Evaluation of the efficacy and safety of Melatonin in moderately ill patients with COVID-19: A structured summary of a study protocol for a randomized controlled trial
AbstractObjectivesWe will evaluate the efficacy and safety of Melatonin, compared to the standard therapeutic regimen on clinical symptoms and serum inflammatory parameters in patients with confirmed COVID-19, who are moderately ill.Trial designThis is a single-center, randomized, double-blind, placebo-controlled clinical trial with a parallel-group design conducted at Shahid Mohammadi Hospital, Bandar Abbas, Iran.ParticipantsAll patients admitted to Severe Acute Respiratory Syndrome Departments of Shahid Mohammadi Hospital, Bandar Abbas, Iran will be screened for the following criteria.Inclusion criteria:1. Age ≥20 year...
Source: Trials - October 26, 2020 Category: Research Source Type: clinical trials
The clinical effect of Nano micelles containing curcumin as a therapeutic supplement in patients with COVID-19 and the immune responses balance changes following treatment: A structured summary of a study protocol for a randomised controlled trial
This study is conducted as a prospective, placebo-controlled with parallel group, single-center randomized clinical trial on COVID-19 patients.ParticipantsPatients are selected from the COVID-19 ward of Shahid Mohammadi Hospital in Bandar Abbas, Iran.Inclusion criteria:1. Real time PCR-approved positive COVID-19 test.2. Both gender3. Age between 18 and 75 years4. Signing a written consent5. Lack of participation in other clinical trialsExclusion criteria:1. Pregnancy or lactation2. Allergy to turmeric or curcumin3. Smoking4. Patient connected to the ventilator5. SaO2 less than 90% or PaO2 less than 8 kPa6. Having comorbidi...
Source: Trials - October 22, 2020 Category: Research Source Type: clinical trials
The Efficacy of Famotidine in improvement of outcomes in Hospitalized COVID-19 Patients: A structured summary of a study protocol for a randomised controlled trial
This study aims to investigate the effect of Famotidine on the recovery process of COVID-19 patients.Trial designThis phase III randomized clinical trial was designed with two parallel arms, placebo-controlled, single-blind, and concealed allocation.ParticipantsAll COVID-19 patients admitted to Shahid Mohammadi Hospital in Bandar Abbas whose PCR test results are positive for SARS-Cov-2 and sign the written consent of the study are included in the study and immunocompromised patients, end-stage renal disease, moderate renal failure (clearance Creatinine 30 to 50 ml/min) or stage 4 severe chronic kidney disease or need for d...
Source: Trials - October 13, 2020 Category: Research Source Type: clinical trials
Effects of Ginger on clinical manifestations and paraclinical features of patients with Severe Acute Respiratory Syndrome due to COVID-19: A structured summary of a study protocol for a randomized controlled trial
AbstractObjectivesWe investigate the effects of Ginger, compared to the usual therapeutic regimen on clinical manifestations and paraclinical features in patients with confirmed COVID-19 that are moderately ill.Trial designThis is a single center, randomized, double-blind, placebo-controlled clinical trial with parallel group design.ParticipantsInclusion criteria:1. Patients admitted to Severe Acute Respiratory Syndrome (SARS) Departments at Shahid Mohammadi Hospital, Bandar Abbas, Iran2. Age ≥18 years (weight ≥35 kg)3. Hospitalized ≤48 hours4. Confirmed SARS-CoV-2 diagnosis (Positive polymerase chain reaction (PCR))...
Source: Trials - October 9, 2020 Category: Research Source Type: clinical trials
Effects of Licorice on clinical symptoms and laboratory signs in moderately ill patients with pneumonia from COVID-19: A structured summary of a study protocol for a randomized controlled trial
This study is being conducted at Shahid Mohammadi Hospital, Bandar Abbas, Iran.ParticipantsBoth male and female patients with ≥18 years of age (≥ 35 kg of weight), admitted at the Shahid Mohammadi Hospital, Hormozgan University of Medical Sciences, Bandar Abbas for treatment, screened for the following criteria.Inclusion criteria:1. Confirmed diagnosis of SARS-CoV-2 infection (via polymerase chain reaction [PCR] and/or antibody test).2. Presenting as moderate COVID-19 pneumonia (via chest computed tomography (CT) and/or X-ray) requiring hospitalization.3. Hospitalized ≤48 hours.4. Signing informed consent and willing...
Source: Trials - September 14, 2020 Category: Research Source Type: clinical trials
Does propolis affect the quality of life and complications in subjects with irritable bowel syndrome (diagnosed with Rome IV criteria)? A study protocol of the randomized, double-blinded, placebo-controlled clinical trial
DiscussionWe hypothesize that propolis supplementation would be useful for treating IBS through its antioxidants, anti-inflammatory, and prebiotic properties. This trial will show the results of propolis supplementation, whether positive or negative, on IBS. If the current trial confirms our hypothesis, propolis supplementation can be a new choice in adjunctive therapy of IBS.Trial registrationIranian Registry of Clinical Trials IRCT20190708044154N1. Registered on 26 December 2019. Updated on 13 February 2020.https://en.irct.ir/trial/40983SponsorTabriz University of Medical Sciences, Tabriz, Iran (Source: Trials)
Source: Trials - August 4, 2020 Category: Research Source Type: clinical trials
Efficacy of high-dose versus low-dose vitamin D supplementation on serum levels of inflammatory factors and mortality rate in severe traumatic brain injury patients: study protocol for a randomized placebo-controlled trial
DiscussionIf this randomized clinical trial demonstrates reductions in inflammatory cytokines, it would provide evidence for a multicenter clinical trial to evaluate the efficacy of vitamin D supplementation in neurocritically ill patients. Since vitamin D supplements are inexpensive and safe, this clinical trial could have the potential to improve clinical outcomes in traumatic brain injury patients through reduction of inflammation and infection-associated morbidity and mortality rates.Trial registrationIranian Registry of Clinical Trials,IRCT20180619040151N3. Registered on 10 August 2019. (Source: Trials)
Source: Trials - July 28, 2020 Category: Research Source Type: clinical trials
Intermediate-dose vs Standard Prophylactic Anticoagulation and Statin vs Placebo in ICU Patients With COVID-19
Condition: Covid19 Interventions: Drug: intermediate dose Enoxaparin/ unfractionated heparin; Drug: standard prophylactic dose Enoxaparin/ unfractionated heparin; Drug: Atorvastatin 20mg; Drug: Matched placebo Sponsors: Rajaie Cardiovascular Medical and Research Center; Brigham and Women's Hospital; Tehran Heart Center; Masih Daneshvari Hospital; Hazrat Rasool Hospital; Modarres Hospital; Firuzgar hospital affiliated to Iran University of Medical Sciences; Imam Khomeini Hos pital; Sina Hospital, Iran; Tabriz University of Medical Sciences Recruiting (S...
Source: ClinicalTrials.gov - July 24, 2020 Category: Research Source Type: clinical trials
Intermediate-dose vs Standard Prophylactic Anticoagulation and Statin vs Placebo in ICU Patients With COVID-19
Condition: Covid19 Interventions: Drug: intermediate dose Enoxaparin/ unfractionated heparin; Drug: standard prophylactic dose Enoxaparin/ unfractionated heparin; Drug: Atorvastatin 20mg; Drug: Matched placebo Sponsors: Rajaie Cardiovascular Medical and Research Center; Brigham and Women's Hospital; Tehran Heart Center; Masih Daneshvari Hospital; Hazrat Rasool Hospital; Modarres Hospital; Firuzgar hospital affiliated to Iran University of Medical Sciences; Imam Khomeini Hos pital; Sina Hospital, Iran; Tabriz University of Medical Sciences Not yet recru...
Source: ClinicalTrials.gov - July 24, 2020 Category: Research Source Type: clinical trials
