A validated method for simultaneous quantification of four antiretrovirals in dried blood spot and plasma using LC-MS/MS: Application to efavirenz therapeutic drug monitoring in pregnant patients
CONCLUSIONS: The method was successfully applied to quantify efavirenz in DBS samples obtained from HIV-1 infected pregnant volunteers under antiretroviral therapy. The concentrations of efavirenz in DBS and plasma were comparable according to Passing-Bablok regression and Bland-Altman analysis.PMID:38649089 | DOI:10.1016/j.clinbiochem.2024.110765 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - April 22, 2024 Category: Biochemistry Authors: Maira Ludna Duarte Aurylanne Mikaelle Brand ão Silva Jos é Wellithom Viturino da Silva Davi Pereira Santana Whocely Victor de Castro Luiz Cl áudio Arraes de Alencar Danilo C ésar Galindo Bedor Leila Bastos Leal Source Type: research
A validated method for simultaneous quantification of four antiretrovirals in dried blood spot and plasma using LC-MS/MS: Application to efavirenz therapeutic drug monitoring in pregnant patients
CONCLUSIONS: The method was successfully applied to quantify efavirenz in DBS samples obtained from HIV-1 infected pregnant volunteers under antiretroviral therapy. The concentrations of efavirenz in DBS and plasma were comparable according to Passing-Bablok regression and Bland-Altman analysis.PMID:38649089 | DOI:10.1016/j.clinbiochem.2024.110765 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - April 22, 2024 Category: Biochemistry Authors: Maira Ludna Duarte Aurylanne Mikaelle Brand ão Silva Jos é Wellithom Viturino da Silva Davi Pereira Santana Whocely Victor de Castro Luiz Cl áudio Arraes de Alencar Danilo C ésar Galindo Bedor Leila Bastos Leal Source Type: research
A validated method for simultaneous quantification of four antiretrovirals in dried blood spot and plasma using LC-MS/MS: Application to efavirenz therapeutic drug monitoring in pregnant patients
CONCLUSIONS: The method was successfully applied to quantify efavirenz in DBS samples obtained from HIV-1 infected pregnant volunteers under antiretroviral therapy. The concentrations of efavirenz in DBS and plasma were comparable according to Passing-Bablok regression and Bland-Altman analysis.PMID:38649089 | DOI:10.1016/j.clinbiochem.2024.110765 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - April 22, 2024 Category: Biochemistry Authors: Maira Ludna Duarte Aurylanne Mikaelle Brand ão Silva Jos é Wellithom Viturino da Silva Davi Pereira Santana Whocely Victor de Castro Luiz Cl áudio Arraes de Alencar Danilo C ésar Galindo Bedor Leila Bastos Leal Source Type: research
A validated method for simultaneous quantification of four antiretrovirals in dried blood spot and plasma using LC-MS/MS: Application to efavirenz therapeutic drug monitoring in pregnant patients
CONCLUSIONS: The method was successfully applied to quantify efavirenz in DBS samples obtained from HIV-1 infected pregnant volunteers under antiretroviral therapy. The concentrations of efavirenz in DBS and plasma were comparable according to Passing-Bablok regression and Bland-Altman analysis.PMID:38649089 | DOI:10.1016/j.clinbiochem.2024.110765 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - April 22, 2024 Category: Biochemistry Authors: Maira Ludna Duarte Aurylanne Mikaelle Brand ão Silva Jos é Wellithom Viturino da Silva Davi Pereira Santana Whocely Victor de Castro Luiz Cl áudio Arraes de Alencar Danilo C ésar Galindo Bedor Leila Bastos Leal Source Type: research
Structural Analysis of Anti-Retroviral Drug Raltegravir and its Potential Impurity C: Investigation of Solubility and Stability
CrystEngComm, 2024, Accepted Manuscript DOI: 10.1039/D3CE01071F, PaperPalash Sanphui, TKS Fayaz, Hemanth Kumar Chanduluru, Puja Lal, Animesh Ghosh, Vladimir V. Chernyshev Raltegravir (hereafter RLT) is a human immunodeficiency virus integrase strand transfer inhibitor that is prescribed for the treatment of HIV-1 infection. The drug belongs to biopharmaceutics classification system (BCS) class... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - CrystEngComm latest articles)
Source: RSC - CrystEngComm latest articles - December 13, 2023 Category: Chemistry Authors: Palash Sanphui Source Type: research
Incidence of Hyperlipidemia among Adults Initiating Antiretroviral Therapy in the HIV Outpatient Study (HOPS), USA, 2007-2021
AIDS Res Treat. 2023 Nov 30;2023:4423132. doi: 10.1155/2023/4423132. eCollection 2023.ABSTRACTCurrent U.S. guidelines recommend integrase strand transfer inhibitor (INSTI)-based antiretroviral therapy (ART) as initial treatment for people with HIV (PWH). We assessed long-term effects of INSTI use on lipid profiles in routine HIV care. We analyzed medical record data from the HIV Outpatient Study's participants in care from 2007 to 2021. Hyperlipidemia was defined based on clinical diagnoses, treatments, and laboratory results. We calculated hyperlipidemia incidence rates and rate ratios (RRs) during initial ART and assesse...
Source: AIDS Research and Treatment - December 11, 2023 Category: Infectious Diseases Authors: Jun Li Selom Agbobli-Nuwoaty Frank J Palella Richard M Novak Ellen Tedaldi Cynthia Mayer Jonathan D Mahnken Qingjiang Hou Kimberly Carlson Angela M Thompson-Paul Marcus D Durham Kate Buchacz Source Type: research
