The antibiogram of pus cultures in federal tertiary care hospital, Islamabad and its utility in antimicrobial stewardship
CONCLUSION: The generation of a local antibiogram specific to the hospital setting is essential to effectively manage infections empirically and preserve the efficacy of existing antibiotics. By implementing antimicrobial stewardship practices based on a better understanding of antibiotic susceptibility patterns, we can contribute to the mitigation of antibiotic resistance and improve patient outcomes.PMID:38682051 | PMC:PMC11055436 | DOI:10.18502/ijm.v16i1.14871 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - April 29, 2024 Category: Microbiology Authors: Farhan Kursheed Asraar Tabassum Umme Farwa Samia Wazir Muhammad Shafiq Ahmareen Khalid Sheikh Source Type: research
The relationship between the World Index for Sustainability and Health (WISH) score and mental health in women: A cross-sectional study
The objective of this cross-sectional study was to explore the relationship between a newly developed dietary index for health and sustainability, and psychological disorders among Iranian women. Participants in this cross-sectional study included 479 women living in Tehran with no history of chronic disease. A validated 168-item food frequency questionnaire was used to assess dietary intake. The World Index for Sustainability and Health (WISH) was calculated, consisting of four sub-scores: less healthy, healthy, low environmental impact, and high environmental impact. Participants psychological status was assessed using t...
Source: The British Journal of Nutrition - April 29, 2024 Category: Nutrition Authors: Alireza Jafari Keyhan Lotfi Hadis Mozaffari Behzad Zamani Manije Darooghegi Mofrad Ali Sheikhi Pamela J Surkan Leila Azadbakht Source Type: research
In vitro evaluation of inhibitory effect of Lactobacillus reuteri supernatant on the replication of herpes simplex virus type 1 and expression of UL54, UL52 and UL27 genes
CONCLUSION: The study findings indicated that the supernatant of L. reuteri has a potent anti-HSV-1 effect especially if it is incubated with the virus before inoculation into the cell. Its possible antiviral mechanism is to inhibit the virus by binding to it or changing the surface structure of the virus. Metabolites of L. reuteri can be considered as a novel inhibitor of HSV-1 infection.PMID:38682053 | PMC:PMC11055432 | DOI:10.18502/ijm.v16i1.14877 (Source: Herpes)
Source: Herpes - April 29, 2024 Category: Infectious Diseases Authors: Faezeh Ebneali Mohammad Shayestehpour Ahmad Piroozmand Hossein Sedaghat Shaghayegh Yazdani Zahrasadat Fateminasab Source Type: research
Comparison of CIMT and FMD in the Brachial Artery between Children with Acyanotic Congenital Heart Disease and Healthy Controls: A Case-Control Study
CONCLUSION: Based on our results, CIMT and FMD assessment may help detect early changes in peripheral vessels associated with atherosclerosis in the future in ACHD. Further studies are needed to confirm our findings.PMID:38680641 | PMC:PMC11053238 | DOI:10.18502/jthc.v18i4.14824 (Source: Atherosclerosis)
Source: Atherosclerosis - April 29, 2024 Category: Cardiology Authors: Alireza Ahmadi Mehdi Ghaderian Hajar Nourmohammadi Mohammad Reza Sabri Bahar Dehghan Chehreh Mahdavi Source Type: research
A Comprehensive Integration of Data Regarding the Correlation of TNF- α rs1800629 Polymorphism with Susceptibility to Cervical Cancer
CONCLUSIONS: The findings from this meta-analysis suggest that the TNF-α rs1800629 polymorphism is a risk factor for cervical cancer in the general population, particularly in Caucasian and African women. However, further well-designed studies are warranted to validate these findings.PMID:38679974 | DOI:10.31557/APJCP.2024.25.4.1155 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Zahra Marzbanrad Mojgan Karimi-Zarchi Somayeyeh Noei-Teymoordash Maryam Motamedinasab Sepideh Azizi Shahla Noori-Ardebili Maedeh Barahman Maryam Yeganegi Ali Masoudi Kamran Alijanpour Maryam Aghasipour Kazem Aghili Hossein Neamatzadeh Source Type: research
Cytotoxic and apoptotic effects of Ferula gummosa Boiss: extract on human breast adenocarcinoma cell line
CONCLUSION: F. gummosa exhibited pro-apoptotic, anti-proliferative, and anti-metastatic effects on MCF-7 cells. It is therefore recommended that detailed future research be done on different parts of the plant or its secondary metabolites to find anti-cancer lead compounds.PMID:38683376 | DOI:10.1007/s11033-024-09364-1 (Source: Mol Biol Cell)
Source: Mol Biol Cell - April 29, 2024 Category: Molecular Biology Authors: Roghayeh Rashidi Ali Roohbakhsh Leila Mohtashami Leila Mobasheri Hamidreza Kheradmand Mohammad Sadegh Amiri Ahmad Ghorbani Seyed Hadi Mousavi Source Type: research
Evaluation of the safety and efficacy of biosimilar recombinant growth hormone in children with growth hormone deficiency: non-inferiority, randomized, parallel, multicentric and Phase III trial
CONCLUSIONS: The finding of this study indicated that Somatin® and Norditropin® have comparable efficacy and safety profiles.CLINICAL TRIAL REGISTRATION: www.IRCT.ir IRCT20171122037571N1.PMID:38682328 | DOI:10.1080/14740338.2024.2348576 (Source: Expert Opinion on Drug Safety)
Source: Expert Opinion on Drug Safety - April 29, 2024 Category: Drugs & Pharmacology Authors: Hossein Zaeri Shahriar Omidvar Nazli Servatian Serajaddin Arefnia Nasrin Khademolreza Hossein Amini Behnam Taghavi Mahin Hashemipour Peyman Eshraghi Mahmoud Ghasemi Robabeh Ghergherehchi Elham Maleki Hossein Moravej Shahab Noorian Fahimeh Soheilipour Seti Source Type: research
Assessing the possible association between MTHFR (rs1801133) and GPx-1 (rs1050450) polymorphisms with the risk of type 2 diabetes, diabetic neuropathy, and diabetic retinopathy
CONCLUSION: The MTHFR TT genotype increased the risk of neuropathy in diabetic patients significantly. The GPx-1 CT genotype is related to increased retinopathy risk among diabetic patients. Both MTHFR and Gpx-1 TT genotypes were associated with higher BMI levels.PMID:38683407 | DOI:10.1007/s11033-024-09519-0 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 29, 2024 Category: Molecular Biology Authors: Soheila Asadi Zohreh Rahimi Maryam Kohsari Fatemeh Babajani Mohammad Amiri Nazanin Jalilian Rozita Naseri Lida Haghnazari Source Type: research
Cytotoxic and apoptotic effects of Ferula gummosa Boiss: extract on human breast adenocarcinoma cell line
CONCLUSION: F. gummosa exhibited pro-apoptotic, anti-proliferative, and anti-metastatic effects on MCF-7 cells. It is therefore recommended that detailed future research be done on different parts of the plant or its secondary metabolites to find anti-cancer lead compounds.PMID:38683376 | DOI:10.1007/s11033-024-09364-1 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 29, 2024 Category: Molecular Biology Authors: Roghayeh Rashidi Ali Roohbakhsh Leila Mohtashami Leila Mobasheri Hamidreza Kheradmand Mohammad Sadegh Amiri Ahmad Ghorbani Seyed Hadi Mousavi Source Type: research
In vitro evaluation of inhibitory effect of Lactobacillus reuteri supernatant on the replication of herpes simplex virus type 1 and expression of UL54, UL52 and UL27 genes
CONCLUSION: The study findings indicated that the supernatant of L. reuteri has a potent anti-HSV-1 effect especially if it is incubated with the virus before inoculation into the cell. Its possible antiviral mechanism is to inhibit the virus by binding to it or changing the surface structure of the virus. Metabolites of L. reuteri can be considered as a novel inhibitor of HSV-1 infection.PMID:38682053 | PMC:PMC11055432 | DOI:10.18502/ijm.v16i1.14877 (Source: Herpes)
Source: Herpes - April 29, 2024 Category: Infectious Diseases Authors: Faezeh Ebneali Mohammad Shayestehpour Ahmad Piroozmand Hossein Sedaghat Shaghayegh Yazdani Zahrasadat Fateminasab Source Type: research
The relationship between the World Index for Sustainability and Health (WISH) score and mental health in women: A cross-sectional study
The objective of this cross-sectional study was to explore the relationship between a newly developed dietary index for health and sustainability, and psychological disorders among Iranian women. Participants in this cross-sectional study included 479 women living in Tehran with no history of chronic disease. A validated 168-item food frequency questionnaire was used to assess dietary intake. The World Index for Sustainability and Health (WISH) was calculated, consisting of four sub-scores: less healthy, healthy, low environmental impact, and high environmental impact. Participants psychological status was assessed using t...
Source: The British Journal of Nutrition - April 29, 2024 Category: Nutrition Authors: Alireza Jafari Keyhan Lotfi Hadis Mozaffari Behzad Zamani Manije Darooghegi Mofrad Ali Sheikhi Pamela J Surkan Leila Azadbakht Source Type: research
Secretome of adipose derived-mesenchymal stem cells reduces the < em > Vibrio cholerae < /em > attachment to Caco-2 cells and subsequent inflammatory responses
CONCLUSION: The secretome of AD-MSCs can play a critical role in inhibiting bacterial colonization, and subsequent inflammatory responses, and maintaining the integrity of the epithelial barrier. The secretome may be effective in the prevention of hypovolemic shock.PMID:38682070 | PMC:PMC11055443 | DOI:10.18502/ijm.v16i1.14875 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - April 29, 2024 Category: Microbiology Authors: Alireza Moulazade Sara Soudi Bita Bakhshi Source Type: research
Diagnostic insights into disseminated histoplasmosis: a case report highlighting bone marrow analysis
We present a case of a 43-year-old immunocompromised female patient diagnosed with disseminated histoplasmosis on bone marrow examination, at clinical laboratory of Kasturba Hospital, Manipal, Karnataka, India. The patient, presenting with symptoms like weight loss, appetite loss, and pancytopenia, underwent bone marrow aspiration and biopsy. The bone marrow studies revealed HIV-associated changes and the yeast form of Histoplasma capsulatum, confirming disseminated histoplasmosis. Bone marrow examination is highlighted as a diagnostic tool with significant sensitivity in such cases. The report stresses on the importance o...
Source: Iranian Journal of Microbiology - April 29, 2024 Category: Microbiology Authors: Vaanya Kaushik Ruchee Khanna Vinay Khanna Muralidhar Varma Source Type: research
Human herpesvirus type 6 in patients with systemic lupus erythematosus
CONCLUSION: Although patients with SLE had a higher prevalence of HHV-6 compared with healthy people, there is no strong link between HHV-6 infection and SLE. Future research is necessary because this data does not support the hypothesis that human herpesvirus 6 plays a role in the pathogenesis of SLE.PMID:38682068 | PMC:PMC11055447 | DOI:10.18502/ijm.v16i1.14883 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - April 29, 2024 Category: Microbiology Authors: Mohammad Shayestehpour Elnaz Vatani Batool Zamani Ahmad Piroozmand Shaghayegh Yazdani Kamal Esalatmanesh Zahrasadat Fateminasab Source Type: research
Evaluation of antibody titers in COVID-19 patients with cerebral or pulmonary symptoms and mild symptoms
CONCLUSION: The findings of this study revealed that the risk of central nervous system involvement increases with age and that older people have lower antibody levels than younger people. Consequently, strengthening the immune systems of people over the age of 78 during this pandemic through vaccination and nutrition is very effective in reducing mortality in this age group.PMID:38682065 | PMC:PMC11055446 | DOI:10.18502/ijm.v16i1.14881 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - April 29, 2024 Category: Microbiology Authors: Nazanin Joudaki Samireh Ghafouri Kowsar Bavarsad Farbod Farhadi Marzieh Abbasi Nasab Sara Afzalzadeh Hamidreza Moradzadegan Roya Salehi Kahyesh Source Type: research
