Intractable Generalized Epilepsy: Therapeutic Approaches
AbstractPurpose of ReviewTo summarize recent developments in therapeutic options, both medical and surgical, for patients with drug-resistant generalized epilepsy syndromes, which continue to be a multifaceted challenge for patients and physicians.Recent FindingsNewer generation pharmaceutical options are now available, such as brivaracetam, rufinamide, lacosamide, perampanel, and cannabidiol. Less restrictive dietary options appear to be nearly as effective as classic ketogenic diet for amelioration of seizures. The latest implantable devices include responsive neurostimulation and deep brain stimulation. Corpus callosoto...
Source: Current Neurology and Neuroscience Reports - February 26, 2019 Category: Neuroscience Source Type: research
Intractable Generalized Epilepsy: Therapeutic Approaches.
Abstract
PURPOSE OF REVIEW: To summarize recent developments in therapeutic options, both medical and surgical, for patients with drug-resistant generalized epilepsy syndromes, which continue to be a multifaceted challenge for patients and physicians.
RECENT FINDINGS: Newer generation pharmaceutical options are now available, such as brivaracetam, rufinamide, lacosamide, perampanel, and cannabidiol. Less restrictive dietary options appear to be nearly as effective as classic ketogenic diet for amelioration of seizures. The latest implantable devices include responsive neurostimulation and deep brai...
Source: Epilepsy Curr - February 26, 2019 Category: Neurology Authors: Hwang ST, Stevens SJ, Fu AX, Proteasa SV Tags: Curr Neurol Neurosci Rep Source Type: research
Use of Newer Anticonvulsants for the Treatment of Status Epilepticus
This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - February 5, 2019 Category: Drugs & Pharmacology Authors: Salia Farrokh,
Michael Erdman,
John Bon,
Eljim Tesoro Tags: SI on Prevention Strategies in the Critically Ill Source Type: research
Newer antiepileptic drugs discontinuation due to adverse effects: An observational study
Conclusions: AEs in newer antiepileptic drugs are extremely prevalent. Our observation revealed that skin rashes and paresthesia were the most probable causes of treatment discontinuation because of AEs. (Source: Annals of Indian Academy of Neurology)
Source: Annals of Indian Academy of Neurology - December 26, 2018 Category: Neurology Authors: Mehdi Golpayegani Farhad Salari Kurosh Gharagozli Source Type: research
Efficacy of rufinamide in childhood refractory epilepsy.
The objective of this study was to evaluate the reliability of rufinamide and its impact on seizure frequency in patients diagnosed with drug-resistant epilepsy, where seizures could not be controlled with `classical` antiepileptic drugs. We retrospectively reviewed the data of epileptic patients who were followed up between January 2004 and December 2014 in the Pediatric Neurology Department. Patients who were diagnosed with `drug resistant epilepsy` and treated with rufinamide were evaluated. Decrease in seizure frequency and drug side effects were assessed as parameters. A total of 38 patients (14 girls, 24 boys) with a...
Source: The Turkish Journal of Pediatrics - December 5, 2018 Category: Pediatrics Authors: Yıldız EP, Hızlı Z, Bektaş G, Ulak-Özkan M, Tatlı B, Aydınlı N, Çalışkan M, Özmen M Tags: Turk J Pediatr Source Type: research
Evaluation of WO2014121383 A1: a process for preparation of rufinamide and intermediates
. (Source: Expert Opinion on Therapeutic Patents)
Source: Expert Opinion on Therapeutic Patents - November 16, 2018 Category: Drugs & Pharmacology Authors: Barnali Maiti Balamurali M M Kaushik Chanda Source Type: research
The Pharmacological Management of Lennox-Gastaut Syndrome and Critical Literature Review
Publication date: Available online 26 October 2018Source: SeizureAuthor(s): Alberto Verrotti, Pasquale Striano, Giulia Iapadre, Luca Zagaroli, Paolo Bonanni, Giangennaro Coppola, Maurizio Elia, Oriano Mecarelli, Emilio Franzoni, De Liso Paola, Federico Vigevano, Paolo CuratoloAbstractLennox-Gastaut syndrome (LGS) is a severe epileptic encephalopathy with a prevalence of 1–2% of all patients with epilepsy. It is characterized by multiple pharmaco-resistant seizure types, including tonic, atypical absences and tonic or atonic drop attacks, and the presence of electroencephalographic abnormalities, such as slow-spike waves ...
Source: Seizure - October 27, 2018 Category: Neurology Source Type: research
Inflammatory theory of diseases: What has it got to do with late-onset LGS?
Lennox-Gastaut syndrome (LGS) is the most common epileptic encephalopathy in children presenting between 3 and 5 years of age. It is a complex age-related epilepsy syndrome with multiple possible etiologies such as hypoxic ischemic injuries, genetic syndromes, cerebral cortical malformations, and tumors. The etiology may remain elusive in approximately 25% of the cases.1 Similar to many other childhood epilepsy syndromes, the age at onset can be variable but can be delayed into adulthood. LGS is characterized by multiple seizure types, abnormal EEG characteristics, and cognitive decline. Nonconvulsive status epilepticus, p...
Source: Neurology Clinical Practice - October 15, 2018 Category: Neurology Authors: Singh, A. Tags: All Neuropsychology/Behavior, All Epilepsy/Seizures, Antiepileptic drugs, EEG Editorial Source Type: research
Pharmacokinetic Considerations with the Use of Antiepileptic Drugs in Patients with HIV and Organ Transplants.
Abstract
PURPOSE OF REVIEW: Antiepileptic drugs are frequently administered to patients with HIV infection or in recipients of organ transplants. The potentially serious drug-drug interactions between the "classic" antiepileptic drugs, antiretrovirals, and immunosuppressants have been extensively studied. Evidence-based information on the second and third generation of antiepileptic drugs is almost non-existent. The purpose of this review is to analyze the pharmacokinetic profile of these newer agents to assess their potential for drug interactions with antiretrovirals and immunosuppressants.
RECEN...
Source: Epilepsy Curr - October 9, 2018 Category: Neurology Authors: Asconapé JJ Tags: Curr Neurol Neurosci Rep Source Type: research
Pharmacokinetic Considerations with the Use of Antiepileptic Drugs in Patients with HIV and Organ Transplants
AbstractPurpose of ReviewAntiepileptic drugs are frequently administered to patients with HIV infection or in recipients of organ transplants. The potentially serious drug-drug interactions between the “classic” antiepileptic drugs, antiretrovirals, and immunosuppressants have been extensively studied. Evidence-based information on the second and third generation of antiepileptic drugs is almost non-existent. The purpose of this review is to analyze the pharmacokinetic profile of these newer a gents to assess their potential for drug interactions with antiretrovirals and immunosuppressants.Recent FindingsAs a group, th...
Source: Current Neurology and Neuroscience Reports - October 9, 2018 Category: Neuroscience Source Type: research
Practice guideline update summary: Efficacy and tolerability of the new antiepileptic drugs I: Treatment of new-onset epilepsy: Report of the American Epilepsy Society and the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology.
Authors: Kanner AM, Ashman E, Gloss D, Harden C, Bourgeois B, Bautista JF, Abou-Khalil B, Burakgazi-Dalkilic E, Park EL, Stern J, Hirtz D, Nespeca M, Gidal B, Faught E, French J
Abstract
Objective: To update the 2004 American Academy of Neurology (AAN) guideline for treating new-onset focal or generalized epilepsy (GE) with second- and third-generation antiepileptic drugs (AEDs). Methods: The 2004 AAN criteria was used to systematically review literature (January 2003 to November 2015), classify pertinent studies according to the therapeutic rating scheme, and link recommendations to evidence strength. Res...
Source: Epilepsy Currents - September 27, 2018 Category: Neurology Tags: Epilepsy Curr Source Type: research
Practice guideline update summary: Efficacy and tolerability of the new antiepileptic drugs II: Treatment-resistant epilepsy: Report of the American Epilepsy Society and the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology.
Authors: Kanner AM, Ashman E, Gloss D, Harden C, Bourgeois B, Bautista JF, Abou-Khalil B, Burakgazi-Dalkilic E, Park EL, Stern J, Hirtz D, Nespeca M, Gidal B, Faught E, French J
Abstract
Objective: To update the 2004 American Academy of Neurology (AAN) guideline for managing treatment-resistant (TR) epilepsy with second- and third-generation antiepileptic drugs (AEDs). Methods: 2004 criteria were used to systematically review literature (January 2003 to November 2015), classify pertinent studies according to the therapeutic rating scheme, and link recommendations to evidence strength. Results: Forty-two ar...
Source: Epilepsy Currents - September 27, 2018 Category: Neurology Tags: Epilepsy Curr Source Type: research
Evaluation of long-term safety, tolerability, and behavioral outcomes with adjunctive rufinamide in pediatric patients ( ≥1 to < 4 years old) with Lennox-Gastaut syndrome: Final results from randomized study 303.
Evaluation of long-term safety, tolerability, and behavioral outcomes with adjunctive rufinamide in pediatric patients (≥1 to <4 years old) with Lennox-Gastaut syndrome: Final results from randomized study 303.
Eur J Paediatr Neurol. 2018 Sep 27;:
Authors: Arzimanoglou A, Ferreira J, Satlin A, Olhaye O, Kumar D, Dhadda S, Bibbiani F
Abstract
OBJECTIVE: Evaluate the long-term safety, tolerability, and behavioral effects of adjunctive rufinamide in pediatric patients (≥1 to <4 years old) with inadequately controlled seizures associated with Lennox-Gastaut syndrome (LGS).
...
Source: European Journal of Paediatric Neurology - September 27, 2018 Category: Neurology Authors: Arzimanoglou A, Ferreira J, Satlin A, Olhaye O, Kumar D, Dhadda S, Bibbiani F Tags: Eur J Paediatr Neurol Source Type: research
