A validated method for simultaneous quantification of four antiretrovirals in dried blood spot and plasma using LC-MS/MS: Application to efavirenz therapeutic drug monitoring in pregnant patients

CONCLUSIONS: The method was successfully applied to quantify efavirenz in DBS samples obtained from HIV-1 infected pregnant volunteers under antiretroviral therapy. The concentrations of efavirenz in DBS and plasma were comparable according to Passing-Bablok regression and Bland-Altman analysis.PMID:38649089 | DOI:10.1016/j.clinbiochem.2024.110765

https://pubmed.ncbi.nlm.nih.gov/38649089/?utm_source=no_user_agent&utm_medium=rs...

Source: Clinical Biochemistry - April 22, 2024 Category: Biochemistry Authors: Maira Ludna Duarte Aurylanne Mikaelle Brand ão Silva Jos é Wellithom Viturino da Silva Davi Pereira Santana Whocely Victor de Castro Luiz Cl áudio Arraes de Alencar Danilo C ésar Galindo Bedor Leila Bastos Leal Source Type: research