2P or not 2P: The Question of Seizure Initiation.
Authors: Somarowthu A, Goldberg EM Abstract [Box: see text]. PMID: 32686512 [PubMed - as supplied by publisher] (Source: Epilepsy Currents)
Source: Epilepsy Currents - July 21, 2020 Category: Neurology Tags: Epilepsy Curr Source Type: research

Intracranial EEG in the 21st Century.
Authors: Jobst BC, Bartolomei F, Diehl B, Frauscher B, Kahane P, Minotti L, Sharan A, Tardy N, Worrell G, Gotman J Abstract Intracranial electroencephalography (iEEG) has been the mainstay of identifying the seizure onset zone (SOZ), a key diagnostic procedure in addition to neuroimaging when considering epilepsy surgery. In many patients, iEEG has been the basis for resective epilepsy surgery, to date still the most successful treatment for drug-resistant epilepsy. Intracranial EEG determines the location and resectability of the SOZ. Advances in recording and implantation of iEEG provide multiple options in the 2...
Source: Epilepsy Currents - July 18, 2020 Category: Neurology Tags: Epilepsy Curr Source Type: research

When the Brakes Fail: Basal Ganglia and Seizure Generalization.
Authors: Englot DJ PMID: 32550828 [PubMed] (Source: Epilepsy Currents)
Source: Epilepsy Currents - June 21, 2020 Category: Neurology Tags: Epilepsy Curr Source Type: research

Measure for Measure: Measuring the Usefulness of Measuring Antiseizure Medication Levels.
Authors: Faught E PMID: 32550829 [PubMed] (Source: Epilepsy Currents)
Source: Epilepsy Currents - June 21, 2020 Category: Neurology Tags: Epilepsy Curr Source Type: research

Seeking Alpha: Can Neurofeedback Actually Work?
Authors: Salpekar JA PMID: 32550830 [PubMed] (Source: Epilepsy Currents)
Source: Epilepsy Currents - June 21, 2020 Category: Neurology Tags: Epilepsy Curr Source Type: research

Task-Specific Interictal Spiking: Adding to the Complexity.
Authors: Barr WB PMID: 32550831 [PubMed] (Source: Epilepsy Currents)
Source: Epilepsy Currents - June 21, 2020 Category: Neurology Tags: Epilepsy Curr Source Type: research

An Eye for an Eye: A Randomized Placebo-Controlled Trial of IVIG in Antibody-Mediated Encephalitis.
Authors: Gaspard N PMID: 32550832 [PubMed] (Source: Epilepsy Currents)
Source: Epilepsy Currents - June 21, 2020 Category: Neurology Tags: Epilepsy Curr Source Type: research

Further Evidence Breastfeeding by Women With Epilepsy Is Safe: Are Mothers Getting the Message?
Authors: Noe K PMID: 32550833 [PubMed] (Source: Epilepsy Currents)
Source: Epilepsy Currents - June 21, 2020 Category: Neurology Tags: Epilepsy Curr Source Type: research

Functional Hemispherectomy in Adults: All We Have to Sphere Is Sphere Itself.
Authors: Gross RE PMID: 32550834 [PubMed] (Source: Epilepsy Currents)
Source: Epilepsy Currents - June 21, 2020 Category: Neurology Tags: Epilepsy Curr Source Type: research

The Value of Localizing Subclinical Seizures.
Authors: King-Stephens D PMID: 32550835 [PubMed] (Source: Epilepsy Currents)
Source: Epilepsy Currents - June 21, 2020 Category: Neurology Tags: Epilepsy Curr Source Type: research

Ictal Inhibition: Sync Globally, Slack Locally.
Authors: Lillis KP PMID: 32550836 [PubMed] (Source: Epilepsy Currents)
Source: Epilepsy Currents - June 21, 2020 Category: Neurology Tags: Epilepsy Curr Source Type: research

Chronic DREADD Isn't As Bad As It Sounds.
Authors: Hyder SK, Forcelli PA PMID: 32550837 [PubMed] (Source: Epilepsy Currents)
Source: Epilepsy Currents - June 21, 2020 Category: Neurology Tags: Epilepsy Curr Source Type: research

RAP-ALO(N)G and Make Me Smart.
Authors: Goldman A PMID: 32550838 [PubMed] (Source: Epilepsy Currents)
Source: Epilepsy Currents - June 21, 2020 Category: Neurology Tags: Epilepsy Curr Source Type: research

Leaky Blood-Brain Barrier: A Double Whammy for the Brain.
Authors: Wang Y PMID: 32550839 [PubMed] (Source: Epilepsy Currents)
Source: Epilepsy Currents - June 21, 2020 Category: Neurology Tags: Epilepsy Curr Source Type: research

Stopped At the Border: Cortical Spreading Depolarization Blocks Seizure Propagation.
Authors: Stafstrom CE PMID: 32550840 [PubMed] (Source: Epilepsy Currents)
Source: Epilepsy Currents - June 21, 2020 Category: Neurology Tags: Epilepsy Curr Source Type: research

E-I E-I Woe: Mossy Cell Regulation of Granule Cell Activity in Temporal Lobe Epilepsy.
Authors: Goicouria L, Liu J PMID: 32550841 [PubMed] (Source: Epilepsy Currents)
Source: Epilepsy Currents - June 21, 2020 Category: Neurology Tags: Epilepsy Curr Source Type: research

Rodent EEG: Expanding the Spectrum of Analysis.
Authors: Maheshwari A Abstract In epilepsy research, the analysis of rodent electroencephalogram (EEG) has been performed by many laboratories with a variety of techniques. However, the acquisition and basic analysis of rodent EEG have only recently been standardized. Since a number of software platforms and increased computational power have become widely available, advanced rodent EEG analysis is now more accessible to investigators working with rodent models of epilepsy. In this review, the approach to the analysis of rodent EEG will be examined, including the evaluation of both epileptiform and background activ...
Source: Epilepsy Currents - May 2, 2020 Category: Neurology Tags: Epilepsy Curr Source Type: research

Magnetoencephalography-Established but not yet Essential.
Authors: Shih JJ PMID: 32313499 [PubMed] (Source: Epilepsy Currents)
Source: Epilepsy Currents - April 22, 2020 Category: Neurology Tags: Epilepsy Curr Source Type: research

Most Experts Agree  … But What About Other EEG Readers?
Most Experts Agree … But What About Other EEG Readers? Epilepsy Curr. 2020 Mar-Apr;20(2):78-79 Authors: Noe K PMID: 32313500 [PubMed] (Source: Epilepsy Currents)
Source: Epilepsy Currents - April 22, 2020 Category: Neurology Tags: Epilepsy Curr Source Type: research

How Would You Like Your Epileptic Network? Linear, Nonlinear, Virtual?
Authors: Gotman J PMID: 32313501 [PubMed] (Source: Epilepsy Currents)
Source: Epilepsy Currents - April 22, 2020 Category: Neurology Tags: Epilepsy Curr Source Type: research

Do Interictal Rates Influence Treatment Outcomes in Temporal Lobe Epilepsy?
Authors: King-Stephens D PMID: 32313502 [PubMed] (Source: Epilepsy Currents)
Source: Epilepsy Currents - April 22, 2020 Category: Neurology Tags: Epilepsy Curr Source Type: research

Remarkably High Efficacy of Cenobamate in Adults With Focal-Onset Seizures: A Double-Blind, Randomized, Placebo-Controlled Trial.
Authors: Vossler DG PMID: 32313503 [PubMed] (Source: Epilepsy Currents)
Source: Epilepsy Currents - April 22, 2020 Category: Neurology Tags: Epilepsy Curr Source Type: research

Phenotype to Genotype and Back Again.
Authors: Mefford HC PMID: 32313504 [PubMed] (Source: Epilepsy Currents)
Source: Epilepsy Currents - April 22, 2020 Category: Neurology Tags: Epilepsy Curr Source Type: research

The Devil's in the Details: How to Harness Inhibition for Seizure Control.
Authors: Krook-Magnuson E PMID: 32313505 [PubMed] (Source: Epilepsy Currents)
Source: Epilepsy Currents - April 22, 2020 Category: Neurology Tags: Epilepsy Curr Source Type: research

Get With the (Developmental) Program.
Authors: Maguire JL PMID: 32313506 [PubMed] (Source: Epilepsy Currents)
Source: Epilepsy Currents - April 22, 2020 Category: Neurology Tags: Epilepsy Curr Source Type: research

The Beauty and the Dish: Brain Organoids Go Active.
Authors: Sanchez-Aguilera A, Menendez de la Prida L PMID: 32313507 [PubMed] (Source: Epilepsy Currents)
Source: Epilepsy Currents - April 22, 2020 Category: Neurology Tags: Epilepsy Curr Source Type: research

Sustainable Brain Activity and no End in Sight-What's in It for Status Epilepticus?
Authors: Gross C PMID: 32313508 [PubMed] (Source: Epilepsy Currents)
Source: Epilepsy Currents - April 22, 2020 Category: Neurology Tags: Epilepsy Curr Source Type: research

A 2020 View on the Genetics of Developmental and Epileptic Encephalopathies.
Authors: Happ HC, Carvill GL Abstract Developmental and epileptic encephalopathies (DEEs) can be primarily attributed to genetic causes. The genetic landscape of DEEs has been largely shaped by the rise of high-throughput sequencing, which led to the discovery of new DEE-associated genes and helped identify de novo pathogenic variants. We discuss briefly the contribution of de novo variants to DEE and also focus on alternative inheritance models that contribute to DEE. First, autosomal recessive inheritance in outbred populations may have a larger contribution than previously appreciated, accounting for up to 13% o...
Source: Epilepsy Currents - March 15, 2020 Category: Neurology Tags: Epilepsy Curr Source Type: research

Born to Be Wild: A Case for Targeting Ectopic Adult Born Granule Cells for Seizure Control.
Authors: Corrubia L, Santhakumar V Abstract [Box: see text]. PMID: 32037879 [PubMed] (Source: Epilepsy Currents)
Source: Epilepsy Currents - February 12, 2020 Category: Neurology Tags: Epilepsy Curr Source Type: research

Focus on the Focus.
Authors: Ewell LA Abstract [Box: see text]. PMID: 32037880 [PubMed] (Source: Epilepsy Currents)
Source: Epilepsy Currents - February 12, 2020 Category: Neurology Tags: Epilepsy Curr Source Type: research

Epilepsy Benchmarks Area I: Understanding the Causes of the Epilepsies and Epilepsy-Related Neurologic, Psychiatric, and Somatic Conditions.
Authors: Chang BS, Krishnan V, Dulla CG, Jette N, Marsh ED, Dacks PA, Whittemore V, Poduri A, NINDS/AES Epilepsy Research Benchmark Stewards Committee Abstract The 2014 NINDS Benchmarks for Epilepsy Research included area I: Understand the causes of the epilepsies and epilepsy-related neurologic, psychiatric, and somatic conditions. In preparation for the 2020 Curing Epilepsies Conference, where the Benchmarks will be revised, this review will cover scientific progress toward that Benchmark, with emphasize on studies since 2016. PMID: 31965828 [PubMed - as supplied by publisher] (Source: Epilepsy Currents)
Source: Epilepsy Currents - January 23, 2020 Category: Neurology Tags: Epilepsy Curr Source Type: research

2020 Epilepsy Benchmarks Area III: Improved Treatment Options for Controlling Seizures and Epilepsy-Related Conditions Without Side Effects.
Authors: Traynelis SF, Dlugos D, Henshall D, Mefford HC, Rogawski MA, Staley KJ, Dacks PA, Whittemore V, Poduri A, National Institutes of Neurological Disorders and Stroke (NINDS)/American Epilepsy Society (AES) Epilepsy Research Benchmark Stewards Abstract The goals of Epilepsy Benchmark Area III involve identifying areas that are ripe for progress in terms of controlling seizures and patient symptoms in light of the most recent advances in both basic and clinical research. These goals were developed with an emphasis on potential new therapeutic strategies that will reduce seizure burden and improve quality of lif...
Source: Epilepsy Currents - January 23, 2020 Category: Neurology Tags: Epilepsy Curr Source Type: research

Epilepsy Benchmarks Area II: Prevent Epilepsy and Its Progression.
Authors: Binder DK, Boison D, Eid T, Frankel WN, Mingorance A, Smith BN, Dacks PA, Whittemore V, Poduri A, AES/NINDS Epilepsy Benchmarks Stewards Abstract Area II of the 2014 Epilepsy Research Benchmarks aims to establish goals for preventing the development and progression of epilepsy. In this review, we will highlight key advances in Area II since the last summary of research progress and opportunities was published in 2016. We also highlight areas of investigation that began to develop before 2016 and in which additional progress has been made more recently. PMID: 31937124 [PubMed - as supplied by publisher]...
Source: Epilepsy Currents - January 16, 2020 Category: Neurology Tags: Epilepsy Curr Source Type: research

The System xc- Cystine/Glutamate Antiporter: An Exciting Target for Antiepileptogenic Therapy?
Authors: Gallagher M Abstract [Box: see text]. PMID: 31893940 [PubMed - as supplied by publisher] (Source: Epilepsy Currents)
Source: Epilepsy Currents - January 3, 2020 Category: Neurology Tags: Epilepsy Curr Source Type: research

SUDEP: The Worst in Epilepsy and the Hardest to Image.
Authors: Englot DJ Abstract [Box: see text]. PMID: 31884816 [PubMed - as supplied by publisher] (Source: Epilepsy Currents)
Source: Epilepsy Currents - December 31, 2019 Category: Neurology Tags: Epilepsy Curr Source Type: research

Memory Decline Following Epilepsy Surgery: Can We Predict Who Will Pay the Price?
Authors: Barr WB Abstract [Box: see text]. PMID: 31876174 [PubMed - as supplied by publisher] (Source: Epilepsy Currents)
Source: Epilepsy Currents - December 27, 2019 Category: Neurology Tags: Epilepsy Curr Source Type: research

The Benchmarks: Progress and Emerging Priorities in Epilepsy Research.
Authors: Poduri A, Whittemore VH PMID: 31868039 [PubMed - as supplied by publisher] (Source: Epilepsy Currents)
Source: Epilepsy Currents - December 24, 2019 Category: Neurology Tags: Epilepsy Curr Source Type: research

From Standard of Care to Personalized (Art of) Medicine: Two Novel GABA-A Receptor β3 Subunit Mutations Associated With Epilepsy Syndromes.
From Standard of Care to Personalized (Art of) Medicine: Two Novel GABA-A Receptor β3 Subunit Mutations Associated With Epilepsy Syndromes. Epilepsy Curr. 2019 Dec 18;:1535759719889624 Authors: Velisek L Abstract [Box: see text]. PMID: 31852240 [PubMed - as supplied by publisher] (Source: Epilepsy Currents)
Source: Epilepsy Currents - December 20, 2019 Category: Neurology Tags: Epilepsy Curr Source Type: research

Age Is Just a Number: Adults Deserve the Same Access to Genetic Testing as Children.
Authors: Perry MS Abstract [Box: see text]. PMID: 31838893 [PubMed - as supplied by publisher] (Source: Epilepsy Currents)
Source: Epilepsy Currents - December 17, 2019 Category: Neurology Tags: Epilepsy Curr Source Type: research

Mind the Gate to Improve Comorbid Cognitive Impairments in Epilepsy.
Authors: Maguire J Abstract [Box: see text]. PMID: 31814437 [PubMed - as supplied by publisher] (Source: Epilepsy Currents)
Source: Epilepsy Currents - December 10, 2019 Category: Neurology Tags: Epilepsy Curr Source Type: research

Show Me the Meaning of Being Lonely (and Its Effects on Seizure Burden and Comorbidities).
Authors: Lozano L, Christian CA Abstract [Box: see text]. PMID: 31786949 [PubMed - as supplied by publisher] (Source: Epilepsy Currents)
Source: Epilepsy Currents - December 4, 2019 Category: Neurology Tags: Epilepsy Curr Source Type: research

Ketogenic Dietary Therapy Controversies for Its Second Century.
Authors: Kossoff E, Cervenka M Abstract As the ketogenic diet approaches 100 years of continuous use, we reflect on its successes and consider new avenues of research for the next century. One controversial question is regarding whether ketogenic dietary therapies could be successful first-line treatments for epilepsy. Second, is it possible to mimic the mechanisms of action of ketogenic dietary therapy with a drug (eg, a tablet formulation)? A third controversy worthy of future study involves its expanded usage in adults with refractory epilepsy and its role in treating women of childbearing age. Finally, as flexi...
Source: Epilepsy Currents - December 4, 2019 Category: Neurology Tags: Epilepsy Curr Source Type: research

Emerging Roles for Microglial Phagocytic Signaling in Epilepsy.
Authors: Wyatt-Johnson SK, Brewster AL Abstract Microglia are the resident immune cells and professional phagocytes of the central nervous system. However, little is known about the contribution of their phagocytic signaling to the neuropathology and pathophysiology of epilepsy. Here, we summarize and discuss the implications of recent evidence supporting that aberrant microglia phagocytic activity and alterations in phagocytosis signaling molecules occur in association with microglia-neuronal contacts, neuronal/synaptic loss, and spontaneous recurrent seizures in human and preclinical models of epilepsy. This body...
Source: Epilepsy Currents - December 4, 2019 Category: Neurology Tags: Epilepsy Curr Source Type: research

From Point A to Point B, and What it Means for Epilepsy.
Authors: Krook-Magnuson E Abstract [Box: see text]. PMID: 31791134 [PubMed - as supplied by publisher] (Source: Epilepsy Currents)
Source: Epilepsy Currents - December 4, 2019 Category: Neurology Tags: Epilepsy Curr Source Type: research

Earlier Is Not Always Better: Outcomes When Epilepsy Occurs in Early Life Versus Adolescence.
Authors: Nickels K Abstract [Box: see text]. PMID: 31791135 [PubMed - as supplied by publisher] (Source: Epilepsy Currents)
Source: Epilepsy Currents - December 4, 2019 Category: Neurology Tags: Epilepsy Curr Source Type: research

Network Changes after Epilepsy Surgery: It's Time to Reconnect.
Authors: Englot DJ Abstract [Box: see text]. PMID: 31749378 [PubMed - as supplied by publisher] (Source: Epilepsy Currents)
Source: Epilepsy Currents - November 23, 2019 Category: Neurology Tags: Epilepsy Curr Source Type: research

What Do We Want? INHIBITION. When Do We Want it? NOW.
Authors: Maguire JL Abstract [Box: see text]. PMID: 31718334 [PubMed] (Source: Epilepsy Currents)
Source: Epilepsy Currents - November 14, 2019 Category: Neurology Tags: Epilepsy Curr Source Type: research

Seizing the Neuroinflammatory Target: The Quest Continues.
Authors: Sharma AA, Szaflarski JP Abstract [Box: see text]. PMID: 31718335 [PubMed] (Source: Epilepsy Currents)
Source: Epilepsy Currents - November 14, 2019 Category: Neurology Tags: Epilepsy Curr Source Type: research

American Epilepsy Society (AES): Written Comments to Norman E. "Ned" Sharpless, MD, Acting Commissioner of Food and Drugs, U.S. Food and Drug Administration (FDA), Department of Health and Human Services (HHS): on Docket ID# FDA-2019-N-1482, Scientific Data and Information about Products Containing Cannabis or Cannabis-Derived Compounds; Public Hearing; Request for Comments: Submitted on: July 16, 2019.
American Epilepsy Society (AES): Written Comments to Norman E. "Ned" Sharpless, MD, Acting Commissioner of Food and Drugs, U.S. Food and Drug Administration (FDA), Department of Health and Human Services (HHS): on Docket ID# FDA-2019-N-1482, Scientific Data and Information about Products Containing Cannabis or Cannabis-Derived Compounds; Public Hearing; Request for Comments: Submitted on: July 16, 2019. Epilepsy Curr. 2019 Oct 22;:1535759719878716 Authors: Welty TE, Chapman KE, Faught RE, Kotloski RJ PMID: 31640419 [PubMed - as supplied by publisher] (Source: Epilepsy Currents)
Source: Epilepsy Currents - October 24, 2019 Category: Neurology Tags: Epilepsy Curr Source Type: research

Finally, Some Neurophysiologic Good News-Favorable Prognosis in Coma.
Authors: Husain AM Abstract [Box: see text]. PMID: 31608668 [PubMed - as supplied by publisher] (Source: Epilepsy Currents)
Source: Epilepsy Currents - October 15, 2019 Category: Neurology Tags: Epilepsy Curr Source Type: research