Core Drug
bunakis
Charalambos Gogos
Giota Touloumi
Recent research on antiretroviral treatment (ART) for HIV suggests that integrase strand transfer inhibitors (INSTIs) cause faster weight gain compared to other drug classes. Here, we investigated changes in body mass index (BMI) and obesity prevalence after treatment initiation and corresponding differences between drug classes. Data were derived from a large collaborative cohort in Greece. Included individuals were adults who started ART, in or after 2010, while previously ART naïve and achieved virologic response within the first year of ART. Data were analys...
Source: Viruses - July 29, 2022 Category: Virology Authors: Nikos Pantazis Vasilios Papastamopoulos Anastasia Antoniadou Georgios Adamis Vasilios Paparizos Simeon Metallidis Helen Sambatakou Mina Psichogiou Maria Chini Georgios Chrysos Periklis Panagopoulos Nikolaos V. Sipsas Emmanouil Barbunakis Charalambos Gogos Tags: Article Source Type: research
Brief Report: Blood and Genital Fluid Viral Load Trajectories Among Treated and Untreated Persons With Acute HIV Infection in Malawi
Background:
Persons with acute HIV infection (AHI) are highly infectious and responsible for a disproportionate share of incident infections. Immediate antiretroviral therapy (ART) rapidly reduces blood viral loads (VLs), but genital VLs after ART initiation during AHI are less well described.
Setting:
Lilongwe, Malawi, 2012–2014.
Methods:
HIV-seronegative and HIV-serodiscordant persons aged ≥18 years were screened for AHI (RNA positive) and randomized to standard of care, behavioral intervention, or behavioral intervention plus short-term ART (raltegravir/emtricitabine/tenofovir) (1:2:2). Persons who...
Source: JAIDS Journal of Acquired Immune Deficiency Syndromes - April 11, 2022 Category: Infectious Diseases Tags: Clinical Science Source Type: research
Molecules, Vol. 27, Pages 2287: Ligand and Structure-Based In Silico Determination of the Most Promising SARS-CoV-2 nsp16-nsp10 2 & prime;-o-Methyltransferase Complex Inhibitors among 3009 FDA Approved Drugs
Molecules, Vol. 27, Pages 2287: Ligand and Structure-Based In Silico Determination of the Most Promising SARS-CoV-2 nsp16-nsp10 2′-o-Methyltransferase Complex Inhibitors among 3009 FDA Approved Drugs
Molecules doi: 10.3390/molecules27072287
Authors:
Ibrahim H. Eissa
Mohamed S. Alesawy
Abdulrahman M. Saleh
Eslam B. Elkaeed
Bshra A. A. Alsfouk
Abdul-Aziz M. M. El-Attar
Ahmed M. Metwaly
As a continuation of our earlier work against SARS-CoV-2, seven FDA-approved drugs were designated as the best SARS-CoV-2 nsp16-nsp10 2′-o-methyltransferase (2′OMTase) inhibitors throug...
Source: Molecules - March 31, 2022 Category: Chemistry Authors: Ibrahim H. Eissa Mohamed S. Alesawy Abdulrahman M. Saleh Eslam B. Elkaeed Bshra A. A. Alsfouk Abdul-Aziz M. M. El-Attar Ahmed M. Metwaly Tags: Article Source Type: research
Real-World Characterization of the Portuguese Population Living with HIV who Initiated Raltegravir Based-Regimens: The REALITY Study
CONCLUSION: Raltegravir-based regimens seem like a valid therapeutic option in heterogeneous populations of HIV-infected patients, in patients with previous ART experience and as part of first-line therapeutic options alongside with the latest generation of drugs from its class.PMID:35333155 | DOI:10.20344/amp.16785 (Source: Acta Medica Portuguesa)
Source: Acta Medica Portuguesa - March 25, 2022 Category: General Medicine Authors: Ros ário Serrão Kamal Mansinho Fernando Maltez Nuno Marques Alexandre Carvalho Ros ário Pazos Alexandra Zagalo Josefina Mendez Isabel Neves Joaquim Oliveira Patr ícia Pacheco Ricardo Correia de Abreu Ana Cl áudia Miranda Paula Camacho Laura Paix ão Source Type: research
Integrase Strand Transfer Inhibitor (INSTI) Genotypic Resistance Analysis in Treatment-nNaive, INSTI Free Antiretroviral-Experienced and INSTI-Experienced Turkish Patients Infected with HIV-1
CONCLUSION: Our findings provide data for treatment and resistance management of INSTIs and may provide feedback for INSTIs resistance surveillance consensus-building efforts. In viral rebound under INSTI treatment, INSTI-resistant mutations follow typical INSTI resistance pathways and high resistance rates. INSTI resistance genotypic analysis should be considered before any DTG-based regimes can be initiated in the future, and reduced DTG susceptibility should be carefully monitored and investigated.PMID:35240975 | DOI:10.2174/1570162X20666220303104509 (Source: Current HIV Research)
Source: Current HIV Research - March 4, 2022 Category: Infectious Diseases Authors: Murat Sayan Figen Sarigul Yildirim Sila Akhan Ilkay Karaoglan Halis Akalin Source Type: research
Integrase Strand Transfer Inhibitor (INSTI) Genotypic Resistance Analysis in Treatment-nNaive, INSTI Free Antiretroviral-Experienced and INSTI-Experienced Turkish Patients Infected with HIV-1
CONCLUSION: Our findings provide data for treatment and resistance management of INSTIs and may provide feedback for INSTIs resistance surveillance consensus-building efforts. In viral rebound under INSTI treatment, INSTI-resistant mutations follow typical INSTI resistance pathways and high resistance rates. INSTI resistance genotypic analysis should be considered before any DTG-based regimes can be initiated in the future, and reduced DTG susceptibility should be carefully monitored and investigated.PMID:35240975 | DOI:10.2174/1570162X20666220303104509 (Source: Current HIV Research)
Source: Current HIV Research - March 4, 2022 Category: Infectious Diseases Authors: Murat Sayan Figen Sarigul Yildirim Sila Akhan Ilkay Karaoglan Halis Akalin Source Type: research
Integrase Strand Transfer Inhibitor (INSTI) Genotypic Resistance Analysis in Treatment-nNaive, INSTI Free Antiretroviral-Experienced and INSTI-Experienced Turkish Patients Infected with HIV-1
CONCLUSION: Our findings provide data for treatment and resistance management of INSTIs and may provide feedback for INSTIs resistance surveillance consensus-building efforts. In viral rebound under INSTI treatment, INSTI-resistant mutations follow typical INSTI resistance pathways and high resistance rates. INSTI resistance genotypic analysis should be considered before any DTG-based regimes can be initiated in the future, and reduced DTG susceptibility should be carefully monitored and investigated.PMID:35240975 | DOI:10.2174/1570162X20666220303104509 (Source: Current HIV Research)
Source: Current HIV Research - March 4, 2022 Category: Infectious Diseases Authors: Murat Sayan Figen Sarigul Yildirim Sila Akhan Ilkay Karaoglan Halis Akalin Source Type: research
Integrase Strand Transfer Inhibitor (INSTI) Genotypic Resistance Analysis in Treatment-nNaive, INSTI Free Antiretroviral-Experienced and INSTI-Experienced Turkish Patients Infected with HIV-1
CONCLUSION: Our findings provide data for treatment and resistance management of INSTIs and may provide feedback for INSTIs resistance surveillance consensus-building efforts. In viral rebound under INSTI treatment, INSTI-resistant mutations follow typical INSTI resistance pathways and high resistance rates. INSTI resistance genotypic analysis should be considered before any DTG-based regimes can be initiated in the future, and reduced DTG susceptibility should be carefully monitored and investigated.PMID:35240975 | DOI:10.2174/1570162X20666220303104509 (Source: Current HIV Research)
Source: Current HIV Research - March 4, 2022 Category: Infectious Diseases Authors: Murat Sayan Figen Sarigul Yildirim Sila Akhan Ilkay Karaoglan Halis Akalin Source Type: research
