Convenience, efficacy, safety, and durability of INSTI-based antiretroviral therapies: evidence from the Italian MaSTER cohort
CONCLUSION: One-third of the population experienced an interruption of any drugs included in INSTI therapy in this study. The most frequent reason for interruption was safety concerns which accounted for one-fifth of interruptions among the full study population, mainly switched to DTG. The hazard for interruption was higher for low baseline CD4 + T-cell counts, higher baseline HIV-RNA, non-Italian nationality, older age, PWID and possible co-infections with hepatitis viruses. The risk ratio was higher for past history of cART use compared to persons who were cART naive, use of regimens containing 3 drugs compared to regim...
Source: Cell Research - August 18, 2023 Category: Cytology Authors: Shannan N Rich Paola Nasta Eugenia Quiros-Roldan Paolo Fusco Alice Tondinelli Cecilia Costa Chiara Fornabaio Nicola Mazzini Mattia Prosperi Carlo Torti Giampiero Carosi MaSTER cohort group Source Type: research
