Anxiolytic potential of resveratrol and rufinamide combination by modulating GABA-ergic transmission: insights from experiments, molecular docking and dynamics simulations
J Physiol Pharmacol. 2023 Oct;74(5). doi: 10.26402/jpp.2023.5.02. Epub 2023 Dec 6.ABSTRACTResveratrol is a polyphenolic phytocompound known to possess anxiolytic-like effects but its impact on central gammaaminobutyric acid (GABA) modulation has never been explored. The purpose of this study was to analyze the anxiolytic-like effects of resveratrol alone and in combination with rufinamide, an antiepileptic drug which has never been studied for its anxiolytic potential. The BALB/c mice were tested in a battery of behavior testing after administration of resveratrol (50 mg/kg) and rufinamide (50 mg/kg) alone and in combinati...
Source: J Physiol Pharmacol - December 12, 2023 Category: Drugs & Pharmacology Authors: A Parveen F Alqahtani S Javaid W Ashraf F Siddique R Rawat M F Rasool T Ahmad F Alasmari I Imran Source Type: research
Anxiolytic potential of resveratrol and rufinamide combination by modulating GABA-ergic transmission: insights from experiments, molecular docking and dynamics simulations
J Physiol Pharmacol. 2023 Oct;74(5). doi: 10.26402/jpp.2023.5.02. Epub 2023 Dec 6.ABSTRACTResveratrol is a polyphenolic phytocompound known to possess anxiolytic-like effects but its impact on central gammaaminobutyric acid (GABA) modulation has never been explored. The purpose of this study was to analyze the anxiolytic-like effects of resveratrol alone and in combination with rufinamide, an antiepileptic drug which has never been studied for its anxiolytic potential. The BALB/c mice were tested in a battery of behavior testing after administration of resveratrol (50 mg/kg) and rufinamide (50 mg/kg) alone and in combinati...
Source: Journal of Physiology and Pharmacology - December 12, 2023 Category: Drugs & Pharmacology Authors: A Parveen F Alqahtani S Javaid W Ashraf F Siddique R Rawat M F Rasool T Ahmad F Alasmari I Imran Source Type: research
Anxiolytic potential of resveratrol and rufinamide combination by modulating GABA-ergic transmission: insights from experiments, molecular docking and dynamics simulations
J Physiol Pharmacol. 2023 Oct;74(5). doi: 10.26402/jpp.2023.5.02. Epub 2023 Dec 6.ABSTRACTResveratrol is a polyphenolic phytocompound known to possess anxiolytic-like effects but its impact on central gammaaminobutyric acid (GABA) modulation has never been explored. The purpose of this study was to analyze the anxiolytic-like effects of resveratrol alone and in combination with rufinamide, an antiepileptic drug which has never been studied for its anxiolytic potential. The BALB/c mice were tested in a battery of behavior testing after administration of resveratrol (50 mg/kg) and rufinamide (50 mg/kg) alone and in combinati...
Source: J Physiol Pharmacol - December 12, 2023 Category: Drugs & Pharmacology Authors: A Parveen F Alqahtani S Javaid W Ashraf F Siddique R Rawat M F Rasool T Ahmad F Alasmari I Imran Source Type: research
Anxiolytic potential of resveratrol and rufinamide combination by modulating GABA-ergic transmission: insights from experiments, molecular docking and dynamics simulations
J Physiol Pharmacol. 2023 Oct;74(5). doi: 10.26402/jpp.2023.5.02. Epub 2023 Dec 6.ABSTRACTResveratrol is a polyphenolic phytocompound known to possess anxiolytic-like effects but its impact on central gammaaminobutyric acid (GABA) modulation has never been explored. The purpose of this study was to analyze the anxiolytic-like effects of resveratrol alone and in combination with rufinamide, an antiepileptic drug which has never been studied for its anxiolytic potential. The BALB/c mice were tested in a battery of behavior testing after administration of resveratrol (50 mg/kg) and rufinamide (50 mg/kg) alone and in combinati...
Source: Journal of Physiology and Pharmacology - December 12, 2023 Category: Drugs & Pharmacology Authors: A Parveen F Alqahtani S Javaid W Ashraf F Siddique R Rawat M F Rasool T Ahmad F Alasmari I Imran Source Type: research
Anxiolytic potential of resveratrol and rufinamide combination by modulating GABA-ergic transmission: insights from experiments, molecular docking and dynamics simulations
J Physiol Pharmacol. 2023 Oct;74(5). doi: 10.26402/jpp.2023.5.02. Epub 2023 Dec 6.ABSTRACTResveratrol is a polyphenolic phytocompound known to possess anxiolytic-like effects but its impact on central gammaaminobutyric acid (GABA) modulation has never been explored. The purpose of this study was to analyze the anxiolytic-like effects of resveratrol alone and in combination with rufinamide, an antiepileptic drug which has never been studied for its anxiolytic potential. The BALB/c mice were tested in a battery of behavior testing after administration of resveratrol (50 mg/kg) and rufinamide (50 mg/kg) alone and in combinati...
Source: J Physiol Pharmacol - December 12, 2023 Category: Drugs & Pharmacology Authors: A Parveen F Alqahtani S Javaid W Ashraf F Siddique R Rawat M F Rasool T Ahmad F Alasmari I Imran Source Type: research
Anxiolytic potential of resveratrol and rufinamide combination by modulating GABA-ergic transmission: insights from experiments, molecular docking and dynamics simulations
J Physiol Pharmacol. 2023 Oct;74(5). doi: 10.26402/jpp.2023.5.02. Epub 2023 Dec 6.ABSTRACTResveratrol is a polyphenolic phytocompound known to possess anxiolytic-like effects but its impact on central gammaaminobutyric acid (GABA) modulation has never been explored. The purpose of this study was to analyze the anxiolytic-like effects of resveratrol alone and in combination with rufinamide, an antiepileptic drug which has never been studied for its anxiolytic potential. The BALB/c mice were tested in a battery of behavior testing after administration of resveratrol (50 mg/kg) and rufinamide (50 mg/kg) alone and in combinati...
Source: Journal of Physiology and Pharmacology - December 12, 2023 Category: Drugs & Pharmacology Authors: A Parveen F Alqahtani S Javaid W Ashraf F Siddique R Rawat M F Rasool T Ahmad F Alasmari I Imran Source Type: research
Anxiolytic potential of resveratrol and rufinamide combination by modulating GABA-ergic transmission: insights from experiments, molecular docking and dynamics simulations
J Physiol Pharmacol. 2023 Oct;74(5). doi: 10.26402/jpp.2023.5.02. Epub 2023 Dec 6.ABSTRACTResveratrol is a polyphenolic phytocompound known to possess anxiolytic-like effects but its impact on central gammaaminobutyric acid (GABA) modulation has never been explored. The purpose of this study was to analyze the anxiolytic-like effects of resveratrol alone and in combination with rufinamide, an antiepileptic drug which has never been studied for its anxiolytic potential. The BALB/c mice were tested in a battery of behavior testing after administration of resveratrol (50 mg/kg) and rufinamide (50 mg/kg) alone and in combinati...
Source: J Physiol Pharmacol - December 12, 2023 Category: Drugs & Pharmacology Authors: A Parveen F Alqahtani S Javaid W Ashraf F Siddique R Rawat M F Rasool T Ahmad F Alasmari I Imran Source Type: research
Anxiolytic potential of resveratrol and rufinamide combination by modulating GABA-ergic transmission: insights from experiments, molecular docking and dynamics simulations
J Physiol Pharmacol. 2023 Oct;74(5). doi: 10.26402/jpp.2023.5.02. Epub 2023 Dec 6.ABSTRACTResveratrol is a polyphenolic phytocompound known to possess anxiolytic-like effects but its impact on central gammaaminobutyric acid (GABA) modulation has never been explored. The purpose of this study was to analyze the anxiolytic-like effects of resveratrol alone and in combination with rufinamide, an antiepileptic drug which has never been studied for its anxiolytic potential. The BALB/c mice were tested in a battery of behavior testing after administration of resveratrol (50 mg/kg) and rufinamide (50 mg/kg) alone and in combinati...
Source: Journal of Physiology and Pharmacology - December 12, 2023 Category: Drugs & Pharmacology Authors: A Parveen F Alqahtani S Javaid W Ashraf F Siddique R Rawat M F Rasool T Ahmad F Alasmari I Imran Source Type: research
Anxiolytic potential of resveratrol and rufinamide combination by modulating GABA-ergic transmission: insights from experiments, molecular docking and dynamics simulations
J Physiol Pharmacol. 2023 Oct;74(5). doi: 10.26402/jpp.2023.5.02. Epub 2023 Dec 6.ABSTRACTResveratrol is a polyphenolic phytocompound known to possess anxiolytic-like effects but its impact on central gammaaminobutyric acid (GABA) modulation has never been explored. The purpose of this study was to analyze the anxiolytic-like effects of resveratrol alone and in combination with rufinamide, an antiepileptic drug which has never been studied for its anxiolytic potential. The BALB/c mice were tested in a battery of behavior testing after administration of resveratrol (50 mg/kg) and rufinamide (50 mg/kg) alone and in combinati...
Source: J Physiol Pharmacol - December 12, 2023 Category: Drugs & Pharmacology Authors: A Parveen F Alqahtani S Javaid W Ashraf F Siddique R Rawat M F Rasool T Ahmad F Alasmari I Imran Source Type: research
Anxiolytic potential of resveratrol and rufinamide combination by modulating GABA-ergic transmission: insights from experiments, molecular docking and dynamics simulations
J Physiol Pharmacol. 2023 Oct;74(5). doi: 10.26402/jpp.2023.5.02. Epub 2023 Dec 6.ABSTRACTResveratrol is a polyphenolic phytocompound known to possess anxiolytic-like effects but its impact on central gammaaminobutyric acid (GABA) modulation has never been explored. The purpose of this study was to analyze the anxiolytic-like effects of resveratrol alone and in combination with rufinamide, an antiepileptic drug which has never been studied for its anxiolytic potential. The BALB/c mice were tested in a battery of behavior testing after administration of resveratrol (50 mg/kg) and rufinamide (50 mg/kg) alone and in combinati...
Source: Journal of Physiology and Pharmacology - December 12, 2023 Category: Drugs & Pharmacology Authors: A Parveen F Alqahtani S Javaid W Ashraf F Siddique R Rawat M F Rasool T Ahmad F Alasmari I Imran Source Type: research
Anxiolytic potential of resveratrol and rufinamide combination by modulating GABA-ergic transmission: insights from experiments, molecular docking and dynamics simulations
J Physiol Pharmacol. 2023 Oct;74(5). doi: 10.26402/jpp.2023.5.02. Epub 2023 Dec 6.ABSTRACTResveratrol is a polyphenolic phytocompound known to possess anxiolytic-like effects but its impact on central gammaaminobutyric acid (GABA) modulation has never been explored. The purpose of this study was to analyze the anxiolytic-like effects of resveratrol alone and in combination with rufinamide, an antiepileptic drug which has never been studied for its anxiolytic potential. The BALB/c mice were tested in a battery of behavior testing after administration of resveratrol (50 mg/kg) and rufinamide (50 mg/kg) alone and in combinati...
Source: J Physiol Pharmacol - December 12, 2023 Category: Drugs & Pharmacology Authors: A Parveen F Alqahtani S Javaid W Ashraf F Siddique R Rawat M F Rasool T Ahmad F Alasmari I Imran Source Type: research
Anxiolytic potential of resveratrol and rufinamide combination by modulating GABA-ergic transmission: insights from experiments, molecular docking and dynamics simulations
J Physiol Pharmacol. 2023 Oct;74(5). doi: 10.26402/jpp.2023.5.02. Epub 2023 Dec 6.ABSTRACTResveratrol is a polyphenolic phytocompound known to possess anxiolytic-like effects but its impact on central gammaaminobutyric acid (GABA) modulation has never been explored. The purpose of this study was to analyze the anxiolytic-like effects of resveratrol alone and in combination with rufinamide, an antiepileptic drug which has never been studied for its anxiolytic potential. The BALB/c mice were tested in a battery of behavior testing after administration of resveratrol (50 mg/kg) and rufinamide (50 mg/kg) alone and in combinati...
Source: J Physiol Pharmacol - December 12, 2023 Category: Drugs & Pharmacology Authors: A Parveen F Alqahtani S Javaid W Ashraf F Siddique R Rawat M F Rasool T Ahmad F Alasmari I Imran Source Type: research
Anxiolytic potential of resveratrol and rufinamide combination by modulating GABA-ergic transmission: insights from experiments, molecular docking and dynamics simulations
J Physiol Pharmacol. 2023 Oct;74(5). doi: 10.26402/jpp.2023.5.02. Epub 2023 Dec 6.ABSTRACTResveratrol is a polyphenolic phytocompound known to possess anxiolytic-like effects but its impact on central gammaaminobutyric acid (GABA) modulation has never been explored. The purpose of this study was to analyze the anxiolytic-like effects of resveratrol alone and in combination with rufinamide, an antiepileptic drug which has never been studied for its anxiolytic potential. The BALB/c mice were tested in a battery of behavior testing after administration of resveratrol (50 mg/kg) and rufinamide (50 mg/kg) alone and in combinati...
Source: Journal of Physiology and Pharmacology - December 12, 2023 Category: Drugs & Pharmacology Authors: A Parveen F Alqahtani S Javaid W Ashraf F Siddique R Rawat M F Rasool T Ahmad F Alasmari I Imran Source Type: research
Anxiolytic potential of resveratrol and rufinamide combination by modulating GABA-ergic transmission: insights from experiments, molecular docking and dynamics simulations
J Physiol Pharmacol. 2023 Oct;74(5). doi: 10.26402/jpp.2023.5.02. Epub 2023 Dec 6.ABSTRACTResveratrol is a polyphenolic phytocompound known to possess anxiolytic-like effects but its impact on central gammaaminobutyric acid (GABA) modulation has never been explored. The purpose of this study was to analyze the anxiolytic-like effects of resveratrol alone and in combination with rufinamide, an antiepileptic drug which has never been studied for its anxiolytic potential. The BALB/c mice were tested in a battery of behavior testing after administration of resveratrol (50 mg/kg) and rufinamide (50 mg/kg) alone and in combinati...
Source: J Physiol Pharmacol - December 12, 2023 Category: Drugs & Pharmacology Authors: A Parveen F Alqahtani S Javaid W Ashraf F Siddique R Rawat M F Rasool T Ahmad F Alasmari I Imran Source Type: research
