A single-center, open-labeled, randomized, 6-month, parallel-group study to assess the safety and efficacy of allogeneic cultured keratinocyte sheet transplantation for deep second-degree burn wounds: rationale and design of phase I/II clinical trial
This study will explain the design and rationale of a cellular-based skin substitute for the first time in Iran. In addition, this work proposes this product being registered as an off-the-shelf product for burn wound management in the country.Trial registrationIranian Registry of Clinical Trials (IRCT) IRCT20080728001031N31, 2022-04-23 for phase I and IRCT20080728001031N36, 2024-03-15 for phase II. (Source: Trials)
Source: Trials - April 1, 2024 Category: Research Source Type: clinical trials
The effect of selenium supplementation on oxidative stress, clinical symptoms and mental health status in patients with migraine: a study protocol for a double-blinded randomized clinical trial
DiscussionOxidative stress is recognized as a key contributor to migraine pathogenesis. Selenium is an essential trace element with antioxidant properties, capable of crossing the blood –brain barrier (BBB), holding promise to alleviate the oxidative stress and neurotoxicity. Thus, selenium may beneficially affect clinical symptoms and oxidative stress as well as the quality of life in migraine patients.Trial registrationThis trial was registered in the Iranian Registry of Clinical Trials (https://www.irct.ir/) on 27 May 2023 with the code number IRCT20121216011763N60. (Source: Trials)
Source: Trials - March 22, 2024 Category: Research Source Type: clinical trials
Evaluation of the efficiency of nanomicellar formulation of fat-soluble vitamins in patients with cystic fibrosis: the study protocol for a randomized controlled trial
DiscussionDue to persistent fat-soluble vitamin deficiency in CF disease, the nanomicelle formulation could be proposed as a new delivery method of fat-soluble vitamins in the treatment of cystic fibrosis.Trial registrationIranian Registry of Clinical Trials IRCT20220415054541N1. Registered on July 23, 2022. (Source: Trials)
Source: Trials - January 16, 2024 Category: Research Source Type: clinical trials
Cupping Therapy in Chronic Nonspecific Low Back Pain
Conditions: Chronic Low-back Pain; Chronic Non-specific Low Back Pain; Low Back Pain; Cupping Therapy Interventions: Other: True dry cupping therapy; Other: Sham cupping therapy Sponsors: Iran University of Medical Sciences Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 5, 2024 Category: Research Source Type: clinical trials
The Use of Isocapnic Hyperventilation (iHV) for Treatment of Methanol Poisoned Patients
Conditions: Methanol Poisoning Interventions: Device: isocapnic hyperventilation Sponsors: Oslo University Hospital; Loghman-Hakim Hospital, Teheran, Iran; Shohada-e-Tajrish Hospital, Teheran, Iran; Baharloo Hospital, Teheran, Iran; Imam Reza Hospital, Mashhad University of Medical Sciences, Iran; Khorshid Hospital, Isfahan University of Medical Sciences, Iran Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 18, 2023 Category: Research Source Type: clinical trials
The Effect of High-power Laser Therapy on Pain, Functional Disability, Range of Motion and Pressure Pain Threshold in Subjects With Radicular Low Back Pain Due to Intervertebral Disc Herniation
Conditions: Radiculopathy, Lumbosacral Region; Radiculopathy Lumbar Interventions: Radiation: High intensity laser therapy; Other: Motor control exercise Sponsors: Iran University of Medical Sciences Enrolling by invitation (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 30, 2023 Category: Research Source Type: clinical trials
The effects of intermittent fasting diet alone or in combination with probiotic supplementation in comparison with calorie-restricted diet on metabolic and hormonal profile in patients with polycystic ovary syndrome: study protocol for a randomized clinical trial
DiscussionWe hypothesized that 10-h TRE administered alone or in combination with probiotic supplementation to overweight and obese PCOS subjects would lead to weight loss and improved metabolic, hormonal, inflammatory, and antioxidant markers compared to control subjects following a standard 3-meal-per-day CR diet.Ethical aspectsThe current trial received approval from the Medical Ethics Committee of Tehran University of Medical Sciences, Tehran, Iran (IR.TUMS.MEDICNE.REC.1401.425).Trial registrationIranian Registry of Clinical Trials IRCT20121110011421N5. Registered on 3 October 2022. (Source: Trials)
Source: Trials - October 25, 2023 Category: Research Source Type: clinical trials
The effect of patient-led goal setting approach combined with pain neuroscience education or manual therapy in patients with chronic low back pain: protocol for a parallel-group randomized controlled trial
DiscussionThis trial will demonstrate which supplementary intervention can better improve the impact of a patient-led goal-setting approach to treat LBP. If successful, the results will potentially have implications for athletic trainers, physiotherapists, and health care practitioners.Trial registrationIRCT Iranian Registry of Clinical Trials IRCT20210927052616N1. Registered on November 03, 2021. (Source: Trials)
Source: Trials - September 8, 2023 Category: Research Source Type: clinical trials
Chia Seeds in Hypertriglyceridemia
Condition: Hypertriglyceridemia Interventions: Other: Control; Dietary Supplement: Omega-3 supplementation; Other: Chia seed Sponsors: Shahid Beheshti University; National Nutrition and Food Technology Research Institute, Tehran,Iran Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - September 1, 2023 Category: Research Source Type: clinical trials
