The efficacy of N-Acetylcysteine in severe COVID-19 patients: A structured summary of a study protocol for a randomised controlled trial
In this study, we evaluate the efficacy of N-Acetylcysteine in patients with severe COVID-19.Trial designThis is a prospective, randomized, single-blinded, phase 3 controlled clinical trial with two arms (ratio 1:1) parallel-group design of 40 patients, using the placebo in the control group.ParticipantsAll severe COVID-19 patients with at least one of the following five conditions: (respiration rate> 30 per minute), hypoxemia (O2 ≤ saturation, arterial oxygen partial pressure ratio<300), pulmonary infiltration (> 50% of lung area during 24 48 h), Lactate dehydrogenase (LDH)> 245 U / l, Progressive lymphopeni...
Source: Trials - April 12, 2021 Category: Research Source Type: clinical trials
Effects of pomegranate juice ( Punica Granatum ) on inflammatory biomarkers and complete blood count in patients with COVID-19: a structured summary of a study protocol for a randomized clinical trial
This study is conducted to investigate efficacy of pomegranate juice on inflammatory biomarkers, C-reactive protein (CRP), interleukin 6(IL-6), erythrocyte sedimentation rate (ESR) and complete blood count (CBC) in hospitalized patients with mild to moderate coronavirus disease 2019 (COVID- 19).Trial DesignThis is a randomized, placebo-controlled, double-blind, parallel 2-arm (1:1 ratio) clinical trial.ParticipantsPatients with COVID-19 admitted to hospitals in Yasuj City, Kohgiluyeh and Boyer-Ahmad Province, Iran.Inclusion CriteriaInformed consentPatients 18 years of age or olderDiagnosis of COVID-19 based on real-time po...
Source: Trials - April 2, 2021 Category: Research Source Type: clinical trials
Evaluation of the effect of melatonin in patients with COVID-19-induced pneumonia admitted to the Intensive Care Unit: A structured summary of a study protocol for a randomized controlled trial
This study is being conducted at Shahid Mohammadi Hospital, Bandar Abbas, Iran.ParticipantsAll patients admitted to the ICU of Shahid Mohammadi Hospital, Bandar Abbas, Iran, will be screened for the following criteria.Inclusion criteria1. Age>20 years2. Definitive diagnosis of COVID-19 based on RT-PCR or/and serological testing3. Severe pneumonia and lung involvement in imaging4. Signing informed consentExclusion criteria1. Underlying diseases, including convulsive disorders, chronic hepatic and renal diseases2. Use of mechanical ventilation3. History of known allergy to Melatonin4. Pregnancy and breastfeedingInterventi...
Source: Trials - March 8, 2021 Category: Research Source Type: clinical trials
Evaluation of the efficacy and safety of inhaled magnesium sulphate in combination with standard treatment in patients with moderate or severe COVID-19: A structured summary of a study protocol for a randomised controlled trial
AbstractObjectivesBasic and clinical studies have shown that magnesium sulphate ameliorates lung injury and controls asthma attacks by anti-inflammatory and bronchodilatory effects. Both intravenous and inhaled magnesium sulphate have a clinical impact on acute severe asthma by inhibition of airway smooth muscle contraction. Besides, magnesium sulphate can dilate constricted pulmonary arteries and reduce pulmonary artery resistance. However, it may affect systemic arteries when administered intravenously. A large number of patients with covid-19 admitted to the hospital suffer from pulmonary involvement. COVID-19 can cause...
Source: Trials - January 18, 2021 Category: Research Source Type: clinical trials
The impact of computer-based cognitive training intervention on the quality of life among elderly people: a randomized clinical trial
ConclusionsBased on the results, ARAM showed transition and long-term effects on QoL in elderly people by improving cognitive functions such as selective attention and working memory.Trial registrationIranian Registry of Clinical TrialsIRCT2016122731602N1. Registered on June 21, 2017 (Source: Trials)
Source: Trials - January 11, 2021 Category: Research Source Type: clinical trials
The efficacy and safety of Ivermectin in patients with mild and moderate COVID-19: A structured summary of a study protocol for a randomized controlled trial
AbstractObjectivesWe will evaluate the efficacy and safety of Ivermectin in patients with mild and moderately severe COVID-19.Trial designThis is a phase 3, single-center, randomized, open-label, controlled trial with a 2-arm parallel-group design (1:1 ratio).ParticipantsThe Severe Acute Respiratory Syndrome Departments of the Shahid Mohammadi Hospital, Bandar Abbas, Iran, will screen for patients age ≥ 20 years and weight ≥35 kg for the following criteria:Inclusion criteria for patients with mild COVID-19 symptoms (outpatients)Diagnosed mild pneumonia using computed tomography (CT) and/or chest X-ray (CX-R) ima...
Source: Trials - January 4, 2021 Category: Research Source Type: clinical trials
Effects of curcumin-piperine co-supplementation on clinical signs, duration, severity, and inflammatory factors in patients with COVID-19: a structured summary of a study protocol for a randomised controlled trial
This study aims to investigate the efficacy of curcumin-piperine co-supplementation on disease duration, severity and clinical symptoms, and inflammatory mediators in patients with coronavirus (COVID-19).Trial designThis is a randomized, placebo-controlled, double-blind, parallel arm clinical trial.ParticipantsAll patients aged 20-75 years with the diagnosis of Covid-19 based on the PCR test. The exclusion criteria will include an age less than 20 and more than 75 years, current use of warfarin or other anticoagulant drugs, and the presence of sensitivity to herbal products such as turmeric and pepper.This study will be co...
Source: Trials - December 17, 2020 Category: Research Source Type: clinical trials
Efficacy of a web application for stress management among Iranian college students during COVID-19 outbreak: a study protocol for randomized controlled trials
This study aims to evaluate an evidence-based web application (Naranj) for stress management among Iranian college students.Methods and designThis study aims to present a protocol related to a randomized controlled trial among Iranian college students. The study will be conducted on 100 students from two colleges of Shiraz University of Medical Sciences in Iran. The participants will be randomly assigned to the intervention and control groups. The intervention group participants will be provided with a web application, whereas the control group ones will be provided with an app unrelated to stress management. The primary o...
Source: Trials - December 14, 2020 Category: Research Source Type: clinical trials
